메뉴 건너뛰기




Volumn 14, Issue 1, 2015, Pages 289-297

The NOTCH ligand JAGGED2 promotes pancreatic cancer metastasis independent of NOTCH signaling activation

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE B; JAGGED 2 PROTEIN; JAGGED1; MYC PROTEIN; NERVE CELL ADHESION MOLECULE; NOTCH1 RECEPTOR; PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR SNAIL1; TRANSCRIPTION FACTOR SNAIL2; TRANSCRIPTION FACTOR ZEB1; TRANSCRIPTION FACTOR ZEB2; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; CALCIUM BINDING PROTEIN; JAG2 PROTEIN, HUMAN; MEMBRANE PROTEIN; NOTCH RECEPTOR; SERRATE PROTEINS; SIGNAL PEPTIDE;

EID: 84921473903     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-14-0501     Document Type: Article
Times cited : (30)

References (34)
  • 2
    • 0030739314 scopus 로고    scopus 로고
    • Pain as a predictor of outcome in patients with operable pancreatic carcinoma
    • Kelsen DP, Portenoy R, Thaler H, Tao Y, Brennan M. Pain as a predictor of outcome in patients with operable pancreatic carcinoma. Surgery 1997;122:53-9.
    • (1997) Surgery , vol.122 , pp. 53-59
    • Kelsen, D.P.1    Portenoy, R.2    Thaler, H.3    Tao, Y.4    Brennan, M.5
  • 3
    • 65249147725 scopus 로고    scopus 로고
    • Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer
    • Mullendore ME, Koorstra JB, Li YM, Offerhaus GJ, Fan X, Henderson CM, et al. Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer. Clin Cancer Res 2009;15:2291-301.
    • (2009) Clin Cancer Res , vol.15 , pp. 2291-2301
    • Mullendore, M.E.1    Koorstra, J.B.2    Li, Y.M.3    Offerhaus, G.J.4    Fan, X.5    Henderson, C.M.6
  • 4
    • 84855293870 scopus 로고    scopus 로고
    • Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma
    • Vizio B, Mauri FA, Prati A, Trivedi P, Giacobino A, Novarino A, et al. Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma. Oncol Rep 2012;27:69-76.
    • (2012) Oncol Rep , vol.27 , pp. 69-76
    • Vizio, B.1    Mauri, F.A.2    Prati, A.3    Trivedi, P.4    Giacobino, A.5    Novarino, A.6
  • 5
    • 79953329774 scopus 로고    scopus 로고
    • The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice
    • Yang Y, Ahn YH, Gibbons DL, Zang Y, Lin W, Thilaganathan N, et al. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. J Clin Invest 2011;121:1373-85.
    • (2011) J Clin Invest , vol.121 , pp. 1373-1385
    • Yang, Y.1    Ahn, Y.H.2    Gibbons, D.L.3    Zang, Y.4    Lin, W.5    Thilaganathan, N.6
  • 6
    • 85027941540 scopus 로고    scopus 로고
    • Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells
    • Xing F, Okuda H, Watabe M, Kobayashi A, Pai SK, Liu W, et al. Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells. Oncogene 2011;30:4075-86.
    • (2011) Oncogene , vol.30 , pp. 4075-4086
    • Xing, F.1    Okuda, H.2    Watabe, M.3    Kobayashi, A.4    Pai, S.K.5    Liu, W.6
  • 7
    • 84880873734 scopus 로고    scopus 로고
    • Bone marrow-derived CD11b+Jagged2+ cells promote epithelial-to-mesenchymal transition and metastasization in colorectal cancer
    • Caiado F, Carvalho T, Rosa I, Remedio L, Costa A, Matos J, et al. Bone marrow-derived CD11b+Jagged2+ cells promote epithelial-to-mesenchymal transition and metastasization in colorectal cancer. Cancer Res 2013;73:4233-46.
