-
1
-
-
84883076264
-
Severe sepsis and septic shock
-
Angus, D. C., and T. van der Poll. 2013. Severe sepsis and septic shock. N. Engl. J. Med. 369: 840-851.
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 840-851
-
-
Angus, D.C.1
Van Der Poll, T.2
-
2
-
-
84888325490
-
Sepsis-induced immunosuppression: From cellular dysfunctions to immunotherapy
-
Hotchkiss, R. S., G. Monneret, and D. Payen. 2013. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat. Rev. Immunol. 13: 862-874.
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 862-874
-
-
Hotchkiss, R.S.1
Monneret, G.2
Payen, D.3
-
3
-
-
0032770246
-
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
-
Hotchkiss, R. S., P. E. Swanson, B. D. Freeman, K. W. Tinsley, J. P. Cobb, G. M. Matuschak, T. G. Buchman, and I. E. Karl. 1999. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit. Care Med. 27: 1230-1251.
-
(1999)
Crit. Care Med.
, vol.27
, pp. 1230-1251
-
-
Hotchkiss, R.S.1
Swanson, P.E.2
Freeman, B.D.3
Tinsley, K.W.4
Cobb, J.P.5
Matuschak, G.M.6
Buchman, T.G.7
Karl, I.E.8
-
4
-
-
85043216069
-
Lymphopenia is associated with worse outcomes in patients with severe sepsis
-
Chien, Y. C., K. P. Chung, J. S. Cheng, H. T. Chang, and C. J. Yu. 2012. Lymphopenia is associated with worse outcomes in patients with severe sepsis. Am. J. Respir. Crit. Care Med. 185: A5992.
-
(2012)
Am. J. Respir. Crit. Care Med.
, vol.185
-
-
Chien, Y.C.1
Chung, K.P.2
Cheng, J.S.3
Chang, H.T.4
Yu, C.J.5
-
5
-
-
84862766869
-
A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis
-
Boomer, J. S., J. Shuherk-Shaffer, R. S. Hotchkiss, and J. M. Green. 2012. A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit. Care 16: R112.
-
(2012)
Crit. Care
, vol.16
, pp. R112
-
-
Boomer, J.S.1
Shuherk-Shaffer, J.2
Hotchkiss, R.S.3
Green, J.M.4
-
6
-
-
77951648850
-
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis
-
Unsinger, J., M. McGlynn, K. R. Kasten, A. S. Hoekzema, E. Watanabe, J. T. Muenzer, J. S. McDonough, J. Tschoep, T. A. Ferguson, J. E. McDunn, et al. 2010. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J. Immunol. 184: 3768-3779.
-
(2010)
J. Immunol.
, vol.184
, pp. 3768-3779
-
-
Unsinger, J.1
McGlynn, M.2
Kasten, K.R.3
Hoekzema, A.S.4
Watanabe, E.5
Muenzer, J.T.6
McDonough, J.S.7
Tschoep, J.8
Ferguson, T.A.9
McDunn, J.E.10
-
7
-
-
77956403940
-
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis
-
Brahmamdam, P., S. Inoue, J. Unsinger, K. C. Chang, J. E. McDunn, and R. S. Hotchkiss. 2010. Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J. Leukoc. Biol. 88: 233-240.
-
(2010)
J. Leukoc. Biol.
, vol.88
, pp. 233-240
-
-
Brahmamdam, P.1
Inoue, S.2
Unsinger, J.3
Chang, K.C.4
McDunn, J.E.5
Hotchkiss, R.S.6
-
8
-
-
33847401104
-
Multiple triggers of cell death in sepsis: Death receptor and mitochondrial-mediated apoptosis
-
Chang, K. C., J. Unsinger, C. G. Davis, S. J. Schwulst, J. T. Muenzer, A. Strasser, and R. S. Hotchkiss. 2007. Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J. 21: 708-719.
-
(2007)
FASEB J.
, vol.21
, pp. 708-719
-
-
Chang, K.C.1
Unsinger, J.2
Davis, C.G.3
Schwulst, S.J.4
Muenzer, J.T.5
Strasser, A.6
Hotchkiss, R.S.7
-
9
-
-
0033052453
-
Protective effects of C5a blockade in sepsis
-
Czermak, B. J., V. Sarma, C. L. Pierson, R. L. Warner, M. Huber-Lang, N. M. Bless, H. Schmal, H. P. Friedl, and P. A. Ward. 1999. Protective effects of C5a blockade in sepsis. Nat. Med. 5: 788-792.
