Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 5, 2013, Pages 3440-3450

  Mohan, Kabhilan ^a,b   Kecova, Helga ^b   Hernandez Merino, Elena ^b   Kardon, Randy H ^a,c   Harper, Matthew M ^a  

^a Veterans Administration   (United States)

^b IOWA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Blast injury; Pattern electroretinography; Traumatic brain injury; Traumatic optic neuropathy

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLAST INJURY; CELL DAMAGE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ELECTRORETINOGRAPHY; EVOKED VISUAL RESPONSE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; OPTIC NERVE; OPTIC NERVE LESION; OXIDATIVE STRESS; PHENOL RED THREAD TEAR TEST; PRIORITY JOURNAL; PUPIL REFLEX; RETINA GANGLION CELL; RETINA TEAR; RETINAL NERVE FIBER LAYER THICKNESS; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; TRAUMATIC BRAIN INJURY;

BLAST INJURY; PATTERN ELECTRORETINOGRAPHY; TRAUMATIC BRAIN INJURY; TRAUMATIC OPTIC NEUROPATHY;

ALDEHYDES; AMYLOID BETA-PEPTIDES; ANIMALS; BLAST INJURIES; BRAIN INJURIES; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; IMMUNOHISTOCHEMISTRY; LIGHT; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE II; OPTIC NERVE INJURIES; REFLEX, PUPILLARY; RETINA; RETINAL GANGLION CELLS; TEARS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84878117450     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-11522     Document Type: Article

References (32)

