Cytokine modulation correlates with severity of monkeypox disease in humans

Journal of Clinical Virology

Volumn 63, Issue , 2015, Pages 42-45

  Johnston, Sara C ^a   Johnson, Joshua C ^a,d   Stonier, Spencer W ^a   Lin, Kenny L ^a   Kisalu, Neville K ^b,e   Hensley, Lisa E ^a,d   Rimoin, Anne W ^c  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Integrated Research Facility   (United States)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Cytokine; Cytokine storm; Monkeypox; Orthopoxvirus; Regulatory T cell

Indexed keywords

ALPHA INTERFERON; CXCL9 CHEMOKINE; CYTOKINE; EOTAXIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CYTOKINE RESPONSE; CYTOKINE STORM; DEMOCRATIC REPUBLIC CONGO; DISEASE SEVERITY; DISEASE SURVEILLANCE; FEMALE; HUMAN; IMMUNOMODULATION; MALE; MONKEYPOX; MONKEYPOX VIRUS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SCORING SYSTEM; YOUNG ADULT; ANIMAL; BLOOD; IMMUNOLOGY; INFANT; PATHOLOGY; SEVERITY OF ILLNESS INDEX;

ADOLESCENT; ADULT; ANIMALS; CHILD; CHILD, PRESCHOOL; CYTOKINES; DEMOCRATIC REPUBLIC OF THE CONGO; FEMALE; HUMANS; INFANT; MALE; MONKEYPOX; MONKEYPOX VIRUS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84921283412     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2014.12.001     Document Type: Article

References (24)

1. Rimoin A.W., Mulembakani P.M., Johnston S.C., Lloyd Smith J.O., Kisalu N.K., Kinkela T.L., et al. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:16262-16267.
2. Rubins K.H., Hensley L.E., Jahrling P.B., Whitney A.R., Geisbert T.W., Huggins J.W., et al. The host response to smallpox: analysis of the gene expression program in peripheral blood cells in a nonhuman primate model. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:15190-15195.
3. Jahrling P.B., Hensley L.E., Martinez M.J., Leduc J.W., Rubins K.H., Relman D.A., et al. Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:15196-15200.
4. Martin D.B. The cause of death in smallpox: an examination of the pathology record. Mil. Med. 2002, 167:546-551.
5. Tisoncik J.R., Korth M.J., Simmons C.P., Farrar J., Martin T.R., Katze M.G. Into the eye of the cytokine storm. Microbiol. Mol. Biol. Rev. 2012, 76:16-32.
6. Kugelman J.R., Johnston S.C., Mulembakani P.M., Kisalu N., Lee M.S., Koroleva G., et al. Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo. Emerg. Infect. Dis. 2014, 20:232-239.
7. Hooper J.W., Thompson E., Wilhelmsen C., Zimmerman M., Ichou M.A., Steffen S.E., et al. Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox. J. Virol. 2004, 78:4433-4443.
8. Sharma D.P., Ramsay A.J., Maguire D.J., Rolph M.S., Ramshaw I.A. Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo. J. Virol. 1996, 70:7103-7107.
9. Howell M.D., Gallo R.L., Boguniewicz M., Jones J.F., Wong C., Streib J.E., et al. Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity 2006, 24:341-348.
10. van Den Broek M., Bachmann M.F., Kohler G., Barner M., Escher R., Zinkernagel R., et al. IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2. J. Immunol. 2000, 164:371-378.
11. Sinuani I., Beberashvili I., Averbukh Z., Sandbank J. Role of IL-10 in the progression of kidney disease. World J. Transplant. 2013, 3:91-98.
12. Chapoval S., Dasgupta P., Dorsey N.J., Keegan A.D. Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6. J. Leukoc. Biol. 2010, 87:1011-1018.
13. Shevach E.M. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 2009, 30:636-645.
14. Akbari O., Freeman G.J., Meyer E.H., Greenfield E.A., Chang T.T., Sharpe A.H., et al. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat. Med. 2002, 8:1024-1032.
15. Wurster A.L., Rodgers V.L., Satoskar A.R., Whitters M.J., Young D.A., Collins M., et al. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J. Exp. Med. 2002, 196:969-977.
16. Kastenmuller W., Gasteiger G., Subramanian N., Sparwasser T., Busch D.H., Belkaid Y., et al. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J. Immunol. 2011, 187:3186-3197.
17. Haeryfar S.M., DiPaolo R.J., Tscharke D.C., Bennink J.R., Yewdell J.W. Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities. J. Immunol. 2005, 174:3344-3351.
18. Ganesh B.B., Cheatem D.M., Sheng J.R., Vasu C., Prabhakar B.S. GM-CSF-induced CD11c+CD8a- dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis. Int. Immunol. 2009, 21:269-282.
19. Sheng J.R., Li L., Ganesh B.B., Vasu C., Prabhakar B.S., Meriggioli M.N. Suppression of experimental autoimmune myasthenia gravis by granulocyte-macrophage colony-stimulating factor is associated with an expansion of FoxP3+ regulatory T cells. J. Immunol. 2006, 177:5296-5306.
20. Sheng J.R., Li L.C., Ganesh B.B., Prabhakar B.S., Meriggioli M.N. Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis. Clin. Immunol. 2008, 128:172-180.
21. Pedersen A.E., Lauritsen J.P. CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2. Scand. J. Immunol. 2009, 70:40-43.
22. Thornton A.M., Shevach E.M. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998, 188:287-296.
23. Pandiyan P., Zheng L., Ishihara S., Reed J., Lenardo M.J. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat. Immunol. 2007, 8:1353-1362.
24. Mills K.H. Regulatory T cells: friend or foe in immunity to infection?. Nat. Rev. Immunol. 2004, 4:841-855.