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Volumn 16, Issue 1, 2015, Pages 19-26

Melatonin therapy for REM sleep behavior disorder: A critical review of evidence

Author keywords

Calmodulin; Drug therapy; Melatonin; Parasomnia; REM sleep behavior disorder

Indexed keywords

CLONAZEPAM; MELATONIN; PLACEBO; CENTRAL DEPRESSANT AGENT;

EID: 84921325608     PISSN: 13899457     EISSN: 18785506     Source Type: Journal    
DOI: 10.1016/j.sleep.2014.09.011     Document Type: Review
Times cited : (138)

References (63)
  • 1
    • 84872182043 scopus 로고    scopus 로고
    • The parasomnias: mechanisms and treatment
    • Tinuper P., Bisulli F., Provini F. The parasomnias: mechanisms and treatment. Epilepsia 2012, 53(Suppl. 7):12-19. 10.1111/j.1528-1167.2012.03710.x.
    • (2012) Epilepsia , vol.53 , pp. 12-19
    • Tinuper, P.1    Bisulli, F.2    Provini, F.3
  • 2
    • 77949903007 scopus 로고    scopus 로고
    • REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions
    • Boeve B.F. REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci 2010, 1184:15-54. 10.1111/j.1749-6632.2009.05115.x.
    • (2010) Ann N Y Acad Sci , vol.1184 , pp. 15-54
    • Boeve, B.F.1
  • 3
    • 84881545339 scopus 로고    scopus 로고
    • New aspects in the pathophysiology of rapid eye movement sleep behavior disorder: the potential role of glutamate, gamma-aminobutyric acid, and glycine
    • Luppi P.H., Clément O., Valencia Garcia S., Brischoux F., Fort P. New aspects in the pathophysiology of rapid eye movement sleep behavior disorder: the potential role of glutamate, gamma-aminobutyric acid, and glycine. Sleep Med 2013, 14(8):714-718.
    • (2013) Sleep Med , vol.14 , Issue.8 , pp. 714-718
    • Luppi, P.H.1    Clément, O.2    Valencia Garcia, S.3    Brischoux, F.4    Fort, P.5
  • 5
    • 0033984647 scopus 로고    scopus 로고
    • Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases
    • Olson E.J., Boeve B.F., Silber M.H. Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. Brain 2000, 123(Pt 2):331-339.
    • (2000) Brain , vol.123 , pp. 331-339
    • Olson, E.J.1    Boeve, B.F.2    Silber, M.H.3
  • 7
    • 0027135613 scopus 로고
    • REM sleep behavior disorder: an update on a series of 96 patients and a review of the world literature
    • Schenck C., Hurwitz T., Mahowald M. REM sleep behavior disorder: an update on a series of 96 patients and a review of the world literature. J Sleep Res 1993, 2:224-231.
    • (1993) J Sleep Res , vol.2 , pp. 224-231
    • Schenck, C.1    Hurwitz, T.2    Mahowald, M.3
  • 8
    • 0024420686 scopus 로고
    • A polysomnographic and clinical report on sleep-related injury in 100 adult patients
    • Schenck C.H., Milner D.M., Hurwitz T.D., Bundlie S.R., Mahowald M.W. A polysomnographic and clinical report on sleep-related injury in 100 adult patients. Am J Psychiatry 1989, 146(9):1166-1173.
    • (1989) Am J Psychiatry , vol.146 , Issue.9 , pp. 1166-1173
    • Schenck, C.H.1    Milner, D.M.2    Hurwitz, T.D.3    Bundlie, S.R.4    Mahowald, M.W.5
  • 9
    • 0008602728 scopus 로고
    • REM behavior disorder causing bilateral subdural hematomas [abstract]
    • Gross P.T. REM behavior disorder causing bilateral subdural hematomas [abstract]. Sleep Res 1992, 21:204.
    • (1992) Sleep Res , vol.21 , pp. 204
    • Gross, P.T.1
  • 10
    • 0028930644 scopus 로고
    • Violent sleep-related behavior leading to subdural hemorrhage
    • Dyken M.E., Lin-Dyken D.C., Seaba P., Yamada T. Violent sleep-related behavior leading to subdural hemorrhage. Arch Neurol 1995, 52(3):318-321.
