New aspects in the pathophysiology of rapid eye movement sleep behavior disorder: The potential role of glutamate, gamma-aminobutyric acid, and glycine

Sleep Medicine

Volumn 14, Issue 8, 2013, Pages 714-718

  Luppi, Pierre Hervé ^a,b,c,d,e   Clément, Olivier ^a,b,c,d,e   Valencia Garcia, Sara ^a,b,c,d,e   Brischoux, Frédéric ^a,b,c,d,e   Fort, Patrice ^a,b,c,d,e  

^a INSERM   (France)

^b CNRS   (France)

^c LYON NEUROSCIENCE RESEARCH CENTER   (France)

^d UNIVERSITÉ DE LYON   (France)

^e UNIVERSITÉ LYON 1   (France)

Author keywords

Brainstem; GABA; Glycine; Motor cortex; Muscle twitches; Parkinson

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CLONAZEPAM; FLUOXETINE; GLUTAMIC ACID; GLYCINE; IMIPRAMINE; MELATONIN; MIRTAZAPINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRICYCLIC ANTIDEPRESSANT AGENT;

DRUG MECHANISM; GABAERGIC TRANSMISSION; HUMAN; MOTONEURON; MOTOR CORTEX; MUSCLE ATONIA; MUSCLE CONTRACTION; NERVE CELL DEGENERATION; NEUROTRANSMISSION; NONHUMAN; PARASOMNIA; PARKINSON DISEASE; PATHOPHYSIOLOGY; PONS; PRIORITY JOURNAL; REM SLEEP; REVIEW; RISK FACTOR; SUBLATERODORSAL TEGMENTAL NUCLEUS;

BRAINSTEM; GABA; GLYCINE; MOTOR CORTEX; MUSCLE TWITCHES; PARKINSON;

ANIMALS; BRAIN STEM; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GLYCINE; HUMANS; MOTOR CORTEX; REM SLEEP BEHAVIOR DISORDER;

EID: 84881545339     PISSN: 13899457     EISSN: 18785506     Source Type: Journal    
DOI: 10.1016/j.sleep.2013.02.004     Document Type: Review

References (63)

