The antidiabetic effect of low doses of moringa oleifera lam. Seeds on streptozotocin induced diabetes and diabetic nephropathy in male rats

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Al Malki, Abdulrahman L ^a   El Rabey, Haddad A ^a,b  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b UNIVERSITY OF SADAT CITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; AMYLASE; ANTIOXIDANT; CREATININE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HERBACEOUS AGENT; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 6; LIPID PEROXIDE; LIVER ENZYME; NITROGEN; POTASSIUM; SODIUM; STREPTOZOCIN; UREA; URIC ACID; WATER; ANTIDIABETIC AGENT; ELECTROLYTE; GLUCOSE BLOOD LEVEL; PLANT EXTRACT;

ADULT; ALBINO RAT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CREATININE URINE LEVEL; DIABETIC NEPHROPATHY; FLUID INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE URINE LEVEL; GLUCOSURIA; KIDNEY HOMOGENATE; KIDNEY PARENCHYMA; LIPID PEROXIDATION; LOW DRUG DOSE; MALE; MORINGA OLEIFERA; NITROGEN URINE LEVEL; NONHUMAN; PLANT SEED; POTASSIUM BLOOD LEVEL; POTASSIUM URINE LEVEL; POWDER; PROTEIN URINE LEVEL; RAT; SODIUM URINE LEVEL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UREA NITROGEN BLOOD LEVEL; URINALYSIS; ANIMAL; BLOOD; CHEMISTRY; COMPLICATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DIET RESTRICTION; DOSE RESPONSE; DRINKING; DRUG EFFECTS; ENZYMOLOGY; KIDNEY; KIDNEY FUNCTION TEST; LIVER; METABOLISM; ORGAN SIZE; PANCREAS; PATHOLOGY; PATHOPHYSIOLOGY; PHYTOTHERAPY;

MORINGA; MORINGA OLEIFERA; RATTUS;

ALPHA-AMYLASES; ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; ELECTROLYTES; FASTING; HEMOGLOBIN A, GLYCOSYLATED; HYPOGLYCEMIC AGENTS; INTERLEUKIN-6; KIDNEY; KIDNEY FUNCTION TESTS; LIPID PEROXIDATION; LIVER; MALE; MORINGA OLEIFERA; ORGAN SIZE; PANCREAS; PHYTOTHERAPY; PLANT EXTRACTS; RATS; SEEDS; STREPTOZOCIN;

EID: 84921419571     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/381040     Document Type: Article

References (34)

