5-HT2B Receptor Antagonists Reduce Nerve Injury-Induced Tactile Allodynia and Expression of 5-HT2B Receptors

Drug Development Research

Volumn 76, Issue 1, 2015, Pages 31-39

  Pineda Farias, Jorge B ^a   Velázquez Lagunas, Isabel ^a,b   Barragán Iglesias, Paulino ^a   Cervantes Durán, Claudia ^a   Granados Soto, Vinicio ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

2,5 dimethoxy 4 iodoamphetamine hydrochloride; 5 HT2 B receptors; allodynia; LY 266097; RS 127445; spinal processing

Indexed keywords

1 [(2 CHLORO 3,4 DIMETHOXYPHENYL)METHYL] 2,3,4,9 TETRAHYDRO 6 METHYL 1H PYRIDO[3,4 B]INDOLE; 2 AMINO 4 (4 FLUORONAPHTH 1 YL) 6 ISOPROPYLPYRIDINE; SEROTONIN 2B RECEPTOR; SEROTONIN 2B RECEPTOR ANTAGONIST; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PROTEIN EXPRESSION; RAT; SPINAL GANGLION; SPINAL NERVE LIGATION INJURY; WESTERN BLOTTING;

EID: 84921713001     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.21238     Document Type: Article

References (49)

