Cognitive intervention therapy as treatment for behaviour disorders in Alzheimer disease: Evidence on efficacy and neurobiological correlations;Las terapias de intervención cognitiva en el tratamiento de los trastornos de conducta en la enfermedad de Alzheimer. Evidencias sobre su eficacia y correlaciones neurobiológicas

Neurologia

Volumn 30, Issue 1, 2015, Pages 8-15

  Garcia Alberca J M ^a  

^a INSTITUTO ANDALUZ DE NEUROCIENCIA Y CONDUCTA   (Spain)

Author keywords

Alzheimer disease; Behavioural and psychological symptoms; Cognitive stimulation; Efficacy evaluation; Non pharmacological treatment; Psychosocial therapies

Indexed keywords

CHOLINESTERASE INHIBITOR; MEMANTINE; AMINO ACID RECEPTOR BLOCKING AGENT;

ALZHEIMER DISEASE; BEHAVIOR DISORDER; CAREGIVER; CAREGIVER BURDEN; CLINICAL PRACTICE; COGNITION; COGNITIVE THERAPY; DAILY LIFE ACTIVITY; FUNCTIONAL STATUS; HEALTH CARE COST; HUMAN; QUALITY OF LIFE; RESIDENTIAL CARE; SHORT SURVEY; DRUG COMBINATION; FEMALE; MALE; MENTAL DISORDERS; NEUROBIOLOGY; PROCEDURES; PSYCHOLOGY;

ALZHEIMER DISEASE; CAREGIVERS; CHOLINESTERASE INHIBITORS; COGNITIVE THERAPY; DRUG THERAPY, COMBINATION; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HUMANS; MALE; MEMANTINE; MENTAL DISORDERS; NEUROBIOLOGY;

EID: 84921867263     PISSN: 02134853     EISSN: 15781968     Source Type: Journal    
DOI: 10.1016/j.nrl.2012.10.002     Document Type: Short Survey

References (87)

