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Volumn 115, Issue 1, 2014, Pages 4-12

An integrated approach for prioritizing pharmaceuticals found in the environment for risk assessment, monitoring and advanced research

Author keywords

Adverse outcome pathways; Environmental risk assessment; Intelligent testing; Pharmaceuticals in the environment; Prioritization

Indexed keywords

ENVIRONMENTAL TECHNOLOGY; HAZARDS; MAMMALS;

EID: 84921633473     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2014.01.021     Document Type: Article
Times cited : (77)

References (62)
  • 1
    • 10744221336 scopus 로고    scopus 로고
    • Screening analysis of human pharmaceutical compounds in the US surface waters
    • Anderson P.D. Screening analysis of human pharmaceutical compounds in the US surface waters. Environ. Sci. Technol. 2004, 38:838-849.
    • (2004) Environ. Sci. Technol. , vol.38 , pp. 838-849
    • Anderson, P.D.1
  • 4
    • 75749144557 scopus 로고    scopus 로고
    • Leveraging mammalian pharmaceutical toxicology and pharmacology data to predict chronic fish responses to pharmaceuticals
    • Berninger J.P., Brooks B.W. Leveraging mammalian pharmaceutical toxicology and pharmacology data to predict chronic fish responses to pharmaceuticals. Toxicol. Lett. 2010, 193:69-78.
    • (2010) Toxicol. Lett. , vol.193 , pp. 69-78
    • Berninger, J.P.1    Brooks, B.W.2
  • 5
    • 85028168689 scopus 로고    scopus 로고
    • Leveraging Available Data for Contaminants of Emerging Concern to Develop an Understanding of Environmental Hazard
    • Ph.D. dissertation, Baylor University, Waco, Texas.
    • Berninger, J.P., 2011. Leveraging Available Data for Contaminants of Emerging Concern to Develop an Understanding of Environmental Hazard. Ph.D. dissertation, Baylor University, Waco, Texas.
    • (2011)
    • Berninger, J.P.1
  • 7
    • 57449095204 scopus 로고    scopus 로고
    • Herbicidal effects of sulfamethoxazole in Lemna gibba: using p-aminobenzoic acid as a biomarker of effect
    • Brain R.A., Ramirez A.J., Fulton B.A., Chambliss C.K., Brooks B.W. Herbicidal effects of sulfamethoxazole in Lemna gibba: using p-aminobenzoic acid as a biomarker of effect. Environ. Sci. Technol. 2008, 42:8965-8970.
    • (2008) Environ. Sci. Technol. , vol.42 , pp. 8965-8970
    • Brain, R.A.1    Ramirez, A.J.2    Fulton, B.A.3    Chambliss, C.K.4    Brooks, B.W.5
  • 8
    • 84860583431 scopus 로고    scopus 로고
    • Human pharmaceuticals in the aquatic environment: a critical review of recent toxicological studies and considerations for toxicity testing
    • Brausch J.M., Connors K.A., Brooks B.W., Rand G.M. Human pharmaceuticals in the aquatic environment: a critical review of recent toxicological studies and considerations for toxicity testing. Rev. Environ. Contam. Toxicol. 2012, 218:1-99.
    • (2012) Rev. Environ. Contam. Toxicol. , vol.218 , pp. 1-99
    • Brausch, J.M.1    Connors, K.A.2    Brooks, B.W.3    Rand, G.M.4
  • 10
    • 73449124810 scopus 로고    scopus 로고
    • Pharmaceuticals and personal care products: research needs for the next decade
    • Brooks B.W., Huggett D.B., Boxall A.B.A. Pharmaceuticals and personal care products: research needs for the next decade. Environ. Toxicol. Chem. 2009, 28:2469-2472.
    • (2009) Environ. Toxicol. Chem. , vol.28 , pp. 2469-2472
    • Brooks, B.W.1    Huggett, D.B.2    Boxall, A.B.A.3
  • 11
    • 84905578509 scopus 로고    scopus 로고
    • Risk assessment considerations for veterinary medicines in aquatic systems
    • American Chemical Society, Washington DC, K. Henderson, J. Coats (Eds.)