    • (2013) Cancer Res , vol.73 , pp. 4233-4246
    • Caiado, F.1    Carvalho, T.2    Rosa, I.3    Remedio, L.4    Costa, A.5    Matos, J.6
  • 8
    • 84887181161 scopus 로고    scopus 로고
    • High expression of Notch ligand Jagged2 is associated with the metastasis and recurrence in urothelial carcinoma of bladder
    • Li W, Liu M, Feng Y, Huang YF, Xu YF, Che JP, et al. High expression of Notch ligand Jagged2 is associated with the metastasis and recurrence in urothelial carcinoma of bladder. Int J Clin Exp Pathol 2013;6:2430-40.
    • (2013) Int J Clin Exp Pathol , vol.6 , pp. 2430-2440
    • Li, W.1    Liu, M.2    Feng, Y.3    Huang, Y.F.4    Xu, Y.F.5    Che, J.P.6
  • 9
    • 0032574993 scopus 로고    scopus 로고
    • Notch-1 signaling requires ligand-induced proteolytic release of intracellular domain
    • Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signaling requires ligand-induced proteolytic release of intracellular domain. Nature 1998;393:382-6.
    • (1998) Nature , vol.393 , pp. 382-386
    • Schroeter, E.H.1    Kisslinger, J.A.2    Kopan, R.3
  • 10
    • 33644749306 scopus 로고    scopus 로고
    • Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
    • Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 2006;124:973-83.
    • (2006) Cell , vol.124 , pp. 973-983
    • Nam, Y.1    Sliz, P.2    Song, L.3    Aster, J.C.4    Blacklow, S.C.5
  • 11
    • 33644761961 scopus 로고    scopus 로고
    • Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA
    • Wilson JJ, Kovall RA. Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell 2006;124:985-96.
    • (2006) Cell , vol.124 , pp. 985-996
    • Wilson, J.J.1    Kovall, R.A.2
  • 12
    • 10744223624 scopus 로고    scopus 로고
    • Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
    • Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, et al. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 2003;3:565-76.
    • (2003) Cancer Cell , vol.3 , pp. 565-576
    • Miyamoto, Y.1    Maitra, A.2    Ghosh, B.3    Zechner, U.4    Argani, P.5    Iacobuzio-Donahue, C.A.6
  • 13
    • 84877149088 scopus 로고    scopus 로고
    • Notch signaling in pancreatic cancer: Oncogene or tumor suppressor?
    • Avila JL, Kissil JL. Notch signaling in pancreatic cancer: oncogene or tumor suppressor? Trends Mol Med 2013;19:320-7.
    • (2013) Trends Mol Med , vol.19 , pp. 320-327
    • Avila, J.L.1    Kissil, J.L.2
  • 14
    • 84866064437 scopus 로고    scopus 로고
    • The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models
    • Mizuma M, Rasheed ZA, Yabuuchi S, Omura N, Campbell NR, de Wilde RF, et al. The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models. Mol Cancer Ther 2012;11:1999-2009.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1999-2009
    • Mizuma, M.1    Rasheed, Z.A.2    Yabuuchi, S.3    Omura, N.4    Campbell, N.R.5    De Wilde, R.F.6
  • 15
    • 84867687369 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and pancreatic tumor initiating CD44+/EpCAM +cells are inhibited by gamma-secretase inhibitor IX
    • Palagani V, El Khatib M, Kossatz U, Bozko P, Muller MR, Manns MP, et al. Epithelial mesenchymal transition and pancreatic tumor initiating CD44+/EpCAM +cells are inhibited by gamma-secretase inhibitor IX. PLoS ONE 2012;7:e46514.
    • (2012) PLoS ONE , vol.7 , pp. e46514
    • Palagani, V.1    El Khatib, M.2    Kossatz, U.3    Bozko, P.4    Muller, M.R.5    Manns, M.P.6
  • 16
    • 77953158971 scopus 로고    scopus 로고
    • Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma
    • Hanlon L, Avila JL, Demarest RM, Troutman S, Allen M, Ratti F, et al. Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. Cancer Res 2010;70:4280-6.
    • (2010) Cancer Res , vol.70 , pp. 4280-4286
    • Hanlon, L.1    Avila, J.L.2    Demarest, R.M.3    Troutman, S.4    Allen, M.5    Ratti, F.6
  • 17
    • 65249125270 scopus 로고    scopus 로고
    • Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma
    • Plentz R, Park JS, Rhim AD, Abravanel D, Hezel AF, Sharma SV, et al. Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology 2009;136:1741-9 e6.
