메뉴 건너뛰기




Volumn 27, Issue 2, 2014, Pages 268-283

Is there a role for vitamin C in preventing osteoporosis and fractures? A review of the potential underlying mechanisms and current epidemiological evidence

Author keywords

Ascorbic acid; Bone mineral density; Collagen; Fracture risk; Vitamin C

Indexed keywords

ASCORBIC ACID; COLLAGEN;

EID: 84921904726     PISSN: 09544224     EISSN: 14752700     Source Type: Journal    
DOI: 10.1017/S0954422414000195     Document Type: Review
Times cited : (43)

References (91)
  • 1
    • 0027222768 scopus 로고
    • Consensus development conference: Diagnosis, prophylaxis, and treatment of osteoporosis
    • Anonymous
    • Anonymous (1993) Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 94, 646-650.
    • (1993) Am J Med , vol.94 , pp. 646-650
  • 2
    • 0031040829 scopus 로고    scopus 로고
    • Who are candidates for prevention and treatment for osteoporosis
    • European Foundation for Osteoporosis and National Osteoporosis Foundation (1997) Who are candidates for prevention and treatment for osteoporosis. Osteoporos Int 7, 1-6.
    • (1997) Osteoporos Int , vol.7 , pp. 1-6
  • 3
    • 33750209491 scopus 로고    scopus 로고
    • An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
    • Johnell O & Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17, 1726-1733.
    • (2006) Osteoporos Int , vol.17 , pp. 1726-1733
    • Johnell, O.1    Kanis, J.A.2
  • 6
    • 0030898212 scopus 로고    scopus 로고
    • Nutritional influences on bone mineral density: A cross-sectional study in premenopausal women
    • New SA, Bolton-Smith C, Grubb DA, et al. (1997) Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr 65, 1831-1839.
    • (1997) Am J Clin Nutr , vol.65 , pp. 1831-1839
    • New, S.A.1    Bolton-Smith, C.2    Grubb, D.A.3
  • 7
    • 0032961761 scopus 로고    scopus 로고
    • Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women
    • Tucker KL, Hannan MT, Chen H, et al. (1999) Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 69, 727-736.
    • (1999) Am J Clin Nutr , vol.69 , pp. 727-736
    • Tucker, K.L.1    Hannan, M.T.2    Chen, H.3
  • 8
    • 0033982885 scopus 로고    scopus 로고
    • Dietary influences on bone mass and bone metabolism: Further evidence of a positive link between fruit and vegetable consumption and bone health?
    • New SA, Robins SP, Campbell MK, et al. (2000) Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr 71, 142-151.
    • (2000) Am J Clin Nutr , vol.71 , pp. 142-151
    • New, S.A.1    Robins, S.P.2    Campbell, M.K.3
  • 9
    • 33745622459 scopus 로고    scopus 로고
    • Fruit and vegetable intakes and bone mineral status: A cross sectional study in 5 age and sex cohorts
    • Prynne CJ, Mishra GD, O'Connell MA, et al. (2006) Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts. Am J Clin Nutr 83, 1420-1428.
    • (2006) Am J Clin Nutr , vol.83 , pp. 1420-1428
    • Prynne, C.J.1    Mishra, G.D.2    O'Connell, M.A.3
  • 10
    • 38149023195 scopus 로고    scopus 로고
    • The balance of bone health: Tipping the scales in favor of potassium-rich, bicarbonate-rich foods
    • Lanham-New SA (2008) The balance of bone health: tipping the scales in favor of potassium-rich, bicarbonate-rich foods. J Nutr 138, 172S-177S.
    • (2008) J Nutr , vol.138 , pp. 172S-177S
    • Lanham-New, S.A.1
  • 11
    • 0031865039 scopus 로고    scopus 로고
    • The relation of dietary vitamin C intake to bone mineral density: Results from the PEPI study
    • Hall SL & Greendale GA (1998) The relation of dietary vitamin C intake to bone mineral density: results from the PEPI study. Calcif Tissue Int 63, 183-189.
    • (1998) Calcif Tissue Int , vol.63 , pp. 183-189
    • Hall, S.L.1    Greendale, G.A.2
  • 12
    • 0035449963 scopus 로고    scopus 로고
    • Relation of ascorbic acid to bone mineral density and self-reported fractures among US adults
    • Simon JA & Hudes ES (2001) Relation of ascorbic acid to bone mineral density and self-reported fractures among US adults. Am J Epidemiol 154, 427-433.
    • (2001) Am J Epidemiol , vol.154 , pp. 427-433
    • Simon, J.A.1    Hudes, E.S.2
  • 14
    • 84921910562 scopus 로고    scopus 로고
    • [Food Standards Agency and Institute of Food Research, editor]. Cambridge: Royal Society of Chemistry
    • Royal Society of Chemistry (2002) McCance and Widdow-son's the Composition of Foods, 6th summary ed., [Food Standards Agency and Institute of Food Research, editor]. Cambridge: Royal Society of Chemistry.
