-
2
-
-
84860367978
-
Aldosterone blockade and the mineralocorticoid receptor in the management of chronic kidney disease: Current concepts and emerging treatment paradigms
-
Shavit L, Lifschitz MD, Epstein M. Aldosterone blockade and the mineralocorticoid receptor in the management of chronic kidney disease: current concepts and emerging treatment paradigms. Kidney Int. 2012;81:955-968.
-
(2012)
Kidney Int.
, vol.81
, pp. 955-968
-
-
Shavit, L.1
Lifschitz, M.D.2
Epstein, M.3
-
3
-
-
79955622277
-
Mineralocorticoid receptor activation and blockade: An emerging paradigm in chronic kidney disease
-
Bertocchio JP, Warnock DG, Jaisser F. Mineralocorticoid receptor activation and blockade: an emerging paradigm in chronic kidney disease. Kidney Int. 2011;79:1051-1060.
-
(2011)
Kidney Int.
, vol.79
, pp. 1051-1060
-
-
Bertocchio, J.P.1
Warnock, D.G.2
Jaisser, F.3
-
4
-
-
84901284184
-
Mineralocorticoid receptor antagonists in heart failure: Past, present and future perspectives
-
Vizzardi E, Regazzoni V, Caretta G, Gavazzoni M, Sciatti E, Bonadei I, Trichaki E, Raddino R, Metra M. Mineralocorticoid receptor antagonists in heart failure: past, present and future perspectives. IJC Heart Vessels. 2014;3:6-14.
-
(2014)
IJC Heart Vessels.
, vol.3
, pp. 6-14
-
-
Vizzardi, E.1
Regazzoni, V.2
Caretta, G.3
Gavazzoni, M.4
Sciatti, E.5
Bonadei, I.6
Trichaki, E.7
Raddino, R.8
Metra, M.9
-
5
-
-
84856339877
-
Aldosterone, mineralocorticoid receptor, and heart failure
-
Messaoudi S, Azibani F, Delcayre C, Jaisser F. Aldosterone, mineralocorticoid receptor, and heart failure. Mol Cell Endocrinol. 2012;350:266-272.
-
(2012)
Mol Cell Endocrinol.
, vol.350
, pp. 266-272
-
-
Messaoudi, S.1
Azibani, F.2
Delcayre, C.3
Jaisser, F.4
-
6
-
-
0042320418
-
Aldosterone in chronic kidney and cardiac disease
-
Hostetter TH, Ibrahim HN. Aldosterone in chronic kidney and cardiac disease. J Am Soc Nephrol. 2003;14:2395-2401.
-
(2003)
J Am Soc Nephrol.
, vol.14
, pp. 2395-2401
-
-
Hostetter, T.H.1
Ibrahim, H.N.2
-
7
-
-
78049291946
-
The role of 11-hydroxysteroid dehydrogenase type 2 in human hypertension
-
Ferrari P. The role of 11-hydroxysteroid dehydrogenase type 2 in human hypertension. Biochim Biophys Acta. 2010;1802:1178-1187.
-
(2010)
Biochim Biophys Acta.
, vol.1802
, pp. 1178-1187
-
-
Ferrari, P.1
-
8
-
-
66949166631
-
Effects of aldosterone on coronary function
-
Benard L, Milliez P, Ambroisine ML, Messaoudi S, Samuel JL, Delcayre C. Effects of aldosterone on coronary function. Pharmacol Rep. 2009;61:58-66.
-
(2009)
Pharmacol Rep.
, vol.61
, pp. 58-66
-
-
Benard, L.1
Milliez, P.2
Ambroisine, M.L.3
Messaoudi, S.4
Samuel, J.L.5
Delcayre, C.6
-
9
-
-
79959517161
-
Aldosterone and the mineralocorticoid receptor
-
Messaoudi S, Jaisser F. Aldosterone and the mineralocorticoid receptor. Eur Heart J Suppl. 2011;13 (Suppl B):B4-B9.
-
(2011)
Eur Heart J Suppl.
, vol.13
, pp. B4-B9
-
-
Messaoudi, S.1
Jaisser, F.2
-
11
-
-
79956364204
-
Cell membraneassociated mineralocorticoid receptors? New evidence
-
Krug AW, Pojoga LH, Williams GH, Adler GK. Cell membraneassociated mineralocorticoid receptors? New evidence. Hypertension. 2011;57:1019-1025.
-
(2011)
Hypertension.
, vol.57
, pp. 1019-1025
-
-
Krug, A.W.1
Pojoga, L.H.2
Williams, G.H.3
Adler, G.K.4
-
13
-
-
79953199333
-
The mineralocorticoid receptor in heart: Different effects in different cells
-
Jaisser F, Swynghedauw B, Delcayre C. The mineralocorticoid receptor in heart: different effects in different cells. Hypertension. 2011;57:679-680.
-
(2011)
Hypertension.
