-
1
-
-
84861986053
-
Wnt/beta-Catenin Signaling and Disease
-
Clevers, H. and Nusse, R. (2012) Wnt/beta-Catenin Signaling and Disease Cell 149, 1192-1205
-
(2012)
Cell
, vol.149
, pp. 1192-1205
-
-
Clevers, H.1
Nusse, R.2
-
2
-
-
33744791463
-
Wnt signaling: Is the party in the nucleus?
-
Willert, K. and Jones, K. A. (2006) Wnt signaling: is the party in the nucleus? Genes Dev. 20, 1394-1404
-
(2006)
Genes Dev.
, vol.20
, pp. 1394-1404
-
-
Willert, K.1
Jones, K.A.2
-
3
-
-
62849106337
-
Beta-Catenin hits chromatin: Regulation of Wnt target gene activation
-
Mosimann, C., Hausmann, G., and Basler, K. (2009) beta-Catenin hits chromatin: regulation of Wnt target gene activation Nat. Rev. Mol. Cell Biol. 10, 276-U257
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 276-U257
-
-
Mosimann, C.1
Hausmann, G.2
Basler, K.3
-
4
-
-
77049099785
-
Histone methyltransferases in cancer
-
Albert, M. and Helin, K. (2010) Histone methyltransferases in cancer Semin. Cell Dev. Biol. 21, 209-220
-
(2010)
Semin. Cell Dev. Biol.
, vol.21
, pp. 209-220
-
-
Albert, M.1
Helin, K.2
-
6
-
-
35548934558
-
MLL translocations, histone modifications and leukaemia stem-cell development
-
Krivtsov, A. V. and Armstrong, S. A. (2007) MLL translocations, histone modifications and leukaemia stem-cell development Nat. Rev. Cancer 7, 823-833
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 823-833
-
-
Krivtsov, A.V.1
Armstrong, S.A.2
-
7
-
-
0037172665
-
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
-
Feng, Q., Wang, H. B., Ng, H. H., Erdjument-Bromage, H., Tempst, P., Struhl, K., and Zhang, Y. (2002) Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain Curr. Biol. 12, 1052-1058
-
(2002)
Curr. Biol.
, vol.12
, pp. 1052-1058
-
-
Feng, Q.1
Wang, H.B.2
Ng, H.H.3
Erdjument-Bromage, H.4
Tempst, P.5
Struhl, K.6
Zhang, Y.7
-
8
-
-
17444375685
-
HDOT1L links histone methylation to leukemogenesis
-
Okada, Y., Feng, Q., Lin, Y., Jiang, Q., Li, Y., Coffield, V. M., Su, L., Xu, G., and Zhang, Y. (2005) hDOT1L links histone methylation to leukemogenesis Cell 121, 167-178
-
(2005)
Cell
, vol.121
, pp. 167-178
-
-
Okada, Y.1
Feng, Q.2
Lin, Y.3
Jiang, Q.4
Li, Y.5
Coffield, V.M.6
Su, L.7
Xu, G.8
Zhang, Y.9
-
9
-
-
84886929228
-
Targeting recruitment of Disruptor of Telomeric Silencing 1-like (DOT1L) characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion protiens
-
Shen, C. X., Jo, S. Y., Liao, C. Z., Hess, J. L., and Nikolovska-Coleska, Z. (2013) Targeting recruitment of Disruptor of Telomeric Silencing 1-like (DOT1L) characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion protiens J. Biol. Chem. 288, 30585-30596
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 30585-30596
-
-
Shen, C.X.1
Jo, S.Y.2
Liao, C.Z.3
Hess, J.L.4
Nikolovska-Coleska, Z.5
-
10
-
-
79960058024
-
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
-
Daigle, S. R., Olhava, E. J., Therkelsen, C. A., Majer, C. R., Sneeringer, C. J., Song, J., Johnston, L. D., Scott, M. P., Smith, J. J., Xiao, Y. H., Jin, L., Kuntz, K. W., Chesworth, R., Moyer, M. P., Bernt, K. M., Tseng, J. C., Kung, A. L., Armstrong, S. A., Copeland, R. A., Richon, V. M., and Pollock, R. M. (2011) Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor Cancer Cell 20, 53-65
-
(2011)
Cancer Cell
, vol.20
, pp. 53-65
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.A.3
Majer, C.R.4
Sneeringer, C.J.5
Song, J.6
Johnston, L.D.7
Scott, M.P.8
Smith, J.J.9
Xiao, Y.H.10
Jin, L.11
Kuntz, K.W.12
Chesworth, R.13
Moyer, M.P.14
Bernt, K.M.15
Tseng, J.C.16
Kung, A.L.17
Armstrong, S.A.18
Copeland, R.A.19
Richon, V.M.20
Pollock, R.M.21
more..
