Aldosterone induces electrical remodeling independent of hypertension

International Journal of Cardiology

Volumn 164, Issue 2, 2013, Pages 170-178

  Dartsch, Theresa ^a   Fischer, Robert ^b,c   Gapelyuk, Andrej ^c,d   Weiergraeber, Marco ^e   Ladage, Dennis ^a   Schneider, Toni ^a   Schirdewan, Alexander ^b   Reuter, Hannes ^a   Mueller Ehmsen, Jochen ^a   Zobel, Carsten ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d HUMBOLDT UNIVERSITY   (Germany)

^e Federal Institute for Drugs and Medical Devices Bundesinstitut für Arzneimittel und Medizinprodukte   (Germany)

Author keywords

Aldosterone; Electrical remodeling; Hypertrophy; Sudden cardiac death

Indexed keywords

ALDOSTERONE; CALCINEURIN; CALCIUM CHANNEL L TYPE; EPLERENONE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.3; MESSENGER RNA; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV1.5; POTASSIUM CHANNEL KV4.2; POTASSIUM CHANNEL KV4.3; SPIRONOLACTONE; UNCLASSIFIED DRUG; ALDOSTERONE ANTAGONIST; ION CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE POTENTIAL; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE TACHYCARDIA; HYPERTENSION; LONG TERM EXPOSURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SUBUNIT; QT PROLONGATION; RAT; ANIMAL MODEL; BLOOD PRESSURE MEASUREMENT; HEART FAILURE; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE REMODELING; MAGNETOCARDIOGRAPHY; OSMOTIC MINIPUMP; SUDDEN CARDIAC DEATH;

ALDOSTERONE; ANIMALS; HYPERTENSION; MALE; RATS; RATS, WISTAR; TACHYCARDIA, VENTRICULAR; VENTRICULAR REMODELING;

EID: 84875228346     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2011.06.100     Document Type: Article

References (61)