, vol.57
, pp. 679-680
-
-
Jaisser, F.1
Swynghedauw, B.2
Delcayre, C.3
-
14
-
-
79953224745
-
Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function
-
Lother A, Berger S, Gilsbach R, Rösner S, Ecke A, Barreto F, Bauersachs J, Schütz G, Hein L. Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function. Hypertension. 2011;57:746-754.
-
(2011)
Hypertension.
, vol.57
, pp. 746-754
-
-
Lother, A.1
Berger, S.2
Gilsbach, R.3
Rösner, S.4
Ecke, A.5
Barreto, F.6
Bauersachs, J.7
Schütz, G.8
Hein, L.9
-
15
-
-
79751529118
-
Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction
-
Fraccarollo D, Berger S, Galuppo P, Kneitz S, Hein L, Schütz G, Frantz S, Ertl G, Bauersachs J. Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction. Circulation. 2011;123:400-408.
-
(2011)
Circulation.
, vol.123
, pp. 400-408
-
-
Fraccarollo, D.1
Berger, S.2
Galuppo, P.3
Kneitz, S.4
Hein, L.5
Schütz, G.6
Frantz, S.7
Ertl, G.8
Bauersachs, J.9
-
16
-
-
33646199206
-
Regulation of cardiac and renal mineralocorticoid receptor expression by captopril following myocardial infarction in rats
-
de Resende MM, Kauser K, Mill JG. Regulation of cardiac and renal mineralocorticoid receptor expression by captopril following myocardial infarction in rats. Life Sci. 2006;78:3066-3073.
-
(2006)
Life Sci.
, vol.78
, pp. 3066-3073
-
-
De Resende, M.M.1
Kauser, K.2
Mill, J.G.3
-
17
-
-
20544464438
-
Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias
-
Ouvrard-Pascaud A, Sainte-Marie Y, Bénitah JP, et al. Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias. Circulation. 2005;111:3025-3033.
-
(2005)
Circulation.
, vol.111
, pp. 3025-3033
-
-
Ouvrard-Pascaud, A.1
Sainte-Marie, Y.2
Bénitah, J.P.3
-
18
-
-
34250742595
-
Spironolactone modulates expressions of cardiac mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 2 and prevents ventricular remodeling in post-infarct rat hearts
-
Takeda M, Tatsumi T, Matsunaga S, Hayashi H, Kimata M, Honsho S, Nishikawa S, Mano A, Shiraishi J, Yamada H, Takahashi T, Matoba S, Kobara M, Matsubara H. Spironolactone modulates expressions of cardiac mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 2 and prevents ventricular remodeling in post-infarct rat hearts. Hypertens Res. 2007;30:427-437.
-
(2007)
Hypertens Res.
, vol.30
, pp. 427-437
-
-
Takeda, M.1
Tatsumi, T.2
Matsunaga, S.3
Hayashi, H.4
Kimata, M.5
Honsho, S.6
Nishikawa, S.7
Mano, A.8
Shiraishi, J.9
Yamada, H.10
Takahashi, T.11
Matoba, S.12
Kobara, M.13
Matsubara, H.14
-
19
-
-
33645816971
-
Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats
-
Nagata K, Obata K, Xu J, Ichihara S, Noda A, Kimata H, Kato T, Izawa H, Murohara T, Yokota M. Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats. Hypertension. 2006;47:656-664.
-
(2006)
Hypertension.
, vol.47
, pp. 656-664
-
-
Nagata, K.1
Obata, K.2
Xu, J.3
Ichihara, S.4
Noda, A.5
Kimata, H.6
Kato, T.7
Izawa, H.8
Murohara, T.9
Yokota, M.10
-
20
-
-
84896776352
-
The mineralocorticoid receptor promotes fibrotic remodeling in atrial fibrillation
-
Lavall D, Selzer C, Schuster P, Lenski M, Adam O, Schäfers HJ, Böhm M, Laufs U. The mineralocorticoid receptor promotes fibrotic remodeling in atrial fibrillation. J Biol Chem. 2014;289:6656-6668.
-
(2014)
J Biol Chem.
, vol.289
, pp. 6656-6668
-
-
Lavall, D.1
Selzer, C.2
Schuster, P.3
Lenski, M.4
Adam, O.5
Schäfers, H.J.6
Böhm, M.7
Laufs, U.8
-
21
-
-
18244379073
-
Mineralocorticoid receptor is overexpressed in cardiomyocytes of patients with congestive heart failure
-
Yoshida M, Ma J, Tomita T, Morikawa N, Tanaka N, Masamura K, Kawai Y, Miyamori I. Mineralocorticoid receptor is overexpressed in cardiomyocytes of patients with congestive heart failure. Congest Heart Fail. 2005;11:12-16.
-
(2005)
Congest Heart Fail.