1. Finkel S.I., Costa e Silva J., Cohen G. Behavioral and psychological sings and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment. Int Psychogeriatr 1996, 8(Suppl 3):S497-S500.
2. Craig D., Mirakhur A., Hart D.J., McIlroy S.P., Passmore A.P. A cross sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer's disease. Am J Geriatr Psychiatry 2005, 13:460-468.
3. Lyketsos C.G., López O., Jones B. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment. Results from cardiovascular health study. JAMA 2002, 288:1475-1483.
4. García-Alberca J.M., Lara J.P., Berthier M.L., Barbancho M.A., Green C., González-Barón S. Can impairment in memory, language and executive functions predict neuropsychiatric symptoms in Alzheimer's disease (AD)? Findings from a cross-sectional study. Arch Gerontol Geriatr 2011, 52:264-269.
5. Tatsumi H., Nakaaki S., Torii K., Shinagawa Y., Watanabe N., Murata Y., et al. Neuropsychiatric symptoms predict change in quality of life of Alzheimer disease patients: a two-year follow-up study. Psychiatry Clin Neurosci 2009, 3:374-384.
6. Molinuevo J.L., Hernández B. Perfil del cuidador informal asociado al manejo clínico del paciente con enfermedad de Alzheimer no respondedor al tratamiento sintomático de la enfermedad. Neurologia 2011, 26:518-527.
7. García-Alberca J.M., Cruz B., Lara J.P., Garrido V., Gris E., Lara A., et al. Disengagement coping partially mediates the relationship between caregiver burden and anxiety and depression in caregivers of people with Alzheimer's disease Results from the MÁLAGA-AD study. J Affect Disord 2012, 136:848-856.
8. Phillips V.L., Diwan S. The incremental effect of dementia-related problem behaviors on the time to nursing home placement in poor, frail, demented older people. J Am Geriatr Soc 2003, 51:188-193.
9. Lesser J.M., Hughes S. Psychosis-related disturbances. Psychosis, agitation, and disinhibition in Alzheimer's disease: definitions and treatment options. Geriatrics 2006, 61:14-20.
10. Murman D.L., Chen Q., Powell M.C., Kuo S.B., Bradley C.J., Colenda C.C. The incremental direct costs associated with behavioral symptoms in AD. Neurology 2002, 59:1721-1729.
11. Salzman C., Jeste D.V., Meyer R.E., Cohen-Mansfield J., Cummings J., Grossberg G.T., et al. Elderly patients with dementia-related symptoms of severe agitation and aggression: consensus statement on treatment options, clinical trials methodology, and policy. Clin Psychiatry 2008, 69:889-898.
12. Black W., Almeida O.P. A systematic review of the association between the behavioral and psychological symptoms of dementia and burden of care. Int Psychogeriatr 2004, 16:295-315.
13. Rymer S., Salloway S., Norton L. Impaired awareness, behavior disturbance, and caregiver burden in Alzheimer disease. Alzheimer Dis Assoc Disord 2002, 16:248-253.
14. Zarit S.H., Reever K.E., Bach-Peterson J. Relatives of the impaired elderly: correlates of feeling of burden. Gerontologist 1980, 20:649-655.
15. García-Alberca J.M., Cruz B., Lara J.P., Garrido V., Gris E., Lara A. Anxiety and depression are associated with coping strategies in caregivers of Alzheimer's disease patients: results from the MÁLAGA-AD study. Int Psychogeriatr 2012, 24:1325-1334.
16. Gauthier S., Cummings J.L., Ballard C., Brodaty H., Grossberg G., Robert P., et al. Management of behavioral problems in Alzheimer's disease. Int Psychogeriatr 2010, 22:346-372.
17. Migneco O., Benoit M., Koulibaly P.M., Dygai I., Bertogliati C., Desvignes P., et al. Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: a study in Alzheimer's disease and nondemented patients. Neuroimage 2001, 13:896-902.
18. Marshall G.A., Fairbanks L.A., Tekin S., Vinters H.V., Cummings J.L. Neuropathologic correlates of apathy in Alzheimer's disease. Dement Geriatr Cogn Disord 2006, 21:144-147.
19. Holthoff V.A., Beuthien-Baumann B., Kalbe E., Lüdecke S., Lenz O., Zündorf G., et al. Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression. Biol Psychiatry 2005, 57:412-421.
20. Hirono N., Mori E., Ishii K., Ikejiri Y., Imamura T., Shimomura T., et al. Frontal lobe hypometabolism and depression in Alzheimer's disease. Neurology 1998, 50:380-383.