    • (1995) Arch Neurol , vol.52 , Issue.3 , pp. 318-321
    • Dyken, M.E.1    Lin-Dyken, D.C.2    Seaba, P.3    Yamada, T.4
  • 11
    • 84861234367 scopus 로고    scopus 로고
    • REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease
    • McCarter S.J., St Louis E.K., Boeve B.F. REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease. Curr Neurol Neurosci Rep 2012, 12:182-192.
    • (2012) Curr Neurol Neurosci Rep , vol.12 , pp. 182-192
    • McCarter, S.J.1    St Louis, E.K.2    Boeve, B.F.3
  • 12
    • 85047682144 scopus 로고    scopus 로고
    • Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder
    • Postuma R.B., Gagnon J.F., Vendette M., et al. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 2009, 72:1296-1301.
    • (2009) Neurology , vol.72 , pp. 1296-1301
    • Postuma, R.B.1    Gagnon, J.F.2    Vendette, M.3
  • 13
    • 84881546787 scopus 로고    scopus 로고
    • Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder
    • Boeve B.F., Silber M.H., Ferman T.J., et al. Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder. Sleep Med 2013, 14:754-762.
    • (2013) Sleep Med , vol.14 , pp. 754-762
    • Boeve, B.F.1    Silber, M.H.2    Ferman, T.J.3
  • 14
    • 84881553335 scopus 로고    scopus 로고
    • Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series
    • Schenck C.H., Boeve B.F., Mahowald M.W. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med 2013, 14:744-748.
    • (2013) Sleep Med , vol.14 , pp. 744-748
    • Schenck, C.H.1    Boeve, B.F.2    Mahowald, M.W.3
  • 15
    • 84862907599 scopus 로고    scopus 로고
    • Probable REM sleep behavior disorder increases risk for mild cognitive impairment and Parkinson's disease: a population-based study
    • Boot B.P., Boeve B.F., Roberts R.O., et al. Probable REM sleep behavior disorder increases risk for mild cognitive impairment and Parkinson's disease: a population-based study. Ann Neurol 2012, 71:49-56.
    • (2012) Ann Neurol , vol.71 , pp. 49-56
    • Boot, B.P.1    Boeve, B.F.2    Roberts, R.O.3
  • 17
    • 84868026844 scopus 로고    scopus 로고
    • Parasomnias: an updated review
    • Howell M.J. Parasomnias: an updated review. Neurother 2012, 9(4):753-775. 10.1007/s13311-012-0143-8.
    • (2012) Neurother , vol.9 , Issue.4 , pp. 753-775
    • Howell, M.J.1
  • 18
    • 84887123703 scopus 로고    scopus 로고
    • Antidepressants and REM sleep behavior disorder: isolated side effect or neurodegenerative signal?
    • Postuma R.B., Gagnon J.F., Tuineaig M., Bertrand J.A., Latreille V., Desjardins C., et al. Antidepressants and REM sleep behavior disorder: isolated side effect or neurodegenerative signal?. Sleep 2013, 36(11):1579-1585.
    • (2013) Sleep , vol.36 , Issue.11 , pp. 1579-1585
    • Postuma, R.B.1    Gagnon, J.F.2    Tuineaig, M.3    Bertrand, J.A.4    Latreille, V.5    Desjardins, C.6
  • 19
    • 35748939082 scopus 로고    scopus 로고
    • Rapid eye movement sleep behavior disorder
    • Gugger J.J., Wagner M.L. Rapid eye movement sleep behavior disorder. Ann Pharmacother 2007, 41:1833-1841.
    • (2007) Ann Pharmacother , vol.41 , pp. 1833-1841
    • Gugger, J.J.1    Wagner, M.L.2
  • 20
    • 77749245945 scopus 로고    scopus 로고
    • Best practice guide for the treatment of REM sleep behavior disorder (RBD)
    • Aurora R.N., Zak R.S., Maganti R.K., et al. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med 2010, 6(1):85-95.
    • (2010) J Clin Sleep Med , vol.6 , Issue.1 , pp. 85-95
    • Aurora, R.N.1    Zak, R.S.2    Maganti, R.K.3
  • 21
    • 84874262357 scopus 로고    scopus 로고
    • Treatment outcomes in REM sleep behavior disorder
    • McCarter S.J., Boswell C.L., St Louis E.K., et al. Treatment outcomes in REM sleep behavior disorder. Sleep Med 2013, 14(3):237-242. 10.1016/j.sleep.2012.09.018.