-
(1999)
Nat. Med.
, vol.5
, pp. 788-792
-
-
Czermak, B.J.1
Sarma, V.2
Pierson, C.L.3
Warner, R.L.4
Huber-Lang, M.5
Bless, N.M.6
Schmal, H.7
Friedl, H.P.8
Ward, P.A.9
-
10
-
-
0036615932
-
C5a receptor and thymocyte apoptosis in sepsis
-
Riedemann, N. C., R. F. Guo, I. J. Laudes, K. Keller, V. J. Sarma, V. Padgaonkar, F. S. Zetoune, and P. A. Ward. 2002. C5a receptor and thymocyte apoptosis in sepsis. FASEB J. 16: 887-888.
-
(2002)
FASEB J.
, vol.16
, pp. 887-888
-
-
Riedemann, N.C.1
Guo, R.F.2
Laudes, I.J.3
Keller, K.4
Sarma, V.J.5
Padgaonkar, V.6
Zetoune, F.S.7
Ward, P.A.8
-
11
-
-
1842333302
-
Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor
-
Höpken, U. E., B. Lu, N. P. Gerard, and C. Gerard. 1997. Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. J. Exp. Med. 186: 749-756.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 749-756
-
-
Höpken, U.E.1
Lu, B.2
Gerard, N.P.3
Gerard, C.4
-
12
-
-
28844434626
-
An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2
-
Gerard, N. P., B. Lu, P. Liu, S. Craig, Y. Fujiwara, S. Okinaga, and C. Gerard. 2005. An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. J. Biol. Chem. 280: 39677-39680.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 39677-39680
-
-
Gerard, N.P.1
Lu, B.2
Liu, P.3
Craig, S.4
Fujiwara, Y.5
Okinaga, S.6
Gerard, C.7
-
13
-
-
0027248166
-
Structure and binding properties of monoclonal antibodies to core histones from autoimmune mice
-
Monestier, M., T. M. Fasy, M. J. Losman, K. E. Novick, and S. Muller. 1993. Structure and binding properties of monoclonal antibodies to core histones from autoimmune mice. Mol. Immunol. 30: 1069-1075.
-
(1993)
Mol. Immunol.
, vol.30
, pp. 1069-1075
-
-
Monestier, M.1
Fasy, T.M.2
Losman, M.J.3
Novick, K.E.4
Muller, S.5
-
14
-
-
61449154547
-
Immunodesign of experimental sepsis by cecal ligation and puncture
-
Rittirsch, D., M. S. Huber-Lang, M. A. Flierl, and P. A. Ward. 2009. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat. Protoc. 4: 31-36.
-
(2009)
Nat. Protoc.
, vol.4
, pp. 31-36
-
-
Rittirsch, D.1
Huber-Lang, M.S.2
Flierl, M.A.3
Ward, P.A.4
-
15
-
-
84884195188
-
Vascular endothelial growth factor receptor inhibitor SU5416 suppresses lymphocyte generation and immune responses in mice by increasing plasma corticosterone
-
Grailer, J. J., and D. A. Steeber. 2013. Vascular endothelial growth factor receptor inhibitor SU5416 suppresses lymphocyte generation and immune responses in mice by increasing plasma corticosterone. PLoS ONE 8: e75390.
-
(2013)
PLoS ONE
, vol.8
-
-
Grailer, J.J.1
Steeber, D.A.2
-
16
-
-
84890506255
-
Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury
-
Bosmann, M., J. J. Grailer, R. Ruemmler, N. F. Russkamp, F. S. Zetoune, J. V. Sarma, T. J. Standiford, and P. A. Ward. 2013. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J. 27: 5010-5021.
-
(2013)
FASEB J.
, vol.27
, pp. 5010-5021
-
-
Bosmann, M.1
Grailer, J.J.2
Ruemmler, R.3
Russkamp, N.F.4
Zetoune, F.S.5
Sarma, J.V.6
Standiford, T.J.7
Ward, P.A.8
-
17
-
-
84880028085
-
The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation
-
Bosmann, M., M. D. Haggadone, F. S. Zetoune, J. V. Sarma, and P. A. Ward. 2013. The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation. Eur. J. Immunol. 43: 1907-1913.
-
(2013)
Eur. J. Immunol.
