Protein painting reveals solvent-excluded drug targets hidden within native protein-protein interfaces

Nature Communications

Volumn 5, Issue , 2014, Pages

  Luchini, Alessandra ^a   Espina, Virginia ^a   Liotta, Lance A ^a  

^a GEORGE MASON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE DERIVATIVE; AMIDE; ARGININE DERIVATIVE; BRIDGED PEPTIDE; DEUTERIUM; DYE; INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; MONOCLONAL ANTIBODY; PROTEINASE; SYNTHETIC PEPTIDE; TRYPSIN; COLORING AGENT; PEPTIDE; SOLVENT;

ANTIBODY; DRUG; LIGAND; PEPTIDE; PROTEIN; SOLVENT;

ABSORPTION SPECTROPHOTOMETRY; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL REACTION; COMPUTER MODEL; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DENATURATION; DEUTERIUM HYDROGEN EXCHANGE; DRUG TARGETING; ENZYME METABOLISM; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; INTRACELLULAR SIGNALING; KINETICS; LEARNING ALGORITHM; LIGAND BINDING; MATHEMATICAL MODEL; MOLECULAR SIZE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN PAINTING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; SURFACE PROPERTY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; IMMUNOLOGY; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; MOLECULARLY TARGETED THERAPY; MOUSE; PROCEDURES; PROTEIN CONFORMATION; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; COLORING AGENTS; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN-1BETA; MASS SPECTROMETRY; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR TARGETED THERAPY; PEPTIDES; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; RECEPTORS, INTERLEUKIN-1 TYPE I; SOLVENTS; TRYPSIN;

EID: 84921515827     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5413     Document Type: Article

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