, vol.11
, pp. 12-16
-
-
Yoshida, M.1
Ma, J.2
Tomita, T.3
Morikawa, N.4
Tanaka, N.5
Masamura, K.6
Kawai, Y.7
Miyamori, I.8
-
22
-
-
33751236177
-
Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus
-
Guo C, Martinez-Vasquez D, Mendez GP, Toniolo MF, Yao TM, Oestreicher EM, Kikuchi T, Lapointe N, Pojoga L, Williams GH, Ricchiuti V, Adler GK. Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus. Endocrinology. 2006;147:5363-5373.
-
(2006)
Endocrinology.
, vol.147
, pp. 5363-5373
-
-
Guo, C.1
Martinez-Vasquez, D.2
Mendez, G.P.3
Toniolo, M.F.4
Yao, T.M.5
Oestreicher, E.M.6
Kikuchi, T.7
Lapointe, N.8
Pojoga, L.9
Williams, G.H.10
Ricchiuti, V.11
Adler, G.K.12
-
23
-
-
24744454626
-
Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria
-
Quinkler M, Zehnder D, Eardley KS, Lepenies J, Howie AJ, Hughes SV, Cockwell P, Hewison M, Stewart PM. Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria. Circulation. 2005;112:1435-1443.
-
(2005)
Circulation.
, vol.112
, pp. 1435-1443
-
-
Quinkler, M.1
Zehnder, D.2
Eardley, K.S.3
Lepenies, J.4
Howie, A.J.5
Hughes, S.V.6
Cockwell, P.7
Hewison, M.8
Stewart, P.M.9
-
24
-
-
0036838616
-
Aldosterone induces a vascular inflammatory phenotype in the rat heart
-
Rocha R, Rudolph AE, Frierdich GE, Nachowiak DA, Kekec BK, Blomme EA, McMahon EG, Delyani JA. Aldosterone induces a vascular inflammatory phenotype in the rat heart. Am J Physiol Heart Circ Physiol. 2002;283:H1802-H1810.
-
(2002)
Am J Physiol Heart Circ Physiol.
, vol.283
, pp. H1802-H1810
-
-
Rocha, R.1
Rudolph, A.E.2
Frierdich, G.E.3
Nachowiak, D.A.4
Kekec, B.K.5
Blomme, E.A.6
McMahon, E.G.7
Delyani, J.A.8
-
25
-
-
82855181170
-
A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone
-
López-Andrés N, Martin-Fernandez B, Rossignol P, Zannad F, Lahera V, Fortuno MA, Cachofeiro V, Díez J. A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone. Am J Physiol Heart Circ Physiol. 2011;301:H2372-H2382.
-
(2011)
Am J Physiol Heart Circ Physiol.
, vol.301
, pp. H2372-H2382
-
-
López-Andrés, N.1
Martin-Fernandez, B.2
Rossignol, P.3
Zannad, F.4
Lahera, V.5
Fortuno, M.A.6
Cachofeiro, V.7
Díez, J.8
-
26
-
-
79952190148
-
Aldosterone-induced kidney injury is mediated by NF B activation
-
Fukuda S, Horimai C, Harada K, Wakamatsu T, Fukasawa H, Muto S, Itai A, Hayashi M. Aldosterone-induced kidney injury is mediated by NFB activation. Clin Exp Nephrol. 2011;15:41-49.
-
(2011)
Clin Exp Nephrol.
, vol.15
, pp. 41-49
-
-
Fukuda, S.1
Horimai, C.2
Harada, K.3
Wakamatsu, T.4
Fukasawa, H.5
Muto, S.6
Itai, A.7
Hayashi, M.8
-
27
-
-
84875228346
-
Aldosterone induces electrical remodeling independent of hypertension
-
Dartsch T, Fischer R, Gapelyuk A, Weiergraeber M, Ladage D, Schneider T, Schirdewan A, Reuter H, Mueller-Ehmsen J, Zobel C. Aldosterone induces electrical remodeling independent of hypertension. Int J Cardiol. 2013;164:170-178.
-
(2013)
Int J Cardiol.
, vol.164
, pp. 170-178
-
-
Dartsch, T.1
Fischer, R.2
Gapelyuk, A.3
Weiergraeber, M.4
Ladage, D.5
Schneider, T.6
Schirdewan, A.7
Reuter, H.8
Mueller-Ehmsen, J.9
Zobel, C.10
-
28
-
-
0029810416
-
Role of aldosterone in the remnant kidney model in the rat
-
Greene EL, Kren S, Hostetter TH. Role of aldosterone in the remnant kidney model in the rat. J Clin Invest. 1996;98:1063-1068.
-
(1996)
J Clin Invest.
, vol.98
, pp. 1063-1068
-
-
Greene, E.L.1
Kren, S.2
Hostetter, T.H.3
-
29
-
-
84870208124
-
Blood pressure has only minor influence on aldosterone-induced oxidative stress and DNA damage in vivo
-
Queisser N, Amann K, Hey V, Habib SL, Schupp N. Blood pressure has only minor influence on aldosterone-induced oxidative stress and DNA damage in vivo. Free Radic Biol Med. 2013;54:17-25.