-
11
-
-
84875217644
-
Bromo-deaza-SAH: A potent and selective DOT1L inhibitor
-
Yu, W. Y., Smil, D., Li, F. L., Tempel, W., Fedorov, O., Nguyen, K. T., Bolshan, Y., Al-Awar, R., Knapp, S., Arrowsmith, C. H., Vedadi, M., Brown, P. J., and Schapira, M. (2013) Bromo-deaza-SAH: A potent and selective DOT1L inhibitor Bioorg. Med. Chem. 21, 1787-1794
-
(2013)
Bioorg. Med. Chem.
, vol.21
, pp. 1787-1794
-
-
Yu, W.Y.1
Smil, D.2
Li, F.L.3
Tempel, W.4
Fedorov, O.5
Nguyen, K.T.6
Bolshan, Y.7
Al-Awar, R.8
Knapp, S.9
Arrowsmith, C.H.10
Vedadi, M.11
Brown, P.J.12
Schapira, M.13
-
12
-
-
77949409084
-
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)
-
Mohan, M., Herz, H. M., Takahashi, Y. H., Lin, C. Q., Lai, K. C., Zhang, Y., Washburn, M. P., Florens, L., and Shilatifard, A. (2010) Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom) Genes Dev. 24, 574-589
-
(2010)
Genes Dev.
, vol.24
, pp. 574-589
-
-
Mohan, M.1
Herz, H.M.2
Takahashi, Y.H.3
Lin, C.Q.4
Lai, K.C.5
Zhang, Y.6
Washburn, M.P.7
Florens, L.8
Shilatifard, A.9
-
13
-
-
78649920369
-
The Leukemia-Associated Mllt10/Af10-Dot1lAreTcf4/beta-Catenin Coactivators Essential for Intestinal Homeostasis
-
Mahmoudi, T., Boj, S. F., Hatzis, P., Li, V. S. W., Taouatas, N., Vries, R. G. J., Teunissen, H., Begthel, H., Korving, J., Mohammed, S., Heck, A. J. R., and Clevers, H. (2010) The Leukemia-Associated Mllt10/Af10-Dot1lAreTcf4/beta-Catenin Coactivators Essential for Intestinal Homeostasis PLoS Biol. 8, e1000539
-
(2010)
PLoS Biol.
, vol.8
, pp. 1000539
-
-
Mahmoudi, T.1
Boj, S.F.2
Hatzis, P.3
Li, V.S.W.4
Taouatas, N.5
Vries, R.G.J.6
Teunissen, H.7
Begthel, H.8
Korving, J.9
Mohammed, S.10
Heck, A.J.R.11
Clevers, H.12
-
14
-
-
84861422537
-
Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis
-
Betancourt, M. C. C., Cailotto, F., Kerkhof, H. J., Cornelis, F. M. F., Doherty, S. A., Hart, D. J., Hofman, A., Luyten, F. P., Maciewicz, R. A., Mangino, M., Metrustry, S., Muir, K., Peters, M. J., Rivadeneira, F., Wheeler, M., Zhang, W. Y., Arden, N., Spector, T. D., Uitterlinden, A. G., Doherty, M., Lories, R. J. U., Valdes, A. M., and van Meurs, J. B. J. (2012) Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis Proc. Natl. Acad. Sci. U. S. A. 109, 8218-8223
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 8218-8223
-
-
Betancourt, M.C.C.1
Cailotto, F.2
Kerkhof, H.J.3
Cornelis, F.M.F.4
Doherty, S.A.5
Hart, D.J.6
Hofman, A.7
Luyten, F.P.8
Maciewicz, R.A.9
Mangino, M.10
Metrustry, S.11
Muir, K.12
Peters, M.J.13
Rivadeneira, F.14
Wheeler, M.15
Zhang, W.Y.16
Arden, N.17
Spector, T.D.18
Uitterlinden, A.G.19
Doherty, M.20
Lories, R.J.U.21
Valdes, A.M.22
Van Meurs, J.B.J.23
more..