    • (2002) McCance and Widdow-son's the Composition of Foods, 6th Summary Ed
  • 15
    • 0029125787 scopus 로고
    • Alteration of bone status with ascorbic acid deficiency in ODS (osteogenic disorder Shionogi) rats
    • Togari A, Arai M, Nakagawa S, et al. (1995) Alteration of bone status with ascorbic acid deficiency in ODS (osteogenic disorder Shionogi) rats. Jpn J Pharmacol 68, 255-261.
    • (1995) Jpn J Pharmacol , vol.68 , pp. 255-261
    • Togari, A.1    Arai, M.2    Nakagawa, S.3
  • 16
    • 0036787988 scopus 로고    scopus 로고
    • Morphological influence of ascorbic acid deficiency on endochondral ossification in osteogenic disorder Shionogi rat
    • Sakamoto Y & Takano Y (2002) Morphological influence of ascorbic acid deficiency on endochondral ossification in osteogenic disorder Shionogi rat. Anat Rec 268, 93-104.
    • (2002) Anat Rec , vol.268 , pp. 93-104
    • Sakamoto, Y.1    Takano, Y.2
  • 17
    • 80052579694 scopus 로고    scopus 로고
    • Morphological assessment of bone mineralization in tibial metaphyses of ascorbic acid-deficient ODS rats
    • Hasegawa T, Li M, Hara K, et al. (2011) Morphological assessment of bone mineralization in tibial metaphyses of ascorbic acid-deficient ODS rats. Biomed Res 32, 259-269.
    • (2011) Biomed Res , vol.32 , pp. 259-269
    • Hasegawa, T.1    Li, M.2    Hara, K.3
  • 18
    • 80055002537 scopus 로고    scopus 로고
    • Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking
    • Nojiri H, Saita Y, Morikawa D, et al. (2011) Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking. J Bone Miner Res 26, 2682-2694.
    • (2011) J Bone Miner Res , vol.26 , pp. 2682-2694
    • Nojiri, H.1    Saita, Y.2    Morikawa, D.3
  • 19
    • 31844443695 scopus 로고
    • The environment and disease: Association or causation?
    • Hill AB (1965) The environment and disease: association or causation? Proc R Soc Med 58, 295-300.
    • (1965) Proc R Soc Med , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 20
    • 7144266908 scopus 로고
    • The biochemical role of ascorbic acid in connective tissue
    • Robertson WV (1961) The biochemical role of ascorbic acid in connective tissue. Ann N Y Acad Sci 92, 159-167.
    • (1961) Ann N y Acad Sci , vol.92 , pp. 159-167
    • Robertson, W.V.1
  • 21
    • 57349198799 scopus 로고    scopus 로고
    • Cell passage and composition of culture medium effects proliferation and differentiation of human osteoblast-like cells from facial bone
    • Pradel W, Mai R, Gedrange T, et al. (2008) Cell passage and composition of culture medium effects proliferation and differentiation of human osteoblast-like cells from facial bone. J Physiol Pharmacol 59, Suppl. 5, 47-58.
    • (2008) J Physiol Pharmacol , vol.59 , pp. 47-58
    • Pradel, W.1    Mai, R.2    Gedrange, T.3
  • 22
    • 78651256353 scopus 로고    scopus 로고
    • Vitamin C-deficiency stimulates osteoclastogenesis with an increase in RANK expression
    • Hie M & Tsukamoto I (2011) Vitamin C-deficiency stimulates osteoclastogenesis with an increase in RANK expression. J Nutr Biochem 22, 164-171.
    • (2011) J Nutr Biochem , vol.22 , pp. 164-171
    • Hie, M.1    Tsukamoto, I.2
  • 23
    • 84866326772 scopus 로고    scopus 로고
    • Vitamin C deficiency accelerates bone loss inducing an increase in PPAR-g expression in SMP30 knockout mice
    • Park JK, Lee EM, Kim AY, et al. (2012) Vitamin C deficiency accelerates bone loss inducing an increase in PPAR-g expression in SMP30 knockout mice. Int J Exp Pathol 93, 332-340.
    • (2012) Int J Exp Pathol , vol.93 , pp. 332-340
    • Park, J.K.1    Lee, E.M.2    Kim, A.Y.3
  • 24
    • 84866646256 scopus 로고    scopus 로고
    • An in vitro study of osteoblast vitality influenced by the vitamins C and e
    • Urban K, Hohling HJ, Luttenberg B, et al. (2012) An in vitro study of osteoblast vitality influenced by the vitamins C and E. Head Face Med 8, 25.
    • (2012) Head Face Med , vol.8 , pp. 25
    • Urban, K.1    Hohling, H.J.2    Luttenberg, B.3
  • 25
    • 77951255684 scopus 로고    scopus 로고
    • Ascorbic acid accelerates osteoclast formation and death
    • Le Nihouannen D, Barralet JE, Fong JE, et al. (2010) Ascorbic acid accelerates osteoclast formation and death. Bone 46, 1336-1343.
