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Volumn 5, Issue 24, 2014, Pages 12811-12819

DEPTOR has growth suppression activity against pancreatic cancer cells

Author keywords

DEPTOR; Growth suppression; mTOR pathway; Pancreatic cancer

Indexed keywords

INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN DEPTOR; PROTEIN S6; S6 KINASE; TUMOR PROTEIN; UNCLASSIFIED DRUG; DEPTOR PROTEIN, HUMAN; SIGNAL PEPTIDE;

EID: 84921418298     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2659     Document Type: Article
Times cited : (26)

References (31)
  • 2
    • 77951231349 scopus 로고    scopus 로고
    • mTOR and cancer: many loops in one pathway
    • Efeyan A, Sabatini DM. mTOR and cancer: many loops in one pathway. Curr Opin Cell Biol. 2010; 22:169-176.
    • (2010) Curr Opin Cell Biol. , vol.22 , pp. 169-176
    • Efeyan, A.1    Sabatini, D.M.2
  • 3
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell. 2007; 12:9-22.
    • (2007) Cancer Cell. , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 4
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: insights into a complex relationship
    • Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer. 2006; 6:729-734.
    • (2006) Nat Rev Cancer. , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 5
    • 77449090901 scopus 로고    scopus 로고
    • Dynamic balancing: DEPTOR tips the scales
    • Proud CG. Dynamic balancing: DEPTOR tips the scales. J Mol Cell Biol. 2009; 1:61-63.
    • (2009) J Mol Cell Biol. , vol.1 , pp. 61-63
    • Proud, C.G.1
  • 6
    • 81855228182 scopus 로고    scopus 로고
    • mTOR Generates an Auto-Amplification Loop by Triggering the betaTrCP- and CK1alpha-Dependent Degradation of DEPTOR
    • Duan S, Skaar JR, Kuchay S, Toschi A, Kanarek N, Ben-Neriah Y, Pagano M. mTOR Generates an Auto-Amplification Loop by Triggering the betaTrCP- and CK1alpha-Dependent Degradation of DEPTOR. Mol Cell. 2011; 44:317-324.
    • (2011) Mol Cell. , vol.44 , pp. 317-324
    • Duan, S.1    Skaar, J.R.2    Kuchay, S.3    Toschi, A.4    Kanarek, N.5    Ben-Neriah, Y.6    Pagano, M.7
  • 8
    • 81855167585 scopus 로고    scopus 로고
    • DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy
    • Zhao Y, Xiong X, Sun Y. DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy. Molecular Cell. 2011; 44:304-316.
    • (2011) Molecular Cell. , vol.44 , pp. 304-316
    • Zhao, Y.1    Xiong, X.2    Sun, Y.3
  • 10
    • 79951689476 scopus 로고    scopus 로고
    • SCF E3 ubiquitin ligases as anticancer targets
    • Jia L, Sun Y. SCF E3 ubiquitin ligases as anticancer targets. Curr Cancer Drug Targets. 2011; 11:347-356.
    • (2011) Curr Cancer Drug Targets. , vol.11 , pp. 347-356
    • Jia, L.1    Sun, Y.2
  • 12
    • 9644253003 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells
    • Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA. The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. Oncogene. 2004; 23:8571-8580.
    • (2004) Oncogene. , vol.23 , pp. 8571-8580
    • Asano, T.1    Yao, Y.2    Zhu, J.3    Li, D.4    Abbruzzese, J.L.5    Reddy, S.A.6
  • 15
    • 77957150824 scopus 로고    scopus 로고
    • KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
    • Morris JPt Wang, SC Hebrok. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer. 2010; 10:683-695.
    • (2010) Nat Rev Cancer. , vol.10 , pp. 683-695
    • Morris, J.P.T.1    Wang, S.C.2    Hebrok3
  • 16
    • 0031936947 scopus 로고    scopus 로고
    • Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
    • Ruggeri BA, Huang L, Wood M, Cheng JQ, Testa JR. Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Molecular carcinogenesis. 1998; 21:81-86.
    • (1998) Molecular carcinogenesis. , vol.21 , pp. 81-86
    • Ruggeri, B.A.1    Huang, L.2    Wood, M.3    Cheng, J.Q.4    Testa, J.R.5
  • 18
    • 34250698168 scopus 로고    scopus 로고
    • NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review)
    • Zhang Z, Rigas B. NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review). Int J Oncol. 2006; 29:185-192.
    • (2006) Int J Oncol. , vol.29 , pp. 185-192
    • Zhang, Z.1    Rigas, B.2
  • 19
    • 0032943591 scopus 로고    scopus 로고
