A novel MitoNEET ligand, TT01001, improves diabetes and ameliorates mitochondrial function in db/db mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 352, Issue 2, 2015, Pages 338-345

  Takahashi, Takehiro ^a   Yamamoto, Masashi ^a   Amikura, Kazutoshi ^a   Kato, Kozue ^a   Serizawa, Takashi ^a   Serizawa, Kanako ^a   Akazawa, Daisuke ^a   Aoki, Takumi ^a   Kawai, Koji ^a   Ogasawara, Emi ^b   Hayashi, Jun Ichi ^b   Nakada, Kazuto ^b   Kainoh, Mie ^a  

^a TORAY INDUSTRIES INC   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYL 4 [3 (3,5 DICHLOROPHENYL)THIOUREIDO]PIPERIDINE 1 CARBOXYLATE; GLITAZONE DERIVATIVE; MITOCHONDRIAL DNA; MITONEET PROTEIN; OUTER MEMBRANE PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; CISD1 PROTEIN, HUMAN; ETHYL 4-(3-(3,5-DICHLOROPHENYL)THIOUREIDO)PIPERIDINE-1-CARBOXYLATE; GLUCOSE BLOOD LEVEL; IRON BINDING PROTEIN; LIGAND; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MITONEET PROTEIN, MOUSE; PIPERIDINE DERIVATIVE; THIOUREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; HYPERLIPIDEMIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MUSCLE MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; SKELETAL MUSCLE; WEIGHT GAIN; ANALOGS AND DERIVATIVES; ANALYSIS; ANIMAL; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; ENZYMOLOGY; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETICS; GLUCOSE BLOOD LEVEL; HUMAN; INBRED MOUSE STRAIN; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SURFACE PLASMON RESONANCE;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DNA, MITOCHONDRIAL; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; HYPOGLYCEMIC AGENTS; IRON-BINDING PROTEINS; LIGANDS; MALE; MEMBRANE PROTEINS; MICE, INBRED STRAINS; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL PROTEINS; PIPERIDINES; PPAR GAMMA; SURFACE PLASMON RESONANCE; THIOUREA;

EID: 84921290159     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.220673     Document Type: Article

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