    • (2010) Bone , vol.46 , pp. 1336-1343
    • Le Nihouannen, D.1    Barralet, J.E.2    Fong, J.E.3
  • 26
    • 0031781484 scopus 로고    scopus 로고
    • Osteoclast differentiation requires ascorbic acid
    • Ragab AA, Lavish SA, Banks MA, et al. (1998) Osteoclast differentiation requires ascorbic acid. J Bone Miner Res 13, 970-977.
    • (1998) J Bone Miner Res , vol.13 , pp. 970-977
    • Ragab, A.A.1    Lavish, S.A.2    Banks, M.A.3
  • 27
    • 0034465867 scopus 로고    scopus 로고
    • Role of ascorbic acid in the osteoclast formation: Induction of osteoclast differentiation factor with formation of the extracellular collagen matrix
    • Otsuka E, Kato Y, Hirose S, et al. (2000) Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix. Endocrinology 141, 3006-3011.
    • (2000) Endocrinology , vol.141 , pp. 3006-3011
    • Otsuka, E.1    Kato, Y.2    Hirose, S.3
  • 28
    • 35348853867 scopus 로고    scopus 로고
    • Osteoblast protects osteoclast devoid of sodium-dependent vitamin C transporters from oxidative cytotoxicity of ascorbic acid
    • Takarada T, Hinoi E, Kambe Y, et al. (2007) Osteoblast protects osteoclast devoid of sodium-dependent vitamin C transporters from oxidative cytotoxicity of ascorbic acid. Eur J Pharmacol 575, 1-11.
    • (2007) Eur J Pharmacol , vol.575 , pp. 1-11
    • Takarada, T.1    Hinoi, E.2    Kambe, Y.3
  • 29
    • 24044528550 scopus 로고    scopus 로고
    • Ascorbic acid promotes osteoclastogenesis from embryonic stem cells
    • Tsuneto M, Yamazaki H, Yoshino M, et al. (2005) Ascorbic acid promotes osteoclastogenesis from embryonic stem cells. Biochem Biophys Res Commun 335, 1239-1246.
    • (2005) Biochem Biophys Res Commun , vol.335 , pp. 1239-1246
    • Tsuneto, M.1    Yamazaki, H.2    Yoshino, M.3
  • 30
    • 21444447819 scopus 로고    scopus 로고
    • Ascorbic acid inhibits osteoclastogenesis of RAW264.7 cells induced by receptor activated nuclear factor kB ligand (RANKL) in vitro
    • Xiao XH, Liao EY, Zhou HD, et al. (2005) Ascorbic acid inhibits osteoclastogenesis of RAW264.7 cells induced by receptor activated nuclear factor kB ligand (RANKL) in vitro. J Endocrinol Invest 28, 253-260.
    • (2005) J Endocrinol Invest , vol.28 , pp. 253-260
    • Xiao, X.H.1    Liao, E.Y.2    Zhou, H.D.3
  • 31
    • 0026047388 scopus 로고
    • Role of ascorbic acid in the regulation of proliferation in osteoblast-like MC3T3-E1 cells
    • Harada S, Matsumoto T & Ogata E (1991) Role of ascorbic acid in the regulation of proliferation in osteoblast-like MC3T3-E1 cells. J Bone Miner Res 6, 903-908.
    • (1991) J Bone Miner Res , vol.6 , pp. 903-908
    • Harada, S.1    Matsumoto, T.2    Ogata, E.3
  • 32
    • 0032781360 scopus 로고    scopus 로고
    • Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid
    • Otsuka E, Yamaguchi A, Hirose S, et al. (1999) Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid. Am J Physiol Cell Physiol 277, C132-C138.
    • (1999) Am J Physiol Cell Physiol , vol.277 , pp. C132-C138
    • Otsuka, E.1    Yamaguchi, A.2    Hirose, S.3
  • 33
    • 0033213830 scopus 로고    scopus 로고
    • Development of the osteoblast phenotype in primary human osteo-blasts in culture: Comparison with rat calvarial cells in osteoblast differentiation
    • Siggelkow H, Rebenstorff K, Kurre W, et al. (1999) Development of the osteoblast phenotype in primary human osteo-blasts in culture: comparison with rat calvarial cells in osteoblast differentiation. J Cell Biochem 75, 22-35.
    • (1999) J Cell Biochem , vol.75 , pp. 22-35
    • Siggelkow, H.1    Rebenstorff, K.2    Kurre, W.3
  • 34
    • 20144369605 scopus 로고    scopus 로고
    • Effect of Vitamin C on pre-osteoblast gene expression
    • Carinci F, Pezzetti F, Spina AM, et al. (2005) Effect of Vitamin C on pre-osteoblast gene expression. Arch Oral Biol 50, 481-496.
    • (2005) Arch Oral Biol , vol.50 , pp. 481-496
    • Carinci, F.1    Pezzetti, F.2    Spina, A.M.3
  • 35
    • 14244250617 scopus 로고    scopus 로고
    • Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation
    • Ali AA, Weinstein RS, Stewart SA, et al. (2005) Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology 146, 1226-1235.