    • (2013) Sleep Med , vol.14 , Issue.3 , pp. 237-242
    • McCarter, S.J.1    Boswell, C.L.2    St Louis, E.K.3
  • 22
    • 0030830445 scopus 로고    scopus 로고
    • Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations
    • Kunz D., Bes F. Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations. Neuropsychobiology 1997, 36:211-214.
    • (1997) Neuropsychobiology , vol.36 , pp. 211-214
    • Kunz, D.1    Bes, F.2
  • 23
    • 0041562707 scopus 로고    scopus 로고
    • Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients
    • Boeve B.F., Silber M.H., Ferman T.J. Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep Med 2003, 4(4):281-284. 10.1016/S1389-9457(03)00072-8.
    • (2003) Sleep Med , vol.4 , Issue.4 , pp. 281-284
    • Boeve, B.F.1    Silber, M.H.2    Ferman, T.J.3
  • 24
    • 0031021914 scopus 로고    scopus 로고
    • Melatonin in humans
    • Brzezinski A. Melatonin in humans. N Engl J Med 1997, 336:186-195.
    • (1997) N Engl J Med , vol.336 , pp. 186-195
    • Brzezinski, A.1
  • 25
    • 0027205307 scopus 로고
    • The effect of evening bright light in delaying the circadian rhythms and lengthening the sleep of early morning awakening insomniacs
    • Lack L., Wright H. The effect of evening bright light in delaying the circadian rhythms and lengthening the sleep of early morning awakening insomniacs. Sleep 1993, 16(5):436-443.
    • (1993) Sleep , vol.16 , Issue.5 , pp. 436-443
    • Lack, L.1    Wright, H.2
  • 26
    • 0032777392 scopus 로고    scopus 로고
    • A new concept for melatonin deficit: on pineal calcification and melatonin excretion
    • Kunz D., Schmitz S., Mahlberg R., Mohr A., Stöter C., Wolf K.J., et al. A new concept for melatonin deficit: on pineal calcification and melatonin excretion. Neuropsychopharmacology 1999, 21:756-772.
    • (1999) Neuropsychopharmacology , vol.21 , pp. 756-772
    • Kunz, D.1    Schmitz, S.2    Mahlberg, R.3    Mohr, A.4    Stöter, C.5    Wolf, K.J.6
  • 27
    • 35649003870 scopus 로고    scopus 로고
    • Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake
    • Zeitzer J.M., Duffy J.F., Lockley S.W., Dijk D.J., Czeisler C.A. Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake. Sleep 2007, 30(11):1437-1443.
    • (2007) Sleep , vol.30 , Issue.11 , pp. 1437-1443
    • Zeitzer, J.M.1    Duffy, J.F.2    Lockley, S.W.3    Dijk, D.J.4    Czeisler, C.A.5
  • 28
    • 0020436536 scopus 로고
    • Age-dependent reduction in serum melatonin concentrations in healthy human subjects
    • Iguichi H., Kato K.I., Ibayashi H. Age-dependent reduction in serum melatonin concentrations in healthy human subjects. J Clin Endocrinol Metab 1982, 55(1):27-29.
    • (1982) J Clin Endocrinol Metab , vol.55 , Issue.1 , pp. 27-29
    • Iguichi, H.1    Kato, K.I.2    Ibayashi, H.3
  • 29
    • 0028202804 scopus 로고
    • Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance
    • Dollins A.B., Zhdanova I.V., Wurtman R.J., Lynch H.J., Deng M.H. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci U S A 1994, 91(5):1824-1828.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.5 , pp. 1824-1828
    • Dollins, A.B.1    Zhdanova, I.V.2    Wurtman, R.J.3    Lynch, H.J.4    Deng, M.H.5
  • 30
    • 77958521416 scopus 로고    scopus 로고
    • A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder
    • Kunz D., Mahlberg R. A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder. J Sleep Res 2010, 19(4):591-596. 10.1111/j.1365-2869.2010.00848.x.
    • (2010) J Sleep Res , vol.19 , Issue.4 , pp. 591-596
    • Kunz, D.1    Mahlberg, R.2
  • 31
    • 0033430105 scopus 로고    scopus 로고
    • Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation
    • Kunz D., Bes F. Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation. Mov Disord 1999, 14(3):507-511.