-
(2013)
Free Radic Biol Med.
, vol.54
, pp. 17-25
-
-
Queisser, N.1
Amann, K.2
Hey, V.3
Habib, S.L.4
Schupp, N.5
-
30
-
-
78951469092
-
Structural, functional, and molecular alterations produced by aldosterone plus salt in rat heart: Association with enhanced serum and glucocorticoid-regulated kinase-1 expression
-
Martín-Fernández B, de las Heras N, Miana M, Ballesteros S, Delgado C, Song S, Hintze T, Cachofeiro V, Lahera V. Structural, functional, and molecular alterations produced by aldosterone plus salt in rat heart: association with enhanced serum and glucocorticoid-regulated kinase-1 expression. J Cardiovasc Pharmacol. 2011;57:114-121.
-
(2011)
J Cardiovasc Pharmacol.
, vol.57
, pp. 114-121
-
-
Martín-Fernández, B.1
De Las Heras, N.2
Miana, M.3
Ballesteros, S.4
Delgado, C.5
Song, S.6
Hintze, T.7
Cachofeiro, V.8
Lahera, V.9
-
31
-
-
84858293934
-
Aldosterone stimulates nuclear factorkappa B activity and transcription of intercellular adhesion molecule-1 and connective tissue growth factor in rat mesangial cells via serum-and glucocorticoid-inducible protein kinase-1
-
Terada Y, Ueda S, Hamada K, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Kagawa T, Horino T, Takao T. Aldosterone stimulates nuclear factorkappa B activity and transcription of intercellular adhesion molecule-1 and connective tissue growth factor in rat mesangial cells via serum-and glucocorticoid-inducible protein kinase-1. Clin Exp Nephrol. 2012;16:81-88.
-
(2012)
Clin Exp Nephrol.
, vol.16
, pp. 81-88
-
-
Terada, Y.1
Ueda, S.2
Hamada, K.3
Shimamura, Y.4
Ogata, K.5
Inoue, K.6
Taniguchi, Y.7
Kagawa, T.8
Horino, T.9
Takao, T.10
-
32
-
-
33644895071
-
Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy
-
Neves MF, Amiri F, Virdis A, Diep QN, Schiffrin EL; CIHR Multidisciplinary Research Group on Hypertension. Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy. Can J Physiol Pharmacol. 2005;83:999-1006.
-
(2005)
Can J Physiol Pharmacol.
, vol.83
, pp. 999-1006
-
-
Neves, M.F.1
Amiri, F.2
Virdis, A.3
Diep, Q.N.4
Schiffrin, E.L.5
-
33
-
-
62449219251
-
Aldosterone-induced TGF-beta1 expression is regulated by mitogen-activated protein kinases and activator protein-1 in mesangial cells
-
Han JS, Choi BS, Yang CW, Kim YS. Aldosterone-induced TGF-beta1 expression is regulated by mitogen-activated protein kinases and activator protein-1 in mesangial cells. J Korean Med Sci. 2009;24 Suppl:S195-S203.
-
(2009)
J Korean Med Sci.
, vol.24
, pp. S195-S203
-
-
Han, J.S.1
Choi, B.S.2
Yang, C.W.3
Kim, Y.S.4
-
34
-
-
79955064277
-
Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in a transgenic model of RAAS overexpression
-
Habibi J, DeMarco VG, Ma L, Pulakat L, Rainey WE, Whaley-Connell AT, Sowers JR. Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in a transgenic model of RAAS overexpression. Am J Physiol Heart Circ Physiol. 2011;300:H1484-H1491.
-
(2011)
Am J Physiol Heart Circ Physiol.
, vol.300
, pp. H1484-H1491
-
-
Habibi, J.1
Demarco, V.G.2
Ma, L.3
Pulakat, L.4
Rainey, W.E.5
Whaley-Connell, A.T.6
Sowers, J.R.7
-
35
-
-
74749102175
-
Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice
-
Kagiyama S, Matsumura K, Goto K, Otsubo T, Iida M. Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice. Regul Pept. 2010;160:133-139.
-
(2010)
Regul Pept.
, vol.160
, pp. 133-139
-
-
Kagiyama, S.1
Matsumura, K.2
Goto, K.3
Otsubo, T.4
Iida, M.5
-
36
-
-
20544458728
-
Aldosterone increases plasminogen activator inhibitor-1 synthesis in rat cardiomyocytes
-
Chun TY, Pratt JH. Aldosterone increases plasminogen activator inhibitor-1 synthesis in rat cardiomyocytes. Mol Cell Endocrinol. 2005;239:55-61.
-
(2005)
Mol Cell Endocrinol.