, vol.43
, pp. 1907-1913
-
-
Bosmann, M.1
Haggadone, M.D.2
Zetoune, F.S.3
Sarma, J.V.4
Ward, P.A.5
-
18
-
-
43249098418
-
Functional roles for C5a receptors in sepsis
-
Rittirsch, D., M. A. Flierl, B. A. Nadeau, D. E. Day, M. Huber-Lang, C. R. Mackay, F. S. Zetoune, N. P. Gerard, K. Cianflone, J. Köhl, et al. 2008. Functional roles for C5a receptors in sepsis. Nat. Med. 14: 551-557.
-
(2008)
Nat. Med.
, vol.14
, pp. 551-557
-
-
Rittirsch, D.1
Flierl, M.A.2
Nadeau, B.A.3
Day, D.E.4
Huber-Lang, M.5
Mackay, C.R.6
Zetoune, F.S.7
Gerard, N.P.8
Cianflone, K.9
Köhl, J.10
-
19
-
-
70449107044
-
Extracellular histones are major mediators of death in sepsis
-
Xu, J., X. Zhang, R. Pelayo, M. Monestier, C. T. Ammollo, F. Semeraro, F. B. Taylor, N. L. Esmon, F. Lupu, and C. T. Esmon. 2009. Extracellular histones are major mediators of death in sepsis. Nat. Med. 15: 1318-1321.
-
(2009)
Nat. Med.
, vol.15
, pp. 1318-1321
-
-
Xu, J.1
Zhang, X.2
Pelayo, R.3
Monestier, M.4
Ammollo, C.T.5
Semeraro, F.6
Taylor, F.B.7
Esmon, N.L.8
Lupu, F.9
Esmon, C.T.10
-
20
-
-
80051882006
-
Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury
-
Xu, J., X. Zhang, M. Monestier, N. L. Esmon, and C. T. Esmon. 2011. Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J. Immunol. 187: 2626-2631.
-
(2011)
J. Immunol.
, vol.187
, pp. 2626-2631
-
-
Xu, J.1
Zhang, X.2
Monestier, M.3
Esmon, N.L.4
Esmon, C.T.5
-
21
-
-
84896844884
-
Histones trigger sterile inflammation by activating the NLRP3 inflammasome
-
Allam, R., M. N. Darisipudi, J. Tschopp, and H. J. Anders. 2013. Histones trigger sterile inflammation by activating the NLRP3 inflammasome. Eur. J. Immunol. 43: 3336-3342.
-
(2013)
Eur. J. Immunol.
, vol.43
, pp. 3336-3342
-
-
Allam, R.1
Darisipudi, M.N.2
Tschopp, J.3
Anders, H.J.4
-
22
-
-
84883557385
-
Coagulopathy, catecholamines, and biomarkers of endothelial damage in experimental human endotoxemia and in patients with severe sepsis: A prospective study
-
Ostrowski, S. R., R. M. Berg, N. A. Windeløv, M. A. Meyer, R. R. Plovsing, K. Møller, and P. I. Johansson. 2013. Coagulopathy, catecholamines, and biomarkers of endothelial damage in experimental human endotoxemia and in patients with severe sepsis: a prospective study. J. Crit. Care 28: 586-596.
-
(2013)
J. Crit. Care
, vol.28
, pp. 586-596
-
-
Ostrowski, S.R.1
Berg, R.M.2
Windeløv, N.A.3
Meyer, M.A.4
Plovsing, R.R.5
Møller, K.6
Johansson, P.I.7
-
23
-
-
84902199760
-
Critical role for the NLRP3 inflammasome during acute lung injury
-
Grailer, J. J., B. A. Canning, M. Kalbitz, M. D. Haggadone, R. M. Dhond, A. V. Andjelkovic, F. S. Zetoune, and P. A. Ward. 2014. Critical role for the NLRP3 inflammasome during acute lung injury. J. Immunol. 192: 5974-5983.
-
(2014)
J. Immunol.
, vol.192
, pp. 5974-5983
-
-
Grailer, J.J.1
Canning, B.A.2
Kalbitz, M.3
Haggadone, M.D.4
Dhond, R.M.5
Andjelkovic, A.V.6
Zetoune, F.S.7
Ward, P.A.8
-
24
-
-
84886020148
-
Histones-mediated lymphocyte apoptosis during sepsis is dependent on p38 phosphorylation and mitochondrial permeability transition
-
Liu, Z. G., S. Y. Ni, G. M. Chen, J. Cai, Z. H. Guo, P. Chang, and Y. S. Li. 2013. Histones-mediated lymphocyte apoptosis during sepsis is dependent on p38 phosphorylation and mitochondrial permeability transition. PLoS ONE 8: e77131.
