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Volumn 33, Issue 40, 2014, Pages 4823-4836

RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789

Author keywords

Endocytosis; ERK1 2; FGF1; FGFR1; RSK2; Serine phosphorylation; Signaling

Indexed keywords

ALANINE; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; RAS PROTEIN; RSK 2; SERINE 789; SERINE DERIVATIVE; UNCLASSIFIED DRUG; FGFR1 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR; PROTEIN BINDING; RIBOSOMAL PROTEIN S6 KINASE, 90KDA, POLYPEPTIDE 3; S6 KINASE; SERINE;

EID: 84921763784     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.425     Document Type: Article
Times cited : (24)

References (36)
  • 1
    • 0027344852 scopus 로고
    • Structural and functional diversity in the FGF receptor multigene family
    • Johnson DE, Williams LT. Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res 1993;60:1-41.
    • (1993) Adv Cancer Res , vol.60 , pp. 1-41
    • Johnson, D.E.1    Williams, L.T.2
  • 3
    • 79959713140 scopus 로고    scopus 로고
    • Fibroblast growth factors and their receptors in cancer
    • Wesche J, Haglund K, Haugsten EM. Fibroblast growth factors and their receptors in cancer. Biochem J 2011;437:199-213.
    • (2011) Biochem J , vol.437 , pp. 199-213
    • Wesche, J.1    Haglund, K.2    Haugsten, E.M.3
  • 4
    • 75149170979 scopus 로고    scopus 로고
    • Fibroblast growth factor signalling: From development to cancer
    • Turner N, Grose R. Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer 2010;10:116-129.
    • (2010) Nat Rev Cancer , vol.10 , pp. 116-129
    • Turner, N.1    Grose, R.2
  • 5
    • 78649679778 scopus 로고    scopus 로고
    • Roles of fibroblast growth factor receptors in carcinogenesis
    • Haugsten EM, Wiedlocha A, Olsnes S, Wesche J. Roles of fibroblast growth factor receptors in carcinogenesis. Mol Cancer Res 2010;8:1439-1452.
    • (2010) Mol Cancer Res , vol.8 , pp. 1439-1452
    • Haugsten, E.M.1    Wiedlocha, A.2    Olsnes, S.3    Wesche, J.4
  • 6
    • 84866851740 scopus 로고    scopus 로고
    • Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
    • Peifer M, Fernandez-Cuesta L, Sos ML, George J, Seidel D, Kasper LH et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet 2012;44:1104-1110.
    • (2012) Nat Genet , vol.44 , pp. 1104-1110
    • Peifer, M.1    Fernandez-Cuesta, L.2    Sos, M.L.3    George, J.4    Seidel, D.5    Kasper, L.H.6
  • 7
    • 84864509652 scopus 로고    scopus 로고
    • FGFR1 is amplified during the progression of in situ to invasive breast carcinoma
    • Jang MH, Kim EJ, Choi Y, Lee HE, Kim YJ, Kim JH et al. FGFR1 is amplified during the progression of in situ to invasive breast carcinoma. Breast Cancer Res 2012;14:R115.
    • (2012) Breast Cancer Res , vol.14 , pp. R115
    • Jang, M.H.1    Kim, E.J.2    Choi, Y.3    Lee, H.E.4    Kim, Y.J.5    Kim, J.H.6
  • 8
    • 78650451788 scopus 로고    scopus 로고
    • Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
    • Weiss J, Sos ML, Seidel D, Peifer M, Zander T, Heuckmann JM et al. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med 2010;2:62ra93.
    • (2010) Sci Transl Med , vol.2 , pp. 62ra93
    • Weiss, J.1    Sos, M.L.2    Seidel, D.3    Peifer, M.4    Zander, T.5    Heuckmann, J.M.6
  • 9
    • 84861520898 scopus 로고    scopus 로고
    • Spatial regulation of receptor tyrosine kinases in development and cancer
    • Casaletto JB, McClatchey AI. Spatial regulation of receptor tyrosine kinases in development and cancer. Nat Rev Cancer 2012;12:387-400.
    • (2012) Nat Rev Cancer , vol.12 , pp. 387-400
    • Casaletto, J.B.1    McClatchey, A.I.2
  • 10
    • 41049103244 scopus 로고    scopus 로고
    • Sprouty proteins, masterminds of receptor tyrosine kinase signaling
    • Cabrita MA, Christofori G. Sprouty proteins, masterminds of receptor tyrosine kinase signaling. Angiogenesis 2008;11:53-62.
    • (2008) Angiogenesis , vol.11 , pp. 53-62
    • Cabrita, M.A.1    Christofori, G.2
  • 11
    • 2342483086 scopus 로고    scopus 로고
    • Promotion and attenuation of FGF signaling through the Ras-MAPK pathway
    • Tsang M, Dawid IB. Promotion and attenuation of FGF signaling through the Ras-MAPK pathway. Sci STKE 2004;2004:e17.
    • (2004) Sci STKE , vol.2004 , pp. e17
    • Tsang, M.1    Dawid, I.B.2
  • 12
    • 0036771763 scopus 로고    scopus 로고
    • The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors
    • Lax I, Wong A, Lamothe B, Lee A, Frost A, Hawes J et al. The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors. Mol Cell 2002;10:709-719.
    • (2002) Mol Cell , vol.10 , pp. 709-719