, vol.239
, pp. 55-61
-
-
Chun, T.Y.1
Pratt, J.H.2
-
37
-
-
84455205914
-
Mineralocorticoid receptor-dependent proximal tubule injury is mediated by a redox-sensitive mTOR/S6K1 pathway
-
Whaley-Connell AT, Habibi J, Nistala R, DeMarco VG, Pulakat L, Hayden MR, Joginpally T, Ferrario CM, Parrish AR, Sowers JR. Mineralocorticoid receptor-dependent proximal tubule injury is mediated by a redox-sensitive mTOR/S6K1 pathway. Am J Nephrol. 2012;35:90-100.
-
(2012)
Am J Nephrol.
, vol.35
, pp. 90-100
-
-
Whaley-Connell, A.T.1
Habibi, J.2
Nistala, R.3
Demarco, V.G.4
Pulakat, L.5
Hayden, M.R.6
Joginpally, T.7
Ferrario, C.M.8
Parrish, A.R.9
Sowers, J.R.10
-
38
-
-
47549114629
-
Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats
-
Taira M, Toba H, Murakami M, Iga I, Serizawa R, Murata S, Kobara M, Nakata T. Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats. Eur J Pharmacol. 2008;589:264-271.
-
(2008)
Eur J Pharmacol.
, vol.589
, pp. 264-271
-
-
Taira, M.1
Toba, H.2
Murakami, M.3
Iga, I.4
Serizawa, R.5
Murata, S.6
Kobara, M.7
Nakata, T.8
-
39
-
-
84865589272
-
Additive amelioration of oxidative stress and cardiac function by combined mineralocorticoid and angiotensin receptor blockers in postinfarct failing hearts
-
Noda K, Kobara M, Hamada J, Yoshifuji Y, Shiraishi T, Tanaka T, Wang J, Toba H, Nakata T. Additive amelioration of oxidative stress and cardiac function by combined mineralocorticoid and angiotensin receptor blockers in postinfarct failing hearts. J Cardiovasc Pharmacol. 2012;60:140-149.
-
(2012)
J Cardiovasc Pharmacol.
, vol.60
, pp. 140-149
-
-
Noda, K.1
Kobara, M.2
Hamada, J.3
Yoshifuji, Y.4
Shiraishi, T.5
Tanaka, T.6
Wang, J.7
Toba, H.8
Nakata, T.9
-
40
-
-
84899619364
-
Eplerenonemediated regression of electrical activation delays and myocardial fibrosis in heart failure
-
Tanaka-Esposito C, Varahan S, Jeyaraj D, Lu Y, Stambler BS. Eplerenonemediated regression of electrical activation delays and myocardial fibrosis in heart failure. J Cardiovasc Electrophysiol. 2014;25:537-544.
-
(2014)
J Cardiovasc Electrophysiol.
, vol.25
, pp. 537-544
-
-
Tanaka-Esposito, C.1
Varahan, S.2
Jeyaraj, D.3
Lu, Y.4
Stambler, B.S.5
-
41
-
-
84879797410
-
Spironolactone inhibits apoptosis in rat mesangial cells under hyperglycaemic conditions via the Wnt signalling pathway
-
Zhu D, Yu H, He H, Ding J, Tang J, Cao D, Hao L. Spironolactone inhibits apoptosis in rat mesangial cells under hyperglycaemic conditions via the Wnt signalling pathway. Mol Cell Biochem. 2013;380:185-193.
-
(2013)
Mol Cell Biochem.
, vol.380
, pp. 185-193
-
-
Zhu, D.1
Yu, H.2
He, H.3
Ding, J.4
Tang, J.5
Cao, D.6
Hao, L.7
-
42
-
-
34548029979
-
New insights into the pathophysiology of cyclosporine nephrotoxicity: A role of aldosterone
-
Bobadilla NA, Gamba G. New insights into the pathophysiology of cyclosporine nephrotoxicity: a role of aldosterone. Am J Physiol Renal Physiol. 2007;293:F2-F9.
-
(2007)
Am J Physiol Renal Physiol.
, vol.293
, pp. F2-F9
-
-
Bobadilla, N.A.1
Gamba, G.2
-
43
-
-
0016682588
-
Blood pressure, sodium intake, and sodium related hormones in the Yanomamo Indians, a "no-salt" culture
-
Oliver WJ, Cohen EL, Neel JV. Blood pressure, sodium intake, and sodium related hormones in the Yanomamo Indians, a "no-salt" culture. Circulation. 1975;52:146-151.
-
(1975)
Circulation.
, vol.52
, pp. 146-151
-
-
Oliver, W.J.1
Cohen, E.L.2
Neel, J.V.3
-
44
-
-
84864245115
-
Oxidative stressinduced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats
-
Kitada K, Nakano D, Liu Y, Fujisawa Y, Hitomi H, Shibayama Y, Shibata H, Nagai Y, Mori H, Masaki T, Kobori H, Nishiyama A. Oxidative stressinduced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats. PLoS One. 2012;7:e41896.
-
(2012)
PLoS One.
