Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice

Endocrinology (United States)

Volumn 156, Issue 2, 2015, Pages 660-669

  Vega, Aurélie ^a,b,c,d   Martinot, Emmanuelle ^a,b,c,d   Baptissart, Marine ^a,b,c,d   De Haze, Angélique ^a,b,c,d   Saru, Jean Paul ^a,b,c,d   Baron, Silvère ^a,b,c,d   Caira, Françoise ^a,b,c,d   Schoonjans, Kristina ^e   Lobaccaro, Jean Marc A ^a,b,c,d   Volle, David H ^a,b,c,d  

^a INSERM   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

^c CNRS   (France)

^d CRNH AUVERGNE   (France)

^e EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; GONADORELIN ANTAGONIST; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LUTEINIZING HORMONE; ORPHAN NUCLEAR RECEPTOR; ORPHAN NUCLEAR RECEPTOR NR0B2; TESTOSTERONE; UNCLASSIFIED DRUG; CELL RECEPTOR; GONADORELIN RECEPTOR; NUCLEAR RECEPTOR SUBFAMILY 0, GROUP B, MEMBER 2;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE REPRESSION; GERM CELL; HORMONAL REGULATION; HORMONE ACTION; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IN VIVO STUDY; LEYDIG CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEROIDOGENESIS; TESTOSTERONE SYNTHESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; PHYSIOLOGY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL LINE; CHORIONIC GONADOTROPIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LEYDIG CELLS; MALE; MICE, INBRED C57BL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, LHRH; SIGNAL TRANSDUCTION; TESTOSTERONE;

EID: 84921647842     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1418     Document Type: Article

References (39)