    • (1999) Mov Disord , vol.14 , Issue.3 , pp. 507-511
    • Kunz, D.1    Bes, F.2
  • 32
    • 0034979639 scopus 로고    scopus 로고
    • Melatonin therapy for REM sleep behavior disorder
    • Takeuchi N., Uchimura N., Hashizume Y., et al. Melatonin therapy for REM sleep behavior disorder. Psychiatry Clin Neurosci 2001, 55(3):267-269. 10.1046/j.1440-1819.2001.00854.x.
    • (2001) Psychiatry Clin Neurosci , vol.55 , Issue.3 , pp. 267-269
    • Takeuchi, N.1    Uchimura, N.2    Hashizume, Y.3
  • 34
    • 84881550009 scopus 로고    scopus 로고
    • Melatonin in rapid eye movement sleep behavior disorder: why does it work?
    • Kunz D. Melatonin in rapid eye movement sleep behavior disorder: why does it work?. Sleep Med 2013, 14(8):705-706. 10.1016/j.sleep.2013.05.004.
    • (2013) Sleep Med , vol.14 , Issue.8 , pp. 705-706
    • Kunz, D.1
  • 35
    • 39749146383 scopus 로고    scopus 로고
    • A systematic review of prevalence studies of depression in Parkinson's disease
    • quiz 313
    • Reijnders J.S., Ehrt U., Weber W.E., Aarsland D., Leentjens A.F. A systematic review of prevalence studies of depression in Parkinson's disease. Mov Disord 2008, 23(2):183-189. quiz 313. 10.1002/mds.21803.
    • (2008) Mov Disord , vol.23 , Issue.2 , pp. 183-189
    • Reijnders, J.S.1    Ehrt, U.2    Weber, W.E.3    Aarsland, D.4    Leentjens, A.F.5
  • 36
    • 0037174346 scopus 로고    scopus 로고
    • Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study
    • Lyketsos C.G., Lopez O., Jones B., Fitzpatrick A.L., Breitner J., DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA 2002, 288(12):1475-1483.
    • (2002) JAMA , vol.288 , Issue.12 , pp. 1475-1483
    • Lyketsos, C.G.1    Lopez, O.2    Jones, B.3    Fitzpatrick, A.L.4    Breitner, J.5    DeKosky, S.6
  • 37
    • 3242743861 scopus 로고    scopus 로고
    • Serotonergic antidepressants are associated with REM sleep without atonia
    • Winkelman J.W., James L. Serotonergic antidepressants are associated with REM sleep without atonia. Sleep 2004, 27(2):317-321.
    • (2004) Sleep , vol.27 , Issue.2 , pp. 317-321
    • Winkelman, J.W.1    James, L.2
  • 38
    • 0033791313 scopus 로고    scopus 로고
    • Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment
    • Seabra M.L., Bignotto M., Pinto L.R., Tufik S. Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. J Pineal Res 2000, 29(4):193-200.
    • (2000) J Pineal Res , vol.29 , Issue.4 , pp. 193-200
    • Seabra, M.L.1    Bignotto, M.2    Pinto, L.R.3    Tufik, S.4
  • 40
    • 0842291463 scopus 로고    scopus 로고
    • Melatonin in patients with reduced REM sleep duration: two randomized controlled trials
    • Kunz D., Mahlberg R., Muller C., Tilmann A., Bes F., et al. Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. J Clin Endocrinol Metab 2004, 89(1):128-134.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.1 , pp. 128-134
    • Kunz, D.1    Mahlberg, R.2    Muller, C.3    Tilmann, A.4    Bes, F.5
  • 42
    • 79956315960 scopus 로고    scopus 로고
    • Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice
    • Brooks P.L., Peever J.H. Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice. J Neurosci 2011, 31(19):7111-7121.
    • (2011) J Neurosci , vol.31 , Issue.19 , pp. 7111-7121
    • Brooks, P.L.1    Peever, J.H.2
  • 43
    • 50849149031 scopus 로고
    • A pharmacological model of paradoxical sleep: the role of cholinergic and monoamine systems
    • Karczmar A.G., Longo V.G., Scotti de Carolis A. A pharmacological model of paradoxical sleep: the role of cholinergic and monoamine systems. Physiol Behav 1970, 5:175-182.
