Effects of nicotinamide n-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress

Cellular Physiology and Biochemistry

Volumn 35, Issue 2, 2015, Pages 710-721

  Yu, Tao ^a   Wang, Yong Tao ^a   Chen, Pan ^a,b   Li, Yu Hua ^a   Chen, Yi Xin ^a   Zeng, Hang ^a   Yu, Ai Ming ^c   Huang, Min ^a   Bi, Hui Chang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Invasion; Metabolic stress; Migration; NNMT; PANC 1; Proliferation

Indexed keywords

DEOXYGLUCOSE; GLUCOSE; NICOTINAMIDE METHYLTRANSFERASE; PLASMID VECTOR; RAPAMYCIN; SMALL INTERFERING RNA; NNMT PROTEIN, HUMAN;

ARTICLE; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; METABOLIC STRESS; METASTASIS POTENTIAL; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; PRIORITY JOURNAL; UPREGULATION; CELL MOTION; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; METABOLISM; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGICAL STRESS; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; GENE KNOCKDOWN TECHNIQUES; HUMANS; NICOTINAMIDE N-METHYLTRANSFERASE; PANCREATIC NEOPLASMS; STRESS, PHYSIOLOGICAL; TRANSFECTION; UP-REGULATION;

EID: 84921366370     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000369731     Document Type: Article

References (38)