    • The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao PJ. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res. 1999; 5:119-127.
    • (1999) Clin Cancer Res. , vol.5 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Larry, L.4    Cleary, K.R.5    Chiao, P.J.6
  • 20
    • 1842850737 scopus 로고    scopus 로고
    • Increased expression of NF-kappa B subunits in human pancreatic cancer cells
    • Chandler NM, Canete JJ, Callery MP. Increased expression of NF-kappa B subunits in human pancreatic cancer cells. J Surg Res. 2004; 118:9-14.
    • (2004) J Surg Res. , vol.118 , pp. 9-14
    • Chandler, N.M.1    Canete, J.J.2    Callery, M.P.3
  • 21
    • 13944252061 scopus 로고    scopus 로고
    • Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells
    • Muerkoster S, Arlt A, Sipos B, Witt M, Grossmann M, Kloppel G, Kalthoff H, Folsch UR, Schafer H. Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells. Cancer Res. 2005; 65:1316-1324.
    • (2005) Cancer Res. , vol.65 , pp. 1316-1324
    • Muerkoster, S.1    Arlt, A.2    Sipos, B.3    Witt, M.4    Grossmann, M.5    Kloppel, G.6    Kalthoff, H.7    Folsch, U.R.8    Schafer, H.9
  • 22
    • 0033068154 scopus 로고    scopus 로고
    • The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro
    • Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW. The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev. 1999; 13:270-283.
    • (1999) Genes Dev. , vol.13 , pp. 270-283
    • Winston, J.T.1    Strack, P.2    Beer-Romero, P.3    Chu, C.Y.4    Elledge, S.J.5    Harper, J.W.6
  • 23
    • 79960411515 scopus 로고    scopus 로고
    • Overexpression of DEP domain containing mTOR-interacting protein correlates with poor prognosis in differentiated thyroid carcinoma
    • Pei L, Xie P, Zhou E, Yang Q, Luo Y, Tang Z. Overexpression of DEP domain containing mTOR-interacting protein correlates with poor prognosis in differentiated thyroid carcinoma. Molecular medicine reports. 2011; 4:817-823.
    • (2011) Molecular medicine reports. , vol.4 , pp. 817-823
    • Pei, L.1    Xie, P.2    Zhou, E.3    Yang, Q.4    Luo, Y.5    Tang, Z.6
  • 25
    • 84877587720 scopus 로고    scopus 로고
    • Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation
    • Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Jung DY, Okutsu M, Yan Z, Kim JK, Lin JD. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nat Med. 2013; 19:640-645.
    • (2013) Nat Med. , vol.19 , pp. 640-645
    • Meng, Z.X.1    Li, S.2    Wang, L.3    Ko, H.J.4    Lee, Y.5    Jung, D.Y.6    Okutsu, M.7    Yan, Z.8    Kim, J.K.9    Lin, J.D.10
  • 26
    • 56149109528 scopus 로고    scopus 로고
    • A small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis, and sensitizes lung cancer cells to chemotherapy
    • Sun SH, Zheng M, Ding K, Wang S, Sun Y. A small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis, and sensitizes lung cancer cells to chemotherapy. Cancer Biol Ther. 2008; 7:845-852.
    • (2008) Cancer Biol Ther. , vol.7 , pp. 845-852
    • Sun, S.H.1    Zheng, M.2    Ding, K.3    Wang, S.4    Sun, Y.5
  • 29
    • 27744526342 scopus 로고    scopus 로고
    • A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells
    • Bockbrader KM, Tan M, Sun Y. A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells. Oncogene. 2005; 24:7381-7388.
    • (2005) Oncogene. , vol.24 , pp. 7381-7388
    • Bockbrader, K.M.1    Tan, M.2    Sun, Y.3
  • 30
    • 54749113690 scopus 로고    scopus 로고
    • Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2
    • Zheng M, Morgan-Lappe SE, Yang J, Bockbrader KM, Pamarthy D, Thomas D, Fesik SW, Sun Y. Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2. Cancer Res. 2008; 68:7570-7578.
    • (2008) Cancer Res. , vol.68 , pp. 7570-7578
    • Zheng, M.1    Morgan-Lappe, S.E.2    Yang, J.3    Bockbrader, K.M.4    Pamarthy, D.5    Thomas, D.6    Fesik, S.W.7    Sun, Y.8
  • 31
    • 34248547553 scopus 로고    scopus 로고
    • SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation
    • Gu Q, Tan M, Sun Y. SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation. Cancer Res. 2007; 67:3616-3625.
    • (2007) Cancer Res. , vol.67 , pp. 3616-3625
    • Gu, Q.1    Tan, M.2    Sun, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.