메뉴 건너뛰기




Volumn 13, Issue SUPPL. B, 2011, Pages

Aldosterone and the mineralocorticoid receptor

Author keywords

Aldosterone; Angiotensin II; Cardiovascular disease; Mineralocorticoid receptors; Oxidative stress

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; ALDOSTERONE; ANGIOTENSIN II; EPLERENONE; FAD 286; GLUCOCORTICOID; HORMONE RECEPTOR BLOCKING AGENT; HYDROCORTISONE; MINERALOCORTICOID; MINERALOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR BLOCKING AGENT; OXYGENASE INHIBITOR; SODIUM CHLORIDE; SPIRONOLACTONE; UNCLASSIFIED DRUG;

EID: 79959517161     PISSN: 1520765X     EISSN: 15542815     Source Type: Journal    
DOI: 10.1093/eurheartj/sur004     Document Type: Article
Times cited : (7)

References (60)
  • 1
    • 0011886496 scopus 로고
    • Isolation from the adrenals of a new crystalline hormone with especially high effectiveness on mineral metabolism
    • Simpson SA, Tait JF, Wettstein A, Neher R, Von Euw J, Reichstein T. [Isolation from the adrenals of a new crystalline hormone with especially high effectiveness on mineral metabolism]. Experientia 1953;9:333-335.
    • (1953) Experientia , vol.9 , pp. 333-335
    • Simpson, S.A.1    Tait, J.F.2    Wettstein, A.3    Neher, R.4    Von Euw, J.5    Reichstein, T.6
  • 2
    • 0025675680 scopus 로고
    • Remodeling of the rat right and left ventricles in experimental hypertension
    • Brilla CG, Pick R, Tan LB, Janicki JS, Weber KT. Remodeling of the rat right and left ventricles in experimental hypertension. Circ Res 1990; 67:1355-1364.
    • (1990) Circ Res , vol.67 , pp. 1355-1364
    • Brilla, C.G.1    Pick, R.2    Tan, L.B.3    Janicki, J.S.4    Weber, K.T.5
  • 3
    • 0028360454 scopus 로고
    • Increased cardiac types I and III collagen mRNAs in aldosterone-salt hypertension
    • Robert V, Van Thiem N, Cheav SL, Mouas C, Swynghedauw B, Delcayre C. Increased cardiac types I and III collagen mRNAs in aldosterone-salt hypertension. Hypertension 1994;24:30-36. (Pubitemid 24195401)
    • (1994) Hypertension , vol.24 , Issue.1 , pp. 30-36
    • Robert, V.1    Van Thiem, N.2    Cheav, S.L.3    Mouas, C.4    Swynghedauw, B.5    Delcayre, C.6
  • 4
    • 0027227646 scopus 로고
    • Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism
    • DOI 10.1006/jmcc.1993.1066
    • Brilla CG, Matsubara LS, Weber KT. Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism. J Mol Cell Cardiol 1993;25:563-575. (Pubitemid 23208145)
    • (1993) Journal of Molecular and Cellular Cardiology , vol.25 , Issue.5 , pp. 563-575
    • Brilla, C.G.1    Matsubara, L.S.2    Weber, K.T.3
  • 6
    • 34548500119 scopus 로고    scopus 로고
    • Aldosterone and end-organ damage
    • DOI 10.1042/CS20070123
    • Marney AM, Brown NJ. Aldosterone and end-organ damage. Clin Sci (Lond) 2007;113:267-278. (Pubitemid 47372685)
    • (2007) Clinical Science , vol.113 , Issue.5-6 , pp. 267-278
    • Marney, A.M.1    Brown, N.J.2
  • 7
    • 33845603497 scopus 로고    scopus 로고
    • Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase
    • Johar S, Cave AC, Narayanapanicker A, Grieve DJ, Shah AM. Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J 2006;20: 1546-1548.