1. State of the Art (SOTA) Conferences, U.S. Department of Veterans Affairs. State of the Art IX: Traumatic Brain Injury Research. April 30-May 2, 2008; Washington, DC.
2. Defense and Veterans Brain Injury Center Working Group on the Acute Management of Mild Traumatic Brain Injury in Military Operational Settings: Clinical Practice Guideline and Recommendations. Available at: http://www.pdhealth.mil/ downloads/clinical_practice_guideline_recommendations. pdf. Published December 22, 2006. Accessed June 1, 2012.
3. Goldstein LE, Fisher AM, Tagge CA, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012;4:134-160.
4. Gaetz M, Weinberg H. Electrophysiological indices of persistent post-concussion symptoms. Brain Inj. 2000;14:815-832.
5. Freed S, Hellerstein LF. Visual electrodiagnostic findings in mild traumatic brain injury. Brain Inj. 1997;11:25-36.
6. Lew HL, Dikmen S, Slimp J, et al. Use of somatosensory-evoked potentials and cognitive event-related potentials in predicting outcomes of patients with severe traumatic brain injury. Am J Phys Med Rehabil. 2003;82:53-61; quiz 62-54, 80.
7. Lew HL, Lee EH, Pan SS, Date ES. Electrophysiologic abnormalities of auditory and visual information processing in patients with traumatic brain injury. Am J Phys Med Rehabil. 2004;83:428-433.
8. Rappaport M, Hemmerle AV, Rappaport ML. Intermediate and long latency SEPs in relation to clinical disability in traumatic brain injury patients. Clin Electroencephalogr. 1990;21:188-191.
9. Lachapelle J, Bolduc-Teasdale J, Ptito A, McKerral M. Deficits in complex visual information processing after mild TBI: electrophysiological markers and vocational outcome prognosis. Brain Inj. 2008;22:265-274.
10. Lew HL, Poole JH, Chiang JY, Lee EH, Date ES, Warden D. Event-related potential in facial affect recognition: potential clinical utility in patients with traumatic brain injury. J Rehabil Res Dev. 2005;42:29-34.
11. Du T, Ciuffreda KJ, Kapoor N. Elevated dark adaptation thresholds in traumatic brain injury. Brain Inj. 2005;19:1125-1138.
12. Lew HL, Poole JH, Vanderploeg RD, et al. Program development and defining characteristics of returning military in a VA Polytrauma Network Site. J Rehabil Res Dev. 2007;44:1027-1034.
13. Green W, Ciuffreda KJ, Thiagarajan P, Szymanowicz D, Ludlam DP, Kapoor N. Accommodation in mild traumatic brain injury. J Rehabil Res Dev. 2010;47:183-199.
14. Cockerham GC, Rice TA, Hewes EH, et al. Closed-eye ocular injuries in the Iraq and Afghanistan wars. N Engl J Med. 2011; 364:2172-2173.
15. Goodrich GL, Kirby J, Cockerham G, Ingalla SP, Lew HL. Visual function in patients of a polytrauma rehabilitation center: a descriptive study. J Rehabil Res Dev. 2007;44:929-936.
16. Cockerham GC, Goodrich GL, Weichel ED, et al. Eye and visual function in traumatic brain injury. J Rehabil Res Dev. 2009;46: 811-818.
17. Dougherty AL, MacGregor AJ, Han PP, Heltemes KJ, Galarneau MR. Visual dysfunction following blast-related traumatic brain injury from the battlefield. Brain Inj. 2011;25:8-13.
18. Cernak I, Savic VJ, Kotur J, Prokic V, Veljovic M, Grbovic D. Characterization of plasma magnesium concentration and oxidative stress following graded traumatic brain injury in humans. J Neurotrauma. 2000;17:53-68.
19. Zunic G, Romic P, Vueljic M, Jovanikic O. Very early increase in nitric oxide formation and oxidative cell damage associated with the reduction of tissue oxygenation is a trait of blast casualties. Vojnosanit Pregl. 2005;62:273-280.
20. Mohan K, Harper MM, Kecova H, et al. Characterization of structure and function of the mouse retina using pattern electroretinography, pupil light reflex, and optical coherence tomography. Vet Ophthalmol. 2012;15(suppl 2):94-104.
21. Connolly SE, Hores TA, Smith LE, D'Amore PA. Characterization of vascular development in the mouse retina. Microvasc Res. 1988;36:275-290.
22. Kretschmer WB, Baciut G, Baciut M, Zoder W, Wangerin K. Transverse stability of 3-piece Le Fort I osteotomies. J Oral Maxillofac Surg. 2011;69:861-869.
23. Hines-Beard J, Marchetta J, Gordon S, Chaum E, Geisert EE, Rex TS. A mouse model of ocular blast injury that induces closed globe anterior and posterior pole damage. Exp Eye Res. 2012;99:63-70.
24. Kuehn R, Simard PF, Driscoll I, et al. Rodent model of direct cranial blast injury. J Neurotrauma. 2011;28:2155-2169.
25. Risling M. Evaluation of diffuse blastwave induced brain injury with magnetic resonance imaging. FOI-R-0756-SE. Stockholm: Swedish Defence Research Agency; 2002:1-7.
26. Bach M, Unsoeld AS, Philippin H, et al. Pattern ERG as an early glaucoma indicator in ocular hypertension: a long-term, prospective study. Invest Ophthalmol Vis Sci. 2006;47:4881-4887.
27. Kardon R, Anderson SC, Damarjian TG, Grace EM, Stone E, Kawasaki A. Chromatic pupillometry in patients with retinitis pigmentosa. Ophthalmology. 2011;118:376-381.
28. Wang J, Hamm RJ, Povlishock JT. Traumatic axonal injury in the optic nerve: evidence for axonal swelling, disconnection, dieback, and reorganization. J Neurotrauma. 2011;28:1185-1198.
29. Koliatsos VE, Cernak I, Xu L, et al. A mouse model of blast injury to brain: initial pathological, neuropathological, and behavioral characterization. J Neuropathol Exp Neurol. 2011; 70:399-416.
30. Blumbergs PC, Scott G, Manavis J, Wainwright H, Simpson DA, McLean AJ. Staining of amyloid precursor protein to study axonal damage in mild head injury. Lancet. 1994;344:1055-1056.
31. Blumbergs PC, Scott G, Manavis J, Wainwright H, Simpson DA, McLean AJ. Topography of axonal injury as defined by amyloid precursor protein and the sector scoring method in mild and severe closed head injury. J Neurotrauma. 1995;12:565-572.
32. DeWitt DS, Prough DS. Blast-induced brain injury and posttraumatic hypotension and hypoxemia. J Neurotrauma. 2009;26:877-887.