Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects: Insights from an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) substudy

Journal of the American College of Cardiology

Volumn 58, Issue 19, 2011, Pages 1958-1966

  Rossignol, Patrick ^a,b   Ménard, Jol ^a,d   Fay, Renaud ^a   Gustafsson, Finn ^e   Pitt, Bertram ^f   Zannad, Faiez ^a,c  

^a INSERM   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

^c UNIVERSITY HOSPITAL OF NANCY   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

clinical trial; diuretic; eplerenone; heart failure; potassium

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; EPLERENONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO; POTASSIUM;

ADULT; AGED; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORONARY REPERFUSION; DIURESIS; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PLASMA VOLUME; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE; SYSTOLIC DYSFUNCTION;

AGED; ALDOSTERONE ANTAGONISTS; CLINICAL TRIALS AS TOPIC; DIURESIS; FEMALE; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; POTASSIUM; SPIRONOLACTONE;

EID: 80054975039     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.04.049     Document Type: Article

References (35)

1. M. Jessup, and M.R. Costanzo The cardiorenal syndrome: do we need a change of strategy or a change of tactics? J Am Coll Cardiol 53 2009 597 599
2. M.H. Drazner, J.E. Rame, L.W. Stevenson, and D.L. Dries Prognostic importance of elevated jugular venous pressure and a third heart sound in patients with heart failure N Engl J Med 345 2001 574 581 (Pubitemid 32772099)
3. C. Lucas, W. Johnson, and M.A. Hamilton Freedom from congestion predicts good survival despite previous class iv symptoms of heart failure Am Heart J 140 2000 840 847
4. B. Pitt, W. Remme, and F. Zannad Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction N Engl J Med 348 2003 1309 1321 (Pubitemid 36384098)
5. W.H. Tang, A.C. Parameswaran, A.P. Maroo, and G.S. Francis Aldosterone receptor antagonists in the medical management of chronic heart failure Mayo Clin Proc 80 2005 1623 1630 (Pubitemid 41747065)
6. W. Iraqi, P. Rossignol, and M. Angioi Extracellular cardiac matrix biomarkers in patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure: insights from the eplerenone post-acute myocardial infarction heart failure efficacy and survival study (EPHESUS) study Circulation 119 2009 2471 2479
7. M.B. Strauss, R.K. Davis, J.D. Rosenbaum, and E.C. Rossmeisl Water diuresis produced during recumbency by the intravenous infusion of isotonic saline solution J Clin Invest 30 1951 862 868
8. P.R. Kalra, C. Anagnostopoulos, A.P. Bolger, A.J. Coats, and S.D. Anker The regulation and measurement of plasma volume in heart failure J Am Coll Cardiol 39 2002 1901 1908 (Pubitemid 34628269)
9. K. Dickstein, A. Cohen-Solal, and G. Filippatos ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology Eur J Heart Fail 10 2008 933 989
10. A.S. Levey, J.P. Bosch, J.B. Lewis, T. Greene, N. Rogers, D. Roth Modification of Diet in Renal Disease Study Group A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation Ann Intern Med 130 1999 461 470 (Pubitemid 29135798)
11. A.S. Androne, K. Hryniewicz, A. Hudaihed, D. Mancini, J. Lamanca, and S.D. Katz Relation of unrecognized hypervolemia in chronic heart failure to clinical status, hemodynamics, and patient outcomes Am J Cardiol 93 2004 1254 1259 (Pubitemid 38595679)
12. B. Pitt, F. Zannad, W.J. Remme Randomized Aldactone Evaluation Study Investigators The effect of spironolactone on morbidity and mortality in patients with severe heart failure N Engl J Med 341 1999 709 717 (Pubitemid 29407370)
13. R. Faris, M. Flather, H. Purcell, M. Henein, P. Poole-Wilson, and A. Coats Current evidence supporting the role of diuretics in heart failure: a meta analysis of randomised controlled trials Int J Cardiol 82 2002 149 158 (Pubitemid 34164392)
14. S. Eshaghian, T.B. Horwich, and G.C. Fonarow Relation of loop diuretic dose to mortality in advanced heart failure Am J Cardiol 97 2006 1759 1764 (Pubitemid 43817867)