    • (2006) FASEB J , vol.20 , pp. 1546-1548
    • Johar, S.1    Cave, A.C.2    Narayanapanicker, A.3    Grieve, D.J.4    Shah, A.M.5
  • 12
    • 13444283520 scopus 로고    scopus 로고
    • Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload
    • DOI 10.1161/01.CIR.0000153800.09920.40
    • Kuster GM, Kotlyar E, Rude MK, Siwik DA, Liao R, Colucci WS, Sam F. Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload. Circulation 2005;111: 420-427. (Pubitemid 40204425)
    • (2005) Circulation , vol.111 , Issue.4 , pp. 420-427
    • Kuster, G.M.1    Kotlyar, E.2    Rude, M.K.3    Siwik, D.A.4    Liao, R.5    Colucci, W.S.6    Sam, F.7
  • 17
    • 0035887191 scopus 로고    scopus 로고
    • Effect of successful electrical cardioversion on serum aldosterone in patients with persistent atrial fibrillation
    • DOI 10.1016/S0002-9149(01)01905-1, PII S0002914901019051
    • Goette A, Hoffmanns P, Enayati W, Meltendorf U, Geller JC, Klein HU. Effect of successful electrical cardioversion on serum aldosterone in patients with persistent atrial fibrillation. Am J Cardiol 2001;88: 906-909, A908. (Pubitemid 32995932)
    • (2001) American Journal of Cardiology , vol.88 , Issue.8 , pp. 906-909
    • Goette, A.1    Hoffmanns, P.2    Enayati, W.3    Meltendorf, U.4    Geller J.Christoph5    Klein, H.U.6
  • 19
    • 77950228107 scopus 로고    scopus 로고
    • Effects of spironolactone on atrial structural remodelling in a canine model of atrial fibrillation produced by prolonged atrial pacing
    • Zhao J, Li J, Li W, Li Y, Shan H, Gong Y, Yang B. Effects of spironolactone on atrial structural remodelling in a canine model of atrial fibrillation produced by prolonged atrial pacing. Br J Pharmacol;159: 1584-1594.
    • Br J Pharmacol , vol.159 , pp. 1584-1594
    • Zhao, J.1    Li, J.2    Li, W.3    Li, Y.4    Shan, H.5    Gong, Y.6    Yang, B.7
  • 20
    • 21744457238 scopus 로고    scopus 로고
    • Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes
    • DOI 10.1016/j.cardiores.2005.05.009, PII S000863630500235X
    • Lalevee N, Rebsamen MC, Barrere-Lemaire S, Perrier E, Nargeot J, Benitah JP, Rossier MF. Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes. Cardiovasc Res 2005;67:216-224. (Pubitemid 40943614)
    • (2005) Cardiovascular Research , vol.67 , Issue.2 , pp. 216-224
    • Lalevee, N.1    Rebsamen, M.C.2    Barrere-Lemaire, S.3    Perrier, E.4    Nargeot, J.5    Benitah, J.-P.6    Rossier, M.F.7
  • 22
    • 33745172144 scopus 로고    scopus 로고
    • Beneficial effect of eplerenone on cardiac remodelling and electrical properties of the failing heart
    • De Mello WC. Beneficial effect of eplerenone on cardiac remodelling and electrical properties of the failing heart. J Renin Angiotensin Aldosterone Syst 2006;7:40-46. (Pubitemid 43891244)
    • (2006) JRAAS - Journal of the Renin-Angiotensin-Aldosterone System , vol.7 , Issue.1 , pp. 40-46
    • De Mello, W.C.1
  • 24
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • DOI 10.1056/NEJM199909023411001
    • Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999;341:709-717. (Pubitemid 29407370)
    • (1999) New England Journal of Medicine , vol.341 , Issue.10 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6    Palensky, J.7    Wittes, J.8
  • 26
    • 0029022285 scopus 로고
    • Prerequisite for cardiac aldosterone action. Mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase in the human heart
    • Lombes M, Alfaidy N, Eugene E, Lessana A, Farman N, Bonvalet JP. Prerequisite for cardiac aldosterone action. Mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase in the human heart. Circulation 1995;92:175-182.
    • (1995) Circulation , vol.92 , pp. 175-182
    • Lombes, M.1    Alfaidy, N.2    Eugene, E.3    Lessana, A.4    Farman, N.5    Bonvalet, J.P.6
  • 27
    • 44949169677 scopus 로고    scopus 로고
    • Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion
    • Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ. Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circ Res 2008;102:1359-1367.
