Non-transpeptidase binding arylthioether β-lactams active against Mycobacterium tuberculosis and Moraxella catarrhalis

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 3, 2015, Pages 632-647

  Beck, Tim N ^a   Lloyd, Dina ^a   Kuskovsky, Rostislav ^a   Minah, Jeanette ^a   Arora, Kriti ^c   Plotkin, Balbina J ^b   Green, Jacalyn M ^b   Boshoff, Helena I ^c   Barry, Clifton ^c   Deschamps, Jeffrey ^d   Konaklieva, Monika I ^a  

^a AMERICAN UNIVERSITY   (United States)

^b MIDWESTERN UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d NAVAL RESEARCH LABORATORY   (United States)

Author keywords

Antimicrobial resistance; Moraxella catarrhalis; Mycobacterium tuberculosis; Lactams

Indexed keywords

4 (2 CHLORO 4 FLUOROPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (2 FLUOROPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (2 METHOXYPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (2,4 DICHLOROPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (2,4 DIFLUOROPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (2,5 DIMETHOXYPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (3 CHLORO 4 FLUOROPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (3 FLUOROPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (3 METHOXYPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (3,4 DIFLUOROPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (3,4 DIMETHOXYPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (4 FLUOROPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (4 METHOXYPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (4 METHYLSULFANYLPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (4 NITROPHENOXY)AZETIDIN 2 ONE; 4 (4 NITROPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (4 TRIFLUOROMETHYLPHENOXY)AZETIDIN 2 ONE; 4 (NAPHTHALEN 1 YLSULFANYL)AZETIDIN 2 ONE; 4 (THIOPHEN 2 YLSULFANYL)AZETIDIN 2 ONE; 4 ACETOXY 2 AZETIDINONE; 4 PENTAFLUOROPHENYLSULFANYL AZETIDIN 2 ONE; 4 PHENYLSELANYL AZETIDIN 2 ONE; 4 PHENYLSULFANYL AZETIDIN 2 ONE; 4 [[2 (TRIFLUOROMETHYL)PHENYL]THIO]AZETIDIN 2 ONE; 4 [[3 (TRIFLUOROMETHYL)PHENYL]THIO]AZETIDIN 2 ONE; 4 [[3,5 BIS(TRIFLUOROMETHYL)PHENYL]THIO]AZETIDIN 2 ONE; 4 [[4 (TRIFLUOROMETHYL)PHENYL]THIO]AZETIDIN 2 ONE; BETA LACTAM ANTIBIOTIC; NON TRANSPEPTIDASE BINDING ARYLTHIOETHER BETA LACTAM; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIINFECTIVE AGENT; BETA LACTAM;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CHEMICAL BOND; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG STRUCTURE; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST;

MORAXELLA CATARRHALIS; MYCOBACTERIUM TUBERCULOSIS;

ANTI-BACTERIAL AGENTS; BETA-LACTAMS; MICROBIAL SENSITIVITY TESTS; MORAXELLA (BRANHAMELLA) CATARRHALIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 84921387785     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.11.025     Document Type: Article

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