    • (1970) Physiol Behav , vol.5 , pp. 175-182
    • Karczmar, A.G.1    Longo, V.G.2    Scotti de Carolis, A.3
  • 44
    • 0021592476 scopus 로고
    • Editorial: Rapid Eye Movement (REM) sleep: cholinergic mechanisms
    • Gillin C.J., Sitaram N. Editorial: Rapid Eye Movement (REM) sleep: cholinergic mechanisms. Psychol Med 1984, 14:501-506.
    • (1984) Psychol Med , vol.14 , pp. 501-506
    • Gillin, C.J.1    Sitaram, N.2
  • 45
    • 0001023977 scopus 로고
    • Some behavioral changes in man following anticholinesterase administration
    • Bowers M.B., Goodman E., Sim V.M. Some behavioral changes in man following anticholinesterase administration. Journal of Nervous and Mental Disease 1964, 138:383-389.
    • (1964) Journal of Nervous and Mental Disease , vol.138 , pp. 383-389
    • Bowers, M.B.1    Goodman, E.2    Sim, V.M.3
  • 46
    • 0034718528 scopus 로고    scopus 로고
    • Treatment of REM sleep behavior disorder with donepezil: a report of three cases
    • Ringman J., Simmons J. Treatment of REM sleep behavior disorder with donepezil: a report of three cases. Neurology 2000, 55:870-871.
    • (2000) Neurology , vol.55 , pp. 870-871
    • Ringman, J.1    Simmons, J.2
  • 48
    • 77952958874 scopus 로고    scopus 로고
    • Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs?
    • Markus R.P., Silva C.L.M., Franco D.G., Barbosa E.M., Ferreira Z.S. Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs?. Pharmacol Therapeut 2010, 126:251-262. 10.1016/j.pharmthera.2010.02.009.
    • (2010) Pharmacol Therapeut , vol.126 , pp. 251-262
    • Markus, R.P.1    Silva, C.L.M.2    Franco, D.G.3    Barbosa, E.M.4    Ferreira, Z.S.5
  • 49
    • 33644920991 scopus 로고    scopus 로고
    • Melatonin as a cytoskeletal modulator: implications for cell physiology and disease
    • Benitez-King G. Melatonin as a cytoskeletal modulator: implications for cell physiology and disease. J Pineal Res 2006, 40:1-9.
    • (2006) J Pineal Res , vol.40 , pp. 1-9
    • Benitez-King, G.1
  • 50
    • 0036446013 scopus 로고    scopus 로고
    • The reactivity of serotonin, acetylcholine and KCL-induced contractions to relaxant agents in the rat gastric fundus
    • Buharalioglu C.K., Akar F. The reactivity of serotonin, acetylcholine and KCL-induced contractions to relaxant agents in the rat gastric fundus. Pharmacol Res 2002, 45:325-331. 10.1006/phrs.2002.0950.
    • (2002) Pharmacol Res , vol.45 , pp. 325-331
    • Buharalioglu, C.K.1    Akar, F.2
  • 51
    • 78349244423 scopus 로고    scopus 로고
    • Serotonin induced contraction in isolated intestine from a teleost fish (Carassius auratus): characterization and interactions with melatonin
    • Velarde E., Delgado M.J., Alonso-Gomez A.L. Serotonin induced contraction in isolated intestine from a teleost fish (Carassius auratus): characterization and interactions with melatonin. Neurogastroenterol Motil 2010, 22:364-373. 10.1111/j.1365-2982.2010.01605.x.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 364-373
    • Velarde, E.1    Delgado, M.J.2    Alonso-Gomez, A.L.3
  • 52
    • 0030661684 scopus 로고    scopus 로고
    • Attenuation of serotonin-induced contractures in skeletal muscle from malignant hyperthermia-susceptible patients with dantrolene
    • Wappler F., Scholz J., von Richthofen V., Fiege M., Kochling A., Lambrecht W., et al. Attenuation of serotonin-induced contractures in skeletal muscle from malignant hyperthermia-susceptible patients with dantrolene. Acta Anaesthesiol Scand 1997, 41:1312-1318.
