CoQ10 and L-Carnitine attenuate the effect of high LDL and oxidized LDL on spermatogenesis in male rats

Drug Research

Volumn 64, Issue 10, 2013, Pages 510-515

  Ghanbarzadeh, S ^a,b   Garjani, A ^b   Ziaee, M ^c   Khorrami, A ^b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Coenzyme Q10; L carnitine; LDL; Oxidized LDL; Spermatogenesis

Indexed keywords

ANTIOXIDANT; CARNITINE; CHOLESTEROL; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; OXIDIZED LOW DENSITY LIPOPROTEIN; SEX HORMONE; UBIDECARENONE; CHOLESTEROL INTAKE; LUTEINIZING HORMONE; TESTOSTERONE; UBIQUINONE;

ADULT; ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; DRUG MECHANISM; EPIDIDYMIS; HORMONE BLOOD LEVEL; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PREMEDICATION; RAT; SEMEN ABNORMALITY; SEMINAL VESICLE; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SUPPLEMENTATION; TESTIS; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CELL PROTECTION; CELL SURVIVAL; CHOLESTEROL INTAKE; DISEASE MODEL; DRUG EFFECTS; HYPERCHOLESTEROLEMIA; INFERTILITY, MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SPERMATOZOON; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CARNITINE; CELL SURVIVAL; CHOLESTEROL, DIETARY; CYTOPROTECTION; DISEASE MODELS, ANIMAL; EPIDIDYMIS; HYPERCHOLESTEROLEMIA; INFERTILITY, MALE; LIPOPROTEINS, LDL; LUTEINIZING HORMONE; MALE; MALONDIALDEHYDE; RATS, WISTAR; SPERM COUNT; SPERM MOTILITY; SPERMATOGENESIS; SPERMATOZOA; TESTIS; TESTOSTERONE; UBIQUINONE;

EID: 84921439026     PISSN: 21949379     EISSN: 21949387     Source Type: Journal    
DOI: 10.1055/s-0033-1361176     Document Type: Article

References (41)