, vol.7
, pp. e41896
-
-
Kitada, K.1
Nakano, D.2
Liu, Y.3
Fujisawa, Y.4
Hitomi, H.5
Shibayama, Y.6
Shibata, H.7
Nagai, Y.8
Mori, H.9
Masaki, T.10
Kobori, H.11
Nishiyama, A.12
-
45
-
-
73349142401
-
Mineralocorticoid receptor blockers and chronic kidney disease
-
Jain G, Campbell RC, Warnock DG. Mineralocorticoid receptor blockers and chronic kidney disease. Clin J Am Soc Nephrol. 2009;4:1685-1691.
-
(2009)
Clin J Am Soc Nephrol.
, vol.4
, pp. 1685-1691
-
-
Jain, G.1
Campbell, R.C.2
Warnock, D.G.3
-
46
-
-
79955021142
-
Effect of eplerenone on hypertension-associated renal damage in rats: Potential role of peroxisome proliferator activated receptor gamma (PPAR)
-
Miana M, de Las Heras N, Rodriguez C, Sanz-Rosa D, Martin-Fernandez B, Mezzano S, Lahera V, Martinez-Gonzalez J, Cachofeiro V. Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma (PPAR). J Physiol Pharmacol. 2011;62:87-94.
-
(2011)
J Physiol Pharmacol.
, vol.62
, pp. 87-94
-
-
Miana, M.1
De Las Heras, N.2
Rodriguez, C.3
Sanz-Rosa, D.4
Martin-Fernandez, B.5
Mezzano, S.6
Lahera, V.7
Martinez-Gonzalez, J.8
Cachofeiro, V.9
-
47
-
-
0242543981
-
Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction
-
Fraccarollo D, Galuppo P, Hildemann S, Christ M, Ertl G, Bauersachs J. Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction. J Am Coll Cardiol. 2003;42:1666-1673.
-
(2003)
J Am Coll Cardiol.
, vol.42
, pp. 1666-1673
-
-
Fraccarollo, D.1
Galuppo, P.2
Hildemann, S.3
Christ, M.4
Ertl, G.5
Bauersachs, J.6
-
48
-
-
20144365615
-
Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPKp90RSK, and Rho-kinase pathway
-
Kobayashi N, Hara K, Tojo A, Onozato ML, Honda T, Yoshida K, Mita S, Nakano S, Tsubokou Y, Matsuoka H. Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPKp90RSK, and Rho-kinase pathway. Hypertension. 2005;45:538-544.
-
(2005)
Hypertension.
, vol.45
, pp. 538-544
-
-
Kobayashi, N.1
Hara, K.2
Tojo, A.3
Onozato, M.L.4
Honda, T.5
Yoshida, K.6
Mita, S.7
Nakano, S.8
Tsubokou, Y.9
Matsuoka, H.10
-
49
-
-
78650399880
-
Eplerenone in patients with systolic heart failure and mild symptoms
-
Zannad F, McMurray JJ, Krum H, van Veldhuisen DJ, Swedberg K, Shi H, Vincent J, Pocock SJ, Pitt B; EMPHASIS-HF Study Group. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011;364:11-21.
-
(2011)
N Engl J Med.
, vol.364
, pp. 11-21
-
-
Zannad, F.1
McMurray, J.J.2
Krum, H.3
Van Veldhuisen, D.J.4
Swedberg, K.5
Shi, H.6
Vincent, J.7
Pocock, S.J.8
Pitt, B.9
-
50
-
-
0037417252
-
Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
-
Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, Bittman R, Hurley S, Kleiman J, Gatlin M; Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348:1309-1321.
-
(2003)
N Engl J Med.
, vol.348
, pp. 1309-1321
-
-
Pitt, B.1
Remme, W.2
Zannad, F.3
Neaton, J.4
Martinez, F.5
Roniker, B.6
Bittman, R.7
Hurley, S.8
Kleiman, J.9
Gatlin, M.10
-
51
-
-
0033517302
-
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
-
Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999;341:709-717.
-
(1999)
N Engl J Med.
, vol.341
, pp. 709-717
-
-
Pitt, B.1
Zannad, F.2
Remme, W.J.3
Cody, R.4
Castaigne, A.5
Perez, A.6
Palensky, J.7
Wittes, J.8
-
52
-
-
84882415231
-
Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: A randomized, double-blind trial
-
Pitt B, Kober L, Ponikowski P, Gheorghiade M, Filippatos G, Krum H, Nowack C, Kolkhof P, Kim SY, Zannad F. Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial. Eur Heart J. 2013;34:2453-2463.
-
(2013)
Eur Heart J.
, vol.34
, pp. 2453-2463
-
-
Pitt, B.1
Kober, L.2
Ponikowski, P.3
Gheorghiade, M.4
Filippatos, G.5
Krum, H.6
Nowack, C.7
Kolkhof, P.8
Kim, S.Y.9
Zannad, F.10
-
53
-
-
84864493727
-
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC
-
McMurray JJ, Adamopoulos S, Anker SD, et al.; ESC Committee for Practice Guidelines. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33:1787-1847.