1. Wilson JD, LeihyMW,Shaw G, Renfree MB. Androgen physiology: unsolved problems at the millennium. Mol Cell Endocrinol. 2002; 198(1-2):1-5.
2. Wang RS, Yeh S, Tzeng CR, Chang C. Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice. Endocr Rev. 2009;30(2):119-132.
3. Woolveridge I, Bryden AA, Taylor MF, George NJ, Wu FC, Morris ID. Apoptosis and expression of apoptotic regulators in the human testis following short- and long-term anti-androgen treatment. Mol Hum Reprod. 1998;4(7):701-707.
4. Stocco DM. The role of the StAR protein in steroidogenesis: challenges for the future. J Endocrinol. 2000;164(3):247-253.
5. Papadopoulos V, Amri H, Boujrad N, et al. Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids. 1997;62(1):21-28.
6. Hu M-C, Hsu H-J, Guo I-C, Chung B-C. Function of Cyp11a1 in animal models. Mol Cell Endocrinol. 2004;215(1-2):95-100.
7. Maqdasy S, Baptissart M, Vega A, Baron S, Lobaccaro J-MA, Volle DH. Cholesterol and male fertility: what about orphans and adopted? Mol Cell Endocrinol. 2013;368(1-2):30-46.
8. Stocco DM, Khan SA. Effects of steroidogenesis inducing protein (SIP) on steroid production in MA-10 mouse Leydig tumor cells: utilization of a non-cAMP second messenger pathway. Mol Cell Endocrinol. 1992;84(3):185-194.
9. Simpson ER, Waterman MR. Regulation of the synthesis of steroidogenic enzymes in adrenal cortical cells by ACTH. Annu Rev Physiol. 1988;50:427-440.
10. Bakke M, Zhao L, Hanley NA, Parker KL. SF-1: a critical mediator of steroidogenesis. Mol Cell Endocrinol. 2001;171(1-2):5-7.
11. Meeks JJ, Russell TA, Jeffs B, Huhtaniemi I, Weiss J, Jameson JL. Leydig cell-specific expression of DAX1 improves fertility of the Dax1-deficient mouse. Biol Reprod. 2003;69(1):154-160.
12. Cummins CL, Volle DH, Zhang Y, et al. Liver X receptors regulate adrenal cholesterol balance. J Clin Invest. 2006;116(7):1902-1912.
13. Volle DH, Mouzat K, Duggavathi R, et al. Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility. Mol Endocrinol. 2007;21(5):1014-1027.
14. Kuhl AJ, Ross SM, GaidoKW.CCAAT/enhancer binding protein, but not steroidogenic factor-1, modulates the phthalate-induced dysregulation of rat fetal testicular steroidogenesis. Endocrinology. 2007;148(12):5851-5864.
15. Kim JW, Peng N, Rainey WE, Carr BR, Attia GR. Liver receptor homolog-1 regulates the expression of steroidogenic acute regulatory protein in human granulosa cells. J Clin Endocrinol Metab. 2004;89(6):3042-3047.
16. Martin LJ, Boucher N, Brousseau C, Tremblay JJ. The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I. Mol Endocrinol. 2008;22(9):2021-2037.
17. Manna PR, Dyson MT, Eubank DW, et al. Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family. Mol Endocrinol. 2002;16(1):184-199.
18. Seol W, Choi HS, Moore DD. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996;272(5266):1336-1339.
19. Goodwin B, Jones SA, Price RR, et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell. 2000;6(3):517-526.
20. Lu TT, Makishima M, Repa JJ, et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell. 2000;6(3):507-515.
21. Volle DH, Duggavathi R, Magnier BC, et al. The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice. Genes Dev. 2007;21(3):303-315.
22. Volle DH, Decourteix M, Garo E, et al. The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice. J Clin Invest. 2009;119(12):3752-3764.
23. Dalterio S, Bartke A, Steger R, Mayfield D. Neonatal exposure to DES in BALB/c male mice: effects on pituitary-gonadal function. Pharmacol Biochem Behav. 1985;22(6):1019-1024.
24. Baptissart M, Vega A, Martinot E, et al. Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice. Hepatology. 2014;60(3):1054-1065.
25. Oumeddour A, Viennois E, Caira F, et al. LiverXreceptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology. Biochem Biophys Res Commun. 2014;446(3):656-662.
26. Baron S, Manin M, Aigueperse C, et al. Hormonal and developmental regulation of the mouse aldose reductase-like gene akr1b7 expression in Leydig cells. J Mol Endocrinol. 2003;31(1):71-81.
27. Oosterveer MH, Mataki C, Yamamoto H, et al. LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest. 2012;122(8):2817-2826.
28. Hansson V, Skalhegg BS, Taskén K. Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA. J Steroid Biochem Mol Biol. 2000;73(1-2):81-92.
29. Ahn SW, Gang GT, Tadi S, et al. Phosphoenolpyruvate carboxykinase and glucose-6-phosphatase are required for steroidogenesis in testicular Leydig cells. J Biol Chem. 2012;287(50):41875-41887.
30. Kim YD, Park KG, Lee YS, et al. Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes. 2008;57(2): 306-314.
31. Tartarin P, Guibert E, Touré A, et al. Inactivation of AMPK-1 induces asthenozoospermia and alters spermatozoa morphology. Endocrinology. 2012;153(7):3468-3481.
32. Vega A, Baptissart M, Caira F, Brugnon F, Lobaccaro J-MA, Volle DH. Epigenetic: a molecular link between testicular cancer and environmental exposures. Front Endocrinol (Lausanne). 2012;3:150.
33. Rubin BS. Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects. J Steroid Biochem Mol Biol. 2011; 127(1-2):27-34.
34. Abdou HS, Bergeron F, Tremblay JJ. A cell autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis. Mol Cell Biol. 2014;34(23):4257-4271.
35. Song KH, Park YY, Park KC, et al. The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation. Mol Endocrinol. 2004;18(8):1929-1940.
36. Morgan JA, Cheepala SB, Wang Y, et al. Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4- deficient mice. J Biol Chem. 2012;287(18):14456-14466.
37. Ahn SW, Gang GT, Kim YD, et al. Insulin directly regulates steroidogenesis via induction of the orphan nuclear receptor DAX-1 in testicular Leydig cells. J Biol Chem. 2013;288(22):15937-15946.
38. Trussell JC. Male reproductive endocrinology: when to replace gonadotropins. Semin Reprod Med. 2013;31(4):237-244.
39. Tena-Sempere M, Navarro J, Pinilla L, González LC, Huhtaniemi I, Aguilar E. Neonatal exposure to estrogen differentially alters estrogen receptor- and- mRNAexpression in rat testis during postnatal development. J Endocrinol. 2000;165(2):345-357.