    • Brooks B.W., Huggett D.B., Brain R.A., Ankley G.T. Risk assessment considerations for veterinary medicines in aquatic systems. Veterinary Pharmaceuticals in the Environment 2009, 205-223. American Chemical Society, Washington DC. K. Henderson, J. Coats (Eds.).
    • (2009) Veterinary Pharmaceuticals in the Environment , pp. 205-223
    • Brooks, B.W.1    Huggett, D.B.2    Brain, R.A.3    Ankley, G.T.4
  • 14
    • 75449087350 scopus 로고    scopus 로고
    • Highly active human pharmaceuticals in aquatic systems: a concept for their identification based on their mode of action
    • Christen V., Hickmann S., Rechenberg B., Fent K. Highly active human pharmaceuticals in aquatic systems: a concept for their identification based on their mode of action. Aquat. Toxicol. 2010, 96:167-181.
    • (2010) Aquat. Toxicol. , vol.96 , pp. 167-181
    • Christen, V.1    Hickmann, S.2    Rechenberg, B.3    Fent, K.4
  • 15
    • 34249749916 scopus 로고    scopus 로고
    • Daphnia magna responses to a vertebrate estrogen receptor agonist and an antagonist: a multigenerational study
    • Clubbs R.L., Brooks B.W. Daphnia magna responses to a vertebrate estrogen receptor agonist and an antagonist: a multigenerational study. Ecotoxicol. Environ. Safe. 2007, 67:385-398.
    • (2007) Ecotoxicol. Environ. Safe. , vol.67 , pp. 385-398
    • Clubbs, R.L.1    Brooks, B.W.2
  • 17
    • 63649142301 scopus 로고    scopus 로고
    • Development of a common priority list of pharmaceuticals relevant for the water cycle
    • de Voogt P., Janex-Habibi M.L., Sacher F., Puijker L., Mons M. Development of a common priority list of pharmaceuticals relevant for the water cycle. Water Sci. Technol. 2009, 59:39-46.
    • (2009) Water Sci. Technol. , vol.59 , pp. 39-46
    • de Voogt, P.1    Janex-Habibi, M.L.2    Sacher, F.3    Puijker, L.4    Mons, M.5
  • 19
    • 85028161722 scopus 로고    scopus 로고
    • Contaminants of Emerging Concern in the Tidal Delaware River, Pilot Monitoring Survey 2007-2009, Final Report July 2012 (revised 08.13).
    • Delaware River Basin Commission, 2013. Contaminants of Emerging Concern in the Tidal Delaware River, Pilot Monitoring Survey 2007-2009, Final Report July 2012 (revised 08.13).
    • (2013)
  • 22
    • 84883009377 scopus 로고    scopus 로고
    • Comparison of contaminants of emerging concern removal, discharge and water quality hazards among centralized and on-site wastewater treatment systems receiving common wastewater influent
    • Du B., Price A.E., Scott W.C., Kristofco L.A., Ramirez A.J., Chambliss C.K., Yelderman J.C., Brooks B.W. Comparison of contaminants of emerging concern removal, discharge and water quality hazards among centralized and on-site wastewater treatment systems receiving common wastewater influent. Sci. Total Environ. 2014, 466-467:976-984.
    • (2014) Sci. Total Environ. , pp. 976-984
    • Du, B.1    Price, A.E.2    Scott, W.C.3    Kristofco, L.A.4    Ramirez, A.J.5    Chambliss, C.K.6    Yelderman, J.C.7    Brooks, B.W.8
  • 23
    • 85028137428 scopus 로고    scopus 로고
    • Intelligent Testing Strategies in Ecotoxicology: Mode of Action Approach for Specifically Acting Chemicals, European Centre for Ecotoxicology and Toxicology of Chemicals, Technical Report No. 102, Brussels.
    • ECETOC, 2007. Intelligent Testing Strategies in Ecotoxicology: Mode of Action Approach for Specifically Acting Chemicals, European Centre for Ecotoxicology and Toxicology of Chemicals, Technical Report No. 102, Brussels.
    • (2007)
  • 24
    • 58149464184 scopus 로고    scopus 로고
    • Pre-Authorisation Evaluation of Medicines for Human Use
    • Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use. European Medicines Agency, London, UK.
    • EMA, 2006. Pre-Authorisation Evaluation of Medicines for Human Use. Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use. European Medicines Agency, London, UK.
