Paper-based microfluidic approach for surface-enhanced raman spectroscopy and highly reproducible detection of proteins beyond picomolar concentration

ACS Applied Materials and Interfaces

Volumn 7, Issue 1, 2015, Pages 996-1003

  Saha, Arindam ^a   Jana, Nikhil R ^a  

^a DEPARTMENT OF MATERIALS SCIENCE   (India)

Author keywords

functionalization; microfluidics; nanoparticle; protein detection; SERS

Indexed keywords

AGGLOMERATION; COST EFFECTIVENESS; FLUIDIC DEVICES; LIGHT TRANSMISSION; NANOPARTICLES; PLASMONS; PROTEINS; RAMAN SPECTROSCOPY; SIGNAL DETECTION;

FEMTOMOLAR CONCENTRATION; FUNCTIONALIZATIONS; MICROFLUIDIC PLATFORMS; PAPER-BASED MICROFLUIDICS; POINT OF CARE DIAGNOSTIC; PROTEIN DETECTION; SERS; SURFACE ENHANCED RAMAN SPECTROSCOPY;

MICROFLUIDICS;

BIOTIN; CONCANAVALIN A; GLUCOSE; GOLD; NANOMATERIAL; NANOPARTICLE; PROTEIN; SILICON DIOXIDE; SILVER; THIOL DERIVATIVE;

CHEMISTRY; DEVICES; ELECTROMAGNETIC RADIATION; MICROFLUIDIC ANALYSIS; MICROFLUIDICS; PAPER; PROCEDURES; RAMAN SPECTROMETRY; REPRODUCIBILITY; SURFACE PROPERTY; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET RADIATION;

BIOTIN; CHROMATOGRAPHY, THIN LAYER; CONCANAVALIN A; ELECTROMAGNETIC RADIATION; GLUCOSE; GOLD; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROFLUIDICS; NANOPARTICLES; NANOSTRUCTURES; PAPER; PROTEINS; REPRODUCIBILITY OF RESULTS; SILICON DIOXIDE; SILVER; SPECTRUM ANALYSIS, RAMAN; SULFHYDRYL COMPOUNDS; SURFACE PROPERTIES; ULTRAVIOLET RAYS;

EID: 84921282667     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/am508123x     Document Type: Article

References (63)

