Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats

Food and Chemical Toxicology

Volumn 48, Issue 1, 2010, Pages 345-355

  Hamza, Alaaeldin A ^a,b  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b National Organization of Drug Control and Research   (Egypt)

Author keywords

Anti fibrotic; Carbon tetrachloride; Hepatic fibrosis; Hepatoprotection; Moringa oleifera Lam; Oxidative stress

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CARBONYL DERIVATIVE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; GLOBULIN; HYDROXYPROLINE; MALONALDEHYDE; MORINGA OLEIFERA EXTRACT; MYELOPEROXIDASE; SILYMARIN; SUPEROXIDE DISMUTASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOCHEMISTRY; CELL COUNT; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER FIBROSIS; LIVER INJURY; MALE; MORINGA OLEIFERA; NONHUMAN; OXIDATIVE STRESS; PLANT SEED; RAT; STELLATE CELL; TREATMENT OUTCOME;

ACTINS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; BIPHENYL COMPOUNDS; CARBON TETRACHLORIDE POISONING; COLLAGEN; FERRIC COMPOUNDS; FREE RADICAL SCAVENGERS; HYDROXYPROLINE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CIRRHOSIS; LIVER FUNCTION TESTS; MALE; MALONDIALDEHYDE; MORINGA; MUSCLE, SMOOTH; OXIDATIVE STRESS; PHENOLS; PICRATES; PLANT EXTRACTS; RATS; SEEDS;

MORINGA; MORINGA OLEIFERA; RATTUS;

EID: 72149089298     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.10.022     Document Type: Article

References (28)

1. Anwer F., Latif S., Ashraf M., and Gilani A.H. Moringa oleifera: a food plant with multiple medicinal uses. Phytother. Res. 21 (2007) 17-25
2. Arabshahi D.S., Devi V., and Urooj A. Evaluation of antioxidant activity of some plant extracts and their heat, pH and storage stability. Food Chem. 100 (2007) 1100-1105
3. Bennet R.N., Mellon F.A., Foidl N., Pratt J.H., Dupont M.S., Perkins L., and Kroon P.A. Profiling glucosinolates and phenolics in vegetative and reductive tissues of the multi-purpose tress Moringa oleifera L. (horseradish tree) and Moringa stenopetala L. J. Agric. Food Chem. 51 (2003) 3453-3546
4. Benzie I.F., and Strain J.J. The ferric reducing ability of plasma (FRAP) as a measure of (antioxidant power): the FRAP assay. Anal. Biochem. 293 (1996) 70-76
5. Bharali R., Tabassum J., and Azad M.R. Chemomodulatory effect of Moringa oleifera Lam on hepatic carcinogen metabolizing enzymes, antioxidant parameters and skin papillomagenesis in mice. Asian Pac. J. Cancer Prev. 4 (2003) 131-139
6. Edwards C.A., and O'Brien Jr. W.D. Modified assay for determination of hydroxyproline in a tissue hydrolyzate. Clin. Chem. Acta 104 (1980) 161-167
7. Gerard-Monnier D., Erdelmeier I., Regnard K., Moze-Henry N., Yadan J.C., and Chaudiere J. Reaction of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation. Chem. Res. Toxicol. 11 (1998) 1176-1183
8. Gressner O.A., Weiskirchen R., and Gressner A.M. Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests. Clin. Chem. Acta 381 (2007) 107-113
9. Guevara A.P., Vargas C., Sakurai H., Fujiwara Y., Hashimoto K., Maoka T., Kozuka M., Ito Y., Tokuda H., and Nishino H. An antitumor promoter from Moringa oleifera Lam. Mutat. Res. 440 (1999) 181-188
10. Gui S.Y., Wei W., Wang H., Wu L., Sun W.Y., Chen W.B., and Wu C.Y. Effects and mechanisms of crude astragalosides extraction on liver fibrosis in rats. J. Ethnopharmacol. 103 (2006) 154-159
11. Gutierrez-Ruiz M.C., and Gomez-Quiroz L.E. Liver fibrosis: searching for cell model answers. Liver Int. 155N (2007) 434-439
12. Hamza A.A. Curcuma longa, Glycyrrhiza glabra and Moringa oleifera ameliorate diclofenac-induced hepatoxicity in rats. Am. J. Pharmacol. Toxicol. 2 (2007) 80-88
13. Hillegass L.M., Griswold D.E., Brickson B., and Albrightson-Winslow C. Assessment of myloperoxidase activity in whole rat kidney. J. Pharmacol. Methods 24 (1990) 285-295
14. Kumar A., and Pari L. Antioxidant action of Moringa oleifera Lam (drumstick) against antitubercular drugs induced lipid peroxidation in rats. J. Med. Food 6 (2003) 255-259
15. Lalas S., and Tsaknis J. Characterization of Moringa oleifera seed oil variety. J. Food Compost. Anal. 15 (2002) 65-77
16. Lim Y.Y., and Quah E.P.L. Antioxidant properties of different cultivars of Portylaca oleracea. Food Chem. 103 (2007) 734-740
17. Lin W.C., Kuo S.C., Lin W.L., Fang H.L., and Wang B.C. Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats. World J. Gastroenterol. 12 (2006) 2369-2374
18. Luk J.H., Wang X., Liu P., Wong K.F., Chan K.L., Tong Y., Hui C.K., Lau G.K., and Fan S.T. Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation. Liver Int. 155N (2007) 879-887
19. Mahajan S.G., and Mehta A.A. Effect of Moringa oleifera Lam. Seed extract on ovalbumin-induced airway inflammation in guinea pigs. Inhal. Toxicol. 20 (2008) 897-909
20. Nandi A., and Chatterjee I.B. Assay of superoxide dismutase activity in animal tissues. J. Biosci. 13 (1988) 305-315
21. Natarajan S.K., Thomas S., Ramamoorthy P., Basivireddy J., Pulimmod A.B., Ramachandran A., and Balasubramanian K.A. Oxidative stress in the development of liver cirrhosis. J. Gastroenterol. Hepatol. 21 (2006) 947-957
22. Peterson G.L. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83 (1977) 346-356
23. Reznick A.Z., and Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol. 233 (1994) 357-363
24. Schuppan D., Jia J.D., Brinkhaus B., and Hahn E.G. Herbal products for liver diseases: a therapeutic challenge for the new millennium. Hepatology 30 (1999) 1099-1104
25. Singleton V.L., Orthofer R., and Lamuela-Raventos R.M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. In: Packer L. (Ed). Methods in Enzymology (1999), Academic Press, Harcourt Brace and Company, San Diego, London, New York, Tokyo 152-178
26. Torok N.J. Recent advances in the pathogenesis and diagnosis of liver fibrosis. J. Gastroenterol. 43 (2008) 315-321
27. Tsukada S., Parsons C.J., and Rippe R.A. Mechanism of liver fibrosis. Clin. Chem. Acta 364 (2006) 33-60
28. Varga J., Brenner D.A., and Phan S.H. Methods in Molecular Medicine. Fibrosis Research: Methods and Protocols (2005), Human Press Inc., Totowa, New Jersey Chapters 9 and 11