-
(2012)
Eur Heart J.
, vol.33
, pp. 1787-1847
-
-
McMurray, J.J.1
Adamopoulos, S.2
Anker, S.D.3
-
54
-
-
84894106381
-
Mineralocorticoid receptor blockade in addition to angiotensin converting enzyme inhibitor or angiotensin II receptor blocker treatment: An emerging paradigm in diabetic nephropathy: A systematic review
-
Mavrakanas TA, Gariani K, Martin PY. Mineralocorticoid receptor blockade in addition to angiotensin converting enzyme inhibitor or angiotensin II receptor blocker treatment: an emerging paradigm in diabetic nephropathy: a systematic review. Eur J Intern Med. 2014;25:173-176.
-
(2014)
Eur J Intern Med.
, vol.25
, pp. 173-176
-
-
Mavrakanas, T.A.1
Gariani, K.2
Martin, P.Y.3
-
55
-
-
79953787215
-
Increased serum potassium affects renal outcomes: A post hoc analysis of the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial
-
Miao Y, Dobre D, Heerspink HJ, Brenner BM, Cooper ME, Parving HH, Shahinfar S, Grobbee D, de Zeeuw D. Increased serum potassium affects renal outcomes: a post hoc analysis of the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial. Diabetologia. 2011;54:44-50.
-
(2011)
Diabetologia.
, vol.54
, pp. 44-50
-
-
Miao, Y.1
Dobre, D.2
Heerspink, H.J.3
Brenner, B.M.4
Cooper, M.E.5
Parving, H.H.6
Shahinfar, S.7
Grobbee, D.8
De Zeeuw, D.9
-
56
-
-
3442886513
-
Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study
-
Juurlink DN, Mamdani MM, Lee DS, Kopp A, Austin PC, Laupacis A, Redelmeier DA. Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med. 2004;351:543-551.
-
(2004)
N Engl J Med.
, vol.351
, pp. 543-551
-
-
Juurlink, D.N.1
Mamdani, M.M.2
Lee, D.S.3
Kopp, A.4
Austin, P.C.5
Laupacis, A.6
Redelmeier, D.A.7
-
57
-
-
77953691442
-
Spironolactone use and renal toxicity: Population based longitudinal analysis
-
Wei L, Struthers AD, Fahey T, Watson AD, Macdonald TM. Spironolactone use and renal toxicity: population based longitudinal analysis. BMJ. 2010;340:c1768.
-
(2010)
BMJ.
, vol.340
, pp. c1768
-
-
Wei, L.1
Struthers, A.D.2
Fahey, T.3
Watson, A.D.4
Macdonald, T.M.5
-
58
-
-
55949112567
-
Serum potassium and clinical outcomes in the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS)
-
Pitt B, Bakris G, Ruilope LM, DiCarlo L, Mukherjee R; EPHESUS Investigators. Serum potassium and clinical outcomes in the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). Circulation. 2008;118:1643-1650.
-
(2008)
Circulation.
, vol.118
, pp. 1643-1650
-
-
Pitt, B.1
Bakris, G.2
Ruilope, L.M.3
Dicarlo, L.4
Mukherjee, R.5
-
59
-
-
80054975039
-
Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects. Insights from an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) substudy
-
Rossignol P, Ménard J, Fay R, Gustafsson F, Pitt B, Zannad F. Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects. Insights from an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) substudy. J Am Coll Cardiol. 2011;58:1958-1966.
-
(2011)
J Am Coll Cardiol.
, vol.58
, pp. 1958-1966
-
-
Rossignol, P.1
Ménard, J.2
Fay, R.3
Gustafsson, F.4
Pitt, B.5
Zannad, F.6
-
60
-
-
84896109810
-
Incidence, determinants, and prognostic significance of hyperkalemia and worsening renal function in patients with heart failure receiving the mineralocorticoid receptor antagonist eplerenone or placebo in addition to optimal medical therapy: Results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF)
-
Rossignol P, Dobre D, McMurray JJ, Swedberg K, Krum H, van Veldhuisen DJ, Shi H, Messig M, Vincent J, Girerd N, Bakris G, Pitt B, Zannad F. Incidence, determinants, and prognostic significance of hyperkalemia and worsening renal function in patients with heart failure receiving the mineralocorticoid receptor antagonist eplerenone or placebo in addition to optimal medical therapy: results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF). Circ Heart Fail. 2014;7:51-58.
-
(2014)
Circ Heart Fail.