-
(2013)
PLoS ONE
, vol.8
-
-
Liu, Z.G.1
Ni, S.Y.2
Chen, G.M.3
Cai, J.4
Guo, Z.H.5
Chang, P.6
Li, Y.S.7
-
25
-
-
17044413706
-
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways
-
Hotchkiss, R. S., S. B. Osmon, K. C. Chang, T. H. Wagner, C. M. Coopersmith, and I. E. Karl. 2005. Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J. Immunol. 174: 5110-5118.
-
(2005)
J. Immunol.
, vol.174
, pp. 5110-5118
-
-
Hotchkiss, R.S.1
Osmon, S.B.2
Chang, K.C.3
Wagner, T.H.4
Coopersmith, C.M.5
Karl, I.E.6
-
26
-
-
84866386143
-
Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis
-
McDonald, B., R. Urrutia, B. G. Yipp, C. N. Jenne, and P. Kubes. 2012. Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. Cell Host Microbe 12: 324-333.
-
(2012)
Cell Host Microbe
, vol.12
, pp. 324-333
-
-
McDonald, B.1
Urrutia, R.2
Yipp, B.G.3
Jenne, C.N.4
Kubes, P.5
-
27
-
-
0028839459
-
Immune deficiency following thermal trauma is associated with apoptotic cell death
-
Teodorczyk-Injeyan, J. A., M. Cembrzynska-Nowak, S. Lalani, W. J. Peters, and G. B. Mills. 1995. Immune deficiency following thermal trauma is associated with apoptotic cell death. J. Clin. Immunol. 15: 318-328.
-
(1995)
J. Clin. Immunol.
, vol.15
, pp. 318-328
-
-
Teodorczyk-Injeyan, J.A.1
Cembrzynska-Nowak, M.2
Lalani, S.3
Peters, W.J.4
Mills, G.B.5
-
28
-
-
58149242338
-
Resuscitation with hydroxyethyl starch solution prevents CD4+ T-lymphocyte apoptosis and modulates the balance of T helper type 1 and T helper type 2 responses in the rat with traumatic virgule/shill hemorrhagic shock
-
Zhang, Y., L. Liang, W. Wu, Y. Gao, Z. B. Chen, Z. Y. Liang, and T. B. Liang. 2008. Resuscitation with hydroxyethyl starch solution prevents CD4+ T-lymphocyte apoptosis and modulates the balance of T helper type 1 and T helper type 2 responses in the rat with traumatic virgule/shill hemorrhagic shock. Shock 30: 692-698.
-
(2008)
Shock
, vol.30
, pp. 692-698
-
-
Zhang, Y.1
Liang, L.2
Wu, W.3
Gao, Y.4
Chen, Z.B.5
Liang, Z.Y.6
Liang, T.B.7
-
29
-
-
84872555329
-
Circulating histones are mediators of trauma-associated lung injury
-
Abrams, S. T., N. Zhang, J. Manson, T. Liu, C. Dart, F. Baluwa, S. S. Wang, K. Brohi, A. Kipar, W. Yu, et al. 2013. Circulating histones are mediators of trauma-associated lung injury. Am. J. Respir. Crit. Care Med. 187: 160-169.
-
(2013)
Am. J. Respir. Crit. Care Med.
, vol.187
, pp. 160-169
-
-
Abrams, S.T.1
Zhang, N.2
Manson, J.3
Liu, T.4
Dart, C.5
Baluwa, F.6
Wang, S.S.7
Brohi, K.8
Kipar, A.9
Yu, W.10
-
30
-
-
37549013000
-
The role of C5a in the innate immune response after experimental blunt chest trauma
-
Flierl, M. A., M. Perl, D. Rittirsch, C. Bartl, H. Schreiber, V. Fleig, G. Schlaf, U. Liener, U. B. Brueckner, F. Gebhard, and M. S. Huber-Lang. 2008. The role of C5a in the innate immune response after experimental blunt chest trauma. Shock 29: 25-31.
-
(2008)
Shock
, vol.29
, pp. 25-31
-
-
Flierl, M.A.1
Perl, M.2
Rittirsch, D.3
Bartl, C.4
Schreiber, H.5
Fleig, V.6
Schlaf, G.7
Liener, U.8
Brueckner, U.B.9
Gebhard, F.10
Huber-Lang, M.S.11
|