B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cells

American Journal of Transplantation

Volumn 15, Issue 2, 2015, Pages 346-357

  Gorbacheva, V ^a   Ayasoufi, K ^a   Fan, R ^a   Baldwin, W M ^a   Valujskikh, A ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Alloantibody; basic (laboratory) research; costimulation; immunobiology; science; T cell biology

Indexed keywords

ALLOANTIBODY; APRIL PROTEIN; B CELL ACTIVATING FACTOR; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G2C; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; UNCLASSIFIED DRUG; CD40 ANTIGEN; TNFSF13 PROTEIN, MOUSE; TNFSF13B PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CARDIAC GRAFT REJECTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HEART GRAFT; HEART TRANSPLANTATION; HUMAN; HUMORAL IMMUNITY; MALE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; ANIMAL; ANIMAL MODEL; BAGG ALBINO MOUSE; C57BL MOUSE; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD40; B-CELL ACTIVATING FACTOR; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CD8-POSITIVE T-LYMPHOCYTES; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; IMMUNOLOGIC MEMORY; ISOANTIBODIES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, ANIMAL; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13;

EID: 84921547992     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12984     Document Type: Article

References (37)

1. Brook MO, Wood KJ, Jones ND,. The impact of memory T cells on rejection and the induction of tolerance. Transplantation 2006; 82: 1-9.
2. Valujskikh A,. Targeting T-cell memory: Where do we stand ? Curr Opin Organ Transplant 2008; 13: 344-349.
3. Chen Y, Heeger PS, Valujskikh A,. In vivo helper functions of alloreactive memory CD4+ T cells remain intact despite donor-specific transfusion and anti-CD40 ligand therapy. J Immunol 2004; 172: 5456-5466.
4. Zhang Q, Chen Y, Fairchild RL, Heeger PS, Valujskikh A,. Lymphoid sequestration of alloreactive memory CD4 T cells promotes cardiac allograft survival. J Immunol 2006; 176: 770-777.
5. Zhang QW, Rabant M, Schenk A, Valujskikh A,. ICOS-dependent and -independent functions of memory CD4 T cells in allograft rejection. Am J Transplant 2008; 8: 497-506.
6. Rabant M, Gorbacheva V, Fan R, Yu H, Valujskikh A,. CD40-Independent help by memory CD4 T cells induces pathogenic alloantibody but does not lead to long-lasting humoral immunity. Am J Transplant 2013; 13: 2831-2841.
7. Schneider P,. The role of APRIL and BAFF in lymphocyte activation. Curr Opin Immunol 2005; 17: 282-289.
8. Bossen C, Schneider P,. BAFF, APRIL and their receptors: Structure, function and signaling. Semin Immunol 2006; 18: 263-275.
9. Dillon SR, Gross JA, Ansell SM, Novak AJ,. An APRIL to remember: Novel TNF ligands as therapeutic targets. Nat Rev Drug Discov 2006; 5: 235-246.
10. Mackay F, Leung H,. The role of the BAFF/APRIL system on T cell function. Semin Immunol 2006; 18: 284-289.
11. Ng LG, Sutherland AP, Newton R, et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 2004; 173: 807-817.
12. Wang H, Marsters SA, Baker T, et al. TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat Immunol 2001; 2: 632-637.
13. Ye Q, Wang L, Wells AD, et al. BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol 2004; 34: 2750-2759.
14. Gross JA, Johnston J, Mudri S, et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 2000; 404: 995-999.
15. Martin F, Chan AC,. B cell immunobiology in disease: Evolving concepts from the clinic. Annu Rev Immunol 2006; 24: 467-496.
16. Zekavat G, Rostami SY, Badkerhanian A, et al. In vivo BLyS/BAFF neutralization ameliorates islet-directed autoimmunity in nonobese diabetic mice. J Immunol 2008; 181: 8133-8144.
17. Thibault-Espitia A, Foucher Y, Danger R, et al. BAFF and BAFF-R levels are associated with risk of long-term kidney graft dysfunction and development of donor-specific antibodies. Am J Transplant 2012; 12: 2754-2762.
18. Banham G, Prezzi D, Harford S, et al. Elevated pretransplantation soluble BAFF is associated with an increased risk of acute antibody-mediated rejection. Transplantation 2013; 96: 413-420.
19. Parsons RF, Yu M, Vivek K, et al. Murine islet allograft tolerance upon blockade of the B-lymphocyte stimulator, BLyS/BAFF. Transplantation 2012; 93: 676-685.
20. Sicard A, Phares TW, Yu H, et al. The spleen is the major source of antidonor antibody-secreting cells in murine heart allograft recipients. Am J Transplant 2012; 12: 1708-1719.
21. Amano H, Bickerstaff A, Orosz CG, Novick AC, Toma H, Fairchild RL,. Absence of recipient CCR5 promotes early and increased allospecific antibody responses to cardiac allografts. J Immunol 2005; 174: 6499-6508.
22. Gorbacheva V, Fan R, Li X, Valujskikh A,. Interleukin-17 promotes early allograft inflammation. Am J Pathol 2010; 177: 1265-1273.
23. Benson MJ, Dillon SR, Castigli E, et al. Cutting edge: The dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J Immunol 2008; 180: 3655-3659.
24. Valujskikh A, Pantenburg B, Heeger PS,. Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice. Am J Transplant 2002; 2: 501-509.
25. Rahman ZS, Rao SP, Kalled SL, Manser T,. Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J Exp Med 2003; 198: 1157-1169.
26. Scholz JL, Crowley JE, Tomayko MM, et al. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proc Natl Acad Sci U S A 2008; 105: 15517-15522.
27. Castigli E, Wilson SA, Scott S, et al. TACI and BAFF-R mediate isotype switching in B cells. J Exp Med 2005; 201: 35-39.
28. Litinskiy MB, Nardelli B, Hilbert DM, et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol 2002; 3: 822-829.
29. He B, Raab-Traub N, Casali P, Cerutti A,. EBV-encoded latent membrane protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching. J Immunol 2003; 171: 5215-5224.
30. O'Connor BP, Raman VS, Erickson LD, et al. BCMA is essential for the survival of long-lived bone marrow plasma cells. J Exp Med 2004; 199: 91-98.
31. Vora KA, Wang LC, Rao SP, et al. Cutting edge: Germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function. J Immunol 2003; 171: 547-551.
32. Goenka R, Matthews AH, Zhang B, et al. Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J Exp Med 2014; 211: 45-56.
33. Huard B, Schneider P, Mauri D, Tschopp J, French LE,. T cell costimulation by the TNF ligand BAFF. J Immunol 2001; 167: 6225-6231.
34. Clatworthy MR,. B-cell regulation and its application to transplantation. Transpl Int 2014; 27: 117-128.
35. Ng YH, Oberbarnscheidt MH, Chandramoorthy HC, Hoffman R, Chalasani G,. B cells help alloreactive T cells differentiate into memory T cells. Am J Transplant 2010; 10: 1970-1980.
36. Murata K, Fox-Talbot K, Qian Z, et al. Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants. Am J Transplant 2007; 7: 2605-2614.
37. Liu Z, Davidson A,. BAFF inhibition: A new class of drugs for the treatment of autoimmunity. Exp Cell Res 2011; 317: 1270-1277.