    • (2005) Endocrinology , vol.146 , pp. 1226-1235
    • Ali, A.A.1    Weinstein, R.S.2    Stewart, S.A.3
  • 36
    • 18144380684 scopus 로고    scopus 로고
    • Effects of trans-resveratrol from Polygonum cuspidatum on bone loss using the ovari-ectomized rat model
    • Liu ZP, Li WX, Yu B, et al. (2005) Effects of trans-resveratrol from Polygonum cuspidatum on bone loss using the ovari-ectomized rat model. J Med Food 8, 14-19.
    • (2005) J Med Food , vol.8 , pp. 14-19
    • Liu, Z.P.1    Li, W.X.2    Yu, B.3
  • 37
    • 0023926651 scopus 로고
    • Ascorbic acid specifically increases type i and type III procollagen messenger RNA levels in human skin fibroblast
    • Geesin JC, Darr D, Kaufman R, et al. (1988) Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol 90, 420-424.
    • (1988) J Invest Dermatol , vol.90 , pp. 420-424
    • Geesin, J.C.1    Darr, D.2    Kaufman, R.3
  • 39
    • 0025335666 scopus 로고
    • Regulation of procollagen synthesis and processing during ascorbate-induced extracellular matrix accumulation in vitro
    • Chan D, Lamande SR, Cole WG, et al. (1990) Regulation of procollagen synthesis and processing during ascorbate-induced extracellular matrix accumulation in vitro. Biochem J 269, 175-181.
    • (1990) Biochem J , vol.269 , pp. 175-181
    • Chan, D.1    Lamande, S.R.2    Cole, W.G.3
  • 40
    • 0026543172 scopus 로고
    • Relationship between collagen synthesis and expression of the osteoblast pheno-type in MC3T3-E1 cells
    • Franceschi RT & Iyer BS (1992) Relationship between collagen synthesis and expression of the osteoblast pheno-type in MC3T3-E1 cells. J Bone Miner Res 7, 235-246.
    • (1992) J Bone Miner Res , vol.7 , pp. 235-246
    • Franceschi, R.T.1    Iyer, B.S.2
  • 41
    • 0001312106 scopus 로고
    • Cofactor and substrate requirements of collagen proline hydroxylase
    • Hutton JJ, Tappel AL & Udenfriend S (1967) Cofactor and substrate requirements of collagen proline hydroxylase. Arch Biochem Biophys 118, 231-240.
    • (1967) Arch Biochem Biophys , vol.118 , pp. 231-240
    • Hutton, J.J.1    Tappel, A.L.2    Udenfriend, S.3
  • 42
    • 0016586669 scopus 로고
    • Function of ascorbic acid in collagen metabolism
    • Barnes MJ (1975) Function of ascorbic acid in collagen metabolism. Ann N Y Acad Sci 258, 264-277.
    • (1975) Ann N y Acad Sci , vol.258 , pp. 264-277
    • Barnes, M.J.1
  • 43
    • 0020010503 scopus 로고
    • Posttranslational enzymes in the biosynthesis of collagen: Intracellular enzymes
    • Kivirikko KI & Myllyla R (1982) Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes. Methods Enzymol 82, 245-304.
    • (1982) Methods Enzymol , vol.82 , pp. 245-304
    • Kivirikko, K.I.1    Myllyla, R.2
  • 44
    • 0021329173 scopus 로고
    • Ascorbate is consumed stoichiometrically in the uncoupled reactions catalyzed by prolyl 4-hydroxylase and lysyl hydroxylase
    • Myllyla R, Majamaa K, Gunzler V, et al. (1984) Ascorbate is consumed stoichiometrically in the uncoupled reactions catalyzed by prolyl 4-hydroxylase and lysyl hydroxylase. J Biol Chem 259, 5403-5405.
    • (1984) J Biol Chem , vol.259 , pp. 5403-5405
    • Myllyla, R.1    Majamaa, K.2    Gunzler, V.3
  • 45
    • 0000800535 scopus 로고
    • Function of ascorbic acid in the conversion of proline to collagen hydroxyproline
    • Stone N & Meister A (1962) Function of ascorbic acid in the conversion of proline to collagen hydroxyproline. Nature 194, 555-557.
    • (1962) Nature , vol.194 , pp. 555-557
    • Stone, N.1    Meister, A.2
  • 46
    • 0014010437 scopus 로고
    • Further evidence for the accumulation of a hydroxyproline-deficient, collagenase-degradable protein during collagen biosynthesis in vitro
    • Gottlieb AA, Kaplan A & Udenfriend S (1966) Further evidence for the accumulation of a hydroxyproline-deficient, collagenase-degradable protein during collagen biosynthesis in vitro. J Biol Chem 241, 1551-1555.
    • (1966) J Biol Chem , vol.241 , pp. 1551-1555
    • Gottlieb, A.A.1    Kaplan, A.2    Udenfriend, S.3
  • 47
    • 0013895538 scopus 로고
    • Conversion of proline to collagen hydroxyproline
    • Manning JM & Meister A (1966) Conversion of proline to collagen hydroxyproline. Biochemistry 5, 1154-1165.