    • (2008) Circ Res , vol.102 , pp. 1359-1367
    • Caprio, M.1    Newfell, B.G.2    La Sala, A.3    Baur, W.4    Fabbri, A.5    Rosano, G.6    Mendelsohn, M.E.7    Jaffe, I.Z.8
  • 28
    • 79953199333 scopus 로고    scopus 로고
    • The mineralocorticoid receptor in heart: Differential effects in different cells
    • Jaisser F, Swynghedauw B, Delcayre C. The mineralocorticoid receptor in heart: differential effects in different cells. Hypertension 2011;57:679-680.
    • (2011) Hypertension , vol.57 , pp. 679-680
    • Jaisser, F.1    Swynghedauw, B.2    Delcayre, C.3
  • 30
    • 79953224745 scopus 로고    scopus 로고
    • Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function after chronic pressure overload
    • Lother AB, Berger S, Gilsbach R, Roesner S, Ecke A, Barreto F, Bauersachs J, Schutz G, Hein L. Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function after chronic pressure overload. Hypertension 2011;57:746-754.
    • (2011) Hypertension , vol.57 , pp. 746-754
    • Lother, A.B.1    Berger, S.2    Gilsbach, R.3    Roesner, S.4    Ecke, A.5    Barreto, F.6    Bauersachs, J.7    Schutz, G.8    Hein, L.9
  • 31
    • 70349257487 scopus 로고    scopus 로고
    • Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure
    • Rickard AJ, Morgan J, Tesch G, Funder JW, Fuller PJ, Young MJ. Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure. Hypertension 2009;54:537-543.
    • (2009) Hypertension , vol.54 , pp. 537-543
    • Rickard, A.J.1    Morgan, J.2    Tesch, G.3    Funder, J.W.4    Fuller, P.J.5    Young, M.J.6
  • 32
    • 36349024715 scopus 로고    scopus 로고
    • Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells
    • DOI 10.1161/CIRCULATIONAHA.107.722009
    • Ambroisine ML, Favre J, Oliviero P, Rodriguez C, Gao J, Thuillez C, Samuel JL, Richard V, Delcayre C. Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells. Circulation 2007; 116:2435-2443. (Pubitemid 350145078)
    • (2007) Circulation , vol.116 , Issue.21 , pp. 2435-2443
    • Ambroisine, M.-L.1    Favre, J.2    Oliviero, P.3    Rodriguez, C.4    Gao, J.5    Thuillez, C.6    Samuel, J.-L.7    Richard, V.8    Delcayre, C.9
  • 34
    • 8644229320 scopus 로고    scopus 로고
    • Critical role of CNS effects of aldosterone in cardiac remodeling post-myocardial infarction in rats
    • DOI 10.1016/j.cardiores.2004.08.004, PII S0008636304003505
    • Lal A, Veinot JP, Leenen FH. Critical role of CNS effects of aldosterone in cardiac remodeling post-myocardial infarction in rats. Cardiovasc Res 2004;64:437-447. (Pubitemid 39505423)
    • (2004) Cardiovascular Research , vol.64 , Issue.3 , pp. 437-447
    • Lal, A.1    Veinot, J.P.2    Leenen, F.H.H.3
  • 35
    • 59449107858 scopus 로고    scopus 로고
    • Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction
    • Huang BS, White RA, Ahmad M, Tan J, Jeng AY, Leenen FH. Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction. Cardiovasc Res 2009;81:574-581.
    • (2009) Cardiovasc Res , vol.81 , pp. 574-581
    • Huang, B.S.1    White, R.A.2    Ahmad, M.3    Tan, J.4    Jeng, A.Y.5    Leenen, F.H.6
  • 38
    • 54749104730 scopus 로고    scopus 로고
    • Corticosteroids and redox potential modulate spontaneous contractions in isolated rat ventricular cardiomyocytes
    • Rossier MF, Lenglet S, Vetterli L, Python M, Maturana A. Corticosteroids and redox potential modulate spontaneous contractions in isolated rat ventricular cardiomyocytes. Hypertension 2008;52: 721-728.
    • (2008) Hypertension , vol.52 , pp. 721-728
    • Rossier, M.F.1    Lenglet, S.2    Vetterli, L.3    Python, M.4    Maturana, A.5
  • 40
    • 73349119698 scopus 로고    scopus 로고
    • Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction
    • Mihailidou AS, Loan Le TY, Mardini M, Funder JW. Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction. Hypertension 2009;54:1306-1312.