1. G.F. Tomaselli, D.J. Beuckelmann, and H.G. Calkins Sudden cardiac death in heart failure. The role of abnormal repolarization Circulation 90 5 1994 2534 2539
2. S.Z. Abildstrom, C. Torp-Pedersen, and L. Kober Arrhythmic and sudden death in chronic ischemic heart disease - a review of epidemiological data Card Electrophysiol Rev 6 1-2 2002 5 8
3. A.A. Armoundas, R. Wu, G. Juang, E. Marban, and G.F. Tomaselli Electrical and structural remodeling of the failing ventricle Pharmacol Ther 92 2-3 2001 213 230
4. S. Garg, J. Narula, C. Marelli, and D. Cesario Role of angiotensin receptor blockers in the prevention and treatment of arrhythmias Am J Cardiol 97 6 2006 921 925
5. P. Vantrimpont, J.L. Rouleau, and A. Ciampi Two-year time course and significance of neurohumoral activation in the Survival and Ventricular Enlargement (SAVE) Study Eur Heart J 19 10 1998 1552 1563
6. B. Pitt, F. Zannad, and W.J. Remme The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators N Engl J Med 341 10 1999 709 717
7. B. Pitt, W. Remme, and F. Zannad Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction N Engl J Med 348 14 2003 1309 1321
8. M.J. Janse Electrophysiological changes in heart failure and their relationship to arrhythmogenesis Cardiovasc Res 61 2 2004 208 217
9. M.J. Walker, M.J. Curtis, and D.J. Hearse The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion Cardiovasc Res 22 7 1988 447 455
10. Y. Takeda, T. Yoneda, M. Demura, M. Usukura, and H. Mabuchi Calcineurin inhibition attenuates mineralocorticoid-induced cardiac hypertrophy Circulation 105 6 2002 677 679
11. A. Mano, T. Tatsumi, and J. Shiraishi Aldosterone directly induces myocyte apoptosis through calcineurin-dependent pathways Circulation 110 3 2004 317 323
12. V. Robert, J.S. Silvestre, and D. Charlemagne Biological determinants of aldosterone-induced cardiac fibrosis in rats Hypertension 26 1995 971 978
13. C.G. Brilla, and K.T. Weber Mineralocorticoid excess, dietary sodium, and myocardial fibrosis J Lab Clin Med 120 6 1992 893 901
14. Y. Sun, J. Zhang, L. Lu, S.S. Chen, M.T. Quinn, and K.T. Weber Aldosterone-induced inflammation in the rat heart: role of oxidative stress Am J Pathol 161 5 2002 1773 1781
15. R. Rocha, A.E. Rudolph, and G.E. Frierdich Aldosterone induces a vascular inflammatory phenotype in the rat heart Am J Physiol Heart Circ Physiol 283 5 2002 H1802 H1810
16. K. Yoshida, S. Kim-Mitsuyama, and R. Wake Excess aldosterone under normal salt diet induces cardiac hypertrophy and infiltration via oxidative stress Hypertens Res 28 5 2005 447 455
17. T. Karram, A. Abbasi, and S. Keidar Effects of spironolactone and eprosartan on cardiac remodeling and angiotensin-converting enzyme isoforms in rats with experimental heart failure Am J Physiol Heart Circ Physiol 289 4 2005 H1351 H1358
18. K.J. Schjoedt, K. Rossing, and T.R. Juhl Beneficial impact of spironolactone in diabetic nephropathy Kidney Int 68 6 2005 2829 2836
19. V.J. Dzau, W.S. Colucci, N.K. Hollenberg, and G.H. Williams Relation of the renin-angiotensin-aldosterone system to clinical state in congestive heart failure Circulation 63 1981 645 651
20. I.S. Anand, R. Ferrari, G.S. Kalra, P.L. Wahi, P.A. Poole-Wilson, and P.C. Harris Edema of cardiac origin. Studies of body water and sodium, renal function, hemodynamic indexes, and plasma hormones in untreated congestive cardiac failure Circulation 80 2 1989 299 305
21. M. de Gasparo, U. Joss, and H.P. Ramjoue Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro J Pharmacol Exp Ther 240 2 1987 650 656
22. K. Dickstein, A. Cohen-Solal, and G. Filippatos ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM) Eur Heart J 29 19 2008 2388 2442
23. J.P. Benitah, and G. Vassort Aldosterone upregulates Ca(2+) current in adult rat cardiomyocytes Circ Res 85 12 1999 1139 1145
24. J.P. Benitah, E. Perrier, A.M. Gomez, and G. Vassort Effects of aldosterone on transient outward K + current density in rat ventricular myocytes J Physiol 537 Pt 1 2001 151 160
25. A. Ouvrard-Pascaud, Y. Sainte-Marie, and J.P. Benitah Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias Circulation 111 23 2005 3025 3033
26. B. London, A. Jeron, and J. Zhou Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel Proc Natl Acad Sci USA 95 6 1998 2926 2931
27. M. McLerie, and A.N. Lopatin Dominant-negative suppression of I(K1) in the mouse heart leads to altered cardiac excitability J Mol Cell Cardiol 35 4 2003 367 378
28. J. Miake, E. Marban, and H.B. Nuss Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression J Clin Invest 111 10 2003 1529 1536
29. A.S. Dhamoon, and J. Jalife The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis Heart Rhythm 2 3 2005 316 324
30. G. Seemann, F.B. Sachse, D.L. Weiss, L.J. Ptacek, and M. Tristani-Firouzi Modeling of IK1 mutations in human left ventricular myocytes and tissue Am J Physiol Heart Circ Physiol 292 1 2007 H549 H559
31. J. Li, M. McLerie, and A.N. Lopatin Transgenic upregulation of IK1 in the mouse heart leads to multiple abnormalities of cardiac excitability Am J Physiol Heart Circ Physiol 287 6 2004 H2790 H2802
32. R. Perrier, S. Richard, and Y. Sainte-Marie A direct relationship between plasma aldosterone and cardiac L-type Ca2+ current in mice J Physiol 569 Pt 1 2005 153 162