    • (1966) Biochemistry , vol.5 , pp. 1154-1165
    • Manning, J.M.1    Meister, A.2
  • 48
    • 0015508224 scopus 로고
    • The synthesis of underhydroxylated collagen by 3 T6 mouse fibroblasts in culture
    • Bates CJ, Prynne CJ & Levene CI (1972) The synthesis of underhydroxylated collagen by 3 T6 mouse fibroblasts in culture. Biochim Biophys Acta 263, 397-405.
    • (1972) Biochim Biophys Acta , vol.263 , pp. 397-405
    • Bates, C.J.1    Prynne, C.J.2    Levene, C.I.3
  • 49
    • 0015396218 scopus 로고
    • The effect of ascorbic acid on collagen polypeptide synthesis and proline hydroxylation during the growth of cultured fibroblasts
    • Peterkofsky B (1972) The effect of ascorbic acid on collagen polypeptide synthesis and proline hydroxylation during the growth of cultured fibroblasts. Arch Biochem Biophys 152, 318-328.
    • (1972) Arch Biochem Biophys , vol.152 , pp. 318-328
    • Peterkofsky, B.1
  • 50
    • 0028242767 scopus 로고
    • Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells
    • Franceschi RT, Iyer BS & Cui Y (1994) Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells. J Bone Miner Res 9, 843-854.
    • (1994) J Bone Miner Res , vol.9 , pp. 843-854
    • Franceschi, R.T.1    Iyer, B.S.2    Cui, Y.3
  • 51
    • 0016288606 scopus 로고
    • Collagen biosynthesis. Characterization of subcellular fractions from embyonic chick fibroblasts and the intracellular localization of protocollagen prolyl and protocollagen lysyl hydroxy-lases
    • Harwood R, Grant ME & Jackson DS (1974) Collagen biosynthesis. Characterization of subcellular fractions from embyonic chick fibroblasts and the intracellular localization of protocollagen prolyl and protocollagen lysyl hydroxy-lases. Biochem J 144, 123-130.
    • (1974) Biochem J , vol.144 , pp. 123-130
    • Harwood, R.1    Grant, M.E.2    Jackson, D.S.3
  • 52
    • 0016235443 scopus 로고
    • Hydroxylation of peptide-bound proline and lysine before and after chain completion of the polypeptide chains of procollagen
    • Uitto J & Prockop DJ (1974) Hydroxylation of peptide-bound proline and lysine before and after chain completion of the polypeptide chains of procollagen. Arch Biochem Biophys 164, 210-217.
    • (1974) Arch Biochem Biophys , vol.164 , pp. 210-217
    • Uitto, J.1    Prockop, D.J.2
  • 53
    • 84866869135 scopus 로고    scopus 로고
    • Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts
    • Nabavi N, Pustylnik S & Harrison RE (2012) Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts. PLOS ONE 7, e46265.
    • (2012) PLOS ONE , vol.7 , pp. e46265
    • Nabavi, N.1    Pustylnik, S.2    Harrison, R.E.3
  • 54
    • 38349036270 scopus 로고    scopus 로고
    • Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysis
    • Dehghan M, Akhtar-Danesh N, McMillan CR, et al. (2007) Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysis. Nutr J 6, 41.
    • (2007) Nutr J , vol.6 , pp. 41
    • Dehghan, M.1    Akhtar-Danesh, N.2    McMillan, C.R.3
  • 57
    • 0015216585 scopus 로고
    • Ascorbic acid and toxicity
    • Hoffer A (1971) Ascorbic acid and toxicity. N Engl J Med 285, 635-636.
    • (1971) N Engl J Med , vol.285 , pp. 635-636
    • Hoffer, A.1
  • 58
    • 9644273945 scopus 로고    scopus 로고
    • Dietary factors and the risk of incident kidney stones in men: New insights after 14 years of follow-up
    • Taylor EN, Stampfer MJ & Curhan GC (2004) Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. J Am Soc Nephrol 15, 3225-3232.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3225-3232
    • Taylor, E.N.1    Stampfer, M.J.2    Curhan, G.C.3
  • 59
    • 0033590959 scopus 로고    scopus 로고
    • Criteria and recommendations for vitamin C intake
    • Levine M, Rumsey SC, Daruwala R, et al. (1999) Criteria and recommendations for vitamin C intake. JAMA 281, 1415-1423.
    • (1999) JAMA , vol.281 , pp. 1415-1423
    • Levine, M.1    Rumsey, S.C.2    Daruwala, R.3
  • 60
    • 0030938196 scopus 로고    scopus 로고
    • Serum b-carotene and vitamin C as biomarkers of vegetable and fruit intakes in a community-based sample of French adults
    • Drewnowski A, Rock CL, Henderson SA, et al. (1997) Serum b-carotene and vitamin C as biomarkers of vegetable and fruit intakes in a community-based sample of French adults. Am J Clin Nutr 65, 1796-1802.