1. Siegel R, Naishadham D, Jemal A: Cancer statistics, 2013. CA Cancer J Clin 2013; 63: 11-30.
2. Costello E, Greenhalf W, Neoptolemos JP: New biomarkers and targets in pancreatic cancer and their application to treatment. Nat Rev Gastroenterol Hepatol 2012; 9: 435-444.
3. Stathis A, Moore MJ: Advanced pancreatic carcinoma: Current treatment and future challenges. Nat Rev Clin Oncol 2010; 7: 163-172.
4. Vincent A, Herman J, Schulick R, Hruban RH, Goggins M: Pancreatic cancer. Lancet 2011; 378: 607-620.
5. Brand R: The diagnosis of pancreatic cancer. Cancer J 2001; 7: 287-297.
6. Aksoy S, Szumlanski CL, Weinshilboum RM: Human liver nicotinamide N-methyltransferase cDNA cloning, expression, and biological characterization. J Biol Chem 1994; 269: 14835-14840.
7. Aksoy S, Brandriff BF, Ward A, Little PF, Weinshilboum RM: Human nicotinamide N-methyltransferase gene: Molecular cloning, structural characterization and chromosomal localization. Genomics 1995; 29: 555-561.
8. Markert JM, Fuller CM, Gillespie GY, Bubien JK, McLean LA, Hong RL, Lee K, Gullans SR, Mapstone TB, Benos DJ: Differential gene expression profiling in human brain tumors. Physiol Genomics 2001; 5: 21-33.
9. Okabe H, Satoh S, Kato T, Kitahara O, Yanagawa R, Yamaoka Y, Tsunoda T, Furukawa Y, Nakamura Y: Genome-wide analysis of gene expression in human hepatocellular carcinomas using cdna microarray: Identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res 2001; 61: 2129-2137.
10. Xu JM, Moatamed F, Caldwell JS, Walker JR, Kraiem Z, Taki K, Brent GA, Hershman JM: Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells. J Mol Endocrinol 2003; 88: 4990-4996.
11. Jang JS, Cho HY, Lee YJ, Ha WS, Kim HW: The differential proteome profile of stomach cancer: Identification of the biomarker candidates. Oncol Res 2004; 14: 491-499.
12. Yao M, Tabuchi H, Nagashima Y, Baba M, Nakaigawa N, Ishiguro H, Hamada K, Inayama Y, Kishida T, Hattori K, Yamada-Okabe H, Kubota Y: Gene expression analysis of renal carcinoma: Adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. J Pathol 2005; 205: 377-387.
13. Roessler M, Rollinger W, Palme S, Hagmann ML, Berndt P, Engel AM, Schneidinger B, Pfeffer M, Andres H, Karl J, Bodenmuller H, Ruschoff J, Henkel T, Rohr G, Rossol S, Rosch W, Langen H, Zolg W, Tacke M: Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Clin Cancer Res 2005; 11: 6550-6557.
14. Sartini D, Santarelli A, Rossi V, Goteri G, Rubini C, Ciavarella D, Lo Muzio L, Emanuelli M: Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma. Mol Med 2007; 13: 415-421.
15. Sartini D, Muzzonigro G, Milanese G, Pozzi V, Vici A, Morganti S, Rossi V, Mazzucchelli R, Montironi R, Emanuelli M: Upregulation of tissue and urinary nicotinamide N-methyltransferase in bladder cancer: Potential for the development of a urine-based diagnostic test. Cell Biochem Biophys 2013; 65: 473-483.
16. Sartini D, Morganti S, Guidi E, Rubini C, Zizzi A, Giuliante R, Pozzi V, Emanuelli M: Nicotinamide N-methyltransferase in non-small cell lung cancer: Promising results for targeted anti-cancer therapy. Cell Biochem Biophys 2013; 67: 865-873.
17. Win KT, Lee SW, Huang HY, Lin LC, Lin CY, Hsing CH, Chen LT, Li CF: Nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma. Tumour Biol 2013; 34: 3923-3931.
18. Iacobuzio-Donahue CA, Maitra A, Shen-Ong GL, van Heek T, Ashfaq R, Meyer R, Walter K, Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE, Goggins M, Hruban RH: Discovery of novel tumor markers of pancreatic cancer using global gene expression technology. Am J Pathol 2002; 160: 1239-1249.
19. Rogers CD, Fukushima N, Sato N, Shi C, Prasad N, Hustinx SR, Matsubayashi H, Canto M, Eshleman JR, Hruban RH, Goggins M: Differentiating pancreatic lesions by microarray and qPCR analysis of pancreatic juice rnas. Cancer Biol Ther 2006; 5: 1383-1389.
20. Bi HC, Pan YZ, Qiu JX, Krausz KW, Li F, Johnson CH, Jiang CT, Gonzalez FJ, Yu AM: N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291 altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. Carcinogenesis 2014; 35: 2264-2272.
21. Rini J, Szumlanski C, Guerciolini R, Weinshilboum RM: Human liver nicotinamide N-methyltransferase: Ion-pairing radiochemical assay, biochemical properties and individual variation. Clin Chim Acta 1990; 186: 359-374.
22. D'Andrea FP, Safwat A, Kassem M, Gautier L, Overgaard J, Horsman MR: Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance. Radiother Oncol, 2011. 99 (3): p. 373-8.
23. Parsons RB, Aravindan S, Kadampeswaran A: The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors. Biochem J, 2011. 436 (1): p. 145-55.
24. Thomas MG, Saldanha M, Mistry RJ, Dexter DT, Ramsden DB, Parsons RB: Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling. Cell Death Dis 2013; 4: e669.
25. Zhang J, Wang Y, Li G, Yu H, Xie X: Down-regulation of nicotinamide N-methyltransferase induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway. PLoS One 2014; 9; 2: e89202.
26. Wu Y, Siadaty MS, Berens ME, Hampton GM, Theodorescu D: Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration. Oncogene 2008; 27: 6679-6689.
27. Pozzi V, Mazzotta M, Lo Muzio L, Sartini D, Santarelli A, Renzi E, Rocchetti R, Tomasetti M, Ciavarella D, Emanuelli M: Inhibiting proliferation in KB cancer cells by RNA interference-mediated knockdown of nicotinamide N-methyltransferase expression. Int J Immunopathol Pharmacol 2011; 24: 69-77.
28. Tang SW, Yang TC, Lin WC, Chang WH, Wang CC, Lai MK, Lin JY: Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells. Carcinogenesis 2011; 32: 138-145.
29. Hanahan D, Weinberg RA: Hallmarks of cancer: The next generation. Cell 2011; 144: 646-674.
30. Neesse A, Michl P, Frese KK, Feig C, Cook N, Jacobetz MA, Lolkema MP, Buchholz M, Olive KP, Gress TM, Tuveson DA: Stromal biology and therapy in pancreatic cancer. Gut 2011; 60: 861-868.
31. Dang CV: Links between metabolism and cancer. Genes Dev 2012; 26: 877-890.
32. Papetti M, Herman IM: Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol Cell Physiol 2002; 282: C947-C970.
33. Anderson ARA, Weaver AM, Cummings PT, Quaranta V: Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 2006; 127: 905-915.
34. Gao M, Liang J, Lu Y, Guo H, German P, Bai S, Jonasch E, Yang X, Mills GB, Ding Z: Site-specific activation of Akt protects cells from death induced by glucose deprivation. Oncogene 2014; 33: 745-755.
35. Chin YR, Toker A: Function of Akt/Pkb signaling to cell motility, invasion and the tumor stroma in cancer. Cell Signal 2009; 21: 470-476.
36. Manning BD, Cantley LC: Akt/Pkb signaling: Navigating downstream. Cell 2007; 129: 1261-1274.
37. Izuishi K, Kato K, Ogura T, Kinoshita T, Esumi H: Remarkable tolerance of tumor cells to nutrient deprivation: Possible new biochemical target for cancer therapy. Cancer Res 2000; 60: 6201-6207.
38. Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK, Testa JR: Amplification of Akt2 in human pancreatic cancer cells and inhibition of Akt2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci U S A 1996; 93: 3636-3641.