-
15
-
-
79955948524
-
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
-
Jo, S. Y., Granowicz, E. M., Maillard, I., Thomas, D., and Hess, J. L. (2011) Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation Blood 117, 4759-4768
-
(2011)
Blood
, vol.117
, pp. 4759-4768
-
-
Jo, S.Y.1
Granowicz, E.M.2
Maillard, I.3
Thomas, D.4
Hess, J.L.5
-
16
-
-
84876454836
-
DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions
-
Ho, L. L., Sinha, A., Verzi, M., Bernt, K. M., Armstrong, S., and Shivdasani, R. A. (2013) DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions Mol. Cell. Biol. 33, 1735-1745
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 1735-1745
-
-
Ho, L.L.1
Sinha, A.2
Verzi, M.3
Bernt, K.M.4
Armstrong, S.5
Shivdasani, R.A.6
-
17
-
-
0030975671
-
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC(-/-) colon carcinoma
-
Korinek, V., Barker, N., Morin, P. J., vanWichen, D., deWeger, R., Kinzler, K. W., Vogelstein, B., and Clevers, H. (1997) Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC(-/-) colon carcinoma Science 275, 1784-1787
-
(1997)
Science
, vol.275
, pp. 1784-1787
-
-
Korinek, V.1
Barker, N.2
Morin, P.J.3
Vanwichen, D.4
Deweger, R.5
Kinzler, K.W.6
Vogelstein, B.7
Clevers, H.8
-
18
-
-
0033776383
-
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
-
Coghlan, M. P., Culbert, A. A., Cross, D. A., Corcoran, S. L., Yates, J. W., Pearce, N. J., Rausch, O. L., Murphy, G. J., Carter, P. S., Roxbee Cox, L., Mills, D., Brown, M. J., Haigh, D., Ward, R. W., Smith, D. G., Murray, K. J., Reith, A. D., and Holder, J. C. (2000) Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription ACS Chem. Biol. 7, 793-803
-
(2000)
ACS Chem. Biol.
, vol.7
, pp. 793-803
-
-
Coghlan, M.P.1
Culbert, A.A.2
Cross, D.A.3
Corcoran, S.L.4
Yates, J.W.5
Pearce, N.J.6
Rausch, O.L.7
Murphy, G.J.8
Carter, P.S.9
Roxbee Cox, L.10
Mills, D.11
Brown, M.J.12
Haigh, D.13
Ward, R.W.14
Smith, D.G.15
Murray, K.J.16
Reith, A.D.17
Holder, J.C.18
-
19
-
-
33846643562
-
Canonical Wnt signaling transiently stimulates proliferation and enhances neurogenesis in neonatal neural progenitor cultures
-
Hirsch, C., Campano, L. M., Wohrle, S., and Hecht, A. (2007) Canonical Wnt signaling transiently stimulates proliferation and enhances neurogenesis in neonatal neural progenitor cultures Exp. Cell Res. 313, 572-587
-
(2007)
Exp. Cell Res.