    • (2009) Hypertension , vol.54 , pp. 1306-1312
    • Mihailidou, A.S.1    Loan Le, T.Y.2    Mardini, M.3    Funder, J.W.4
  • 41
    • 0033859180 scopus 로고    scopus 로고
    • Aldosterone and the heart
    • DOI 10.1016/S1043-2760(00)00270-8, PII S1043276000002708
    • Young M, Funder JW. Aldosterone and the heart. Trends Endocrinol Metab 2000;11:224-226. (Pubitemid 30603168)
    • (2000) Trends in Endocrinology and Metabolism , vol.11 , Issue.6 , pp. 224-226
    • Young, M.1    Funder, J.W.2
  • 43
    • 59849118673 scopus 로고    scopus 로고
    • Reconsidering the roles of the mineralocorticoid receptor
    • Funder JW. Reconsidering the roles of the mineralocorticoid receptor. Hypertension 2009;53:286-290.
    • (2009) Hypertension , vol.53 , pp. 286-290
    • Funder, J.W.1
  • 48
    • 16444375794 scopus 로고    scopus 로고
    • Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells
    • DOI 10.1161/01.RES.0000159937.05502.d1
    • Jaffe IZ, Mendelsohn ME. Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells. Circ Res 2005;96: 643-650. (Pubitemid 40478331)
    • (2005) Circulation Research , vol.96 , Issue.6 , pp. 643-650
    • Jaffe, I.Z.1    Mendelsohn, M.E.2
  • 49
    • 77954351476 scopus 로고    scopus 로고
    • Blockade of mineralocorticoid receptors improves salt-induced left-ventricular systolic dysfunction through attenuation of enhanced sympathetic drive in mice with pressure overload
    • Ito K, Hirooka Y, Sunagawa K. Blockade of mineralocorticoid receptors improves salt-induced left-ventricular systolic dysfunction through attenuation of enhanced sympathetic drive in mice with pressure overload. J Hypertens;28:1449-1458.
    • J Hypertens , vol.28 , pp. 1449-1458
    • Ito, K.1    Hirooka, Y.2    Sunagawa, K.3
  • 50
    • 44549083675 scopus 로고    scopus 로고
    • Nongenotropic aldosterone effects and the EGFR: Interaction and biological relevance
    • Grossmann C, Gekle M. Nongenotropic aldosterone effects and the EGFR: interaction and biological relevance. Steroids 2008;73: 973-978.
    • (2008) Steroids , vol.73 , pp. 973-978
    • Grossmann, C.1    Gekle, M.2
  • 51
    • 0032588244 scopus 로고    scopus 로고
    • 1 receptor subtype as a cardiac target of aldosterone: Role in aldosterone-salt-induced fibrosis
    • Robert V, Heymes C, Silvestre JS, Sabri A, Swynghedauw B, Delcayre C. Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: role in aldosterone-salt-induced fibrosis. Hypertension 1999;33:981-986. (Pubitemid 29186395)
    • (1999) Hypertension , vol.33 , Issue.4 , pp. 981-986
    • Robert, V.1    Heymes, C.2    Silvestre, J.-S.3    Sabri, A.4    Swynghedauw, B.5    Delcayre, C.6
  • 52
    • 52449122086 scopus 로고    scopus 로고
    • Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways
    • Montezano AC, Callera GE, Yogi A, He Y, Tostes RC, He G, Schiffrin EL, Touyz RM. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler Thromb Vasc Biol 2008;28:1511-1518.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1511-1518
    • Montezano, A.C.1    Callera, G.E.2    Yogi, A.3    He, Y.4    Tostes, R.C.5    He, G.6    Schiffrin, E.L.7    Touyz, R.M.8
  • 53
    • 67651131121 scopus 로고    scopus 로고
    • Actions of aldosterone in the cardiovascular system: The good, the bad, and the ugly?
    • Gekle M, Grossmann C. Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly?. Pflugers Arch 2009;458: 231-246.
