Serotonin 5-HT2 receptor activation potentiates N-methyl-D-aspartate receptor-mediated ion currents by a protein kinase C-dependent mechanism

Journal of Neuroscience Research

Volumn 45, Issue 2, 1996, Pages 153-160

  Blank, Thomas ^a   Zwart, R ^a   Nijholt, I ^a   Spiess, J ^a  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

modulation; NMDA receptor; phosphorylation; serotonin; Xenopus oocyte

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE C; SEROTONIN 2 RECEPTOR; 1-OLEOYL-2-ACETYLGLYCEROL; DIACYLGLYCEROL; GLYCEROL 2 ACETATE 1 OLEATE; GLYCINE; MAGNESIUM; N METHYLASPARTIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; SEROTONIN; SEROTONIN RECEPTOR;

ANIMAL CELL; ARTICLE; CHANNEL GATING; ENZYME ACTIVATION; ION CURRENT; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; XENOPUS; ANIMAL; BIOSYNTHESIS; BRAIN; CELL MEMBRANE POTENTIAL; DRUG EFFECT; EVOKED RESPONSE; FEMALE; IN VITRO STUDY; METABOLISM; OOCYTE; PHYSIOLOGY; RAT; WISTAR RAT; XENOPUS LAEVIS;

ANIMALS; BRAIN; DIGLYCERIDES; ENZYME ACTIVATION; EVOKED POTENTIALS; FEMALE; GLYCINE; MAGNESIUM; MEMBRANE POTENTIALS; N-METHYLASPARTATE; OOCYTES; PROTEIN KINASE C; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SEROTONIN; SEROTONIN; TETRADECANOYLPHORBOL ACETATE; XENOPUS LAEVIS;

EID: 0029657987     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960715)45:2<153::AID-JNR7>3.0.CO;2-9     Document Type: Article

References (43)

