Management of diabetes mellitus type-2 in the geriatric population: Current perspectives

Journal of Pharmacy and Bioallied Sciences

Volumn 6, Issue 3, 2014, Pages 151-157

  Bajwa, Sukhminder Jit Singh ^a   Sehgal, Vishal ^b   Kalra, Sanjay ^c   Baruah, Manash Pratim ^d  

^a GIAN SAGAR MEDICAL COLLEGE AND HOSPITAL   (India)

^b Wright Center for Graduate Medical Education   (United States)

^c India   (India)

^d Department of Endocrinology ECXEL Center   (India)

Author keywords

Chronic kidney disease; diabetes mellitus; geriatric; new onset diabetes after transplant

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN; INSULIN ASPART; INSULIN DETEMIR; INSULIN GLARGINE; INSULIN GLULISINE; INSULIN LISPRO;

AGING; BLOOD GLUCOSE MONITORING; CHRONIC PAIN; COGNITIVE DEFECT; COST EFFECTIVENESS ANALYSIS; DEPRESSION; DISEASE ASSOCIATION; DRUG EFFECT; FALLING; FRAIL ELDERLY; GERIATRIC CARE; GERIATRIC DISORDER; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN ANALYSIS; HUMAN; HYPERGLYCEMIA; INTENSIVE CARE; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTPATIENT CARE; PERIOPERATIVE PERIOD; POLYPHARMACY; POPULATION RESEARCH; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SURGICAL TECHNIQUE; TREATMENT OUTCOME; TREATMENT PLANNING; URINE INCONTINENCE;

EID: 84921910555     PISSN: None     EISSN: 09757406     Source Type: Journal    
DOI: 10.4103/0975-7406.130956     Document Type: Review

References (76)