1. Agarwal A, Nallella KP, Allamaneni SSR et al. Role of antioxidants in treatment of male infertility: an overview of the literature. Reprod Biomed Online 2004; 8: 616-627
2. Agarwal A, Said TM. Carnitines and male infertility. Reprod Biomed Online 2004; 8: 376-384
3. Aitken RJ, Baker MA, Sawyer D. Oxidative stress in the male germ line and its role in the aetiology of male infertility and genetic disease. Reprod Biomed Online 2003; 7: 65-70
4. Gat Y, Gornish M, Navon U et al. Right varicocele and hypoxia, crucial factors in male infertility: fluid mechanics analysis of the impaired testicular drainage system. Reprod Biomed Online 2006; 13: 510-515
5. Meacham RB, Joyce GF, Wise M et al. Male Infertility. The Journal of Urology 2007; 177: 2058-2066
6. Nieschlag E, Lenzi A. The conventional management of male infertility . International Journal of Gynecology & Obstetrics 2013; In Press
7. Göc¸men AY, Şahin E, Koc¸ak H et al. Levels of asymmetric dimethylarginine, nitric oxide and lipid peroxidation markers in patients with end-stage renal disease having peritoneal dialysis treatment. Clin Biochem 2008; 41: 836-840
8. Kostner K, Neunteufl T, Yang P et al. Elevation of plasma lipid peroxidation products in patients with unstable coronary artery disease. Atherosclerosis 1997; 134: 213-214
9. Pawlak K, Mysliwiec M, Pawlak D. Oxidized low-density lipoprotein (oxLDL) plasma levels and oxLDL to LDL ratio-Are they real oxidative stress markers in dialyzed patients? Life Sci 2013; 92: 253-258
10. Siegel G, Ermilov E, Pries AR et al. The significance of lipid peroxidation in cardiovascular disease. Colloids Surf Physicochem Eng Aspects 2013; In Press
11. Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril 2003; 79: 829-843
12. Agarwal A, Sharma RK, Nallella KP et al. Reactive oxygen species as an independent marker of male factor infertility. Fertil Steril 2006; 86: 878-885
13. Aitken RJ, Irvine DS, Wu FC. Prospective analysis of sperm-oocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility. Am J Obstet Gynecol 1991; 164: 542-551
14. Alkan I, Simsek F, Haklar G et al. Reactive Oxygen Species Production by the Spermatozoa of Patients With Idiopathic Infertility: Relationship to Seminal Plasma Antioxidants. The Journal of Urology 1997; 157: 140-143
15. Aziz N, Saleh RA, Sharma RK et al. Novel association between sperm reactive oxygen species production, sperm morphological defects, and the sperm deformity index. Fertil Steril 2004; 81: 349-354
16. Bargagli E, Olivieri C, Bennett D et al. Oxidative stress in the pathogenesis of diffuse lung diseases: A review. Respir Med 2009; 103: 1245-1256
17. Butterfield DA, Reed T, Newman SF et al. Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radical Biol Med 2007; 43: 658-677
18. Galea E, Launay N, Portero-Otin M et al. Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases? Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2012; 1822: 1475-1488
19. Gizi A, Papassotiriou I, Apostolakou F et al. Assessment of oxidative stress in patients with sickle cell disease: The glutathione system and the oxidant-antioxidant status. Blood Cells Mol Dis 2011; 46: 220-225
20. Mac¸ao LB, Filho DW, Pedrosa RC et al. Antioxidant therapy attenuates oxidative stress in chronic cardiopathy associated with Chagas' disease. Int J Cardiol 2007; 123: 43-49
21. MacNee W. Oxidative stress and lung inflammation in airways disease. Eur J Pharmacol 2001; 429: 195-207
22. Shoham A, Hadziahmetovic M, Dunaief JL et al. Oxidative stress in diseases of the human cornea. Free Radical Biol Med 2008; 45: 1047-1055
23. Tsang AHK, Chung KKK. Oxidative and nitrosative stress in Parkinson's disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2009; 1792: 643-650
24. Forman HJ, Davies KJA, Ursini F. How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radical Biol Med 2013; In Press
25. Mori A, Liu J, Wang X et al. Free radical scavenging by brain homogenate: Implication to free radical damage and antioxidant defense in brain. Neurochem Int 1994; 24: 201-207
26. Pansarasa O, Bertorelli L, Vecchiet J et al. Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle. Free Radical Biol. Med 1999; 27: 617-622
27. Sun Y. Free radicals, antioxidant enzymes, and carcinogenesis. Free Radical Biol Med 1990; 8: 583-599
28. Ball BA, Medina V, Gravance CG et al. Effect of antioxidants on preservation of motility, viability and acrosomal integrity of equine spermatozoa during storage at 5°C. Theriogenology 2001; 56: 577-589
29. Martí JI, Martí E, Cebrián-Pérez JA et al. Survival rate and antioxidant enzyme activity of ram spermatozoa after dilution with different extenders or selection by a dextran swim-up procedure. Theriogenology 2003; 60: 1025-1037
30. Moskovtsev SI, Jarvi K, Mullen JBM et al. Testicular spermatozoa have statistically significantly lower DNA damage compared with ejaculated spermatozoa in patients with unsuccessful oral antioxidant treatment. Fertil Steril 2010; 93: 1142-1146
31. Ahmadvand H, Tavafi M, Khosrowbeygi A. Amelioration of altered antioxidant enzymes activity and glomerulosclerosis by coenzyme Q10 in alloxan-induced diabetic rats. J Diabetes Complicat 2012; 26: 476-482
32. Lee B-J, Huang Y-C, Chen S-J et al. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition 2012; 28: 250-255
33. Ognjanović BI, Marković SD, Pavlović SZ et al. Combined effects of coenzyme Q10 and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart. Environ Toxicol Pharmacol 2006; 22: 219-224
34. Garolla A, Maiorino M, Roverato A et al. Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels. Fertil Steril 2005; 83: 355-361
35. Kozink DM, Estienne MJ, Harper AF et al. Effects of dietary l-carnitine supplementation on semen characteristics in boars. Theriogenology 2004; 61: 1247-1258
36. Talaei-khozani T, Borzoei Z, Aliabadi E et al. Effects of l-carnitine and l-acetyl carnitine on in vitro sperm maturation. Toxicol Lett 2008; 180 Supplement: S243
37. Yeste M, Sancho S, Briz M et al. A diet supplemented with l-carnitine improves the sperm quality of Piétrain but not of Duroc and Large White boars when photoperiod and temperature increase. Theriogenology 2010; 73: 577-586
38. Ghanbarzadeh S, Garjania A, Ziaee M et al. Effects of L-Carnitine and Coenzyme Q10 on Impaired Spermatogenesis Caused by Isoproterenol in Male Rats. DrugRes 2014; In Press
39. Staprans I, Pan X-M, Rapp J et al. Receptor- and Apolipoprotein E-Deficient Mice Oxidized Cholesterol in the Diet Accelerates the Development of Atherosclerosis in LDL. Arterioscler Thromb Vasc Biol 2000; 20: 708-714
40. Rajender S, Rahul P, Mahdi AA. Mitochondria, spermatogenesis and male infertility. Mitochondrion 2010; 10: 419-428
41. Samanta N, Goel HC. Protection against radiation induced damage to spermatogenesis by Podophyllum hexandrum. J Ethnopharmacol 2002; 81: 217-224