    • (1997) Acta Anaesthesiol Scand , vol.41 , pp. 1312-1318
    • Wappler, F.1    Scholz, J.2    von Richthofen, V.3    Fiege, M.4    Kochling, A.5    Lambrecht, W.6
  • 53
    • 51449124059 scopus 로고    scopus 로고
    • Agomelatine: a novel mechanism of antidepressant action involving the melatonergic and the serotonergic system
    • San L., Arranz B. Agomelatine: a novel mechanism of antidepressant action involving the melatonergic and the serotonergic system. Eur Psychiatry 2008, 6:396-402.
    • (2008) Eur Psychiatry , vol.6 , pp. 396-402
    • San, L.1    Arranz, B.2
  • 55
    • 84884303547 scopus 로고    scopus 로고
    • Use of ramelteon for the treatment of secondary REM sleep behavior disorder
    • Nomura T., Kawase S., Watanabe Y., Nakashima K. Use of ramelteon for the treatment of secondary REM sleep behavior disorder. Intern Med 2013, 52:2123-2126. 10.2169/internalmedicine.52.9179.
    • (2013) Intern Med , vol.52 , pp. 2123-2126
    • Nomura, T.1    Kawase, S.2    Watanabe, Y.3    Nakashima, K.4
  • 56
    • 84859857179 scopus 로고    scopus 로고
    • American geriatrics society updated beers criteria for potentially inappropriate medication use in older adults
    • Fick D., Semla T., Beizer J., et al. American geriatrics society updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012, 60(4):616-631. 10.1111/j.1532-5415.2012.03923.x.
    • (2012) J Am Geriatr Soc , vol.60 , Issue.4 , pp. 616-631
    • Fick, D.1    Semla, T.2    Beizer, J.3
  • 57
    • 67650499599 scopus 로고    scopus 로고
    • Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam
    • Anderson K.N., Shneerson J.M. Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam. J Clin Sleep Med 2009, 5(3):235-239.
    • (2009) J Clin Sleep Med , vol.5 , Issue.3 , pp. 235-239
    • Anderson, K.N.1    Shneerson, J.M.2
  • 58
    • 70349662030 scopus 로고    scopus 로고
    • Truly "rational" polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects
    • St Louis E.K. Truly "rational" polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects. Curr Neuropharmacol 2009, 7(2):96-105.
    • (2009) Curr Neuropharmacol , vol.7 , Issue.2 , pp. 96-105
    • St Louis, E.K.1
  • 59
    • 77954693445 scopus 로고    scopus 로고
    • Gait and balance disorders in older adults
    • Salzman B. Gait and balance disorders in older adults. Am Fam Physician 2010, 82(1):61-68.
    • (2010) Am Fam Physician , vol.82 , Issue.1 , pp. 61-68
    • Salzman, B.1
  • 60
    • 0028001746 scopus 로고
    • The pathogenesis of gait hypokinesia in Parkinsons-disease
    • Morris M.E., Iansek R., Matyas T.A., Summers J.J. The pathogenesis of gait hypokinesia in Parkinsons-disease. Brain 1994, 117:1169-1181. 10.1093/brain/117.5.1169.
    • (1994) Brain , vol.117 , pp. 1169-1181
    • Morris, M.E.1    Iansek, R.2    Matyas, T.A.3    Summers, J.J.4
  • 61
    • 84921413418 scopus 로고    scopus 로고
    • Genentech USA, Inc, San Francisco, CA
    • Klonapin® [package insert] 2013, Genentech USA, Inc, San Francisco, CA.
    • (2013)
  • 62
    • 84921413417 scopus 로고    scopus 로고
    • title 21, [Internet]. FDA website, [Published 7.2.14. Updated 9.1.14. Accessed 10.28.14.].
    • Code of federal regulation, title 21, volume 9 [Internet]. FDA website, [Published 7.2.14. Updated 9.1.14. Accessed 10.28.14.]. http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=1308.14.
    • , vol.9
  • 63
    • 84881548028 scopus 로고    scopus 로고
    • Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy-a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group
    • Schenck C.H., Montplaisir J.Y., Frauscher B., et al. Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy-a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group. Sleep Med 2013, 14(8):795-806. 10.1016/j.sleep.2013.02.016.
    • (2013) Sleep Med , vol.14 , Issue.8 , pp. 795-806
    • Schenck, C.H.1    Montplaisir, J.Y.2    Frauscher, B.3


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