Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain

PLoS ONE

Volumn 5, Issue 9, 2010, Pages 1-11

  Sun, Qingxiang ^a   Jackson, Rebecca A ^b   Ng, Cherlyn ^b   Guy, Graeme R ^b   Sivaraman, J ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; SPROUTY 2 PROTEIN; SPROUTY PROTEIN; UNCLASSIFIED DRUG; SERINE; SIGNAL PEPTIDE; SPRY2 PROTEIN, HUMAN; THREONINE;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CHEMICAL BOND; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; PEPTIDE ANALYSIS; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; STRUCTURE ANALYSIS; TYROSINE KINASE BINDING MOTIF; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SRC HOMOLOGY DOMAIN;

AMINO ACID SEQUENCE; BINDING SITES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR, EPIDERMAL GROWTH FACTOR; SERINE; SRC HOMOLOGY DOMAINS; THREONINE;

EID: 77958506612     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012819     Document Type: Article

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