21. Benoit M., Clairet S., Kkoulibaly P.M. Brain perfusion correlates of the apathy inventory dimensions of Alzheimer's disease. Int J Geriatr Psychiatry 2004, 19:864-869.
22. Tekin S., Mega M.S., Masterman D.M., Chow T., Garakian J., Vinters H.V., et al. Orbitofrontal and anterior cingulated cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease. Ann Neurol 2001, 49:355-361.
23. Farber N.B., Rubin E.H., Newcomer J.W., Kinscherf D.A., Miller J.P., Morris J.C., et al. Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis. Arch Gen Psychiatry 2000, 57:1165-1173.
24. Van der Flier W.M., Staekenborg S., Pijnenburg Y.A., Gillissen F., Romkes R., Kok A., et al. Apolipoprotein E genotype influences presence and severity of delusions and aggressive behavior in Alzheimer disease. Dement Geriatr Cogn Disord 2007, 23:42-46.
25. Sierksma A.S., van den Hove D.L.A., Steinbusch H.W.L., Prickaerts J. Major depression, cognitive dysfunction and Alzheimer's disease: is there a link. Eur J Pharmacology 2010, 626:72-82.
26. Zarros A.C., Kalopita K.S., Tsakiris S.T. Serotoninergic impairment and aggressive behaviour in Alzheimer's disease. Acta Neurobiol Exp 2005, 65:277-286.
27. Gsell W., Jungkunz G., Riederer P. Functional neurochemistry of Alzheimer's disease. Curr Pharm Des 2004, 10:265-293.
28. Landes A.M., Sperry S.D., Strauss M.E. Prevalence of apathy, dysphoria, and depression in relation to dementia severity in Alzheimer's disease. J Neuropsychiatry Clin Neurosci 2005, 17:342-349.
29. Cohen-Mansfield J. Theoretical frameworks for behavioural problems in dementia. Alzheimer's Care Quarterly 2000, 1:8-21.
30. Hall G.R., Buckwalter K.C. Progressively lowered stress threshold: a conceptual model for care of adults with Alzheimer's disease. Arch Psychiatr Nurs 1997, 1:399-406.
31. Logsdon R.G., Teri L., Peskind E., Raskind M., Weiner M.F., Tractenberg R.E., et al. Treatment of agitation in AD: a randomized, placebo-controlled clinical trial. Neurology 2000, 55:1271-1278.
32. Cohen-Mansfield J. Nonpharmacologic interventions for inappropriate behaviors in dementia: a review, summary, and critique. Am J Geriatr Psychiatry 2001, 9:361-381.
33. Lyketsos C.G., Colenda C.C., Beck C., Blank K., Doraiswamy M.P., Kalunian D.A., et al. Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer's disease. Am J Geriatr Psychiatry 2006, 14:561-572. Task Force of American Association for Geriatric Psychiatry.
34. Lobo A., Launer L.J., Fratiglioni L., Andersen K., di Carlo A., Breteler M.M., et al. Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 2000, 54(Suppl 5):S4-S9.
35. Bottino C.M., Carvalho I.A., Álvarez A.M., Ávila R., Zukauskas P.R., Bustamante S.E., et al. Cognitive rehabilitation combined with drug treatment in Alzheimer's disease patients: a pilot study. Clin Rehabil 2005, 19:861-869.
36. Seltzer B., Zolnouni P., Nunez M., Goldman R., Kumar D., Ieni J., et al. Efficacy of donepezil in early-stage Alzheimer disease: a randomized placebo-controlled trial. Arch Neurol 2004, 61:1852-1856.
37. Peskind E.R., Potkin S.G., Pomara N., Ott B.R., Graham S.M., Olin J.T., et al. Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial. Am J Geriatr Psychiatry 2006, 14:704-715.
38. Wynn Z.J., Cummings J.L. Cholinesterase inhibitor therapies and neuropsychiatric manifestations of Alzheimer's disease. Dement Geriatr Cogn Disord 2004, 17:100-108.
39. Cummings J.L., McRae T., Zhang R. Effects of donepezil on neuropsychiatric symptoms in patients with dementia and severe behavioral disorders. Am J Geriatr Psychiatry 2006, 14:605-612.
40. Sitzer D.I., Twamley E.W., Jeste D.V. Cognitive training in Alzheimer's disease: a meta-analysis of the literature. Acta Psychiatr Scand 2006, 114:75-90.
41. Spector A., Woods B., Orrell M. Cognitive stimulation for the treatment of Alzheimer's disease. Expert Rev Neurother 2008, 8:751-757.
42. Tadaka E., Kanagawa K. A randomized controlled trial of a group care program for community-dwelling elderly people with dementia. Jpn J Nurs Sci 2004, 1:19-25.