    • (2006)
  • 25
    • 0004060307 scopus 로고    scopus 로고
    • Guidance for Industry. Environmental Assessment of Human Drug and Biologics Applications
    • U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER), Rockville, MD, USA.
    • FDA, 1998. Guidance for Industry. Environmental Assessment of Human Drug and Biologics Applications. U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER), Rockville, MD, USA.
    • (1998)
  • 26
    • 30644479441 scopus 로고    scopus 로고
    • Ecotoxicology of human pharmaceuticals
    • Fent K., Weston A.A., Caminada D. Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 2006, 76:122-159.
    • (2006) Aquat. Toxicol. , vol.76 , pp. 122-159
    • Fent, K.1    Weston, A.A.2    Caminada, D.3
  • 27
    • 77950429952 scopus 로고    scopus 로고
    • Therapeutic levels of levonorgestrel detected in blood plasma of fish: results from screening rainbow trout exposed to treated sewage effluents
    • Fick J., Lindberg R.H., Parkkonen J., Arvidsson B., Tysklind M., Larsson D.G.J. Therapeutic levels of levonorgestrel detected in blood plasma of fish: results from screening rainbow trout exposed to treated sewage effluents. Environ. Sci. Technol. 2010, 44:2661-2666.
    • (2010) Environ. Sci. Technol. , vol.44 , pp. 2661-2666
    • Fick, J.1    Lindberg, R.H.2    Parkkonen, J.3    Arvidsson, B.4    Tysklind, M.5    Larsson, D.G.J.6
  • 28
    • 48749088292 scopus 로고    scopus 로고
    • Evolutionary conservation of human drug targets in organisms used for environmental risk assessments
    • Gunnarsson L., Jauhiainen A., Kristiansson E., Nerman O., Larsson D.G.J. Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ. Sci. Technol. 2008, 42:5807-5814.
    • (2008) Environ. Sci. Technol. , vol.42 , pp. 5807-5814
    • Gunnarsson, L.1    Jauhiainen, A.2    Kristiansson, E.3    Nerman, O.4    Larsson, D.G.J.5
  • 30
    • 0037052865 scopus 로고    scopus 로고
    • Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data
    • Heberer T. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol. Lett. 2002, 131:5-17.
    • (2002) Toxicol. Lett. , vol.131 , pp. 5-17
    • Heberer, T.1
  • 31
    • 2342652328 scopus 로고    scopus 로고
    • A theoretical model for utilizing mammalian pharmacology and safety data to prioritise potential impacts of human pharmaceuticals to fish
    • Huggett D.B., Cook J.C., Ericson J.E., Williams R.T. A theoretical model for utilizing mammalian pharmacology and safety data to prioritise potential impacts of human pharmaceuticals to fish. J. Human Ecol. Risk Assess. 2003, 9:1789-1799.
    • (2003) J. Human Ecol. Risk Assess. , vol.9 , pp. 1789-1799
    • Huggett, D.B.1    Cook, J.C.2    Ericson, J.E.3    Williams, R.T.4
  • 32
    • 84887986258 scopus 로고    scopus 로고
    • Do concentrations of ethinylestradiol, estradiol, and diclofenac in European rivers exceed proposed EU Environmental Quality Standards?
    • press
    • Johnson, A.C., Dumont, E., Williams, R.J., Oldenkamp, R., Cisowska, I., Sumpter, J.P., in press. Do concentrations of ethinylestradiol, estradiol, and diclofenac in European rivers exceed proposed EU Environmental Quality Standards? Environ. Sci. Technol. doi: 10.1021/es4030035.
    • Environ. Sci. Technol.
    • Johnson, A.C.1    Dumont, E.2    Williams, R.J.3    Oldenkamp, R.4    Cisowska, I.5    Sumpter, J.P.6
  • 33
    • 63449087981 scopus 로고    scopus 로고
    • Knowledge and need assessment of pharmaceutical products in environmental waters
    • Final Report, European Commission FP6 project 036864
    • KNAPPE, 2008. Knowledge and need assessment of pharmaceutical products in environmental waters, Final Report, European Commission FP6 project 036864, http://environmentalhealthcollaborative.org/images/KNAPPE_REPORT_FINAL.pdf.