1. D. Mahmood, B. K. Singh, and M. Akhtar, "Diabetic neuropathy: therapies on the horizon, " Journal of Pharmacy and Pharmacology, vol. 61, no. 9, pp. 1137-1145, 2009.
2. S. Shelbaya, H. Amer, S. Seddik et al., "Study of the role of interleukin-6 and highly sensitive C-reactive protein in diabetic nephropathy in type 1 diabetic patients, " European Review for Medical and Pharmacological Sciences, vol. 16, no. 2, pp. 176-182, 2012.
3. Y. S. Kanwar, J. Wada, L. Sun et al., "Diabetic nephropathy: mechanisms of renal disease progression, " Experimental Biology and Medicine, vol. 233, no. 1, pp. 4-11, 2008.
4. S. G. Mahajan, R. G. Mali, and A. A. Mehta, "Protective effect of ethanolic extract of seeds of Moringa oleifera Lam. against inflammation associated with development of arthritis in rats, " Journal of Immunotoxicology, vol. 4, no. 1, pp. 39-47, 2007.
5. A. A. Hamza, "Ameliorative effects of Moringa oleifera Lamseed extract on liver fibrosis in rats, " Food and Chemical Toxicology, vol. 48, no. 1, pp. 345-355, 2010.
6. H. D. Yassa and A. F. Tohamy, "Extractof Moringa oleifera leaves ameliorates streptozotocin-induced Diabetes mellitus in adult rats, " Acta Histochemica, vol. 116, no. 5, pp. 844-854, 2014.
7. M. Mbikay, "Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: a review, " Frontiers in Pharmacology, vol. 3, article 24, 2012.
8. R. V. Karadi, N. B. Gadge, K. R. Alagawadi, and R. V. Savadi, "Effect of Moringa oleifera Lam. Root-wood on ethylene glycol induced urolithiasis in rats, " Journal of Ethnopharmacology, vol. 105, no. 1-2, pp. 306-311, 2006.
9. H. P. S. Makkar, G. Francis, and K. Becker, "Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems, " Animal, vol. 1, no. 9, pp. 1371-1391, 2007.
10. M. R. Kumbhare, V. Guleha, and T. Sivakumar, "Estimation of total phenolic content, cytotoxicity and in-vitro antioxidant activity of stem bark of Moringa oleifera, " Asian Pacific Journal of Tropical Disease, vol. 2, no. 2, pp. 144-150, 2012.
11. M. G. Rajan and h, M. N. Satishkumar, K. Elango, and B. Suresh, "Moringa oleifera Lam. A herbalmedicine for hyperlipidemia: a preclinical report, " Asian Pacific Journal of Tropical Disease, vol. 2, no. 2, pp. 790-795, 2012.
12. V. Lambole and U. Kumar, "Effect of Moringa oleifera Lam. on normal and dexamethasone suppressed wound healing, " Asian Pacific Journal of Tropical Biomedicine, vol. 2, no. 1, pp. S219-S223, 2012.
13. G. A. Asare, B. Gyan, and K. Bugyei, "Toxicological evaluation of the aqueous leaf extract of Moringa oleifera Lam. (Moringaceae), " Journal of Ethnopharmacology, vol. 139, pp. 330-336, 2012.
14. A. Akbarzadeh, D. Norouzian, M. R. Mehrabi et al., "Induction of diabetes by Streptozotocin in rats, " Indian Journal of Clinical Biochemistry, vol. 22, no. 2, pp. 60-64, 2007.
15. L. M. Srivastava, N. Das, and S. Sinha, Essentials of Practical Biochemistry, CBS Publishers and Distributors, 2002.
16. G. Schumann and R. Klauke, "New IFCC reference procedures for the determination of catalytic activity concentrations of five enzymes in serum: preliminary upper reference limits obtained in hospitalized subjects, " Clinica Chimica Acta, vol. 327, no. 1-2, pp. 69-79, 2003.
17. N. W. Tietz and D. F. Shuey, "Reference intervals for alkaline phosphatase activity determined by the IFCC and AACC reference methods, " Clinical Chemistry, vol. 32, no. 8, pp. 1593-1594, 1986.
18. R. A. Drury, E. A. Wallington, and R. Cancerson, Carlton' Histopathological Techniques, Oxford University Press, Oxford, UK, 4th edition, 1976.
19. Statistical Analysis System (SAS), SAS User' Guide: Statistics Version 5, SAS Institute Inc, Cary, NC, USA, 1986.
20. T. Szkudelski, "The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas, " Physiological Research, vol. 50, no. 6, pp. 537-546, 2001.
21. M. S. M. Ardawi, H. A. N. Nasrat, and A. A. Bahnassy, "Serum immunoglobulin concentrations in diabetic patients, " Diabetic Medicine, vol. 11, no. 4, pp. 384-387, 1994.
22. B. Vongsak, P. Sithisarn, S. Mangmool, S. Thongpraditchote, Y. Wongkrajang, and W. Gritsanapan, "Maximizing total phenolics, total flavonoids contents and antioxidant activity of Moringa oleifera leaf extract by the appropriate extraction method, " Industrial Crops and Products, vol. 44, pp. 566-571, 2013.
23. W. A. Ghiridhari, D. Malhati, and K. Geetha, "Anti-diabetic properties of drumstick (Moringa oleifera) leaf tablets, " International Journal of Health and Nutrition, vol. 2, pp. 1-5, 2011.
24. J. N. Kasolo, G. S. Bimenya, L. Ojok, J. Ochieng, and J. W. Ogwal-Okeng, "Phytochemicals and uses of Moringa oleifera leaves in Ugandan rural communities, " Journal of Medicinal Plants Research, vol. 4, no. 9, pp. 753-757, 2010.
25. J. Lako, V. C. Trenerry, M. Wahlqvist, N. Wattanapenpaiboon, S. Sotheeswaran, and R. Premier, "Phytochemical flavonols, carotenoids and the antioxidant properties of awide selection of Fijian fruit, vegetables and other readily available foods, " Food Chemistry, vol. 101, no. 4, pp. 1727-1741, 2007.
26. N. K. Amaglo, R. N. Bennett, R. B. Lo Curto et al., "Profiling selected phytochemicals and nutrients in different tissues of the multipurpose tree Moringa oleifera L., grown in Ghana, " Food Chemistry, vol. 122, no. 4, pp. 1047-1054, 2010.
27. A. A. R. Sayed, "Ferulsinaic acid modulates SOD, GSH, and antioxidant enzymes in diabetic kidney, " Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 580104, 9 pages, 2012.
28. J. Scheller, A. Chalaris, D. Schmidt-Arras, and S. Rose-John, "The pro-and anti-inflammatory properties of the cytokine interleukin-6, " Biochimica et Biophysica Acta-Molecular Cell Research, vol. 1813, no. 5, pp. 878-888, 2011.
29. O. P. Kristiansen and T. M and rup-Poulsen, "Interleukin-6 and diabetes: the good, the bad, or the indifferent?" Diabetes, vol. 54, supplement 2, pp. S114-S124, 2005.
30. F. Awartani, "Serum immunoglobulin levels in type 2 diabetes patients with chronic periodontitis, "The Journal of Contemporary Dental Practice, vol. 11, no. 3, pp. 1-8, 2010.
31. F. Anwar, S. Latif, M. Ashraf, and A. H. Gilani, "Moringa oleifera: a food plant with multiple medicinal uses, " Phytotherapy Research, vol. 21, no. 1, pp. 17-25, 2007.
32. A. T. Afshari, A. Shirpoor, A. Farshid et al., "The effect of ginger on diabetic nephropathy, plasma antioxidant capacity and lipid peroxidation in rats, " Food Chemistry, vol. 101, no. 1, pp. 148-153, 2007.
33. M. Ndong, M. Uehara, S.-I. Katsumata, and K. Suzuki, "Effects of oral administration of Moringa oleifera Lam on glucose tolerance in Goto-Kakizaki and wistar rats, " Journal of Clinical Biochemistry and Nutrition, vol. 40, no. 3, pp. 229-233, 2007.
34. N. H. Parikh, P. K. Parikh, and C. Kothari, "Indigenous plant medicines for health care: treatment of Diabetes mellitus and hyperlipidemia, " Chinese Journal of Natural Medicines, vol. 12, no. 5, pp. 335-344, 2014.