    • (2009) Pflugers Arch , vol.458 , pp. 231-246
    • Gekle, M.1    Grossmann, C.2
  • 54
    • 18244387434 scopus 로고    scopus 로고
    • Aldosterone receptor blockade prevents the transition to cardiac pump dysfunction induced by β-adrenoreceptor activation
    • DOI 10.1161/01.HYP.0000164567.62172.c5
    • Veliotes DG, Woodiwiss AJ, Deftereos DA, Gray D, Osadchii O, Norton GR. Aldosterone receptor blockade prevents the transition to cardiac pump dysfunction induced by beta-adrenoreceptor activation. Hypertension 2005;45:914-920. (Pubitemid 40628937)
    • (2005) Hypertension , vol.45 , Issue.5 , pp. 914-920
    • Veliotes, D.G.A.1    Woodiwiss, A.J.2    Deftereos, D.A.J.3    Gray, D.4    Osadchii, O.5    Norton, G.R.6
  • 55
    • 74149083856 scopus 로고    scopus 로고
    • Attenuation of adverse cardiac effects in prednisolonetreated delta-sarcoglycan-deficient mice by mineralocorticoidreceptor-antagonism
    • Bauer R, Blain A, Greally E, Lochmuller H, Bushby K, MacGowan GA, Straub V. Attenuation of adverse cardiac effects in prednisolonetreated delta-sarcoglycan-deficient mice by mineralocorticoidreceptor- antagonism. Neuromuscul Disord;20:21-28.
    • Neuromuscul Disord , vol.20 , pp. 21-28
    • Bauer, R.1    Blain, A.2    Greally, E.3    Lochmuller, H.4    Bushby, K.5    MacGowan, G.A.6    Straub, V.7
  • 56
    • 44349085313 scopus 로고    scopus 로고
    • Aldosterone and the autocrine modulation of potassium currents and oxidative stress in the diabetic rat heart
    • DOI 10.1038/bjp.2008.114, PII BJP2008114
    • Shimoni Y, Chen K, Emmett T, Kargacin G. Aldosterone and the autocrine modulation of potassium currents and oxidative stress in the diabetic rat heart. Br J Pharmacol 2008;154:675-687. (Pubitemid 351744944)
    • (2008) British Journal of Pharmacology , vol.154 , Issue.3 , pp. 675-687
    • Shimoni, Y.1    Chen, K.2    Emmett, T.3    Kargacin, G.4
  • 57
    • 44049097881 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines
    • Guo C, Ricchiuti V, Lian BQ, Yao TM, Coutinho P, Romero JR, Li J, Williams GH, Adler GK. Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines. Circulation 2008;117:2253-2261.
    • (2008) Circulation , vol.117 , pp. 2253-2261
    • Guo, C.1    Ricchiuti, V.2    Lian, B.Q.3    Yao, T.M.4    Coutinho, P.5    Romero, J.R.6    Li, J.7    Williams, G.H.8    Adler, G.K.9
  • 58
    • 0037208826 scopus 로고    scopus 로고
    • Functional polymorphisms in the mineralocorticoid receptor and amirolide-sensitive sodium channel genes in a patient with sporadic pseudohypoaldosteronism
    • DOI 10.1007/s00439-002-0855-7
    • Arai K, Nakagomi Y, Iketani M, Shimura Y, Amemiya S, Ohyama K, Shibasaki T. Functional polymorphisms in the mineralocorticoid receptor and amirolide-sensitive sodium channel genes in a patient with sporadic pseudohypoaldosteronism. Hum Genet 2003;112: 91-97. (Pubitemid 36869121)
    • (2003) Human Genetics , vol.112 , Issue.1 , pp. 91-97
    • Arai, K.1    Nakagomi, Y.2    Iketani, M.3    Shimura, Y.4    Amemiya, S.5    Ohyama, K.6    Shibasaki, T.7
  • 59
    • 75149149183 scopus 로고    scopus 로고
    • Association of aldosterone concentration and mineralocorticoid receptor genotype with potassium response to spironolactone in patients with heart failure
    • Cavallari LH, Groo VL, Viana MA, Dai Y, Patel SR, Stamos TD. Association of aldosterone concentration and mineralocorticoid receptor genotype with potassium response to spironolactone in patients with heart failure. Pharmacotherapy;30:1-9.
    • Pharmacotherapy , vol.30 , pp. 1-9
    • Cavallari, L.H.1    Groo, V.L.2    Viana, M.A.3    Dai, Y.4    Patel, S.R.5    Stamos, T.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.