Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice

Journal of Biological Chemistry

Volumn 287, Issue 18, 2012, Pages 14456-14466

  Morgan, Jessica A ^a,c   Cheepala, Satish B ^a   Wang, Yao ^a   Neale, Geoff ^a   Adachi, Masashi ^a   Nachagari, Deepa ^a   Leggas, Mark ^a   Zhao, Wenchen ^b   Boyd, Kelli ^a   Venkataramanan, Raman ^b   Schuetz, John D ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT MICE; ANDROGEN PRODUCTION; CAMP-RESPONSE ELEMENT-BINDING PROTEINS; IN-VIVO; INTRACELLULAR CAMP; INTRACELLULAR MESSENGERS; LEYDIG CELLS; MULTIDRUG RESISTANCE; SIDE EFFECT; TARGET GENES;

BIOCHEMISTRY; CELLS; GENE EXPRESSION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

MAMMALS;

CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME P450 2B; CYTOCHROME P450 2B10; LUTEINIZING HORMONE; MULTIDRUG RESISTANCE PROTEIN 4; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GAMETOGENESIS; GENE; GENE EXPRESSION; HOMEOSTASIS; IN VIVO STUDY; LEYDIG CELL; LIVER METABOLISM; MALE; MALE FERTILITY; MOUSE; MRP4 GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TESTOSTERONE SYNTHESIS; UPREGULATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LEYDIG CELLS; LIVER; MALE; MICE; MICE, KNOCKOUT; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RECEPTORS, LH; SPERMATOGENESIS; STEROID HYDROXYLASES; TESTOSTERONE; UP-REGULATION;

MUS;

EID: 84860356361     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.319681     Document Type: Article

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