    • (1997) Am J Clin Nutr , vol.65 , pp. 1796-1802
    • Drewnowski, A.1    Rock, C.L.2    Henderson, S.A.3
  • 61
    • 27144510185 scopus 로고    scopus 로고
    • Serum concentrations of b-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population
    • Galan P, Viteri FE, Bertrais S, et al. (2005) Serum concentrations of b-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population. Eur J Clin Nutr 59, 1181-1190.
    • (2005) Eur J Clin Nutr , vol.59 , pp. 1181-1190
    • Galan, P.1    Viteri, F.E.2    Bertrais, S.3
  • 62
    • 33744901925 scopus 로고    scopus 로고
    • Factors influencing blood concentration of retinol, a-tocopherol, vitamin C, and b-carotene in the French participants of the SU.VI.MAX trial
    • Faure H, Preziosi P, Roussel AM, et al. (2006) Factors influencing blood concentration of retinol, a-tocopherol, vitamin C, and b-carotene in the French participants of the SU.VI.MAX trial. Eur J Clin Nutr 60, 706-717.
    • (2006) Eur J Clin Nutr , vol.60 , pp. 706-717
    • Faure, H.1    Preziosi, P.2    Roussel, A.M.3
  • 63
    • 33644684441 scopus 로고    scopus 로고
    • Plasma ascorbic acid concentrations and fat distribution in 19068 British men and women in the European Prospective Investigation into Cancer and Nutrition Norfolk cohort study
    • Canoy D, Wareham N, Welch A, et al. (2005) Plasma ascorbic acid concentrations and fat distribution in 19068 British men and women in the European Prospective Investigation into Cancer and Nutrition Norfolk cohort study. Am J Clin Nutr 82, 1203-1209.
    • (2005) Am J Clin Nutr , vol.82 , pp. 1203-1209
    • Canoy, D.1    Wareham, N.2    Welch, A.3
  • 64
    • 0022484979 scopus 로고
    • Lower levels of vitamin C and carotenes in plasma of cigarette smokers
    • Chow CK, Thacker RR, Changchit C, et al. (1986) Lower levels of vitamin C and carotenes in plasma of cigarette smokers. J Am Coll Nutr 5, 305-312.
    • (1986) J Am Coll Nutr , vol.5 , pp. 305-312
    • Chow, C.K.1    Thacker, R.R.2    Changchit, C.3
  • 65
    • 0024520196 scopus 로고
    • The influence of smoking on vitamin C status in adults
    • Schectman G, Byrd JC & Gruchow HW (1989) The influence of smoking on vitamin C status in adults. Am J Public Health 79, 158-162.
    • (1989) Am J Public Health , vol.79 , pp. 158-162
    • Schectman, G.1    Byrd, J.C.2    Gruchow, H.W.3
  • 66
    • 0030853422 scopus 로고    scopus 로고
    • Synergism of nutrition, infection, and immunity: An overview
    • Scrimshaw NS & SanGiovanni JP (1997) Synergism of nutrition, infection, and immunity: an overview. Am J Clin Nutr 66, 464S-477S.
    • (1997) Am J Clin Nutr , vol.66 , pp. 464S-477S
    • Scrimshaw, N.S.1    Sangiovanni, J.P.2
  • 67
    • 9244219627 scopus 로고    scopus 로고
    • Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance
    • Levine M, Conry-Cantilena C, Wang Y, et al. (1996) Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 93, 3704-3709.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3704-3709
    • Levine, M.1    Conry-Cantilena, C.2    Wang, Y.3
  • 68
    • 0035859936 scopus 로고    scopus 로고
    • A new recommended dietary allowance of vitamin C for healthy young women
    • Levine M, Wang Y, Padayatty SJ, et al. (2001) A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci USA 98, 9842-9846.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9842-9846
    • Levine, M.1    Wang, Y.2    Padayatty, S.J.3
  • 70
    • 77954648879 scopus 로고    scopus 로고
    • Supplementation of ascorbic acid and a-tocopherol is useful to preventing bone loss linked to oxidative stress in elderly
    • Ruiz-Ramos M, Vargas LA, Van der Goes TIF, et al. (2010) Supplementation of ascorbic acid and a-tocopherol is useful to preventing bone loss linked to oxidative stress in elderly. J Nutr Health Aging 14, 467-472.
    • (2010) J Nutr Health Aging , vol.14 , pp. 467-472
    • Ruiz-Ramos, M.1    Vargas, L.A.2    Van Der Goes, T.I.F.3
  • 71
    • 37349098850 scopus 로고    scopus 로고
    • Effect of antioxidants and exercise on bone metabolism
    • Maimoun L, Simar D, Caillaud C, et al. (2008) Effect of antioxidants and exercise on bone metabolism. J Sports Sci 26, 251-258.
    • (2008) J Sports Sci , vol.26 , pp. 251-258
    • Maimoun, L.1    Simar, D.2    Caillaud, C.3
  • 72
    • 67349245443 scopus 로고    scopus 로고
    • Effect of anti-oxidants combined to resistance training on BMD in elderly women: A pilot study
    • Chuin A, Labonte M, Tessier D, et al. (2009) Effect of anti-oxidants combined to resistance training on BMD in elderly women: a pilot study. Osteoporos Int 20, 1253-1258.
