Gemcitabine-Based Combination Chemotherapy Followed by Radiation With Capecitabine as Adjuvant Therapy for Resected Pancreas Cancer

International Journal of Radiation Oncology Biology Physics

Volumn 75, Issue 5, 2009, Pages 1450-1455

  Desai, Sameer ^a   Ben Josef, Edgar ^b   Griffith, Kent A ^b   Simeone, Diane ^a   Greenson, Joel K ^a   Francis, Isaac R ^a   Hampton, Janet ^b   Colletti, Lisa ^a   Chang, Alfred E ^a   Lawrence, Theodore S ^b   Zalupski, Mark M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Adjuvant therapy; Capecitabine; Combination chemotherapy; Gemcitabine; Pancreas cancer

Indexed keywords

ADJUVANT THERAPY; CAPECITABINE; COMBINATION CHEMOTHERAPY; GEMCITABINE; PANCREAS CANCER;

CHEMOTHERAPY; DECISION MAKING; FLUORINE CONTAINING POLYMERS; MULTIVARIANT ANALYSIS; PATIENT MONITORING; PLATINUM COMPOUNDS; RADIOTHERAPY;

DRUG PRODUCTS;

CAPECITABINE; CISPLATIN; GEMCITABINE;

ADJUVANT THERAPY; ADULT; AGED; ANEMIA; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER LOCALIZATION; CANCER MORTALITY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER SURGERY; CARDIOVASCULAR DISEASE; CHEMOTHERAPY INDUCED EMESIS; CLINICAL ARTICLE; DEHYDRATION; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DYSPNEA; FEMALE; GASTROINTESTINAL TOXICITY; HAND FOOT SYNDROME; HEARING IMPAIRMENT; HOSPITALIZATION; HUMAN; HYPOXIA; MALE; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUROPATHY; NEUTROPENIA; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREATICODUODENECTOMY; PATIENT COMPLIANCE; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RADIATION DOSE; RETROSPECTIVE STUDY; TREATMENT DURATION; TREATMENT OUTCOME;

ADENOCARCINOMA; ADULT; AGED; ANALYSIS OF VARIANCE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; CISPLATIN; DEOXYCYTIDINE; DISEASE-FREE SURVIVAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HUMANS; KARNOFSKY PERFORMANCE STATUS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; RADIOTHERAPY, ADJUVANT; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 71649115667     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.01.023     Document Type: Article

References (28)

1. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2007. CA Cancer J Clin 57 (2007) 43-66
2. Winter J.M., Cameron J.L., Campbell K.A., et al. 1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experience. J Gastrointest Surg 10 (2006) 1199-1210 discussion 1210-1211
3. Sohn T.A., Yeo C.J., Cameron J.L., et al. Resected adenocarcinoma of the pancreas-616 patients: Results, outcomes, and prognostic indicators. J Gastrointest Surg 4 (2000) 567-579
4. Ries L., Melbert D., Krapcho M., et al. SEER cancer statistics review, 1975-2004 (2007), National Cancer Institute, Bethesda, MD
5. Zacharias T., Jaeck D., Oussoultzoglou E., et al. Impact of lymph node involvement on long-term survival after R0 pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas. J Gastrointest Surg 11 (2007) 350-356
6. Howard T.J., Krug J.E., Yu J., et al. A margin-negative R0 resection accomplished with minimal postoperative complications is the surgeon's contribution to long-term survival in pancreatic cancer. J Gastrointest Surg 10 (2006) 1338-1345 discussion 1345-1336
7. Kalser M.H., and Ellenberg S.S. Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 120 (1985) 899-903
8. Klinkenbijl J.H., Jeekel J., Sahmoud T., et al. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg 230 (1999) 776-782 discussion 782-784
9. Neoptolemos J.P., Dunn J.A., Stocken D.D., et al. Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: A randomised controlled trial. Lancet 358 (2001) 1576-1585
10. Neoptolemos J.P., Stocken D.D., Friess H., et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350 (2004) 1200-1210
11. Burris III H.A., Moore M.J., Andersen J., et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 15 (1997) 2403-2413
12. Oettle H., Post S., Neuhaus P., et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial. JAMA 297 (2007) 267-277
13. Regine W.F., Winter K.A., Abrams R.A., et al. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: A randomized controlled trial. JAMA 299 (2008) 1019-1026
14. Sultana A., Smith C.T., Cunningham D., et al. Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer. J Clin Oncol 25 (2007) 2607-2615
15. Heinemann V., Boeck S., Hinke A., et al. Meta-analysis of randomized trials: Evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer. BMC Cancer 8 (2008) 82
16. Brennan M.F., Kattan M.W., Klimstra D., et al. Prognostic nomogram for patients undergoing resection for adenocarcinoma of the pancreas. Ann Surg 240 (2004) 293-298
17. Moore M.J., Goldstein D., Hamm J., et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25 (2007) 1960-1966
18. Kindler H.L., Niedzwiecki D., Hollis D., et al. A double-blind, placebo-controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): A preliminary analysis of Cancer and Leukemia Group B (CALGB). [Abstract]. J Clin Oncol 25 (2007) 199s
19. Philip P.A., Benedetti J., Fenoglio-Preiser C., et al. Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study. [Abstract]. J Clin Oncol 25 (2007) 199s
20. Henderson I.C., Berry D.A., Demetri G.D., et al. Improved outcomes from adding sequential paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer. J Clin Oncol 21 (2003) 976-983
21. Andre T., Boni C., Mounedji-Boudiaf L., et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350 (2004) 2343-2351
22. Winton T., Livingston R., Johnson D., et al. Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer. N Engl J Med 352 (2005) 2589-2597
23. Neuhaus P., Riess H., Post S., et al. CONKO-001: Final results of the randomized, prospective, multicenter phase III trial of adjuvant chemotherapy with gemcitabine versus observation in patients with resected pancreatic cancer (PC) (Abstr.). J Clin Oncol 26 (2008) 214s
24. Herman J.M., Swartz M.J., Hsu C.C., et al. Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: Results of a large, prospectively collected database at the Johns Hopkins Hospital. J Clin Oncol 26 (2008) 3503-3510
25. Corsini M.M., Miller R.C., Haddock M.G., et al. Adjuvant radiotherapy and chemotherapy for pancreatic carcinoma: The Mayo Clinic experience (1975-2005). J Clin Oncol 26 (2008) 3511-3516
26. Schneider B.J., Ben-Josef E., McGinn C.J., et al. Capecitabine and radiation therapy preceded and followed by combination chemotherapy in advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 63 (2005) 1325-1330
27. Linehan D., Tan M., Strasberg S., et al. Adjuvant interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: A single-institution phase II study. Ann Surg 248 (2008) 145-151
28. Nukui Y., Picozzi V.J., and Traverso L.W. Interferon-based adjuvant chemoradiation therapy improves survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am J Surg 179 (2000) 367-371