43. Ballard C., Khan Z., Clack H., Corbett A. Non pharmacological treatment of Alzheimer disease. Can J Psychiatry 2011, 56:589-595.
44. Rabins P.V., Blacker D., Rovner B.W. American Psychiatric Association practice guideline for the treatment of patients with Alzheimer's disease and other dementias 2007, American Psychiatric Association, Arlington VA. Second edition.
45. Woods B., Aguirre E., Spector A.E., Orrell M. Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database Syst Rev 2012, 2:CD005562.
46. Clare L., Woods R.T., Moniz Cook E.D., Orrell M., Spector A. Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia. Cochrane Database Syst Rev 2003, 4:CD003260.
47. Olazarán J., Reisberg B., Clare L., Cruz I., Peña-Casanova J., del Ser T., et al. Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord 2010, 30:161-178.
48. Günther V., Fuchs D., Schett P., Meise U., Rhomberg H.P. Kognitives training bei organischem psychosyndrom (cognitive training in psycho-organic syndromes). Dtsch Med Wochenschr 1991, 116:846-851.
49. Zarit S.H., Zarit J.M., Reever K.E. Memory training for severe memory loss: effects on senile dementia patients and their caregivers. Gerontologist 1982, 22:373-377.
50. Kawashima R., Okita K., Yamazaki R., Tajima N., Yoshida H., Taira M., et al. Reading aloud and arithmetic calculation improve frontal function of people with dementia. J Gerontol A Biol Sci Med Sci 2005, 60:380-384.
51. Quayhagen M.P., Quayhagen M., Corbeil R.R., Hendrix R.C., Jackson J.E., Snyder L., et al. Coping with dementia: evaluation of four nonpharmacologic interventions. Int Psychogeriatr 2000, 12:249-265.
52. Breuil V., de Rotrou J., Forette F., Tortrar D., Ganancia-Ganem A., Frambourt A., et al. Cognitive stimulation of patients with dementia: preliminary results. Int J Geriatr Psychiatry 1994, 9:211-217.
53. Spector A., Thorgrimsen L., Woods B., Royan L., Davies S., Butterworth M., et al. Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia. Br J Psychiatry 2003, 183:248-254.
54. Chapman S.B., Weiner M.F., Rackley A., Hynan L.S., Zientz J. Effects of cognitive communication stimulation for Alzheimer's disease patients treated with donepezil. J Speech Lang Hear Res 2004, 47:1149-1164.
55. Olazarán J., Muñiz R., Reisberg B., Peña-Casanova J., del Ser T., Cruz-Jentoft A.J., et al. Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease. Neurology 2004, 63:2348-2353.
56. Meguro M., Kasai M., Akanuma K., Ishii H., Yamaguchi S., Meguro K. Comprehensive approach of donepezil and psychosocial interventions on cognitive function and quality of life for Alzheimer's disease: the Osaki-Tajiri project. Age Ageing 2008, 37:469-473.
57. Raggi A., Iannaccone S., Marcone A., Ginex V., Ortelli P., Nonis A., et al. The effects of a comprehensive rehabilitation program of Alzheimer's disease in a hospital setting. Behav Neurol 2007, 18:1-6.
58. Talassi E., Guerreschi M., Feriani M., Fedi V., Bianchetti A., Trabucchi M. Effectiveness of a cognitive rehabilitation program in mild dementia (MD) and mild cognitive impairment (MCI): a case control study. Arch Gerontol Geriatr 2007, 44(Suppl. 1):S391-S399.
59. Baines S., Saxby P., Ehlert K. Reality orientation and reminiscence therapy: a controlled cross-over study of elderly confused people. Br J Psychiatry 1987, 151:222-231.
60. Gerber G.J., Prince P.N., Snider H.G., Atchinson K., Dubois L., Kilgour J.A. Group activity and cognitive improvement among patients with Alzheimer's disease. Hosp Community Psychiatry 1991, 42:843-845.
61. Robichaud L., Hebert R., Desrosiers J. Efficacy of a sensory integration program on behaviors of inpatients with dementia. Am J Occup Ther 1994, 48:355-360.
62. Teri L., Gibbons L.E., McCurry S.M., Logsdon R.G., Buchner D.M., Barlow W.E., et al. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA 2003, 290:2015-2022.
63. Van de Winckel A., Fey H., de Weerdt W., Dom R. Cognitive and behavioural effects of music-based exercises in patients with dementia. Clin Rehabil 2004, 18:253-260.
