Effect of glycemic control on corneal nerves and peripheral neuropathy in streptozotocin-induced diabetic C57Bl/6J mice

Journal of the Peripheral Nervous System

Volumn 19, Issue 3, 2014, Pages 205-217

  Yorek, Matthew S ^a,b   Obrosov, Alexander ^c   Shevalye, Hanna ^c   Lupachyk, Sergey ^c   Harper, Matthew M ^a,b,c   Kardon, Randy H ^a,b,c   Yorek, Mark A ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b VA Center of Excellence for Prevention and Treatment of Visual Loss   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

corneal confocal microscopy; corneal nerves; diabetic peripheral neuropathy; nitrotyrosine

Indexed keywords

GLUCOSE; INSULIN; STREPTOZOCIN; ANTIDIABETIC AGENT; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; CORNEA EPITHELIUM; DIABETIC NEUROPATHY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN IMPLANT; INSULIN RELEASE; INSULIN TREATMENT; MOTOR NERVE CONDUCTION; MOUSE; NERVE CONDUCTION; NERVE PLEXUS; NONHUMAN; OPTIC NERVE FIBER; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RETINA GANGLION CELL; RETINA NEUROEPITHELIAL LAYER; SENSORY NERVE CONDUCTION; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; SPINAL GANGLION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; COMPLICATION; CORNEA; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; INNERVATION; NERVE FIBER; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; CORNEA; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; EPITHELIUM, CORNEAL; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; MICE; MICE, INBRED C57BL; NERVE FIBERS; STREPTOZOCIN;

EID: 84921479582     PISSN: 10859489     EISSN: 15298027     Source Type: Journal    
DOI: 10.1111/jns.12086     Document Type: Article

References (38)