, vol.7
, pp. 51-58
-
-
Rossignol, P.1
Dobre, D.2
McMurray, J.J.3
Swedberg, K.4
Krum, H.5
Van Veldhuisen, D.J.6
Shi, H.7
Messig, M.8
Vincent, J.9
Girerd, N.10
Bakris, G.11
Pitt, B.12
Zannad, F.13
-
61
-
-
84907389177
-
Incidence, predictors, and outcomes related to hypo-and hyperkalemia in patients with severe heart failure treated with a mineralocorticoid receptor antagonist
-
Vardeny O, Claggett B, Anand I, Rossignol P, Desai AS, Zannad F, Pitt B, Solomon SD; Randomized Aldactone Evaluation Study (RALES) Investigators. Incidence, predictors, and outcomes related to hypo-and hyperkalemia in patients with severe heart failure treated with a mineralocorticoid receptor antagonist. Circ Heart Fail. 2014;7:573-579.
-
(2014)
Circ Heart Fail.
, vol.7
, pp. 573-579
-
-
Vardeny, O.1
Claggett, B.2
Anand, I.3
Rossignol, P.4
Desai, A.S.5
Zannad, F.6
Pitt, B.7
Solomon, S.D.8
-
62
-
-
77951911801
-
Hypokalemia and outcomes in patients with chronic heart failure and chronic kidney disease: Findings from propensity-matched studies
-
Bowling CB, Pitt B, Ahmed MI, Aban IB, Sanders PW, Mujib M, Campbell RC, Love TE, Aronow WS, Allman RM, Bakris GL, Ahmed A. Hypokalemia and outcomes in patients with chronic heart failure and chronic kidney disease: findings from propensity-matched studies. Circ Heart Fail. 2010;3:253-260.
-
(2010)
Circ Heart Fail.
, vol.3
, pp. 253-260
-
-
Bowling, C.B.1
Pitt, B.2
Ahmed, M.I.3
Aban, I.B.4
Sanders, P.W.5
Mujib, M.6
Campbell, R.C.7
Love, T.E.8
Aronow, W.S.9
Allman, R.M.10
Bakris, G.L.11
Ahmed, A.12
-
63
-
-
63249093678
-
Eplerenone treatment of aortic stenosis [letter]
-
author reply e17
-
Marciniak TA. Eplerenone treatment of aortic stenosis. [letter]. Am Heart J. 2009;157:e15; author reply e17.
-
(2009)
Am Heart J.
, vol.157
, pp. e15
-
-
Marciniak, T.A.1
-
64
-
-
84885231481
-
Aldosterone breakthrough during angiotensin receptor blocker use: More questions than answers
-
Navaneethan SD, Bravo EL. Aldosterone breakthrough during angiotensin receptor blocker use: more questions than answers? Clin J Am Soc Nephrol. 2013;8:1637-1639.
-
(2013)
Clin J Am Soc Nephrol
, vol.8
, pp. 1637-1639
-
-
Navaneethan, S.D.1
Bravo, E.L.2
-
65
-
-
79953720277
-
Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial
-
Pitt B, Anker SD, Bushinsky DA, Kitzman DW, Zannad F, Huang IZ; PEARL-HF Investigators. Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial. Eur Heart J. 2011;32:820-828.
-
(2011)
Eur Heart J.
, vol.32
, pp. 820-828
-
-
Pitt, B.1
Anker, S.D.2
Bushinsky, D.A.3
Kitzman, D.W.4
Zannad, F.5
Huang, I.Z.6
Investigators, P.7
-
66
-
-
84901948477
-
Acute and chronic cardiovascular effects of hyperkalemia: New insights into prevention and clinical management
-
McCullough PA, Beaver TM, Bennett-Guerrero E, Emmett M, Fonarow GC, Goyal A, Herzog CA, Kosiborod M, Palmer BF. Acute and chronic cardiovascular effects of hyperkalemia: new insights into prevention and clinical management. Rev Cardiovasc Med. 2014;15:11-23.
-
(2014)
Rev Cardiovasc Med.
, vol.15
, pp. 11-23
-
-
McCullough, P.A.1
Beaver, T.M.2
Bennett-Guerrero, E.3
Emmett, M.4
Fonarow, G.C.5
Goyal, A.6
Herzog, C.A.7
Kosiborod, M.8
Palmer, B.F.9
-
67
-
-
84856337738
-
Molecular pharmacology of the mineralocorticoid receptor: Prospects for novel therapeutics
-
Kolkhof P, Borden SA. Molecular pharmacology of the mineralocorticoid receptor: prospects for novel therapeutics. Mol Cell Endocrinol. 2012;350:310-317.
-
(2012)
Mol Cell Endocrinol.
, vol.350
, pp. 310-317
-
-
Kolkhof, P.1
Borden, S.A.2
-
68
-
-
84882321401
-
The ARTS of third-generation mineralocorticoid receptor antagonists: Achieving cardiovascular benefit with minimized renal side effects
-
Bauersachs J. The ARTS of third-generation mineralocorticoid receptor antagonists: achieving cardiovascular benefit with minimized renal side effects? Eur Heart J. 2013;34:2426-2428.
-
(2013)
Eur Heart J
, vol.34
, pp. 2426-2428
-
-
Bauersachs, J.1
|