1. Zarowitz BJ. Management of diabetes mellitus in older persons. Geriatr Nurs 2006;27:77-82.
2. Liao EP. Patterns of medication initiation in newly diagnosed diabetes mellitus: Quality and cost implications. Am J Med 2012;125:S1-2.
3. Meneilly GS, Elliott T, Tessier D, Hards L, Tildesley H. NIDDM in the elderly. Diabetes Care 1996;19:1320-5.
4. Rizvi AA. Management of diabetes in older adults. Am J Med Sci 2007;333:35-47.
5. Moritz DJ, Ostfeld AM, Blazer D 2nd, Curb D, Taylor JO, Wallace RB. The health burden of diabetes for the elderly in four communities. Public Health Rep 1994;109:782-90.
6. Kalra S, Kalra B, Saluja S. Dietary management in geriatric patients of diabetes mellitus: Special considerations. Internet J Geriatr Gerontol 2009;5.
7. Abbatecola AM, Paolisso G, Corsonello A, Bustacchini S, Lattanzio F. Antidiabetic oral treatment in older people: Does frailty matter? Drugs Aging 2009;26 Suppl 1:53-62.
8. Blaum CS, Ofstedal MB, Langa KM, Wray LA. Functional status and health outcomes in older americans with diabetes mellitus. J Am Geriatr Soc 2003;51:745-53.
9. Saczynski JS, Jónsdóttir MK, Garcia ME, Jonsson PV, Peila R, Eiriksdottir G, et al. Cognitive impairment: An increasingly important complication of type 2 diabetes: The age, gene/environment susceptibility-Reykjavik study. Am J Epidemiol 2008;168:1132-9.
10. Kalra S, Bajwa SS, Baruah M, Sehgal V. Hypoglycaemia in anesthesiology practice: Diagnostic, preventive, and management strategies. Saudi J Anaesth 2013;7:447-52.
11. Black SA, Markides KS. Depressive symptoms and mortality in older Mexican Americans. Ann Epidemiol 1999;9:45-52.
12. Koliaki C, Doupis J. Linagliptin/Metformin fixed-dose combination treatment: A dual attack to type 2 diabetes pathophysiology. Adv Ther 2012;29:993-1004.
13. Sehgal V, Bajwa SS, Sehgal R, Bajaj A, Khaira U, Kresse V. Polypharmacy and potentially inappropriate medication use as the precipitating factor in readmissions to the hospital. J Fam Med Prim Care 2013;2:194-9.
14. Bajwa SS, Panda A. Alternative medicine and anesthesia: Implications and considerations in daily practice. Ayu 2012;33:475-80.
15. Basevi V, Di Mario S, Morciano C, Nonino F, Magrini N. American Diabetes Association. Standards of medical care in diabetes-2011. Diabetes Care 2011;34 Suppl 1:S11-61.
16. Schwarz PE. Prediabetes: High risk factor for diabetes mellitus type 2?-Successful prevention with early interventions for lifestyle modification. Dtsch Med Wochenschr 2012;137:1788.
17. Herman WH, Fajans SS. Hemoglobin A1c for the diagnosis of diabetes: Practical considerations. Pol Arch Med Wewn 2010;120:37-40.
18. Shibata K, Suzuki S, Sato J, Ohsawa I, Goto S, Iritani I, et al. Diagnostic accuracy of glycohemoglobin A1c (HbA1c) for postprandial hyperglycemia was equivalent to that of fasting blood glucose. J Clin Epidemiol 2005;58:1052-7.
19. Brown JN, Kemp DW, Brice KR. Class effect of erythropoietin therapy on hemoglobin A (1c) in a patient with diabetes mellitus and chronic kidney disease not undergoing hemodialysis. Pharmacotherapy 2009;29:468-72.
20. Ng JM, Cooke M, Bhandari S, Atkin SL, Kilpatrick ES. The effect of iron and erythropoietin treatment on the A1C of patients with diabetes and chronic kidney disease. Diabetes Care 2010;33:2310-3.
21. Abbatecola AM, Paolisso G. Diabetes care targets in older persons. Diabetes Res Clin Pract 2009;86 Suppl 1:S35-40.
22. Inkster B, Zammitt NN, Frier BM. Drug-induced hypoglycaemia in type 2 diabetes. Expert Opin Drug Saf 2012;11:597-614.
23. Suh DC, Kim CM, Choi IS, Plauschinat CA. Comorbid conditions and glycemic control in elderly patients with type 2 diabetes mellitus, 1988 to 1994 to 1999 to 2004. J Am Geriatr Soc 2008;56:484-92.
24. Baruah MP, Kalra S, Unnikrishnan AG, Raza SA, Somasundaram N, John M, et al. Management of hyperglycemia in geriatric patients with diabetes mellitus: South Asian consensus guidelines. Indian J Endocrinol Metab 2011;15:75-90.
25. Brunton SA. Hypoglycemic potential of current and emerging pharmacotherapies in type 2 diabetes mellitus. Postgrad Med 2012;124:74-83.
26. Bao YQ, Zhou J, Zhou M, Cheng YJ, Lu W, Pan XP, et al. Glipizide controlled-release tablets, with or without acarbose, improve glycaemic variability in newly diagnosed Type 2 diabetes. Clin Exp Pharmacol Physiol 2010;37:564-8.
