Treatment outcomes in REM sleep behavior disorder

Sleep Medicine

Volumn 14, Issue 3, 2013, Pages 237-242

  McCarter, Stuart J ^a   Boswell, Christopher L ^a   St Louis, Erik K ^a,b   Dueffert, Lucas G ^a,b   Slocumb, Nancy ^b   Boeve, Bradley F ^a,b   Silber, Michael H ^a,b   Olson, Eric J ^a,b   Tippmann Peikert, Maja ^a,b  

^a Mayo Clinic College of Medicine   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Clonazepam; Falls; Injury; Melatonin; Parasomnia; REM sleep behavior disorder; Retention; Side effects; Synucleinopathy; Tolerability; Treatment

Indexed keywords

ANTIDEPRESSANT AGENT; CLONAZEPAM; MELATONIN; PLACEBO;

AGED; ARTICLE; COMPARATIVE STUDY; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; DOSE RESPONSE; FEMALE; HEALTH SURVEY; HUMAN; INJURY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; OUTCOME VARIABLE; PARASOMNIA; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT OUTCOME; VISUAL ANALOG SCALE;

ADULT; AGED; AGED, 80 AND OVER; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CLONAZEPAM; DRUG THERAPY, COMBINATION; FEMALE; GABA MODULATORS; HEALTH SURVEYS; HUMANS; LONGITUDINAL STUDIES; MALE; MELATONIN; MIDDLE AGED; REM SLEEP BEHAVIOR DISORDER; REM SLEEP PARASOMNIAS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; WOUNDS AND INJURIES;

EID: 84874262357     PISSN: 13899457     EISSN: 18785506     Source Type: Journal    
DOI: 10.1016/j.sleep.2012.09.018     Document Type: Article

References (44)