1. 2B receptor-mediated facilitation in neuropathic pain: up-regulation of PKCγ and engagement of the NMDA receptor in dorsal horn neurons. Pain 154:1865–1877.
2. 2B receptors. Pain 153:1418–1425.
3. Aira Z, Buesa I, Rada D, Gómez-Esteban JC, Azkue JJ. 2014. Coupling of serotonergic input to NMDA receptor-phosphorylation following peripheral nerve injury via rapid, synaptic up-regulation of ND2. Exp Neurol 255:86–95.
4. Aira Z, Buesa I, Salgueiro M, Bilbao J, Aguilera L, Zimmermann M, Azkue JJ. 2010. Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury. Neuroscience 168:831–841.
5. 7 receptors reduces tactile allodynia in the rat. Pharmacol Biochem Behav 99:591–597.
6. Ambriz-Tututi M, Cruz SL, Urquiza-Marín H, Granados-Soto V. 2011. Formalin-induced long-term secondary allodynia and hyperalgesia are maintained by descending facilitation. Pharmacol Biochem Behav 98:417–424.
7. 2B) contractile receptor in the rat stomach fundus. J Med Chem 39:2773–2780.
8. Bardin L, Lavarenne J, Eschalier A. 2000. Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats. Pain 86:11–18.
9. 2 receptor activation potentiates N-methyl-D-aspartate receptor-mediated ion currents by a protein kinase C-dependent mechanism. J Neurosci Res 45:153–160.
10. 2B receptor antagonist. Br J Pharmacol 127:1075–1082.
11. Burgess SE, Gardell LR, Ossipov MH, Malan TP, Vanderah TW, Lai J, Porreca F. 2002. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci 22:5129–5136.
12. Caram-Salas NL, Reyes-García G, Bartoszyk GD, Araiza-Saldaña CI, Ambriz-Tututi M, Rocha-González HI, Arreola-Espino R, Cruz SL, Granados-Soto V. 2007. Subcutaneous, intrathecal and periaqueductal grey administration of asimadoline and ICI-204448 reduces tactile allodynia in the rat. Eur J Pharmacol 573:75–83.
13. 2C receptors in formalin-induced secondary mechanical allodynia and hyperalgesia. Neuroscience 232:169–181.
14. 2B receptors in formalin-induced nociception. Pharmacol Biochem Behav 102:30–35.
15. 3 receptors facilitate behavioural hypersensitivity induced by elevated calcium channel alpha-2-delta-1 protein. Eur J Pain 17:505–513.
16. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. 1994. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53:55–63.
17. Chen JJ, Vasko MR, Wu X, Staeva TP, Baez M, Zgombick JM, Nelson DL. 1998. Multiple subtypes of serotonin receptors are expressed in rat sensory neurons in culture. J Pharmacol Exp Ther 287:1119–1127.
18. 3 receptor for days causes sustained relief from mechanical allodynia following spinal cord injury. J Neurosci Res 87:418–424.
19. q/11 activation and calcium mobilisation in CHO cells. Eur J Pharmacol 594:32–38.
20. DeLeo JA, Rutkowski MD. 2000. Gender differences in rat neuropathic pain sensitivity is dependent on strain. Neurosci Lett 282:197–199.
21. Dixon WJ. 1980. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20:441–462.
22. 2 receptor in A7r5 smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol 333:98–103.
23. 3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade. Mol Pain 10:35.
24. Heinricher MM, Neubert MJ. 2004. Neural basis for the hyperalgesic action of cholecystokinin in the rostral ventromedial medulla. J Neurophysiol 92:1982–1989.
25. 2C receptor mRNA expression in the spinal cord of rat, cat, monkey and human. Neuroreport 5:2617–2620.
26. Hoyer D, Hannon JP, Martin GR. 2002. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71:533–554.
27. Kim SH, Chung JM. 1992. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50:355–363.
28. Kovelowski CJ, Ossipov MH, Sun H, Lai J, Malan TP, Porreca F. 2000. Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat. Pain 87:265–273.
29. Leong ML, Gu M, Speltz-Paiz R, Stahura EI, Mottey N, Steer CJ, Wessendorf M. 2011. Neuronal loss in the rostral ventromedial medulla in a rat model of neuropathic pain. J Neurosci 31:17028–17039.
30. 2B mediates serotonin-induced mechanical hyperalgesia. J Neurosci 31:1410–1418.
31. Liu ZY, Zhuang DB, Lunderberg T, Yu LC. 2002. Involvement of 5-hydroxytryptamine1A receptors in the descending anti-nociceptive pathway from periaqueductal gray to the spinal dorsal horn in intact rats, rats with nerve injury and rats with inflammation. Neuroscience 112:399–407.
32. LoPachin RM, Rudy TA, Yaksh TL. 1981. An improved method for chronic catheterization of the rat spinal subarachnoid space. Physiol Behav 27:559–561.
33. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193:265–275.
34. Marshall TM, Herman DS, Largent-Milnes TM, Badghisi H, Zuber K, Holt SC, Lai J, Porreca F, Vanderah TW. 2012. Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E in the spinal cord. Pain 153:86–94.
35. Nicholson R, Small J, Dixon AK, Spanswick D, Lee K. 2003. Serotonin receptor mRNA expression in rat dorsal root ganglion neurons. Neurosci Lett 337:119–122.
36. Nicotra L, Tuke J, Grace PM, Rolan, PE, Hutchinson MR. 2014. Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed? Front Behav Neurosci 8:40.
37. Ossipov MH, Hong Sun T, Malan P, Lai J, Porreca F. 2000. Mediaiton of spinal nerve injury induced tactile allodynia by descending facilitatory pathways in the dorsolateral funiculus in rats. Neurosci Lett 290:129–132.
38. Pertovaara A, Wei H, Hamalainen MM. 1996. Lidocaine in the rostroventromedial medulla and the periaqueductal gray attenuates allodynia in neuropathic rats. Neurosci Lett 218:127–130.
39. Porreca F, Burgess SE, Gardell LR, Vanderah TW, Malan TP, Ossipov MH, Lappi DA, Lai J. 2001. Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor. J Neurosci 21:5281–5288.
40. 2C receptors in CHO-K1 cells. Br J Pharmacol 128:13–20.
41. Rahman W, Suzuki R, Webber M, Hunt SP, Dickenson AH. 2006. Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation. Pain 123:264–274.
42. 2A/2C receptor agonist, in two rat models of sustained pain. Anesth Analg 96:1072–1078.
43. 2 receptor subtypes. Assay Drug Dev Technol 3:649–659.
44. Suzuki R, Rygh LJ, Dickenson AH. 2004. Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends Pharmacol Sci 25:613–617.
45. Tallarida RJ. 2000. Drug synergism and dose-effect data analysis. New York: Chapman & Hall/CRC.
46. 2B receptor activation on neuropathic pain. Pain 153:1320–1331.
47. Wei F, Dubner R, Zou S, Ren K, Bai G, Wei D, Guo W. 2010. Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain. J Neurosci 30:8624–8636.
48. Wu S, Zhu M, Wang W, Wang Y, Li Y, Yew DT. 2001. Changes of the expression of 5-HT receptor subtype mRNAs in rat dorsal root ganglion by complete Freund's adjuvant-induced inflammation. Neurosci Lett 307:183–186.
49. Zimmermann M. 1983. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109–110.