    • Lax, I.1    Wong, A.2    Lamothe, B.3    Lee, A.4    Frost, A.5    Hawes, J.6
  • 14
    • 84555189440 scopus 로고    scopus 로고
    • Regulation and function of the RSK family of protein kinases
    • Romeo Y, Zhang X, Roux PP. Regulation and function of the RSK family of protein kinases. Biochem J 2012;441:553-569.
    • (2012) Biochem J , vol.441 , pp. 553-569
    • Romeo, Y.1    Zhang, X.2    Roux, P.P.3
  • 15
    • 54249152045 scopus 로고    scopus 로고
    • Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis
    • Haugsten EM, Malecki J, Bjorklund SM, Olsnes S, Wesche J. Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis. Mol Biol Cell 2008;19:3390-3403.
    • (2008) Mol Biol Cell , vol.19 , pp. 3390-3403
    • Haugsten, E.M.1    Malecki, J.2    Bjorklund, S.M.3    Olsnes, S.4    Wesche, J.5
  • 16
    • 33846312875 scopus 로고    scopus 로고
    • BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo
    • Sapkota GP, Cummings L, Newell FS, Armstrong C, Bain J, Frodin M et al. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J 2007;401:29-38.
    • (2007) Biochem J , vol.401 , pp. 29-38
    • Sapkota, G.P.1    Cummings, L.2    Newell, F.S.3    Armstrong, C.4    Bain, J.5    Frodin, M.6
  • 17
    • 0028875925 scopus 로고
    • Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: The N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation
    • Leighton IA, Dalby KN, Caudwell FB, Cohen PT, Cohen P. Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: the N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation. FEBS Lett 1995;375:289-293.
    • (1995) FEBS Lett , vol.375 , pp. 289-293
    • Leighton, I.A.1    Dalby, K.N.2    Caudwell, F.B.3    Cohen, P.T.4    Cohen, P.5
  • 18
    • 13444270324 scopus 로고    scopus 로고
    • Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation
    • Smith JA, Poteet-Smith CE, Xu Y, Errington TM, Hecht SM, Lannigan DA. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res 2005;65:1027-1034.
    • (2005) Cancer Res , vol.65 , pp. 1027-1034
    • Smith, J.A.1    Poteet-Smith, C.E.2    Xu, Y.3    Errington, T.M.4    Hecht, S.M.5    Lannigan, D.A.6
  • 19
    • 84858121800 scopus 로고    scopus 로고
    • The role of ubiquitylation in receptor endocytosis and endosomal sorting
    • Haglund K, Dikic I. The role of ubiquitylation in receptor endocytosis and endosomal sorting. J Cell Sci 2012;125:265-275.
    • (2012) J Cell Sci , vol.125 , pp. 265-275
    • Haglund, K.1    Dikic, I.2
  • 20
    • 44949253112 scopus 로고    scopus 로고
    • Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
    • Sorensen V, Zhen Y, Zakrzewska M, Haugsten EM, Wälchli S, Nilsen T et al. Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus. Mol Cell Biol 2008;28:4129-4141.
    • (2008) Mol Cell Biol , vol.28 , pp. 4129-4141
    • Sorensen, V.1    Zhen, Y.2    Zakrzewska, M.3    Haugsten, E.M.4    Wälchli, S.5    Nilsen, T.6
  • 21
    • 0029030937 scopus 로고
    • EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine 'fingers' and contains a calmodulin-binding IQ motif
    • Mu FT, Callaghan JM, Steele-Mortimer O, Stenmark H, Parton RG, Campbell PL et al. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine 'fingers' and contains a calmodulin-binding IQ motif. J Biol Chem 1995;270:13503-13511.
    • (1995) J Biol Chem , vol.270 , pp. 13503-13511
    • Mu, F.T.1    Callaghan, J.M.2    Steele-Mortimer, O.3    Stenmark, H.4    Parton, R.G.5    Campbell, P.L.6
  • 22
    • 0025941527 scopus 로고
    • A tyrosinephosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
    • Mohammadi M, Honegger AM, Rotin D, Fischer R, Bellot F, Li W et al. A tyrosinephosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol 1991;11:5068-5078.
    • (1991) Mol Cell Biol , vol.11 , pp. 5068-5078
    • Mohammadi, M.1    Honegger, A.M.2    Rotin, D.3    Fischer, R.4    Bellot, F.5    Li, W.6
  • 23
    • 26244457001 scopus 로고    scopus 로고
    • Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors
    • Haugsten EM, Sorensen V, Brech A, Olsnes S, Wesche J. Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors. J Cell Sci 2005;118:3869-3881.
    • (2005) J Cell Sci , vol.118 , pp. 3869-3881
    • Haugsten, E.M.1    Sorensen, V.2    Brech, A.3    Olsnes, S.4    Wesche, J.5
  • 24
    • 0028084984 scopus 로고
    • Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase
    • Gandino L, Longati P, Medico E, Prat M, Comoglio PM. Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase. J Biol Chem 1994;269:1815-1820.
    • (1994) J Biol Chem , vol.269 , pp. 1815-1820