    • (2008)
  • 34
    • 36049043771 scopus 로고    scopus 로고
    • Risks to aquatic organisms posed by human pharmaceutical use
    • Kostich M.S., Lazorchak J.M. Risks to aquatic organisms posed by human pharmaceutical use. Sci. Total Environ. 2008, 389:329-339.
    • (2008) Sci. Total Environ. , vol.389 , pp. 329-339
    • Kostich, M.S.1    Lazorchak, J.M.2
  • 35
    • 84882722995 scopus 로고    scopus 로고
    • Metabolic and reproductive effects of relatively low concentrations of beclomethasone dipropionate, a synthetic glucocorticoid, on fathead minnows
    • Kugathas S., Runnalls T.J., Sumpter J.P. Metabolic and reproductive effects of relatively low concentrations of beclomethasone dipropionate, a synthetic glucocorticoid, on fathead minnows. Environ. Sci. Technol. 2013, 47(16):9487-9495.
    • (2013) Environ. Sci. Technol. , vol.47 , Issue.16 , pp. 9487-9495
    • Kugathas, S.1    Runnalls, T.J.2    Sumpter, J.P.3
  • 36
    • 34548354864 scopus 로고    scopus 로고
    • Effluent from drug manufactures contains extremely high levels of pharmaceuticals
    • Larsson D.G.J., de Pedro C., Paxeus N. Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J. Hazard. Mater. 2007, 148:751-755.
    • (2007) J. Hazard. Mater. , vol.148 , pp. 751-755
    • Larsson, D.G.J.1    de Pedro, C.2    Paxeus, N.3
  • 37
    • 38049033836 scopus 로고    scopus 로고
    • Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and the receiving river
    • Li D., Yang M., Hu J., Ren L., Zhang Y., Li K. Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and the receiving river. Environ. Toxicol. Chem. 2008, 27:80-86.
    • (2008) Environ. Toxicol. Chem. , vol.27 , pp. 80-86
    • Li, D.1    Yang, M.2    Hu, J.3    Ren, L.4    Zhang, Y.5    Li, K.6
  • 39
    • 84871833923 scopus 로고    scopus 로고
    • Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study
    • Margiotta-Casaluci L., Hannah R.E., Sumpter J.P. Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study. Aquat. Toxicol. 2013, 128-129:113-123.
    • (2013) Aquat. Toxicol. , pp. 113-123
    • Margiotta-Casaluci, L.1    Hannah, R.E.2    Sumpter, J.P.3
  • 40
    • 84857686334 scopus 로고    scopus 로고
    • Pharmaceutical plasma concentrations in fish as a prediction tool for toxicity: case studies with 17α-ethinyl estradiol and propranolol
    • SETAC North America, 29th Annual Meeting.
    • Moen, M.A., Owen, S.F., Hutchinson, T.H., Hetheridge, M.J., Constantine, L.A., Sumpter, J.P., Huggett, D.B., 2007. Pharmaceutical plasma concentrations in fish as a prediction tool for toxicity: case studies with 17α-ethinyl estradiol and propranolol. SETAC North America, 29th Annual Meeting.
    • (2007)
    • Moen, M.A.1    Owen, S.F.2    Hutchinson, T.H.3    Hetheridge, M.J.4    Constantine, L.A.5    Sumpter, J.P.6    Huggett, D.B.7
  • 41
    • 85028172274 scopus 로고    scopus 로고
    • O.J. (L 226) 1. Directive of the European Parliament and of the Council of 12 August 2013 amending Directives 2000/60/EC and 2008/105/EC as regards priority substances in the field of water policy - 17 April 2013.
    • O.J., 2013. (L 226) 1. Directive of the European Parliament and of the Council of 12 August 2013 amending Directives 2000/60/EC and 2008/105/EC as regards priority substances in the field of water policy - 17 April 2013.
    • (2013)
  • 42
    • 85028165549 scopus 로고    scopus 로고
    • (Draft) The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins.
    • OECD, 2011a. (Draft) The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins.
    • (2011)
  • 43
    • 84899737135 scopus 로고    scopus 로고
    • Report of the Workshop on Using Mechanistic Information in Forming Chemical Categories
    • OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 138. ENV/JM/MONO(2011) 8.
    • OECD, 2011b. Report of the Workshop on Using Mechanistic Information in Forming Chemical Categories. OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 138. ENV/JM/MONO(2011) 8.