1. Boulton AJ, Kempler P, Ametov A, Ziegler D, (2013). Whither pathogenetic treatments for diabetic polyneuropathy? Diabetes Metab Res Rev 29: 327-333.
2. Chen DK, Frizzi KE, Guernsey LS, Ladt K, Mizisin AP, Calcutt NA, (2013). Repeated monitoring of corneal nerves by confocal microscopy as an index of peripheral neuropathy in type-1 diabetic rodents and the effects of topical insulin. J Peripher Nerv Syst 18: 306-315.
3. Connolly SE, Hores TA, Smith LE, D'Amore PA, (1988). Characterization of vascular development in the mouse retina. Microvasc Res 36: 275-290.
4. Coppey LJ, Davidson EP, Dunlap JA, Lund DD, Yorek MA, (2000). Slowing of motor nerve conduction velocity in streptozotocin-induced diabetic rats is preceded by impaired vasodilation in arterioles that overlie the sciatic nerve. Int J Exp Diabetes Res 1: 131-143.
5. Coppey L, Davidson E, Lu B, Gerard C, Yorek M, (2011). Vasopeptidase inhibitor ilepatril (AVE7688) prevents obesity- and diabetes-induced neuropathy in C57Bl/6J mice. Neuropharmacology 60: 259-266.
6. Davidson EP, Coppey LJ, Holmes A, Yorek MA, (2012a). Changes in corneal innervation and sensitivity and acetylcholine-mediated vascular relaxation of the posterior ciliary artery in a type 2 diabetic rat. Invest Ophthalmol Vis Sci 53: 1182-1187.
7. Davidson EP, Coppey LJ, Yorek MA, (2012b). Early loss of innervation of cornea epithelium in streptozotocin-induced type 1 diabetic rats: improvement with ilepatril treatment. Invest Ophthalmol Vis Sci 53: 8067-8074.
8. Davidson EP, Coppey LJ, Kardon RH, Yorek MA, (2014). Differences and similarities in development of corneal nerve damage and peripheral neuropathy and in diet-induced obesity and type 2 diabetic rats. Invest Ophthalmol Vis Sci 55: 1222-1230.
9. Dunnigan SK, Ebadi H, Breiner A, Katzberg HD, Lovblom LE, Perkins BA, Bril V, (2013). Conduction slowing in diabetic sensorimotor polyneuropathy. Diabetes Care 36: 3684-3690.
10. Figueroa-Romero C, Sadidi M, Feldman EL, (2008). Mechanisms of disease: the oxidative stress theory of diabetic neuropathy. Rev Endocr Metab Disord 9: 301-314.
11. Horowitz SH, (2006). Recent clinical advances in diabetic polyneuropathy. Curr Opin Anaesthesiol 19: 573-578.
12. Kan M, Guo G, Singh B, Singh V, Zochodne DW, (2012). Glucagon-like peptide 1, insulin, sensory neurons, and diabetic neuropathy. J Neuropathol Exp Neurol 71: 494-510.
13. Kles KA, Vinik AI, (2006). Pathophysiology and treatment of diabetic peripheral neuropathy: the case for diabetic neurovascular function as an essential component. Curr Diabetes Rev 2: 131-145.
14. +-exchanger-1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats. Am J Physiol Endocrinol Metab 305: E396-E404.
15. Malik RA, Kallinikos P, Abbott CA, van Schie CHM, Morgan P, Efron N, Boulton AJM, (2003). Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients. Diabetologia 46: 683-688.
16. Mohan K, Harper MM, Kecova H, Ye EA, Lazic T, Sakaguchi DS, Kardon RH, Grozdanic SD, (2012). Characterization of structure and function of the mouse retina using pattern electroretinography, pupil light reflex, and optical coherence tomography. Vet Ophthalmol 15 (Suppl 2): 94-104.
17. Mohan K, Kecova H, Hernandez-Merino E, Kardon RH, Harper MM, (2013). Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury. Invest Ophthalmol Vis Sci 54: 3440-3450.
18. O'Brien PD, Sakowski SA, Feldman EL, (2014). Mouse models of diabetic neuropathy. ILAR J 54: 259-272.
19. Obrosova IG, (2003). Update on the pathogenesis of diabetic neuropathy. Curr Diab Rep 3: 439-445.
20. Obrosova IG, (2009). Diabetes and the peripheral nerve. Biochim Biophys Acta 1792: 931-940.
21. Obrosova IG, Drel VR, Oltman CL, Mashtalir N, Tibrewala J, Groves JT, Yorek MA, (2007). Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats. Am J Physiol Endocrinol Metab 293: E1645-E1655.
22. Oltman CL, Coppey LJ, Gellett JS, Davidson EP, Lund DD, Yorek MA, (2005). Progression of vascular and neural dysfunction in sciatic nerves of Zucker diabetic fatty and Zucker rats. Am J Physiol Endocrinol Metab 289: E113-E122.
23. Pacher P, Obrosova IG, Mabley JG, Szabo C, (2005). Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. Curr Med Chem 12: 267-275.
24. Patel DV, McGhee CNJ, (2008). In vivo laser scanning confocal microscopy confirms that the human corneal sub-basal nerve plexus is a highly dynamic structure. Invest Ophthalmol Vis Sci 49: 3409-3412.
25. Petropoulos IN, Alam U, Fadavi H, Asghar O, Green P, Ponirakis G, Marshall A, Boulton AJ, Tavakoli M, Malik RA, (2013). Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy. Diabetes Care 36: 3646-3651.
26. Pop-Busui R, Sima A, Stevens M, (2006). Diabetic neuropathy and oxidative stress. Diabetes Metab Res Rev 22: 257-273.
27. Quattrini C, Tavakoli M, Jeziorska M, Kallinikos P, Tesfaye S, Finnigan J, Marshall A, Boulton AJ, Efron N, Malik RA, (2007). Surrogate markers of small fiber damage in human diabetic neuropathy. Diabetes 56: 2148-2154.
28. Stavniichuk R, Shevalye H, Lupachyk S, Obrosov A, Groves JT, Obrosova IG, Yorek MA, (2014). Peroxynitrite and protein nitration in the pathogenesis of diabetic peripheral neuropathy. Diabetes Metab Res Rev 30: 669-678.
29. Sullivan KA, Feldman EL, (2005). New developments in diabetic neuropathy. Curr Opin Neurol 18: 586-590.
30. Tahrani AA, Askwith T, Stevens MJ, (2010). Emerging drugs for diabetic neuropathy. Expert Opin Emerg Drugs 15: 661-683.
31. Tavakoli M, Hossain P, Malik RA, (2008). Clinical applications of corneal confocal microscopy. Clin Ophthalmol 2: 435-445.
32. Tavakoli M, Quattrini C, Abbott C, Kallinikos P, Marshall A, Finnigan J, Morgan P, Efron N, Boulton AJM, Malik RA, (2010). Corneal confocal microscopy: a novel non-invasive test to diagnose and stratify the severity of human diabetic neuropathy. Diabetes Care 33: 1792-1797.
33. Tavakoli M, Kallinikos P, Iqbal A, Herbert A, Fadavi H, Efron N, Boulton AJM, Malik RA, (2011). Corneal confocal microscopy detects improvement in corneal nerve morphology with an improvement in risk factors for diabetic neuropathy. Diabet Med 28: 1261-1267.
34. Vincent AM, Hinder LM, Pop-Busui R, Feldman EL, (2009). Hyperlipidemia: a new therapeutic target for diabetic neuropathy. J Peripher Nerv Syst 14: 257-267.
35. Vincent AM, Callaghan BC, Smith AL, Feldman EL, (2011). Diabetic neuropathy: cellular mechanisms as therapeutic targets. Nat Rev Neurol 7: 573-583.
36. Weber D, Kneschke N, Grimm S, Bergheim I, Breusing N, Grune T, (2012). Rapid and sensitive determination of protein-nitrotyrosine by ELISA: application to human plasma. Free Radic Res 46: 276-285.
37. Yorek MA, (2003). The role of oxidative stress in diabetic vascular and neural disease. Free Radic Res 37: 471-480.
38. Yorek MA, (2008). The potential role of angiotensin converting enzyme and vasopeptidase inhibitors in the treatment of diabetic neuropathy. Curr Drug Targets 9: 77-84.