In vitro enzyme-mimic activity and in vivo therapeutic potential of HSJ-0017, a novel Mn porphyrin-based antioxidant enzyme mimic

Experimental Biology and Medicine

Volumn 239, Issue 10, 2014, Pages 1366-1379

  Li, Bao Qiu ^a   Dong, Xin ^b   Li, Na ^b   Gao, Ji You ^b   Yuan, Qiang ^b   Fang, Shi Hong ^b   Gong, Xian Chang ^c   Wang, Shu Juan ^d   Wang, Feng Shan ^a  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Hongli Laboratory Animal Experiment Co Ltd   (China)

^c Jinan Saiwen Pharmaceuticals Inc   (China)

^d Jilin Province A Think Pharmaceutical Co Ltd   (China)

Author keywords

Antioxidant; Free radical; Mn porphyrins; Radioprotection; Superoxide dismutase

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CATALASE; DEXAMETHASONE; GAMMA GLUTAMYLTRANSFERASE; HSJ 0017; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; PORPHYRIN DERIVATIVE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; GASTROINTESTINAL AGENT; MANGANESE (III) MESO-TETRA (3-(2-(2-METHOXY)-ETHOXY) ETHOXY)PHENYL PORPHYRIN CHLORIDE; METALLOPORPHYRIN; NITROBLUE TETRAZOLIUM; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ACTIVITY; EDEMA; ENZYME ASSAY; EXPERIMENTAL LIVER INJURY; HEPATOMA CELL; HISTOPATHOLOGY; HYDROGEN PEROXIDE SCAVENGING ASSAY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PAW EDEMA; RADIATION PROTECTION; RAT; SARCOMA CELL; SOLID TUMOR; THIN LAYER CHROMATOGRAPHY; TUMOR VOLUME; TUMOR XENOGRAFT; ULTRAVIOLET SPECTROPHOTOMETRY; WHOLE BODY RADIATION; ANIMAL; BIOMIMETICS; METABOLISM; OXIDATION REDUCTION REACTION; TREATMENT OUTCOME; WISTAR RAT;

MUS; RATTUS NORVEGICUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BIOMIMETICS; FREE RADICAL SCAVENGERS; GASTROINTESTINAL AGENTS; HYDROGEN PEROXIDE; MALE; METALLOPORPHYRINS; MICE; NITROBLUE TETRAZOLIUM; OXIDATION-REDUCTION; RATS, WISTAR; TREATMENT OUTCOME;

EID: 84921763961     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370214532598     Document Type: Article

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