    • (2011)
  • 44
    • 85028139129 scopus 로고    scopus 로고
    • Proposal for a template, and guidance on developing and assessing the completeness of adverse outcome pathways.
    • OECD, 2012. Proposal for a template, and guidance on developing and assessing the completeness of adverse outcome pathways.
    • (2012)
  • 46
    • 67649743400 scopus 로고    scopus 로고
    • Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry
    • Owen S.F., Huggett D.B., Hutchinson T.H., Hetheridge M.J., Kinter L.B., Ericson J.F., Sumpter J.P. Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry. Aquat. Toxicol. 2009, 93:217-224.
    • (2009) Aquat. Toxicol. , vol.93 , pp. 217-224
    • Owen, S.F.1    Huggett, D.B.2    Hutchinson, T.H.3    Hetheridge, M.J.4    Kinter, L.B.5    Ericson, J.F.6    Sumpter, J.P.7
  • 48
    • 77950316271 scopus 로고    scopus 로고
    • Multigenerational exposure of the estuarine sheepshead minnow (cyprinodon variegatus) to 17b-Estradiol. II. Population-Level Effects through two life cycles
    • Raimondo S., Hemmer B.L., Goodman L.R., et al. Multigenerational exposure of the estuarine sheepshead minnow (cyprinodon variegatus) to 17b-Estradiol. II. Population-Level Effects through two life cycles. Environ. Toxicol. Chemistry 2009, 28(11):2409-2415.
    • (2009) Environ. Toxicol. Chemistry , vol.28 , Issue.11 , pp. 2409-2415
    • Raimondo, S.1    Hemmer, B.L.2    Goodman, L.R.3
  • 51
    • 84858298180 scopus 로고    scopus 로고
    • Priortising pharmaceuticals for environmental risk assessment: towards adequate and feasible first-tier selection
    • Roos V., Gunnarsson L., Fick J., Larsson D.G.J., Ruden C. Priortising pharmaceuticals for environmental risk assessment: towards adequate and feasible first-tier selection. Sci. Total Environ. 2012, 421-422:102-110.
    • (2012) Sci. Total Environ. , pp. 102-110
    • Roos, V.1    Gunnarsson, L.2    Fick, J.3    Larsson, D.G.J.4    Ruden, C.5
  • 52
    • 84874029024 scopus 로고    scopus 로고
    • Several synthetic progestins with different potencies adversely affect reproduction in fish
    • Runnalls T.J., Beresford N., Losty E., Scott A.P., Sumpter J.P. Several synthetic progestins with different potencies adversely affect reproduction in fish. Environ. Sci. Technol. 2013, 47:2077-2084.
    • (2013) Environ. Sci. Technol. , vol.47 , pp. 2077-2084
    • Runnalls, T.J.1    Beresford, N.2    Losty, E.3    Scott, A.P.4    Sumpter, J.P.5
  • 53
    • 0037052833 scopus 로고    scopus 로고
    • Pharmacodynamic activity of drugs and ecotoxicology - can the two be connected?
    • Seiler J.P. Pharmacodynamic activity of drugs and ecotoxicology - can the two be connected?. Toxicol. Lett. 2002, 131:105-115.
    • (2002) Toxicol. Lett. , vol.131 , pp. 105-115
    • Seiler, J.P.1
  • 54
    • 85028149920 scopus 로고    scopus 로고
    • submitted for publication. Use of Acute and Chronic Ecotoxicity Data in Environmental Risk Assessment of Pharmaceuticals
    • Small, J., Caldwell, D.J., Constantine, L. et al. submitted for publication. Use of Acute and Chronic Ecotoxicity Data in Environmental Risk Assessment of Pharmaceuticals, Environ. Toxicol. Chemistry.
    • Environ. Toxicol. Chemistry.
    • Small, J.1    Caldwell, D.J.2    Constantine, L.3
  • 55
    • 84872531630 scopus 로고    scopus 로고
    • The occurrence, cause and consequences of estrogens in the aquatic environment
    • Sumpter J.P., Jobling S. The occurrence, cause and consequences of estrogens in the aquatic environment. Environ. Toxicol. Chem. 2013, 32:249-251.