1. Schenck C.H., Bundlie S.R., Ettinger M.G., Mahowald M.W. Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep 1986, 9:293-308.
2. Iranzo A., Santamaria J., Tolosa E. The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases. Sleep Med Rev 2009, 13:385-401.
3. Thomas A., Bonanni L., Onofrj M. Symptomatic REM sleep behaviour disorder. Neurol Sci 2007, 28(Suppl. 1):S21-S36.
4. Lapierre O., Montplaisir J. Polysomnographic features of REM sleep behavior disorder: development of a scoring method. Neurology 1992, 42:1371-1374.
5. Anderson K.N., Shneerson J.M. Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam. J Clin Sleep Med 2009, 5:235-239.
6. Aserinsky E., Kleitman N. Regularly occurring periods of eye motility and concomitant phenomena during sleep. Science 1953, 118:273-274.
7. Dement W., Kleitman N. The relation of eye movements during sleep to dream activity: an objective method for the study of dreaming. J Exp Psychol 1957, 53:339-346.
8. Jouvet M., Michel F. Corrélations électromyographiques du sommeil chez le chat décortiqué et mésencéphalique chronique. C R Soc Biol 1959, 153:422-425.
9. Jouvet M., Michel F., Courjon J. Sur un stade d'activité électrique cérébrale rapide au cours du sommeil physiologique. C R Seances Soc Biol 1959, 153:1024-1028.
10. Chase M.H., Soja P.J., Morales F.R. Evidence that glycine mediates the postsynaptic potentials that inhibit lumbar motoneurons during the atonia of active sleep. J Neurosci 1989, 9:743-751.
11. Soja P.J., Lopez-Rodriguez F., Morales F.R., Chase M.H. The postsynaptic inhibitory control of lumbar motoneurons during the atonia of active sleep: effect of strychnine on motoneuron properties. J Neurosci 1991, 11:2804-2811.
12. Yamuy J., Fung S.J., Xi M., Morales F.R., Chase M.H. Hypoglossal motoneurons are postsynaptically inhibited during carbachol-induced rapid eye movement sleep. Neuroscience 1999, 94:11-15.
13. Kodama T., Lai Y.Y., Siegel J.M. Changes in inhibitory amino acid release linked to pontine-induced atonia: an in vivo microdialysis study. J Neurosci 2003, 23:1548-1554.
14. Brooks P.L., Peever J.H. Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis. J Neurosci 2012, 32:9785-9795.
15. Brooks P.L., Peever J.H. Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice. J Neurosci 2011, 31:7111-7121. [published online ahead of print May 13, 2011].
16. Chase M.H., Morales F.R. The atonia and myoclonia of active (REM) sleep. Annu Rev Psychol 1990, 41:557-584.
17. Burgess C., Lai D., Siegel J., Peever J. An endogenous glutamatergic drive onto somatic motoneurons contributes to the stereotypical pattern of muscle tone across the sleep-wake cycle. J Neurosci 2008, 28:4649-4660.
18. Lai Y.Y., Kodama T., Siegel J.M. Changes in monoamine release in the ventral horn and hypoglossal nucleus linked to pontine inhibition of muscle tone: an in vivo microdialysis study. J Neurosci 2001, 21:7384-7391.
19. Jelev A., Sood S., Liu H., Nolan P., Horner R.L. Microdialysis perfusion of 5-HT into hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep-wake states in rats. J Physiol 2001, 532(Pt. 2):467-481.
20. Fenik V.B., Davies R.O., Kubin L. REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs. Am J Respir Crit Care Med 2005, 172:1322-1330.
21. Neuzeret P.C., Sakai K., Gormand F., Petitjean T., Buda C., Sastre J.P., et al. Application of histamine or serotonin to the hypoglossal nucleus increases genioglossus muscle activity across the wake-sleep cycle. J Sleep Res 2009, 18:113-121.
22. Krenzer M., Anaclet C., Vetrivelan R., Wang N., Vong L., Lowell B.B., et al. Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia. PLoS ONE 2011, 6:e24998.
23. Holstege J.C., Bongers C.M. A glycinergic projection from the ventromedial lower brainstem to spinal motoneurons. An ultrastructural double labeling study in rat. Brain Res 1991, 566:308-315.
24. Kato G., Yasaka T., Katafuchi T., Furue H., Mizuno M., Iwamoto Y., et al. Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J Neurosci 2006, 26:1787-1794.
25. Holmes C.J., Jones B.E. Importance of cholinergic, GABAergic, serotonergic and other neurons in the medial medullary reticular formation for sleep-wake states studied by cytotoxic lesions in the cat. Neuroscience 1994, 62:1179-1200.
26. Schenkel E., Siegel J.M. REM sleep without atonia after lesions of the medial medulla. Neurosci Lett 1989, 98:159-165.
27. Sapin E., Lapray D., Berod A., Goutagny R., Leger L., Ravassard P., et al. Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep. PLoS ONE 2009, 4:e4272.
28. Kanamori N., Sakai K., Jouvet M. Neuronal activity specific to paradoxical sleep in the ventromedial medullary reticular formation of unresdrained cats. Brain Res 1980, 189:251-255.
29. Lu J., Sherman D., Devor M., Saper C.B. A putative flip-flop switch for control of REM sleep. Nature 2006, 441:589-594.
30. Vetrivelan R., Fuller P.M., Tong Q., Lu J. Medullary circuitry regulating rapid eye movement sleep and motor atonia. J Neurosci 2009, 29:9361-9369.
31. Jouvet M. The paradoxical phase of sleep. Int J Neurol 1965, 5:131-150. [in French].
32. Hendricks J.C., Morrison A.R., Mann G.L. Different behaviors during paradoxical sleep without atonia depend on pontine lesion site. Brain Res 1982, 239:81-105.