27. Skoff RA, Waterbury NV, Shaw RF, Egge JA, Cantrell M. Glycemic control and hypoglycemia in Veterans Health Administration patients converted from glyburide to glipizide. J Manag Care Pharm 2011;17:664-71.
28. Evans JM, Ogston SA, Emslie-Smith A, Morris AD. Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: A comparison of patients treated with sulfonylureas and metformin. Diabetologia 2006;49:930-6.
29. Colhoun HM, Livingstone SJ, Looker HC, Morris AD, Wild SH, Lindsay RS, et al. Scottish Diabetes Research Network Epidemiology Group. Hospitalised hip fracture risk with rosiglitazone and pioglitazone use compared with other glucose-lowering drugs. Diabetologia 2012;55:2929-37.
30. Scott LJ. Repaglinide: A review of its use in type 2 diabetes mellitus. Drugs 2012;72:249-72.
31. Landgraf R. Meglitinide analogues in the treatment of type 2 diabetes mellitus. Drugs Aging 2000;17:411-25.
32. Kumar S, Narwal S, Kumar V, Prakash O. Alpha-glucosidase inhibitors from plants: A natural approach to treat diabetes. Pharmacogn Rev 2011;5:19-29.
33. Bashir MI, Pathan MF, Raza SA, Ahmad J, Khan AK, Ishtiaq O, et al. Role of oral hypoglycemic agents in the management of type 2 diabetes mellitus during Ramadan. Indian J Endocrinol Metab 2012;16:503-7.
34. Yoshida T, Akahoshi F, Sakashita H, Kitajima H, Nakamura M, Sonda S, et a l . Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl) piperazin-1-yl] pyrrolidin-2-y lcarbonyl] thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorg Med Chem 2012;20:5705-19.
35. Thearle M, Brillantes AM. Unique characteristics of the geriatric diabetic population and the role for therapeutic strategies that enhance glucagon-like peptide-1 activity. Curr Opin Clin Nutr Metab Care 2005;8:9-16.
36. VanDeKoppel S, Choe HM, Sweet BV. Managed care perspective on three new agents for type 2 diabetes. J Manag Care Pharm 2008;14:363-80.
37. Berlie H, Hurren KM, Pinelli NR. Glucagon-like peptide-1 receptor agonists as add-on therapy to basal insulin in patients with type 2 diabetes: A systematic review. Diabetes Metab Syndr Obes 2012;5:165-74.
38. Neumiller JJ, Setter SM. Pharmacologic management of the older patient with type 2 diabetes mellitus. Am J Geriatr Pharmacother 2009;7:324-42.
39. Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, et al. Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32:193-203.
40. Nathan DM. Clinical practice. Initial management of glycemia in type 2 diabetes mellitus. N Engl J Med 2002;347:1342-9.
41. Hendra TJ. Starting insulin therapy in elderly patients. J R Soc Med 2002;95:453-5.
42. Bajwa SJ, Kalra S, Baruah M, Bajwa SK. Insulin injection guidelines for peri-operative and critically ill patients. J Sci Soc 2013;40:68-75.
43. Kalra S, Balhara YP, Baruah MP, Chadha M, Chandalia HB, Chowdhury S, et al. Forum for injection techniques, India: The first Indian recommendations for best practice in insulin injection technique. Indian J Endocrinol Metab 2012;16:876-85.
44. Bajwa SJ, Kalra S, Baruah MP, Bajwa SK. An acute need for awareness of insulin injection guidelines in operative and intensive care units. Anesth Essays Res 2013;7:1-3.
45. Strojek K, Bebakar WM, Khutsoane DT, Pesic M, Mahelova S, Thomsen HF, et al. Once-daily initiation with biphasic insulin aspart 30 versus insulin glargine in patients with type 2 diabetes inadequately controlled with oral drugs: An open-label, multinational RCT. Curr Med Res Opin 2009;25:2887-94.
46. Joshi SR, Kalra S, Badgandi M, Rao YS, Chawla M. Designer insulins regimens in clinical practice-pilot multicenter Indian study. J Assoc Physicians India 2005;53:775-9.
47. Unnikrishnan AG, Tibaldi J, Hadley-Brown M, Krentz AJ, Ligthelm R, Damci T, et al. Practical guidance on intensification of insulin therapy with BIAsp 30: A consensus statement. Int J Clin Pract 2009;63:1571-7.
48. Wong J, Yue D. Starting insulin treatment in type 2 diabetes. Aust Preser 2004;27:93-6.
49. Floyd B, Chandra P, Hall S, Phillips C, Alema-Mensah E, Strayhorn G, et al. Comparative analysis of the efficacy of continuous glucose monitoring and self-monitoring of blood glucose in type 1 diabetes mellitus. J Diabetes Sci Technol 2012;6:1094-102.