    • (2013) Environ. Toxicol. Chem. , vol.32 , pp. 249-251
    • Sumpter, J.P.1    Jobling, S.2
  • 56
    • 84857433861 scopus 로고    scopus 로고
    • Influence of drought and total phosphorus on diel pH in wadeable streams: Implications for ecological risk assessment of ionizable contaminants
    • Valenti T.W., Taylor J.T., Back J.A., King R.S., Brooks B.W. Influence of drought and total phosphorus on diel pH in wadeable streams: Implications for ecological risk assessment of ionizable contaminants. Integr. Environ. Assess. Manage. 2011, 7:636-647.
    • (2011) Integr. Environ. Assess. Manage. , vol.7 , pp. 636-647
    • Valenti, T.W.1    Taylor, J.T.2    Back, J.A.3    King, R.S.4    Brooks, B.W.5
  • 57
    • 84857695721 scopus 로고    scopus 로고
    • Human therapeutic plasma levels of the selective serotonin reuptake inhibitor (SSRI) sertraline decrease serotonin reuptake transporter binding and shelter seeking behaviour in adult male fathead minnows
    • Valenti T.W., Gould G.G., Berninger J.P., Connors K.A., Keele N.B., Prosser K.N., Brooks B.W. Human therapeutic plasma levels of the selective serotonin reuptake inhibitor (SSRI) sertraline decrease serotonin reuptake transporter binding and shelter seeking behaviour in adult male fathead minnows. Environ. Sci. Technol. 2012, 46:2427-2435.
    • (2012) Environ. Sci. Technol. , vol.46 , pp. 2427-2435
    • Valenti, T.W.1    Gould, G.G.2    Berninger, J.P.3    Connors, K.A.4    Keele, N.B.5    Prosser, K.N.6    Brooks, B.W.7
  • 58
    • 0026785215 scopus 로고
    • Classifying environmental pollutants. 1: structure-activity relationships for prediction of aquatic toxicity
    • Verhaar H.J.M., van Leeuwen C.J., Hermens J.L.M. Classifying environmental pollutants. 1: structure-activity relationships for prediction of aquatic toxicity. Chemosphere 1992, 25:471-491.
    • (1992) Chemosphere , vol.25 , pp. 471-491
    • Verhaar, H.J.M.1    van Leeuwen, C.J.2    Hermens, J.L.M.3
  • 59
    • 80053461295 scopus 로고    scopus 로고
    • Adverse outcome pathways during early fish development: a conceptual framework for identification of chemical screening and prioritization strategies
    • Volz D.C., Belanger S., Embry M., Padilla S., Sanderson H., Schirmer K., Scholz S., Villeneuve D. Adverse outcome pathways during early fish development: a conceptual framework for identification of chemical screening and prioritization strategies. Toxicol. Sci. 2011, 123:349-358.
    • (2011) Toxicol. Sci. , vol.123 , pp. 349-358
    • Volz, D.C.1    Belanger, S.2    Embry, M.3    Padilla, S.4    Sanderson, H.5    Schirmer, K.6    Scholz, S.7    Villeneuve, D.8
  • 60
    • 84873391360 scopus 로고    scopus 로고
    • A review of the mechanism of action for selective serotonin reuptake inhibitors: do these drugs possess anti-inflammatory properties and is this relevant in the treatment of depression?
    • Walker F.R. A review of the mechanism of action for selective serotonin reuptake inhibitors: do these drugs possess anti-inflammatory properties and is this relevant in the treatment of depression?. Neuropharmacology 2013, 67C:304-317.
    • (2013) Neuropharmacology , vol.67 C , pp. 304-317
    • Walker, F.R.1
  • 61
    • 77249106180 scopus 로고    scopus 로고
    • Using data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: concepts, considerations, and challenges
    • Winter M.J., Owen S.F., Murray-Smith R., Panter G.H., Hetheridge M.J., Kinter L.B. Using data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: concepts, considerations, and challenges. Integr. Environ. Assess. Manage. 2010, 6:38-51.
    • (2010) Integr. Environ. Assess. Manage. , vol.6 , pp. 38-51
    • Winter, M.J.1    Owen, S.F.2    Murray-Smith, R.3    Panter, G.H.4    Hetheridge, M.J.5    Kinter, L.B.6


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