33. Henley K., Morrison A.R. A re-evaluation of the effects of lesions of the pontine tegmentum and locus coeruleus on phenomena of paradoxical sleep in the cat. Acta Neurobiol Exp (Warsz) 1974, 34:215-232.
34. Sastre J.P., Jouvet M. Le comportement onirique du chat [Oneiric behavior in cats]. Physiol Behav 1979, 22:979-989.
35. Jouvet M. Recherches sur les structures nerveuses et les mécanismes responsables des différentes phases du sommeil physiologique. Arch Ital Biol 1962, 100:125-206.
36. Webster H.H., Jones B.E. Neurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-cholinergic cell area in the cat. II. Effects upon sleep-waking states. Brain Res 1988, 458:285-302.
37. Sakai K. Neurons responsible for paradoxical sleep. Sleep: neurotransmitters and neuromodulators 1985, 29-42. Raven Press, New York. A. Wauquier, Janssen Research Foundation (Eds.).
38. Sakai K., Koyama Y. Are there cholinergic and non-cholinergic paradoxical sleep-on neurones in the pons?. NeuroReport 1996, 7:2449-2453.
39. Sakai K., Crochet S., Onoe H. Pontine structures and mechanisms involved in the generation of paradoxical (REM) sleep. Arch Ital Biol 2001, 139:93-107.
40. Luppi P.H., Sakai K., Fort P., Salvert D., Jouvet M. The nuclei of origin of monoaminergic, peptidergic, and cholinergic afferents to the cat nucleus reticularis magnocellularis: a double-labeling study with cholera toxin as a retrograde tracer. J Comp Neurol 1988, 277:1-20.
41. Fort P., Luppi P.H., Wenthold R., Jouvet M. Glycine immunoreactive neurons in the medulla oblongata in cats. C R Acad Sci III 1990, 311:205-212. [in French].
42. Fort P., Luppi P.H., Jouvet M. Glycine-immunoreactive neurones in the cat brain stem reticular formation. NeuroReport 1993, 4:1123-1126.
43. Fort P., Bassetti C.L., Luppi P.H. Alternating vigilance states: new insights regarding neuronal networks and mechanisms. Eur J Neurosci 2009, 29:1741-1753.
44. Verret L., Léger L., Fort P., Luppi P.H. Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recovery. Eur J Neurosci 2005, 21:2488-2504.
45. Boissard R., Gervasoni D., Schmidt M.H., Barbagli B., Fort P., Luppi P.H. The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study. Eur J Neurosci 2002, 16:1959-1973.
46. Clement O., Sapin E., Berod A., Fort P., Luppi P.H. Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic. Sleep 2011, 34:419-423.
47. Pollock M.S., Mistlberger R.E. Rapid eye movement sleep induction by microinjection of the GABA-A antagonist bicuculline into the dorsal subcoeruleus area of the rat. Brain Res 2003, 962:68-77.
48. Sanford L.D., Tang X., Xiao J., Ross R.J., Morrison A.R. GABAergic regulation of REM sleep in reticularis pontis oralis and caudalis in rats. J Neurophysiol 2003, 90:938-945.
49. Xi M.C., Morales F.R., Chase M.H. Evidence that wakefulness and REM sleep are controlled by a GABAergic pontine mechanism. J Neurophysiol 1999, 82:2015-2019.
50. Xi M.C., Morales F.R., Chase M.H. The motor inhibitory system operating during active sleep is tonically suppressed by GABAergic mechanisms during other states. J Neurophysiol 2001, 86:1908-1915.
51. Onoe H., Sakai K. Kainate receptors: a novel mechanism in paradoxical (REM) sleep generation. NeuroReport 1995, 6:353-356.
52. Kodama T., Lai Y.Y., Siegel J.M. Enhanced glutamate release during REM sleep in the rostromedial medulla as measured by in vivo microdialysis. Brain Res 1998, 780:178-181.
53. Lai Y.Y., Siegel J.M. Pontomedullary glutamate receptors mediating locomotion and muscle tone suppression. J Neurosci 1991, 11:2931-2937.
54. Mahowald M.W., Schenck C.H. REM sleep behavior disorder. Principles and practice of sleep medicine 2000, 389-401. Saunders, Philadelphia. M.H. Kryger, T. Roth, W.C. Dement (Eds.).
55. Lai Y.Y., Hsieh K.C., Nguyen D., Peever J., Siegel J.M. Neurotoxic lesions at the ventral mesopontine junction change sleep time and muscle activity during sleep: an animal model of motor disorders in sleep. Neuroscience 2008, 154:431-443.
56. Brooks P.L., Peever J.H. Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia. J Neurosci 2008, 28:3535-3545.
57. Du Beau A., Shakya Shrestha S., Bannatyne B.A., Jalicy S.M., Linnen S., Maxwell D.J. Neurotransmitter phenotypes of descending systems in the rat lumbar spinal cord. Neuroscience 2012, 227:67-79.
58. Holstege G. Descending motor pathways and the spinal motor system: limbic and non-limbic components. Prog Brain Res 1991, 87:307-421.
59. Evarts E.V. Temporal patterns of discharge of pyramidal tract neurons during sleep and waking in the monkey. J Neurophysiol 1964, 27:152-171.
60. Evarts E.V. Relation of cell size to effects of sleep in pyramidal tract neurons. Prog Brain Res 1965, 18:81-91.
61. Oudiette D., Leu-Semenescu S., Roze E., Vidailhet M., De Cock V.C., Golmard J.L., et al. A motor signature of REM sleep behavior disorder. Mov Disord 2012, 27:428-431.
62. Arnulf I. REM sleep behavior disorder: motor manifestations and pathophysiology. Mov Disord 2012, 27:677-689.
63. Wu F.S., Yang Y.C., Tsai J.J. Melatonin potentiates the GABA(A) receptor-mediated current in cultured chick spinal cord neurons. Neurosci Lett 1999, 260:177-180.