Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade

Molecular Pain

Volumn 10, Issue 1, 2014, Pages

  Guo, Wei ^a   Miyoshi, Kan ^b   Dubner, Ronald ^a   Gu, Ming ^a   Li, Man ^c   Liu, Jian ^d   Yang, Jiale ^a   Zou, Shiping ^a   Ren, Ke ^a   Noguchi, Koichi ^b   Wei, Feng ^a  

^a UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

^b HYOGO UNIVERSITY   (Japan)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

5 HT3 receptor; Glia; NMDA receptor; Pain; Proinflammatory cytokines

Indexed keywords

4 AMINO 1 (6 CHLORO 2 PYRIDYL)PIPERIDINE; FRACTALKINE; INTERLEUKIN 18; INTERLEUKIN 1BETA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SEROTONIN 3 RECEPTOR; SHORT HAIRPIN RNA; 4 AMINO 1 (6 CHLORO 2 PYRIDYL)PIPERIDINE HYDROCHLORIDE; 4-AMINO-1-(6-CHLORO-2-PYRIDYL)PIPERIDINE HYDROCHLORIDE; GLIAL FIBRILLARY ACIDIC PROTEIN; PIPERIDINE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVITY; CELL COMMUNICATION; CELL INTERACTION; FACILITATION; GLIA; HINDLIMB; HYPERALGESIA; INFLAMMATION; MALE; MICROGLIA; NERVE CELL; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; RNA INTERFERENCE; ROSTRAL VENTROMEDIAL MEDULLA; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINE; ANIMAL; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; INJURY; METABOLISM; NEURALGIA; NOCICEPTION; PATHOLOGY; PHYSIOLOGY; SPINAL CORD; SPINAL NERVE; SPRAGUE DAWLEY RAT;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HYPERALGESIA; INFLAMMATION; MALE; NEURALGIA; NEUROGLIA; NEURONS; PAIN PERCEPTION; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN ANTAGONISTS; SEROTONIN RECEPTOR AGONISTS; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL NERVES;

EID: 84902957395     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-10-35     Document Type: Article

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