    • (2009) Gastroenterology , vol.136 , pp. 1741-9e6
    • Plentz, R.1    Park, J.S.2    Rhim, A.D.3    Abravanel, D.4    Hezel, A.F.5    Sharma, S.V.6
  • 18
    • 79951813950 scopus 로고    scopus 로고
    • The ZEB1/miR-200 feedback loop controls Notch signaling in cancer cells
    • Brabletz S, Bajdak K, Meidhof S, Burk U, Niedermann G, Firat E, et al. The ZEB1/miR-200 feedback loop controls Notch signaling in cancer cells. EMBO J 2011;30:770-82.
    • (2011) EMBO J , vol.30 , pp. 770-782
    • Brabletz, S.1    Bajdak, K.2    Meidhof, S.3    Burk, U.4    Niedermann, G.5    Firat, E.6
  • 20
    • 78751561435 scopus 로고    scopus 로고
    • miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1
    • Roybal JD, Zang Y, Ahn YH, Yang Y, Gibbons DL, Baird BN, et al. miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1. Mol Cancer Res 2011;9:25-35.
    • (2011) Mol Cancer Res , vol.9 , pp. 25-35
    • Roybal, J.D.1    Zang, Y.2    Ahn, Y.H.3    Yang, Y.4    Gibbons, D.L.5    Baird, B.N.6
  • 21
    • 78049421614 scopus 로고    scopus 로고
    • Notch dimerization is required for leukemogenesis and T-cell development
    • Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, et al. Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev 2010;24:2395-407.
    • (2010) Genes Dev , vol.24 , pp. 2395-2407
    • Liu, H.1    Chi, A.W.2    Arnett, K.L.3    Chiang, M.Y.4    Xu, L.5    Shestova, O.6
  • 22
    • 84870251010 scopus 로고    scopus 로고
    • Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G(0)/G(1) cell cycle arrest and apoptosis
    • Kan WL, Yin C, Xu HX, Xu G, To KK, Cho CH, et al. Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G(0)/G(1) cell cycle arrest and apoptosis. Int J Cancer 2013;132:707-16.
    • (2013) Int J Cancer , vol.132 , pp. 707-716
    • Kan, W.L.1    Yin, C.2    Xu, H.X.3    Xu, G.4    To, K.K.5    Cho, C.H.6
  • 23
    • 79956010254 scopus 로고    scopus 로고
    • JAG2 induction in hypoxic tumor cells alters Notch signaling and enhances endothelial cell tube formation
    • Pietras A, von Stedingk K, Lindgren D, Pahlman S, Axelson H. JAG2 induction in hypoxic tumor cells alters Notch signaling and enhances endothelial cell tube formation. Mol Cancer Res 2011;9:626-36.
    • (2011) Mol Cancer Res , vol.9 , pp. 626-636
    • Pietras, A.1    Von Stedingk, K.2    Lindgren, D.3    Pahlman, S.4    Axelson, H.5
  • 24
    • 84895923153 scopus 로고    scopus 로고
    • NEDD9 promotes lung cancer metastasis through epithelial-mesenchymal transition
    • Jin Y, Li F, Zheng C, Wang Y, Fang Z, Guo C, et al. NEDD9 promotes lung cancer metastasis through epithelial-mesenchymal transition. Int J Cancer 2014;134:2294-304.
    • (2014) Int J Cancer , vol.134 , pp. 2294-2304
    • Jin, Y.1    Li, F.2    Zheng, C.3    Wang, Y.4    Fang, Z.5    Guo, C.6
  • 26
    • 9444269817 scopus 로고    scopus 로고
    • Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines
    • Houde C, Li Y, Song L, Barton K, Zhang Q, Godwin J, et al. Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines. Blood 2004;104:3697-704.