50. Nomura K, Inoue K, Akimoto K. A two-step screening, measurement of HbA1c in association with FPG, may be useful in predicting diabetes. PLoS One 2012;7:e36309.
51. Herman WH, Ma Y, Uwaifo G, Haffner S, Kahn SE, Horton ES, et al. Diabetes Prevention Program Research Group. Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention Program. Diabetes Care 2007;30:2453-7.
52. Alam T, Weintraub N, Weinreb J. What is the proper use of hemoglobin A1c monitoring in the elderly? J Am Med Dir Assoc 2006;7 Suppl 3:S60-4, 59.
53. Tessier D, Avila-Funes JA, Aguilar-Navarro S. Specific needs in the care of elderly with diabetes mellitus. Rev Invest Clin 2010;62:323-6.
54. Khalam A, Dilip C, Shinu C. Drug use evaluation of diabetes mellitus in hospitalized patients of a tertiary care referral hospital. J Basic Clin Physiol Pharmacol 2012;23:173-7.
55. Association Diabetes Association. Standards of medical care in diabetes-2012. Diabetes Care 2012;35 Suppl 1:S11-63.
56. Sinclair AJ. Diabetes in the elderly: A perspective from the United Kingdom. Clin Geriatr Med 1999;15:225-37.
57. Marquess JG. The elderly and diabetes: An age trend and an epidemic converging. Consult Pharm 2008;23 (Suppl B):5-11.
58. Khan R, Foster GR, Chowdhury TA. Managing diabetes in patients with chronic liver disease. Postgrad Med 2012;124:130-7.
59. Bhattacharyya SK, Else BA. Medical costs of managed care in patients with type 2 diabetes mellitus. Clin Ther 1999;21:2131-42.
60. McCowen KC, Malhotra A, Bistrian BR. Stress-induced hyperglycemia. Crit Care Clin 2001;17:107-24.
61. van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001;345:1359-67.
62. Lazar HL. How important is glycemic control during coronary artery bypass? Adv Surg 2012;46:219-35.
63. Pichardo-Lowden A, Gabbay RA. Management of hyperglycemia during the perioperative period. Curr Diab Rep 2012;12:108-18.
64. Arinzon Z, Fidelman Z, Berner YN, Adunsky A. Infection-related hypoglycemia in institutionalized demented patients: A comparative study of diabetic and nondiabetic patients. Arch Gerontol Geriatr 2007;45:191-200.
65. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2006;354:449-61.
66. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, et al. German Competence Network Sepsis [SepNet]. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008;358:125-39.
67. Bajwa SJ. Intensive care management of critically sick diabetic patients. Indian J Endocrinol Metab 2011;15:349-50.
68. Bajwa SS, Kalra S. Glycaemic control in ICU. In: Bajaj S, et al. editors. Vol 1. Endocrine Society of India Manual of Clinical Endocrinology; 2012. p. 115-23.
69. Kosiborod M, Inzucchi SE, Krumholz HM, Xiao L, Jones PG, Fiske S, et al. Glucometrics in patients hospitalized with acute myocardial infarction: Defining the optimal outcomes-based measure of risk. Circulation 2008;117:1018-27.
70. Deedwania P, Kosiborod M, Barrett E, Ceriello A, Isley W, Mazzone T, et al. American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism. Hyperglycemia and acute coronary syndrome: A scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2008;117:1610-9.
71. Pinto DS, Skolnick AH, Kirtane AJ, Murphy SA, Barron HV, Giugliano RP, et al. TIMI Study Group. U-shaped relationship of blood glucose with adverse outcomes among patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol 2005;46:178-80.
72. Svensson AM, McGuire DK, Abrahamsson P, Dellborg M. Association between hyper-and hypoglycaemia and 2 year all-cause mortality risk in diabetic patients with acute coronary events. Eur Heart J 2005;26:1255-61.
73. Malmberg K, Rydén L, Wedel H, Birkeland K, Bootsma A, Dickstein K, et al. DIGAMI 2 Investigators. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): Effects on mortality and morbidity. Eur Heart J 2005;26:650-61.
74. Bajwa SS, Kalra S. Diabeto-anaesthesia: A subspecialty needing endocrine introspection. Indian J Anaesth 2012;56:513-7.
75. Reider J, Lin H, DiNardo M. Efficacy of a guideline for treatment of corticosteroid related hyperglycemia in the hospital. Diabetes 2008;57:A574.
76. Paiva I, Baptista C, Ribeiro C, Leitao P, Carvalheiro M. Diabetes in the elderly: Our reality. Acta Med Port 2006;19:79-84.