A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder

Journal of Sleep Research

Volumn 19, Issue 4, 2010, Pages 591-596

  Kunz, Dieter ^a   Mahlberg, Richard ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Chronobiotic; Circadian rhythms; Lewy body dementia; Melatonin; Neurodegenerative disorder; RBD; REM sleep behaviour disorder; Sleep disorders

Indexed keywords

LEVODOPA; MELATONIN; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DREAM; HUMAN; MALE; MUSCLE ATONIA; PARASOMNIA; PARKINSON DISEASE; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REM SLEEP;

ADULT; AGED; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOUBLE-BLIND METHOD; HUMANS; MALE; MELATONIN; MIDDLE AGED; POLYSOMNOGRAPHY; REM SLEEP BEHAVIOR DISORDER; SLEEP; SLEEP, REM; TREATMENT OUTCOME;

EID: 77958521416     PISSN: 09621105     EISSN: 13652869     Source Type: Journal    
DOI: 10.1111/j.1365-2869.2010.00848.x     Document Type: Article

References (34)

1. American Academy of Sleep Medicine (AASM). ICSD2-The International Classification of Sleep Disorders, 2nd edn. American Academy of Sleep Medicine, Westchester, Illinois, 2006.
2. American Sleep Disorders Association Standards of Practice Committee, Polysomnography Task Force. Practice parameters for the indications for polysomnography and related procedures. Sleep, 1997, 20: 406-422.
3. Bes, F. W., Jobert, M., Müller, L. C. and Schulz, H. The diurnal distribution of sleep propensity: experimental data about the interaction of the propensities for slow wave sleep and REM sleep. J. Sleep Res., 1996, 5: 90-98.
4. Boeve, B. F. Melatonin for treatment of REM sleep behavior disorder: response in 8 patients. Sleep, 2001, 24: A35.
5. Boeve, B. F., Silber, M. H., Ferman, T. J., Kokmen, E., Smith, G. E., Ivnik, R. J., Parisi, J. E., Olson, E. J. and Petersen, R. C. REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. Neurology, 1998, 51: 363-370.
6. Cajochen, C., Krauchi, K., Mori, D., Graw, P. and Wirz-Justice, A. Melatonin and S-20098 increase REM sleep and wake-up propensity without modifying NREM sleep homeostasis. Am. J. Physiol., 1997, 272: R1189-R1196.
7. Dijk, D. J. and Czeisler, C. A. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J. Neurosci., 1995, 15: 3526-3538.
8. Gagnon, J. F., Petit, D., Fantini, M. L., Rompre, S., Gauthier, S., Panisset, M., Robillard, A. and Montplaisir, J. REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease. Sleep, 2006a, 29: 1321-1325.
9. Gagnon, J. F., Postuma, R. B., Mazza, S., Doyon, J. and Montplaisir, J. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. Lancet Neurol., 2006b, 5: 424-432.
10. Gagnon, J. F., Postuma, R. B. and Montplaisir, J. Update on the pharmacology of REM sleep behavior disorder. Neurology, 2006c, 67: 742-747.
11. Iranzo, A., Molinuevo, J. L., Santamaria, J., Serradell, M., Marti, M. J., Valldeoriola, F. and Tolosa, E. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurol., 2006, 5: 572-577.
12. Kunz, D. and Bes, F. Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations. Neuropsychobiology, 1997, 36: 211-214.
13. Kunz, D. and Bes, F. Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation. Mov. Disord., 1999, 14: 507-511.
14. Kunz, D. and Bes, F. Exogenous melatonin in periodic limb movement disorder: an open clinical trial and a hypothesis. Sleep, 2001, 24: 183-187.
15. Kunz, D. and Mahlberg, R. Melatonin: a Chronobiotic that not only shifts rhythms. In: S. R. Pandi-Perumal and D. P. Cardinali (Eds) Melatonin: Biological Basis of its Function in Health and Diseases. Landes Biosciences, Austin, TX, 2004: 1-11.