    • (2004) Blood , vol.104 , pp. 3697-3704
    • Houde, C.1    Li, Y.2    Song, L.3    Barton, K.4    Zhang, Q.5    Godwin, J.6
  • 27
    • 84887170861 scopus 로고    scopus 로고
    • Correlation of Notch1, pAKT and nuclear NF-kappaB expression in triple negative breast cancer
    • Zhu H, Bhaijee F, Ishaq N, Pepper DJ, Backus K, Brown AS, et al. Correlation of Notch1, pAKT and nuclear NF-kappaB expression in triple negative breast cancer. Am J Cancer Res 2013;3:230-9.
    • (2013) Am J Cancer Res , vol.3 , pp. 230-239
    • Zhu, H.1    Bhaijee, F.2    Ishaq, N.3    Pepper, D.J.4    Backus, K.5    Brown, A.S.6
  • 28
    • 0034849519 scopus 로고    scopus 로고
    • Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction
    • Lindner V, Booth C, Prudovsky I, Small D, Maciag T, Liaw L. Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Am J Pathol 2001;159:875-83.
    • (2001) Am J Pathol , vol.159 , pp. 875-883
    • Lindner, V.1    Booth, C.2    Prudovsky, I.3    Small, D.4    Maciag, T.5    Liaw, L.6
  • 29
    • 77958145695 scopus 로고    scopus 로고
    • A Notch ligand, Delta-like 1 functions as an adhesion molecule for mast cells
    • Murata A, Okuyama K, Sakano S, Kajiki M, Hirata T, Yagita H, et al. A Notch ligand, Delta-like 1 functions as an adhesion molecule for mast cells. J Immunol 2010;185:3905-12.
    • (2010) J Immunol , vol.185 , pp. 3905-3912
    • Murata, A.1    Okuyama, K.2    Sakano, S.3    Kajiki, M.4    Hirata, T.5    Yagita, H.6
  • 30
    • 0037424348 scopus 로고    scopus 로고
    • The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage
    • Ikeuchi T, Sisodia SS. The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. J Biol Chem 2003;278:7751-4.
    • (2003) J Biol Chem , vol.278 , pp. 7751-7754
    • Ikeuchi, T.1    Sisodia, S.S.2
  • 31
    • 0141817915 scopus 로고    scopus 로고
    • The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments
    • LaVoie MJ, Selkoe DJ. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J Biol Chem 2003;278:34427-37.
    • (2003) J Biol Chem , vol.278 , pp. 34427-34437
    • LaVoie, M.J.1    Selkoe, D.J.2
  • 32
    • 84860436944 scopus 로고    scopus 로고
    • Non-canonical Notch signaling: Emerging role and mechanism
    • Andersen P, Uosaki H, Shenje LT, Kwon C. Non-canonical Notch signaling: emerging role and mechanism. Trends Cell Biol 2012;22:257-65.
    • (2012) Trends Cell Biol , vol.22 , pp. 257-265
    • Andersen, P.1    Uosaki, H.2    Shenje, L.T.3    Kwon, C.4
  • 33
    • 67349086051 scopus 로고    scopus 로고
    • A hierarchical cascade activated by non-canonical Notch signaling and the mTOR-Rictor complex regulates neglect-induced death in mammalian cells
    • Perumalsamy LR, Nagala M, Banerjee P, Sarin A. A hierarchical cascade activated by non-canonical Notch signaling and the mTOR-Rictor complex regulates neglect-induced death in mammalian cells. Cell Death Differ 2009;16:879-89.
    • (2009) Cell Death Differ , vol.16 , pp. 879-889
    • Perumalsamy, L.R.1    Nagala, M.2    Banerjee, P.3    Sarin, A.4
  • 34
    • 80053568372 scopus 로고    scopus 로고
    • Notch post-translationally regulates beta-catenin protein in stem and progenitor cells
    • Kwon C, Cheng P, King IN, Andersen P, Shenje L, Nigam V, et al. Notch post-translationally regulates beta-catenin protein in stem and progenitor cells. Nat Cell Biol 2011;13:1244-51.
    • (2011) Nat Cell Biol , vol.13 , pp. 1244-1251
    • Kwon, C.1    Cheng, P.2    King, I.N.3    Andersen, P.4    Shenje, L.5    Nigam, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.