    • (2009) Osteoporos Int , vol.20 , pp. 1253-1258
    • Chuin, A.1    Labonte, M.2    Tessier, D.3
  • 73
    • 0041705931 scopus 로고    scopus 로고
    • Effects of dietary nutrients and food groups on bone loss from the proximal femur in men and women in the 7th and 8th decades of age
    • Kaptoge S, Welch A, McTaggart A, et al. (2003) Effects of dietary nutrients and food groups on bone loss from the proximal femur in men and women in the 7th and 8th decades of age. Osteoporos Int 14, 418-428.
    • (2003) Osteoporos Int , vol.14 , pp. 418-428
    • Kaptoge, S.1    Welch, A.2    McTaggart, A.3
  • 74
    • 54749135050 scopus 로고    scopus 로고
    • High vitamin C intake is associated with lower 4-year bone loss in elderly men
    • Sahni S, Hannan MT, Gagnon D, et al. (2008) High vitamin C intake is associated with lower 4-year bone loss in elderly men. J Nutr 138, 1931-1938.
    • (2008) J Nutr , vol.138 , pp. 1931-1938
    • Sahni, S.1    Hannan, M.T.2    Gagnon, D.3
  • 75
    • 0026337524 scopus 로고
    • A population-based comparison of quantitative dual-energy X-ray absorptiometry with dual-photon absorptiometry of the spine and hip
    • Holbrook TL, Barrett-Connor E, Klauber M, et al. (1991) A population-based comparison of quantitative dual-energy X-ray absorptiometry with dual-photon absorptiometry of the spine and hip. Calcif Tissue Int 49, 305-307.
    • (1991) Calcif Tissue Int , vol.49 , pp. 305-307
    • Holbrook, T.L.1    Barrett-Connor, E.2    Klauber, M.3
  • 76
    • 76449092748 scopus 로고    scopus 로고
    • Protective effect of total and supplemental vitamin C intake on the risk of hip fracture-A 17-Year follow-Up from the Framing-ham Osteoporosis Study
    • Sahni S, Hannan MT, Gagnon D, et al. (2009) Protective effect of total and supplemental vitamin C intake on the risk of hip fracture-a 17-year follow-up from the Framing-ham Osteoporosis Study. Osteoporos Int 20, 1853-1861.
    • (2009) Osteoporos Int , vol.20 , pp. 1853-1861
    • Sahni, S.1    Hannan, M.T.2    Gagnon, D.3
  • 77
    • 0031782736 scopus 로고    scopus 로고
    • Low levels of serum ascorbic acid in elderly patients with hip fracture
    • Falch JA, Mowe M & Bohmer T (1998) Low levels of serum ascorbic acid in elderly patients with hip fracture. Scand J Clin Lab Invest 58, 225-228.
    • (1998) Scand J Clin Lab Invest , vol.58 , pp. 225-228
    • Falch, J.A.1    Mowe, M.2    Bohmer, T.3
  • 78
    • 0038360770 scopus 로고    scopus 로고
    • Marked decrease in plasma antioxidants in aged osteoporotic women: Results of a cross-sectional study
    • Maggio D, Barabani M, Pierandrei M, et al. (2003) Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab 88, 1523-1527.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1523-1527
    • Maggio, D.1    Barabani, M.2    Pierandrei, M.3
  • 80
    • 0034949418 scopus 로고    scopus 로고
    • Nutritional status in elderly female hip fracture patients: Comparison with an age-matched home living group attending day centres
    • Lumbers M, New SA, Gibson S, et al. (2001) Nutritional status in elderly female hip fracture patients: comparison with an age-matched home living group attending day centres. Br J Nutr 85, 733-740.
    • (2001) Br J Nutr , vol.85 , pp. 733-740
    • Lumbers, M.1    New, S.A.2    Gibson, S.3
  • 81
    • 79551625680 scopus 로고    scopus 로고
    • Calcium from plant sources is beneficial to lowering the risk of osteoporosis in postme-nopausal Korean women
    • Park HM, Heo J & Park Y (2011) Calcium from plant sources is beneficial to lowering the risk of osteoporosis in postme-nopausal Korean women. Nutr Res 31, 27-32.
    • (2011) Nutr Res , vol.31 , pp. 27-32
    • Park, H.M.1    Heo, J.2    Park, Y.3
  • 82
    • 0035158155 scopus 로고    scopus 로고
    • Vitamin C supplement use and bone mineral density in postmeno-pausal women
    • Morton DJ, Barrett-Connor E & Schneider DL (2001) Vitamin C supplement use and bone mineral density in postmeno-pausal women. J Bone Miner Res 16, 135-140.