15. G.W. Neuberg, A.B. Miller, and C.M. O'Connor Diuretic resistance predicts mortality in patients with advanced heart failure Am Heart J 144 2002 31 38 (Pubitemid 34734752)
16. V. Hasselblad, W. Gattis Stough, and M.R. Shah Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial Eur J Heart Fail 9 2007 1064 1069 (Pubitemid 47451811)
17. M.R. Shah, C.M. O'Connor, G. Sopko, V. Hasselblad, R.M. Califf, and L.W. Stevenson Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness (ESCAPE): design and rationale Am Heart J 141 2001 528 535 (Pubitemid 32260716)
18. G. Cotter, M. Metra, O. Milo-Cotter, H.C. Dittrich, and M. Gheorghiade Fluid overload in acute heart failurere-distribution and other mechanisms beyond fluid accumulation Eur J Heart Fail 10 2008 165 169 (Pubitemid 351222743)
19. G. Cotter, E. Metzkor, and E. Kaluski Randomised trial of high-dose isosorbide dinitrate plus low-dose furosemide versus high-dose furosemide plus low-dose isosorbide dinitrate in severe pulmonary oedema Lancet 351 1998 389 393 (Pubitemid 28064161)
20. Publication Committee for the VMAC Investigators (Vasodilatation in the Management of Acute CHF) Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial JAMA 287 2002 1531 1540
21. J.E. Blair, S. Khan, and M.A. Konstam Weight changes after hospitalization for worsening heart failure and subsequent re-hospitalization and mortality in the everest trial Eur Heart J 30 2009 1666 1673
22. M.A. Konstam, M. Gheorghiade, and J.C. Burnett Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST outcome trial JAMA 297 2007 1319 1331 (Pubitemid 46513233)
23. A. Ahmed, F. Zannad, and T.E. Love A propensity-matched study of the association of low serum potassium levels and mortality in chronic heart failure Eur Heart J 28 2007 1334 1343 (Pubitemid 47355979)
24. S.A. Hunt, W.T. Abraham, and M.H. Chin 2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 53 2009 e1 e90
25. B. Pitt, G. Bakris, L.M. Ruilope, L. DiCarlo, and R. Mukherjee Serum potassium and clinical outcomes in the eplerenone post-acute myocardial infarction heart failure efficacy and survival study (EPHESUS) Circulation 118 2008 1643 1650
26. M. Domanski, J. Norman, B. Pitt, M. Haigney, S. Hanlon, and E. Peyster Diuretic use, progressive heart failure, and death in patients in the studies of left ventricular dysfunction (SOLVD) J Am Coll Cardiol 42 2003 705 708 (Pubitemid 37000189)
27. H.A. Cooper, D.L. Dries, C.E. Davis, Y.L. Shen, and M.J. Domanski Diuretics and risk of arrhythmic death in patients with left ventricular dysfunction Circulation 100 1999 1311 1315 (Pubitemid 29440124)
28. F. Zannad, F. Alla, B. Dousset, A. Perez, B. Pitt RALES investigators Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES) Circulation 102 2000 2700 2706
29. P. Lacolley, C. Labat, A. Pujol, C. Delcayre, A. Benetos, and M. Safar Increased carotid wall elastic modulus and fibronectin in aldosterone-salt- treated rats: effects of eplerenone Circulation 106 2002 2848 2853 (Pubitemid 35396986)
30. G.W. Buffaloe, and F.G. Heineken Plasma volume nomograms for use in therapeutic plasma exchange Transfusion 23 1983 355 357 (Pubitemid 13035902)
31. K.B. Sprenger, K. Huber, W. Kratz, and E. Henze Nomograms for the prediction of patient's plasma volume in plasma exchange therapy from height, weight, and hematocrit J Clin Apher 3 1987 185 190 (Pubitemid 17031846)
32. G. Marenzi, G. Lauri, M. Grazi, E. Assanelli, J. Campodonico, and P. Agostoni Circulatory response to fluid overload removal by extracorporeal ultrafiltration in refractory congestive heart failure J Am Coll Cardiol 38 2001 963 968 (Pubitemid 32912695)
33. K. Gaddam, C. Corros, and E. Pimenta Rapid reversal of left ventricular hypertrophy and intracardiac volume overload in patients with resistant hypertension and hyperaldosteronism: a prospective clinical study Hypertension 55 2010 1137 1142
34. A. Davenport, S.D. Anker, and A. Mebazaa ADQI 7: the clinical management of the cardio-renal syndromes: work group statements from the 7th ADQI consensus conference Nephrol Dial Transplant 25 2010 2077 2089
35. B. Pitt, H. White, and J. Nicolau Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure J Am Coll Cardiol 46 2005 425 431 (Pubitemid 41040281)