16. Kunz, D., Mahlberg, R., Muller, C., Tilmann, A. and Bes, F. Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. J. Clin. Endocrinol. Metab., 2004, 89: 128-134.
17. Kunz, D., Schmitz, S., Mahlberg, R., Mohr, A., Stoter, C., Wolf, K. J. and Herrmann, W. M. A new concept for melatonin deficit: on pineal calcification and melatonin excretion. Neuropsychopharmacology, 1999, 21: 765-772.
18. Lapierre, O. and Montplaisir, J. Polysomnographic features of REM sleep behavior disorder: development of a scoring method. Neurology, 1992, 42: 1371-1374.
19. Mahlberg, R., Kienast, T., Hadel, S., Heidenreich, J. O., Schmitz, S. and Kunz, D. Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patients. Sleep Med., 2009, 10: 439-445.
20. Mahlberg, R., Kunz, D., Sutej, I., Kühl, K. P. and Hellweg, R. Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer's disease: an open-label pilot study using actigraphy. J. Clin. Psychopharmacol., 2004, 24: 456-459.
21. Mahlberg, R., Tilmann, A., Salewski, L. and Kunz, D. Normative data on the daily profile of urinary 6-sulfatoxymelatonin in healthy subjects between the ages of 20 and 84. Psychoneuroendocrinology, 2006a, 31: 634-641.
22. Mahlberg, R., Walther, S., Kalus, P., Bohner, G., Haedel, S., Reischies, F. M., Kuehl, K. P., Hellweg, R. and Kunz, D. Pineal calcification in Alzheimer's disease: an in vivo study using computed tomography. Neurobiol. Aging, 2008, 29: 203-209.
23. Mishima, K., Okawa, M., Hozumi, S. and Hishikawa, Y. Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons. Chronobiol. Int., 2000, 17: 419-432.
24. National Institute of Mental Health. CGI - clinical global impression. In: W. Guy and R. R. Bonato (Eds) Manual for the EDCEU Assessment Battery. NIMH, Bethesda, Chevy Chase, MD, 1970: 12-1-12-6.
25. Olson, E. J., Boeve, B. F. and Silber, M. H. Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. Brain, 2000, 123: 331-339.
26. Plazzi, G., Corsini, R., Provini, F., Pierangeli, G., Martinelli, P., Montagna, P., Lugaresi, E. and Cortelli, P. REM sleep behavior disorders in multiple system atrophy. Neurology, 1997, 48: 1094-1097.
27. Rechtschaffen, A. and Kales, A. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. National Institute of Neurological Diseases and Blindness, Bethesda, MD, 1968.
28. Schenck, C. H., Bundlie, S. R. and Mahowald, M. W. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology, 1996, 46: 388-393.
29. Schenck, C. H. and Mahowald, M. W. REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP. Sleep, 2002, 25: 120-138.
30. Someren van, E. J. W., Kessler, A., Mirmiran, M. and Swaab, D. F. Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients. Biol. Psychiatry, 1997, 41: 955-963.
31. Takeuchi, N., Uchimura, N., Hashizume, Y., Mukai, M., Etoh, Y., Yamamoto, K., Kotorii, T., Ohshima, H., Ohshima, M. and Maeda, H. Melatonin therapy for REM sleep behavior disorder. Psychiatry Clin. Neurosci., 2001, 55: 267-269.
32. Turek, F. W. and Dugovic, C. RBD-an emerging clue to neurodegenerative disorders. Sleep, 2005, 28: 920-921.
33. Van Den Heuvel, C. J., Reid, K. J. and Dawson, D. Effect of atenolol on nocturnal sleep and temperature in young men: reversal by pharmacological doses of melatonin. Physiol. Behav., 1997, 61: 795-802.
34. Wurts, S. W. and Edgar, D. M. Circadian and homeostatic control of rapid eye movement (REM) sleep: promotion of REM tendency by the suprachiasmatic nucleus. J. Neurosci., 2000, 20: 4300-4310.