1. Aniksztejn L, Kleschevnikov A, Ben-Ari Y, Represa A (1992a): Carbachol potentiates NMDA current via protein kinase C in rat hippocampus slices. Soc Neurosci Abstr 18:118.5.
2. Aniksztejn L, Otani S, Ben-Ari Y (1992b): Quisqualate metabotropic receptors modulate NMDA currents and facilitate induction of long-term potentiation through protein kinase C. Eur J Neurosci 4:500-505.
3. Barish ME (1983): A transient calcium-dependent chloride current in the immature Xenopus oocyte. J Physiol (Lond) 342:309-325.
4. Ben-Ari Y, Aniksztejn L, Bregestovski P (1992): Protein kinase C modulation of NMDA currents: an important link for LTP induction. Trends Neurosci 15:333-339.
5. Berridge MJ (1987): Inositol triphosphate and diacyglycerol: two interacting second messengers. Annu Rev Biochem 56:159-193.
6. Blank T, Zwart R, Spiess J (1995): Modulation of NMDA receptors expressed in Xenopus oocytes by serotonin. Soc Neurosci Abstr 21:541.8.
7. Bliss TVP, Collingridge GL (1993): A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
8. Cathala G, Savouret JF, Mendez B, West BL, Karin M, Martial JA, Baxter JD (1983): A method for isolation of intact, translationally active ribonucleic acid. DNA 2:329-335.
9. Chen L, Huang LYM (1991): Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid, Neuron 7:319-326.
10. 2+ block of NMDA-receptor channels as a mechanism of modulation. Nature 356:521-523.
11. Constantine-Paton M, Cline HT, Debski E (1990): Patterned activity, synaptic convergence, and the NMDA receptor in developing visual cortex. Annu Rev Neurosci 13:129-154.
12. Durand GM, Gregor P, Zheng X, Bennett MVL, Uhl GR, Zukin RS (1992): Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C. Proc Natl Acad Sci USA 89:9359-9363.
13. Durand GM, Bennett MVL, Zukin RS (1993): Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. Proc Natl Acad Sci USA 90:6731-6735.
14. Gundersen CB, Miledi R, Parker I (1983): Serotonin receptors induced by exogenous messenger RNA in Xenopus occytes. Proc R Soc Lond [Biol] 219:103-109.
15. Huang KP (1989): The mechanism of protein kinase C activation. Trends Neurosci 12:425-432.
16. Huang FL, Huang KP (1991): Interaction of protein kinase C isozymes with phosphatidylinositol 4,5-bisphosphate. J Biol Chem 266: 8727-8733.
17. Kelso SR, Nelson TE, Leonard JP (1992): Protein kinase C-mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes. J Physiol (Lond) 449:705-718.
18. Kushner L, Lerma J, Zukin RS, Bennett MVL (1988): Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA. Proc Natl Acad Sci USA 85:3250-3254.
19. Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, Mishina M (1992): Molecular diversity of the NMDA receptor channel. Nature 358:36-41.
20. Leonard JP, Kelso SR (1990): Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current. Neuron 2:53-60.
21. Liu L, Brown JC, Webster WW, Morrisett RA, Monaghan DT(1995): Insulin potentiates N-methyl-D-aspartate receptor activity in Xenopus oocytes and rat hippocampus. Neurosci Lett 192:5-8.
22. MacDermot AB, Mayer ML, Westbrook GL, Smith SJ, Barker JL (1986): NMDA receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321:261-263.
23. Miledi R (1982): A calcium-dependent transient outward current in Xenopus laevis oocytes. Proc R Soc Lond [Biol] 215:491-497.
24. Miledi R, Parker I (1984): Chloride current induced by injection of calcium into Xenopus oocytes. J Physiol (Lond) 357:173-183.
25. Mileo AM, Palma E, Polenzani L, Limatola C, Grassi F, Eusebi F (1995): Protein kinase C modulates exogenous acetylcholine current in Xenopus oocytes. J Neurosci Res 41:443-451.
26. Mori H, Yamakura T, Masaki H, Mishina M (1993): Involvement of the carboxyl-terminal region in modulation by TPA of the NMDA receptor channel. NeuroReport 4:519-522.
27. Murase K, Randic M, Shirasaki T, Nakagawa T, Akaike N (1990): Serotonin suppresses N-methyl-D-aspartate responses in acutely isolated spinal dorsal horn neurons of the rat. Brain Res 525:84-91.
28. Nicoll RA, Kauer JA, Malenka RC (1988): The current excitement in long-term potentiation. Neuron 1:97-103.
29. 2 receptors facilitates depolarization of neocortical neurons by N-methyl-D-aspartate. Eur J Pharmacol 231:347-354.
30. Rothman SM, Olney JW (1987): Excitotoxicity and the NMDA receptor. Trends Neurosci 10:299-302.
31. Saudou F, Hen R (1995): 5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates. Neurochem Int 25:503-532.
32. Scheetz AJ, Constantine-Paton M (1994): Modulation of NMDA receptor function: implications for vertebrate neural development. FASEB J 8:745-752.
33. +, and γ-aminobutyrate type A channels. Proc Natl Acad Sci USA 85:6192-6196.
34. Sigel E, Baur R, Malherbe P (1994): Protein kinase C transiently activates heteromeric N-methyl-D-aspartate receptor channels independent of the phosphorylatable C-terminal splice domain and of consensus phosphorylation sites. J Biol Chem 269: 8204-8208.
35. Soderling TR, Tan SE, McGlade-McCulloh E, Yamamoto H, Fukunaga K (1994): Excitatory interactions between glutamate receptors and protein kinases. J Neurobiol 25:304-311.
36. Stühmer W (1992): Electrophysiological recording from Xenopus oocytes. Methods Enzymol 207:319-339.
37. Swope SL, Moss SJ, Blackstone CD, Huganir RL (1992): Phosphorylation of ligand-gated ion channels: a possible mode of synaptic plasticity. FASEB J 6:2514-2523.
38. Takahashi T, Neher E, Sakmann B (1987): Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels. Proc Natl Acad Sci USA 84:5063-5067.
39. Urushihara H, Tohda M, Nomura Y (1992): Selective potentiation of N-methyl-D-aspartate-induced current by protein kinase C in Xenopus oocytes injected with rat brain RNA. J Biol Chem 267:11697-11700.
40. Vaello ML, Ruiz-Gomez A, Lerma J, Mayor F (1994): Modulation of inhibitory glycine receptors by phosphorylation by protein kinase C and cAMP-dependent protein kinase. J Biol Chem 269: 2002-2008.
41. Verdoorn TA, Kleckner NW, Dingledine R (1987): Rat brain N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Science 238:1114-1116.
42. Yamakura T, Mori H, Shimoji K, Mishina M (1993): Phosphorylation of the carboxyl-terminal domain of the ξ1 subunit is not responsible for potentiation by TPA of the NMDA receptor channel. Biochem Biophys Res Commun 196:1537-1544.
43. Yamazaki M, Mori H, Araki K, Mori KJ, Mishina M (1992): Cloning, expression and modulation of a mouse NMDA receptor subunit. FEBS Lett 300:39-45.