, vol.313
, pp. 572-587
-
-
Hirsch, C.1
Campano, L.M.2
Wohrle, S.3
Hecht, A.4
-
20
-
-
84861972831
-
Wnt Signaling through Inhibition of beta-Catenin Degradation in an Intact Axin1 Complex
-
Li, V. S. W., Ng, S. S., Boersema, P. J., Low, T. Y., Karthaus, W. R., Gerlach, J. P., Mohammed, S., Heck, A. J. R., Maurice, M. M., Mahmoudi, T., and Clevers, H. (2012) Wnt Signaling through Inhibition of beta-Catenin Degradation in an Intact Axin1 Complex Cell 149, 1245-1256
-
(2012)
Cell
, vol.149
, pp. 1245-1256
-
-
Li, V.S.W.1
Ng, S.S.2
Boersema, P.J.3
Low, T.Y.4
Karthaus, W.R.5
Gerlach, J.P.6
Mohammed, S.7
Heck, A.J.R.8
Maurice, M.M.9
Mahmoudi, T.10
Clevers, H.11
-
21
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., and Clevers, H. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5 Nature 449, 1003-U1001
-
(2007)
Nature
, vol.449
, pp. 1003-U1001
-
-
Barker, N.1
Van Es, J.H.2
Kuipers, J.3
Kujala, P.4
Van Den Born, M.5
Cozijnsen, M.6
Haegebarth, A.7
Korving, J.8
Begthel, H.9
Peters, P.J.10
Clevers, H.11
-
22
-
-
18644373146
-
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
-
van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A. P., Tion-Pon-Fong, M., Moerer, P., van den Born, M., Soete, G., Pals, S., Eilers, M., Medema, R., and Clevers, H. (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells Cell 111, 241-250
-
(2002)
Cell
, vol.111
, pp. 241-250
-
-
Van De Wetering, M.1
Sancho, E.2
Verweij, C.3
De Lau, W.4
Oving, I.5
Hurlstone, A.6
Van Der Horn, K.7
Batlle, E.8
Coudreuse, D.9
Haramis, A.P.10
Tion-Pon-Fong, M.11
Moerer, P.12
Van Den Born, M.13
Soete, G.14
Pals, S.15
Eilers, M.16
Medema, R.17
Clevers, H.18
-
23
-
-
0032483439
-
Identification of c-MYC as a target of the APC pathway
-
He, T. C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., and Kinzler, K. W. (1998) Identification of c-MYC as a target of the APC pathway Science 281, 1509-1512
-
(1998)
Science
, vol.281
, pp. 1509-1512
-
-
He, T.C.1
Sparks, A.B.2
Rago, C.3
Hermeking, H.4
Zawel, L.5
Da Costa, L.T.6
Morin, P.J.7
Vogelstein, B.8
Kinzler, K.W.9
-
24
-
-
0036148208
-
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
-
Jho, E. H., Zhang, T., Domon, C., Joo, C. K., Freund, J. N., and Costantini, F. (2002) Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway Mol. Cell. Biol. 22, 1172-1183
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1172-1183
-
-
Jho, E.H.1
Zhang, T.2
Domon, C.3
Joo, C.K.4
Freund, J.N.5
Costantini, F.6
-
25
-
-
23844476499
-
P53-dependent transcriptional repression of c-myc is required for G(1) cell cycle arrest
-
Ho, J. S. L., Ma, W. L., Mao, D. Y. L., and Benchimol, S. (2005) p53-dependent transcriptional repression of c-myc is required for G(1) cell cycle arrest Mol. Cell Biol. 25, 7423-7431
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 7423-7431
-
-
Ho, J.S.L.1
Ma, W.L.2
Mao, D.Y.L.3
Benchimol, S.4
-
26
-
-
84857957581
-
Transcriptional regulation of the c-Myc promoter by NFAT1 involves negative and positive NFAT-responsive elements
-
Mognol, G. P., de Araujo-Souza, P. S., Robbs, B. K., Teixeira, L. K., and Viola, J. P. B. (2012) Transcriptional regulation of the c-Myc promoter by NFAT1 involves negative and positive NFAT-responsive elements Cell Cycle 11, 1014-1028
-
(2012)
Cell Cycle
, vol.11
, pp. 1014-1028
-
-
Mognol, G.P.1
De Araujo-Souza, P.S.2
Robbs, B.K.3
Teixeira, L.K.4
Viola, J.P.B.5
-
27
-
-
78751535289
-
AP-1 Regulates Cyclin D1 and c-MYC Transcription in an AKT-Dependent Manner in Response to mTOR Inhibition: Role of AIP4/Itch-Mediated JUNB Degradation
-
Vartanian, R., Masri, J., Martin, J., Cloninger, C., Holmes, B., Artinian, N., Funk, A., Ruegg, T., and Gera, J. (2011) AP-1 Regulates Cyclin D1 and c-MYC Transcription in an AKT-Dependent Manner in Response to mTOR Inhibition: Role of AIP4/Itch-Mediated JUNB Degradation Mol. Cancer Res. 9, 115-130
-
(2011)
Mol. Cancer Res.
, vol.9
, pp. 115-130
-
-
Vartanian, R.1
Masri, J.2
Martin, J.3
Cloninger, C.4
Holmes, B.5
Artinian, N.6
Funk, A.7
Ruegg, T.8
Gera, J.9
|