1. International classification of sleep disorders: diagnositc and coding manual 2005, American Academy of Sleep Medicine, American Academy of Sleep Medicine. 2nd ed.
2. Boeve B.F. REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci 2010, 1184:15-54.
3. Schenck C.H., Bundlie S.R., Ettinger M.G., Mahowald M.W. Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep 1986, 9(2):293-308.
4. Iranzo A., Santamaria J., Tolosa E. The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases. Sleep Med Rev 2009, 13(6):385-401.
5. Olson E.J., Boeve B.F., Silber M.H. Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. Brain J Neurol 2000, 123(Pt. 2):331-339.
6. Frauscher B., Gschliesser V., Brandauer E., Marti I., Furtner M.T., Ulmer H., et al. REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history. Sleep Med 2010, 11(2):167-171.
7. Montplaisir J., Gagnon J.F., Fantini M.L., Postuma R.B., Dauvilliers Y., Desautels A., et al. Polysomnographic diagnosis of idiopathic REM sleep behavior disorder. Mov Disord 2010, 25(13):2044-2051.
8. McCarter S.J., St.Louis E.K., Boeve B.F. REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease. Curr Neurol Neurosci Rep 2012, 12(2):182-192.
9. Ohayon M.M., Schenck C.H. Violent behavior during sleep: prevalence, comorbidity and consequences. Sleep Med 2010, 11(9):941-946.
10. Boot B.P., Boeve B.F., Roberts R.O., Ferman T.J., Geda Y.E., Pankratz V.S., et al. Probable REM sleep behavior disorder increases risk for mild cognitive impairment and Parkinson's disease: a population-based study. Ann Neurol 2012, 71(1):49-56.
11. Boeve B.F., Molano J.R., Ferman T.J., Smith G.E., Lin S.C., Bieniek K., et al. Validation of the mayo sleep questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort. Sleep Med 2011, 12(5):445-453.
12. Chiu H.F., Wing Y.K., Lam L.C., Li S.W., Lum C.M., Leung T., et al. Sleep-related injury in the elderly - an epidemiological study in Hong Kong. Sleep 2000, 23(4):513-517.
13. Bodkin C.L., Schenck C.H. Rapid eye movement sleep behavior disorder in women: relevance to general and specialty medical practice. J Women's Health 2009, 18(12):1955-1963.
14. Ju Y.E., Larson-Prior L., Duntley S. Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. Sleep Med 2011, 12(3):278-283.
15. Bonakis A., Howard R.S., Ebrahim I.O., Merritt S., Williams A. REM sleep behaviour disorder (RBD) and its associations in young patients. Sleep Med 2009, 10(6):641-645.
16. Teman P.T., Tippmann-Peikert M., Silber M.H., Slocumb N.L., Auger R.R. Idiopathic rapid-eye-movement sleep disorder: associations with antidepressants, psychiatric diagnoses, and other factors, in relation to age of onset. Sleep Med 2009, 10(1):60-65.
17. Iranzo A., Lomeña F., Stockner H., Valldeoriola F., Vilaseca I., Salamero M., et al. Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. Lancet Neurol 2010, 9:1070-1077. [corrected].
18. Iranzo A., Molinuevo J.L., Santamaría J., Serradell M., Martí M.J., Valldeoriola F., et al. Rapid-eye movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurol 2006, 5:572-577.
19. Schenck C.H., Lee S.A., Bornemann M.A., Mahowald M.W. Potentially lethal behaviors associated with rapid eye movement sleep behavior disorder (RBD): review of the literature and forensic implications. J Forensic Sci 2009, 54:1475-1484.
20. Aurora R.N., Zak R.S., Maganti R.K., Auerbach S.H., Casey K.R., Chowdhuri S., et al. Best practice guide for the treatment of rem sleep behavior disorder (RBD). J Clin Sleep Med 2010, 6(1):85-95.
21. Gagnon J.F., Postuma R.B., Montplaisir J. Update on the pharmacology of REM sleep behavior disorder. Neurology 2006, 67(5):742-747.
22. Schenck C.H., Mahowald M.W. A polysomnographic, neurologic, psychiatric, and clinical outcome report on 70 consecutive cases with REM sleep behavior disorder (RBD): sustained clonazepam efficacy in 89.5% of 57 treated patients. Clev Clin J Med 1990, 57(Suppl.):S9-S23.
23. Anderson K.N., Shneerson J.M. Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam. J Clin Sleep Med 2009, 5(3):235-239.
24. Boeve B.F., Silber M.H., Ferman T.J. Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep Med 2003, 4:281-284.
25. Schenck C.H., Mahowald M.W. Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep in 170 adults. Am J Med 1996, 100(3):333-337.
26. Takeuchi N., Uchimura N., Hashizume Y., Mukai M., Etoh Y., Yamamoto K., et al. Melatonin therapy for REM sleep behavior disorder. Psychiatry Clin Neurosci 2001, 55:267-269.
27. Kunz D., Mahlberg R. A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder. J Sleep Res 2010, 19(4):591-596.
28. Moraes Wdos S., Poyares D.R., Guilleminault C., Ramos L.R., Bertolucci P.H., Tufik S. The effect of donepezil on sleep and REM sleep EEG in patients with Alzheimer disease: a double-blind placebo-controlled study. Sleep 2006, 29:199-205.
29. Fantini M.L., Gagnon J.F., Filipini D., Montplaisir J. The effects of pramipexole in REM sleep behavior disorder. Neurology 2003, 61:1418-1420.
30. Boeve B.F., Silber M.H., Saper C.B., Ferman T.J., Dickson D.W., Parisi J.E., et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain 2007, 130:2770-2788.
31. McKeith I.G., Dickson D.W., Lowe J., Emre M., O'Brien J.T., Feldman H., et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005, 65(12):1863-1872.
32. Petersen R.C. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004, 256(3):183-194.
33. Wenning G.K., Ben Shlomo T., Magalhães M., Daniel S.E., Quinn N.P. Clinical features and natural history of multiple system atrophy: an analysis of 100 cases. Brain 1994, 117:835-845.
34. Harris P.A., Taylor R., Thielke R., Payne J., Gonzalez N., Conde J.G. Research electronic data capture (REDCap) - a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009, 42(2):377-381.
35. Schenck C., Hurwitz T., Mahowald M. REM sleep behavior disorder: an update on a series of 96 patients and a review of the world literature. J Sleep Res 1993, 2:224-231.
36. Schenck C.H., Bundlie S.R., Mahowald M.W. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology 1996, 46(2):388-393.
37. Ju Y.E., Larson-Prior L., Duntley S. Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. Sleep Med 2011, 12(3):278-283.
38. Huang J., Zhang J., Lam S.P., Li S.X., Ho C.K., Lam V., et al. Amelioration of obstructive sleep apnea in REM sleep behavior disorder: implications for the neuromuscular control of OSA. Sleep 2011, 34(7):909-915.
39. Brooks P.L., Peever J.H. Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice. J Neurosci 2011, 31(19):7111-7121.
40. Attenburrow M.E.J., Cowen P.J., Sharpley A.J. Low dose melatonin improves sleep in healthy middle-aged subjects. Psychopharmacology 1996, 126:179-181.
41. Zhdanova I.V., Wurtman R.J., Morabito C., Piotrovska V.R., Lynch H.J. Effects of low oral doses of melatonin, given 2-4hours before habitual bedtime, on sleep in normal young humans. Sleep 1996, 19(5):423-431.
42. Kunz D., Mahlberg R., Müller C., Tilmann A., Bes F., et al. Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. J Clin Endocrinol Metab 2004, 89(1):128-134.
43. Kunz D., Bes F. Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on rem-sleep regulation. Mov Disord 1999, 14(3):507-511.
44. Howell M.J., Arneson P.A., Schenck C.H. A novel therapy for REM sleep behavior disorder (RBD). J Clin Sleep Med 2011, 7(6):639A-644A.