33. E. Perrier, B.G. Kerfant, and N. Lalevee Mineralocorticoid receptor antagonism prevents the electrical remodeling that precedes cellular hypertrophy after myocardial infarction Circulation 110 7 2004 776 783
34. M. Wagner, E. Rudakova, and T. Volk Aldosterone-induced changes in the cardiac L-type Ca(2+) current can be prevented by antioxidants in vitro and are absent in rats on low salt diet Pflugers Arch 457 2 2008 339 349
35. N. Kim, M.B. Cannell, and P.J. Hunter Changes in the calcium current among different transmural regions contributes to action potential heterogeneity in rat heart Prog Biophys Mol Biol 103 1 2010 28 34
36. E.G. Schouten, J.M. Dekker, P. Meppelink, F.J. Kok, J.P. Vandenbroucke, and J. Pool QT interval prolongation predicts cardiovascular mortality in an apparently healthy population Circulation 84 4 1991 1516 1523
37. M. Zabel, S. Portnoy, and M.R. Franz Electrocardiographic indexes of dispersion of ventricular repolarization: an isolated heart validation study J Am Coll Cardiol 25 3 1995 746 752
38. R.J. MacFadyen, C.S. Barr, and A.D. Struthers Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients Cardiovasc Res 35 1 1997 30 34
39. F.J. Ramires, A. Mansur, and O. Coelho Effect of spironolactone on ventricular arrhythmias in congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy Am J Cardiol 85 10 2000 1207 1211
40. C.S. Barr, C.C. Lang, J. Hanson, M. Arnott, N. Kennedy, and A.D. Struthers Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease Am J Cardiol 76 17 1995 1259 1265
41. D. Levy, R.J. Garrison, D.D. Savage, W.B. Kannel, and W.P. Castelli Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study N Engl J Med 322 22 1990 1561 1566
42. A. Algra, J.G. Tijssen, J.R. Roelandt, J. Pool, and J. Lubsen QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest Circulation 83 6 1991 1888 1894
43. R.E. Ten Eick, D.W. Whalley, and H.H. Rasmussen Connections: heart disease, cellular electrophysiology, and ion channels FASEB J 6 8 1992 2568 2580
44. T. Kahan, and L. Bergfeldt Left ventricular hypertrophy in hypertension: its arrhythmogenic potential Heart 91 2 2005 250 256
45. B. Swynghedauw The acquired long QT during cardiac hypertrophy. Origin, incidence and significance Bull Acad Natl Med 189 1 2005 31 40
46. B. Swynghedauw, C. Baillard, and P. Milliez The long QT interval is not only inherited but is also linked to cardiac hypertrophy J Mol Med 81 6 2003 336 345
47. G.F. Tomaselli, and D.P. Zipes What causes sudden death in heart failure? Circ Res 95 8 2004 754 763
48. G.X. Yan, and C. Antzelevitch Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome Circulation 98 18 1998 1928 1936
49. M. Shimizu, H. Ino, and K. Okeie T-peak to T-end interval may be a better predictor of high-risk patients with hypertrophic cardiomyopathy associated with a cardiac troponin I mutation than QT dispersion Clin Cardiol 25 7 2002 335 339
50. M.J. Young, and J.W. Funder The renin-angiotensin-aldosterone system in experimental mineralocorticoid-salt-induced cardiac fibrosis Am J Physiol 271 5 Pt 1 1996 E883 E888
51. M. Iglarz, R.M. Touyz, E.C. Viel, F. Amiri, and E.L. Schiffrin Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction wtih the renin-angiotension system Am J Hypertens 17 7 2004 597 603
52. N. Morita, A.A. Sovari, and Y. Xie Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress Am J Physiol Heart Circ Physiol 297 5 2009 H1594 H1605
53. N. Gong, I. Bodi, C. Zobel, A. Schwartz, J.D. Molkentin, and P.H. Backx Calcineurin increases cardiac transient outward K + currents via transcriptional up-regulation of Kv4.2 channel subunits J Biol Chem 281 50 2006 38498 38506
54. Dias da Silva VJ, N.E. Ferreira, H.C. Salgado, and R. Fazan Jr. Chronic converting enzyme inhibition normalizes QT interval in aging rats Braz J Med Biol Res 35 9 2002 1025 1031
55. S.R. Coppen, S. Fukushima, and Y. Shintani A factor underlying late-phase arrhythmogenicity after cell therapy to the heart: global downregulation of connexin43 in the host myocardium after skeletal myoblast transplantation Circulation 118 14 Suppl 2008 S138 S144
56. L. Beck, V. Blanc-Guillemaud, O.K. Cherif, B. Jover, and J.M. Davy Effects of spironolactone and fosinopril on the spontaneous and chronic ventricular arrhythmias in a rat model of myocardial infarction Cardiology 96 2 2001 85 93
57. F. Aimond, L. Beck, and P. Gautier Cellular and in vivo electrophysiological effects of dronedarone in normal and postmyocardial infarcted rats J Pharmacol Exp Ther 292 1 2000 415 424
58. C.P. Regan, H.K. Cresswell, R. Zhang, and J.J. Lynch Novel method to assess cardiac electrophysiology in the rat: characterization of standard ion channel blockers J Cardiovasc Pharmacol 46 1 2005 68 75
59. G.R. Li, J. Feng, L. Yue, M. Carrier, and S. Nattel Evidence for two components of delayed rectifier K + current in human ventricular myocytes Circ Res 78 4 1996 689 696
60. J.L. Greenstein, R. Wu, S. Po, G.F. Tomaselli, and R.L. Winslow Role of the calcium-independent transient outward current i(to1) in shaping action potential morphology and duration Circ Res 87 11 2000 1026 1033
61. P. Bailly, J.P. Benitah, M. Mouchoniere, G. Vassort, and P. Lorente Regional alteration of the transient outward current in human left ventricular septum during compensated hypertrophy Circulation 96 4 1997 1266 1274