    • Gandino, L.1    Longati, P.2    Medico, E.3    Prat, M.4    Comoglio, P.M.5
  • 25
    • 0348014544 scopus 로고    scopus 로고
    • Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor
    • Oksvold MP, Thien CB, Widerberg J, Chantry A, Huitfeldt HS, Langdon WY. Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor. Oncogene 2003;22:8509-8518.
    • (2003) Oncogene , vol.22 , pp. 8509-8518
    • Oksvold, M.P.1    Thien, C.B.2    Widerberg, J.3    Chantry, A.4    Huitfeldt, H.S.5    Langdon, W.Y.6
  • 26
    • 0026488236 scopus 로고
    • Mutational removal of the major site of serine phosphorylation of the epidermal growth factor receptor causes potentiation of signal transduction: Role of receptor down-regulation
    • Theroux SJ, Stanley K, Campbell DA, Davis RJ. Mutational removal of the major site of serine phosphorylation of the epidermal growth factor receptor causes potentiation of signal transduction: role of receptor down-regulation. Mol Endocrinol 1992;6:1849-1857.
    • (1992) Mol Endocrinol , vol.6 , pp. 1849-1857
    • Theroux, S.J.1    Stanley, K.2    Campbell, D.A.3    Davis, R.J.4
  • 27
    • 0025219916 scopus 로고
    • Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation
    • Countaway JL, McQuilkin P, Girones N, Davis RJ. Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation. J Biol Chem 1990;265:3407-3416.
    • (1990) J Biol Chem , vol.265 , pp. 3407-3416
    • Countaway, J.L.1    McQuilkin, P.2    Girones, N.3    Davis, R.J.4
  • 28
    • 77958506612 scopus 로고    scopus 로고
    • Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
    • Sun Q, Jackson RA, Ng C, Guy GR, Sivaraman J. Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain. PLoS One 2010;5:e12819.
    • (2010) PLoS One , vol.5 , pp. e12819
    • Sun, Q.1    Jackson, R.A.2    Ng, C.3    Guy, G.R.4    Sivaraman, J.5
  • 29
    • 0037076329 scopus 로고    scopus 로고
    • FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
    • Wong A, Lamothe B, Lee A, Schlessinger J, Lax I. FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. Proc Natl Acad Sci USA 2002;99:6684-6689.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6684-6689
    • Wong, A.1    Lamothe, B.2    Lee, A.3    Schlessinger, J.4    Lax, I.5
  • 30
    • 80155192453 scopus 로고    scopus 로고
    • Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
    • Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F et al. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J 2011;30:3259-3273.
    • (2011) EMBO J , vol.30 , pp. 3259-3273
    • Persaud, A.1    Alberts, P.2    Hayes, M.3    Guettler, S.4    Clarke, I.5    Sicheri, F.6
  • 31
    • 77953167957 scopus 로고    scopus 로고
    • Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor
    • Goh LK, Huang F, Kim W, Gygi S, Sorkin A. Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor. J Cell Biol 2010;189:871-883.
    • (2010) J Cell Biol , vol.189 , pp. 871-883
    • Goh, L.K.1    Huang, F.2    Kim, W.3    Gygi, S.4    Sorkin, A.5
  • 32
    • 3042765843 scopus 로고    scopus 로고
    • Ribosomal S6 kinase as a mediator of keratinocyte growth factor-induced activation of Akt in epithelial cells
    • Pan ZZ, Devaux Y, Ray P. Ribosomal S6 kinase as a mediator of keratinocyte growth factor-induced activation of Akt in epithelial cells. Mol Biol Cell 2004;15:3106-3113.
    • (2004) Mol Biol Cell , vol.15 , pp. 3106-3113
    • Pan, Z.Z.1    Devaux, Y.2    Ray, P.3
  • 33
    • 34548253333 scopus 로고    scopus 로고
    • FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway
    • Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S et al. FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell 2007;12:201-214.
    • (2007) Cancer Cell , vol.12 , pp. 201-214
    • Kang, S.1    Dong, S.2    Gu, T.L.3    Guo, A.4    Cohen, M.S.5    Lonial, S.6
  • 34
    • 65549095986 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival
    • Xian W, Pappas L, Pandya D, Selfors LM, Derksen PW, De Bruin M et al. Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival. Cancer Res 2009;69:2244-2251.
    • (2009) Cancer Res , vol.69 , pp. 2244-2251
    • Xian, W.1    Pappas, L.2    Pandya, D.3    Selfors, L.M.4    Derksen, P.W.5    De Bruin, M.6
  • 36
    • 33845764296 scopus 로고    scopus 로고
    • A guided tour into subcellular colocalization analysis in light microscopy
    • Bolte S, Cordelieres FP. A guided tour into subcellular colocalization analysis in light microscopy. J Microsc 2006;224:213-232.
    • (2006) J Microsc , vol.224 , pp. 213-232
    • Bolte, S.1    Cordelieres, F.P.2


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