64. Cummings J.L., Mega M.S., Gray J., Rosenberg-Thompson S., Carusi D.A., Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994, 44:2308-2314.
65. Yesavage J.A., Brink T.L., Rose T.L., Lum O., Huang V., Adey M., et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 1983, 17:37-49.
66. Spielberger C.D., Gorsuch R.L., Lushene R.E. Manual for the state-trait anxiety inventory 1970, Consulting Psychologist Press, Palo Alto, CA.
67. Niu Y.X., Tan J.P., Guan J.Q., Zhang Z.Q., Wang L.N. Stimulation therapy in the treatment of neuropsychiatric symptoms in Alzheimer's disease: a randomized controlled trial. Clin Rehabil 2010, 24:1102-1111.
68. Feldman H., Gauthier S., Hecker J., Vellas B., Subbiah P., Whalen E. A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease. Neurology 2001, 57:613-620.
69. Binetti G., Magni E., Padovani A., Cappa S.F., Bianchetti A., Trabucchi M. Executive dysfunction in early Alzheimer's disease. J Neurol Neurosurg Psychiatry 1996, 60:91-93.
70. Collette F., van der Linden M., Salmon E. Executive dysfunction in Alzheimer's disease. Cortex 1999, 35:57-72.
71. Swanberg M.M., Tractenberg R.E., Mohs R., Thal L.J., Cummimgs J.L. Executive dysfunction in Alzheimer disease. Arch Neurol 2004, 61:556-560.
72. Loose R., Kaufmann C., Auer D.P., Lange K.W. Human prefrontal and sensory cortical activity during divided attention tasks. Hum Brain Mapp 2003, 18:249-259.
73. Harrison B.J., Shaw M., Yücel M., Purcell R., Brewer W.J., Strother S.C., et al. Functional connectivity during Stroop task performance. Neuroimage 2005, 24:181-191.
74. McPherson S., Fairbanks L., Tiken S. Apathy and executive function in Alzheimer's disease. J Int Neuropsychol Soc 2002, 8:373-381.
75. Nakaaki S., Murata Y., Sato J., Shinagawa Y., Tatsumi H., Hirono N., et al. Greater impairment of ability in the divided attention task is seen in Alzheimer's disease patients with depression than in those without depression. Dement Geriatr Cogn Disord 2007, 23:231-240.
76. Apostolova L.G., Akopyan G.G., Partiali N. Structural correlates of apathy in Alzheimer's disease. Dement Geriatr Cogn Disord 2007, 24:91-97.
77. Landes A.M., Sperry S.D., Strauss M.E., Geldmacher D.S. Apathy in Alzheimer's disease. J Am Geriatr Soc 2001, 49:1700-1707.
78. Gourovitch M.L., Kirkby B.S., Goldberg T.E., Weinberger D.R., Gold J.M., Esposito G., et al. A comparison of rCBF patterns during letter and semantic fluency. Neuropsychology 2000, 14:353-360.
79. Elfgren C.I., Risberg J. Lateralized frontal blood flow increases during fluency tasks: influence of cognitive strategy. Neuropsychologia 1998, 36:505-512.
80. Álvarez J.A., Emory E. Executive function and the frontal lobes: a meta-analytic review. Neuropsychol Rev 2006, 16:17-42.
81. Baudic S., Barba G.D., Thibaudet M.C., Smagghe A., Remy P., Traykov L. Executive function deficits in early Alzheimer's disease and their relations with episodic memory. Arch Clin Neuropsychol 2006, 21:15-21.
82. Nakaaki S., Murata Y., Sato J., Shinagawa Y., Hongo J., Tatsumi H., et al. Association between apathy/depression and executive function in patients with Alzheimer's disease. Int Psychogeriatr 2008, 20:964-975.
83. Yamaguchi H., Maki Y., Yamagami T. Overview of non-pharmacological intervention for dementia and principles of brain-activating rehabilitation. Psychogeriatrics 2010, 10:206-213.
84. Runci S., Doyle C., Redman J. An empirical test of language-relevant interventions on dementia. Int Psychogeriatr 1999, 11:301-311.
85. Sink K.M., Covinsky K.E., Barnes D.E., Newcomer R.J., Yaffe K. Caregiver characteristics are asssociated with neuropsychiatric symptoms of dementia. J Am Geriatr Soc 2006, 54:796-803.
86. Cooper C., Owens C., Katona C., Livingston G. Attachment style and anxiety in carers of people with Alzheimer's disease: results from the LASER-AD study. Int Psychogeriatr 2008, 20:494-507.
87. Farias S.T., Mungas D., Jagust W. Degree of discrepancy between self and other-reported everyday functioning by cognitive status: Dementia, mild cognitive impairment, and healthy elders. Int J Geriatr Psychiatry 2005, 20:827-834.