    • (2001) J Bone Miner Res , vol.16 , pp. 135-140
    • Morton, D.J.1    Barrett-Connor, E.2    Schneider, D.L.3
  • 83
    • 0021874009 scopus 로고
    • Correlates of mid-radius bone density among postmenopausal women: A community study
    • Sowers MR, Wallace RB & Lemke JH (1985) Correlates of mid-radius bone density among postmenopausal women: a community study. Am J Clin Nutr 41, 1045-1053.
    • (1985) Am J Clin Nutr , vol.41 , pp. 1045-1053
    • Sowers, M.R.1    Wallace, R.B.2    Lemke, J.H.3
  • 84
    • 27244437111 scopus 로고    scopus 로고
    • Lack of a relation between vitamin and mineral antioxidants and bone mineral density: Results from the Women's Health Initiative
    • Wolf RL, Cauley JA, Pettinger M, et al. (2005) Lack of a relation between vitamin and mineral antioxidants and bone mineral density: results from the Women's Health Initiative. Am J Clin Nutr 82, 581-588.
    • (2005) Am J Clin Nutr , vol.82 , pp. 581-588
    • Wolf, R.L.1    Cauley, J.A.2    Pettinger, M.3
  • 85
    • 33745161881 scopus 로고    scopus 로고
    • Antioxidant vitamin supplements and markers of bone turnover in a community sample of nonsmoking women
    • Pasco JA, Henry MJ, Wilkinson LK, et al. (2006) Antioxidant vitamin supplements and markers of bone turnover in a community sample of nonsmoking women. J Womens Health (Larchmt) 15, 295-300.
    • (2006) J Womens Health (Larchmt) , vol.15 , pp. 295-300
    • Pasco, J.A.1    Henry, M.J.2    Wilkinson, L.K.3
  • 86
    • 0030724806 scopus 로고    scopus 로고
    • Dietary vitamin C and bone mineral density in postmenopausal women in Washington State, USA
    • Leveille SG, LaCroix AZ, Koepsell TD, et al. (1997) Dietary vitamin C and bone mineral density in postmenopausal women in Washington State, USA. J Epidemiol Community Health 51, 479-485.
    • (1997) J Epidemiol Community Health , vol.51 , pp. 479-485
    • Leveille, S.G.1    Lacroix, A.Z.2    Koepsell, T.D.3
  • 87
    • 78651520975 scopus 로고    scopus 로고
    • Dietary patterns of antioxidant vitamin and carotenoid intake associated with bone mineral density: Findings from post-menopausal Japanese female subjects
    • Sugiura M, Nakamura M, Ogawa K, et al. (2011) Dietary patterns of antioxidant vitamin and carotenoid intake associated with bone mineral density: findings from post-menopausal Japanese female subjects. Osteoporos Int 22, 143-152.
    • (2011) Osteoporos Int , vol.22 , pp. 143-152
    • Sugiura, M.1    Nakamura, M.2    Ogawa, K.3
  • 88
    • 0038742942 scopus 로고    scopus 로고
    • Bone and nutrition in elderly women: Protein, energy, and calcium as main determinants of bone mineral density
    • Ilich JZ, Brownbill RA & Tamborini L (2003) Bone and nutrition in elderly women: protein, energy, and calcium as main determinants of bone mineral density. Eur J Clin Nutr 57, 554-565.
    • (2003) Eur J Clin Nutr , vol.57 , pp. 554-565
    • Ilich, J.Z.1    Brownbill, R.A.2    Tamborini, L.3
  • 89
    • 0001324125 scopus 로고    scopus 로고
    • Biochemical markers of nutrient intake
    • [BM Margetts and M Nelson, editors]. Oxford: Oxford University Press
    • Bates CJ, Thurnham SI, Bingham SA, et al (1997) Biochemical markers of nutrient intake. In Design Concepts in Nutritional Epidemiology, 2nd ed., pp. 170-240 [BM Margetts and M Nelson, editors]. Oxford: Oxford University Press.
    • (1997) Design Concepts in Nutritional Epidemiology, 2nd Ed. , pp. 170-240
    • Bates, C.J.1    Thurnham, S.I.2    Bingham, S.A.3
  • 90
    • 18844470060 scopus 로고    scopus 로고
    • Vitamin C exhibits pro-oxidant properties
    • Podmore ID, Griffiths HR, Herbert KE, et al. (1998) Vitamin C exhibits pro-oxidant properties. Nature 392, 559.
    • (1998) Nature , vol.392 , pp. 559
    • Podmore, I.D.1    Griffiths, H.R.2    Herbert, K.E.3
  • 91
    • 1942517804 scopus 로고    scopus 로고
    • Effects of ascorbic acid and ascorbic acid 2-phosphate, a long-acting vitamin C derivative, on the proliferation and differentiation of human osteoblast-like cells
    • Takamizawa S, Maehata Y, Imai K, et al. (2004) Effects of ascorbic acid and ascorbic acid 2-phosphate, a long-acting vitamin C derivative, on the proliferation and differentiation of human osteoblast-like cells. Cell Biol Int 28, 255-265.
    • (2004) Cell Biol Int , vol.28 , pp. 255-265
    • Takamizawa, S.1    Maehata, Y.2    Imai, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.