Effects of synthetic gestagens on fish reproduction

Environmental Toxicology and Chemistry

Volumn 28, Issue 12, 2009, Pages 2663-2670

  Zeilinger, Jana ^a   Steger Hartmann, Thomas ^a   Maser, Edmund ^b   Goller, Stephan ^c   Vonk, Richardus ^a   Länge, Reinhard ^a  

^a BAYER PHARMA AG   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c Dr U Noack Laboratorien   (Germany)

Author keywords

Environmental risk assessment; Fathead minnow; Progestins; Twenty one day fish reproduction assay

Indexed keywords

AQUATIC ENVIRONMENTS; DE NOVO SYNTHESIS; DOSE RESPONSE RELATIONSHIPS; EFFECT CONCENTRATION; END POINTS; ENVIRONMENTAL EFFECTS; ENVIRONMENTAL RISK ASSESSMENT; FATHEAD MINNOW; LEVONORGESTREL; LOW CONCENTRATIONS; ORGANIZATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; PIMEPHALES PROMELAS; PROGESTINS; REPRODUCTIVE SUCCESS; SCREENING ASSAYS; SEXUAL DEVELOPMENT; STEROIDAL HORMONES;

CONCENTRATION (PROCESS); ENDOCRINOLOGY; FISH; HORMONES; LIQUEFIED NATURAL GAS; MAMMALS; MEATS; RISK MANAGEMENT;

RISK ASSESSMENT;

DROSPIRENONE; LEVONORGESTREL;

CYPRINID; DOSE-RESPONSE RELATIONSHIP; DRUG; ENVIRONMENTAL EFFECT; ENVIRONMENTAL RISK; HORMONE; POLLUTION EXPOSURE; REPRODUCTIVE PRODUCTIVITY; REPRODUCTIVE SUCCESS; RISK ASSESSMENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; EGG PRODUCTION; FEMALE; GONAD; HISTOLOGY; MALE; NONHUMAN; PIMEPHALES PROMELAS; PRIORITY JOURNAL; REPRODUCTION; SEXUAL DEVELOPMENT;

ANDROSTENES; ANIMALS; CYPRINIDAE; FEMALE; GONADS; LEVONORGESTREL; MALE; REPRODUCTION; SPERM MOTILITY;

MAMMALIA; PIMEPHALES PROMELAS;

EID: 73449084468     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/08-485.1     Document Type: Article

References (27)

1. Länge R, Hutchinson TH, Croudace CP, Siegmund F, Schweinfurth H, Hampe P, Panther GH, Sumpter JP. 2001. Effects of the synthetic estrogen 17α-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas). Environ Toxicol Chem 20:1216-1227.
2. Ankley GT, Johnson RD. 2004. Small fish models for identifying and assessing the effects of endocrine-disrupting chemicals. Institute for Laboratory Animal Research Journal 45:469-483.
3. Elger W, Beier S, Pollow K, Garfield R, Shi SQ, Hillisch A. 2003. Conception and pharmacodynamic profile of drospirenone. Steroids 68:891-905.
4. Fuhrmann U, Krattenmacher R, Slater EP, Fritzemeier KH. 1996. The novel progestin drospirenone and its natural counterpart progesterone: Biochemical profile and antiandrogenic potential. Contraception 54:243-251.
5. Sitruk-Ware R. 2004. Pharmacological profile of progestins. Maturitas 47:277-283.
6. Nagahama Y. 1994. Endocrine regulation of gametogenesis in fish. Int J Dev Biol 38:211-229.
7. Kime DE. 1999. A strategy for assessing the effects of xenobiotics on fish reproduction. Sci Total Environ 225:3-11.
8. Kolodziej EP, Gray JL, Sedlak DL. 2003. Quantification of steroid hormones with pheromonal properties in municipal wastewater effluent. Environ Toxicol Chem 22:2622-2629.
9. Kolodziej EP, Harter T, Sedlak DL. 2004. Dairy wastewater, aquaculture, and spawning fish as sources of steroid hormones in the aquatic environment. Environ Sci Technol 38:6377-6384.
10. Rapkin AJ, Sorger SN, Winer SA. 2008. Drospirenone/ethinyl estradiol. Drugs Today 44:133-145.
11. Krattenmacher R. 2000. Drospirenone: Pharmacology and pharmacokinetics of a unique progestogen. Contraception 62:29-38.
12. Rubig A. 2003. Drospirenone: A new cardiovascular-active progestin with antialdosterone and antiandrogenic properties. Climacteric 6(Suppl. 3):49-54.
13. Organization for Economic Cooperation and Development. 2008. Draft Guideline for the Testing of Chemicals. The fish screening assay for the detection of endocrine substances. Paris, France.
14. Harries JE, Runnalls T, Hill T, Harris CA, Maddix S, Sumpter JP, Tyler CR. 2000. Development of a reproductive test for endocrine disrupting chemicals using pair-breeding fathead minnow (Pimephales promelas). Environ Sci Technol 34:3003-3011.
15. European Medicines Agency. 2006. Guideline on environmental risk assessment of medicinal products for human use. Committee for Human Medicinal Products/Safety Working Party/4447/00. London, UK.
16. Leino RL, Jensen KM, Ankley GT. 2005. Gonadal histology and characteristic histopathology associated with endocrine disruption in the adult fathead minnow (Pimephales promelas). Environ Toxicol Pharmacol 19:85-98.
17. Van der Ven LT, Wester PW, Vos JG. 2003. Histopathology as a tool for the evaluation of endocrine disruption in zebrafish (Danio rerio). Environ Toxicol Chem 22:908-913.
18. Ankley GT, Jensen KM, Makynen EA, Kahl MD, Korte JJ, Hornung MW, Henry TR, Denny JS, Leino RL, Wilson VS, Cardon MC, Hartig PC, Gray LE. 2003. Effects of the androgenic growth promoter 17-β-trenbolone on fecundity and reproductive endocrinology of the fathead minnow. Environ Toxicol Chem 22:1350-1360.
19. Jensen KM, Korte JJ, Kahl MD, Pasha MS, Ankley GT. 2001. Aspects of basic reproductive biology and endocrinology in the fathead minnow (Pimephales promelas). Comp Biochem Physiol C Toxicol Pharmacol 128:127-141.
20. Sitruk-Ware R. 2005. Pharmacology of different progestogens: The special case of drospirenone. Climacteric 8:4-12.
21. Nagahama Y, Yamashita M. 2008. Regulation of oocyte maturation in fish. Dev Growth Differ 50(Suppl. 1): 195-219.
22. Roberts RJ. 2001. Fish Pathology, 3rd ed. W.B. Saunders, London, UK.
23. Tyler CR, Sumpter JP. 1996. Oocyte growth and development in teleosts. Rev Fish Biol Fish 6:287-318.
24. Van der Ven LTM, van den Brandhof EJ, Vos JH, Wester PW. 2007. Effects of the estrogen agonist 17β-estradiol and the antagonist tamoxifen in a partial life-cycle assay with zebrafish (Danio rerio). Environ Toxicol Chem 26:92-99.
25. Yaron Z. 1995. Endocrine control of gametogenesis and spawning induction in the carp. Aquaculture 129:49-73.
26. Muhn P, Krattenmacher R, Beier S, Elger W, Schillinger E. 1995. Drospirenone: A novel progestogen with antimineralocorticoid and antiandrogenic activity: Pharmacological characterization in animal models. Contraception 51:99-110.
27. Miguel-Queralt S, Hammond GL. 2008. Sex hormone-binding globulin in fish gills is a portal for sex steroids breached by xenobiotics. Endocrinology 149:4269-4275.