C4-Alkylthiols with activity against Moraxella catarrhalis and Mycobacterium tuberculosis

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 22, 2011, Pages 6842-6852

  Kostova, Maya B ^a   Myers, Carey J ^a   Beck, Tim N ^a   Plotkin, Balbina J ^b   Green, Jacalyn M ^c   Boshoff, Helena I M ^d   Barry III, Clifton E ^d   Deschamps, Jeffrey R ^e   Konaklieva, Monika I ^a  

^a AMERICAN UNIVERSITY   (United States)

^b MIDWESTERN UNIVERSITY   (United States)

^c MIDWESTERN UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e NAVAL RESEARCH LABORATORY   (United States)

Author keywords

Lactams; Antimicrobial resistance; Moraxella catarrhalis; Mycobacterium tuberculosis

Indexed keywords

(2 ETHYL 2 MERCAPTOBUTYLIDENEAMINO)ACETIC ACID ETHYL ESTER; (2 METHYL 2 METHYLDISULFANYLPROPYLIDENEAAMINO)ACETIC ACID ETHYL ESTHER; 2 (4 MERCAPTOPHENOXY) 4 OXO AZETIDINE 1 SULFONIC ACID TETRA N BUTYLAMMONIUM; 2 (4 MERCAPTOPHENYLAMINO) 4 OXO AZETIDINE 1 SULFONIC ACID TETRA N BUTYLAMMONIUM; 2 (4 MERCAPTOPHENYLSULFANYL) 4 OXO AZETIDINE 1 SULFONIC ACID TETRA N BUTYLAMMONIUM; 2 ACETYLSULFANYL 4 OXO AZETIDINE 1 SULFONIC ACID TETRA N BUTYLAMMONIUM; 2 OXO 4 (THIOPHEN 2 YLSULFANYL)AZETIDINE 1 SULFONIC ACID TETRA N BUTYLAMMONIUM; 2 OXO 4 PHENYLSULFANYLAZETIDINE 1 SULFONIC ACID TETRA N BUTYLAMMONIUM; 2ETHYL 2 MERCAPTOBUTAN 1 OL; 4 (2ETHYL 2 MERCAPTOBUTOXY)AZETIDIN 2 ONE; 4 (3 HYROXYPROPYLSULFANYL)AZETIDIN 2 ONE; 4 (3 MERCAPTOPROPOXY)AZETIDIN 2 ONE; 4 (4 MERCAPTOPHENOXY)AZETIDIN 2 ONE; 4 (4 MERCAPTOPHENYLAMINO)AZETIDIN 2 ONE; 4 (4 MERCAPTOPHENYLSULFANYL)AZETIDIN 2 ONE; 4 (THIOPHEN 2 YLSULFANYL)AZETIDIN 2 ONE; 4 ACETHYLTHIO 2 AZETIDINONE; 4 PHENYLSULFANYLAZETIDIN 2 ONE; [2 (1 ETHYL 1 MERCAPTOPROPYL) 3 METHOXY 4 OXO AZETIDIN 1 YL]ACETIC ACID ETHYL ESTER; [2 [1 (ETHOXYCARBONYLMETHYLIMINOMETHYL) 1 ETHYLPROPYLDISULFANYL] 2 ETHYLBUTYLIDENEAMINO]ACETIC ACID ETHYL ESTER; [2 [1 ETHYL 1 (1 ETHYL 1 FORMYLPROPYLDISULFANYL)PROPYL] 3 METHOXY 4 OXO AZETIDIN 1 YL]ACETIC ACID ETHYL ESTER; [2 [1 ETHYL 1 (1 ETHYL 1 FORMYLPROPYLDISULFANYL)PROPYL] 3 METHOXY 4 OXO AZETIDIN 1 YL]ACETIC ACID METHYL ESTER; [2 ETHYL 2 (1 ETHYL 1 FORMYLPROPYLDISULFANYL)BUTYLIDENEAMINO]ACETIC ACID ETHYL ESTER; [2 ETHYL 2 (1 ETHYL 1 FORMYLPROPYLDISULFANYL)BUTYLIDENEAMINO]ACETIC ACID METHYL ESTER; [3 METHOXY 2 (1 METHYL 1 METHYLDISULFANYL ETHYL) 4 OXOAZETIDIN 1 YL]ACETIC ACID ETHYL ESTHER; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; ETHYL 2 (1 ETHYL 1 FORMYLPROPYLDISULFANYL)BUTYRALDEHYDE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; BACTERIAL STRAIN; BACTERIUM ISOLATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN EXPRESSION; WILD TYPE;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BETA-LACTAMS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MORAXELLA (BRANHAMELLA) CATARRHALIS; MYCOBACTERIUM TUBERCULOSIS; SULFHYDRYL COMPOUNDS;

BACTERIA (MICROORGANISMS); MORAXELLA CATARRHALIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 80054979839     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.030     Document Type: Conference Paper

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