1. Manz, A.; Harrison, D. J.; Verpoorte, E. M. J.; Fettinger, J. C.; Paulus, A.; Lüdi, H.; Widmer, H. M. Planar Chips Technology for Miniaturization and Integration of Separation Techniques into Monitoring Systems-Capillary Electrophoresis on a Chip J. Chromatogr. 1992, 593, 253-258
2. Figeys, D.; Pinto, D. Lab-on-a-Chip: A Revolution in Biological and Medical Sciences Anal. Chem. 2000, 72, 330A-335A
3. Whitesides, G. M. The Origins and the Future of Microfluidics Nature 2006, 442, 368-373
4. Atencia, J.; Beebe, D. J. Controlled Microfluidic Interfaces Nature 2005, 437, 648-655
5. Gunther, A.; Jensen, K. F. Multiphase Microfluidics: From Flow Characteristics to Chemical and Materials Synthesis Lab Chip 2006, 6, 1487-1503
6. Haeberle, S.; Zengerle, R. Microfluidic Platforms for Lab-on-a-Chip Applications Lab Chip 2007, 7, 1094-1110
7. Velve-Casquillas, G.; Berre, M. L.; Piel, M.; Tran, P. T. Microfluidic Tools for Cell Biological Research Nano Today 2010, 5, 28-47
8. Nge, P. N.; Rogers, C. I.; Woolley, A. T. Advances in Microfluidic Materials, Functions, Integration, and Applications Chem. Rev. 2013, 113, 2550-2583
9. Elvira, K. S.; Solvas, X. C.; Wootton, R. C. R.; DeMello, A. J. The Past, Present and Potential for Microfluidic Reactor Technology in Chemical Synthesis Nat. Chem. 2013, 5, 905-915
10. Sackmann, E. K.; Fulton, A. L.; Beebe, D. J. The Present and Future Role of Microfluidics in Biomedical Research Nature 2014, 507, 181-189
11. Hu, M.; Yan, J.; He, Y.; Lu, H.; Weng, L.; Song, S.; Fan, C.; Wang, L. Ultrasensitive, Multiplexed Detection of Cancer Biomarkers Directly in Serum by Using a Quantum Dot-Based Microfluidic Protein Chip ACS Nano 2010, 4, 488-494
12. Wang, J.; Onoshima, D.; Aki, M.; Okamoto, Y.; Kaji, N.; Tokeshi, M.; Baba, Y. Label-Free Detection of DNA-Binding Proteins Based on Microfluidic Solid-State Molecular Beacon Sensor Anal. Chem. 2011, 83, 3528-3532
13. Lee, W. B.; Chen, Y. H.; Lin, H.; Shiesh, S. C.; Lee, G. B. An Integrated Microfluidic System for Fast, Automatic Detection of C-Reactive Protein Sens. Actuators B 2011, 157, 710-721
14. Alino, V. J.; Sim, P. H.; Choy, W. T.; Fraser, A.; Yang, K. L. Detecting Proteins in Microfluidic Channels Decorated with Liquid Crystal Sensing Dots Langmuir 2012, 28, 17571-17577
15. Galarreta, B. C.; Tabatabaei, M.; Guieu, V.; Peyrin, E.; Lagugné-Labarthet, F. Microfluidic Channel with Embedded SERS 2D Platform for the Aptamer Detection of Ochratoxin A Anal. Bioanal. Chem. 2013, 405, 1613-1621
16. Tekin, H. C.; Gijs, M. A. M. Ultrasensitive Protein Detection: A Case for Microfluidic Magnetic Bead-Based Assays Lab Chip 2013, 13, 4711-4739
17. Wang, Y.; Ye, Z.; Ping, J.; Jing, S.; Ying, Y. Development of an Aptamer-Based Impedimetric Bioassay Using Microfluidic System and Magnetic Separation for Protein Detection Biosens. Bioelectron. 2014, 59, 106-111
18. Mok, J.; Mindrinos, M. N.; Davis, R. W.; Javanmard, M. Digital Microfluidic Assay for Protein Detection Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 2110-2115
19. Strelau, K. K.; Kretschmer, R.; Möller, R.; Fritzsche, W.; Popp, J. SERS as Tool for the Analysis of DNA-Chips in a Microfluidic Platform Anal. Bioanal. Chem. 2010, 396, 1381-1384
20. Morina, F.; Nishimura, N.; Griscom, L.; LePioufle, B.; Fujita, H.; Takamura, Y.; Tamiya, E. Constraining the Connectivity of Neuronal Networks Cultured on Microelectrode Arrays with Microfluidic Techniques: A Step Towards Neuron-Based Functional Chips Biosens. Bioelectron. 2006, 21, 1093-1100
21. Khademhosseini, A.; Eng, G.; Yeh, J.; Kucharczyk, P. A.; Langer, R.; Vunjak-Novakovic, G.; Radisic, M. Microfluidic Patterning for Fabrication of Contractile Cardiac Organoids Biomed. Microdevices 2007, 9, 149-157
22. He, M.; Edgar, J. C.; Jeffries, G. D. M.; Lorenz, R. M.; Shelby, J. P.; Chiu, D. T. Selective Encapsulation of Single Cells and Subcellular Organelles into Picoliter- and Femtoliter-Volume Droplets Anal. Chem. 2005, 77, 1539-1544
23. Nagrath, S.; Sequist, L. V.; Maheswaran, S.; Bell, D. W.; Irimia, D.; Ulkus, L.; Smith, M. R.; Kwak, E. L.; Digumarthy, S.; Muzikansky, A.; Ryan, P.; Balis, U. J.; Tompkins, R. G.; Haber, D. A.; Toner, M. Isolation of Rare Circulating Tumour Cells in Cancer Patients by Microchip Technology Nature 2007, 450, 1235-1239
24. Meier, M.; Darling, J. K.; Choi, S. H.; Norstrom, E. M.; Sisodia, S. S.; Ismagilov, R. F. Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides Angew. Chem., Int. Ed. 2009, 48, 1487-1489
25. Choi, I.; Huh, Y. S.; Erickson, D. Size-Selective Concentration and Label-Free Characterization of Protein Aggregates Using a Raman Active Nanofluidic Device Lab Chip 2011, 11, 632-638
26. McClain, M. A.; Culbertson, C. T.; Jacobson, S. C.; Allbritton, N. L.; Sims, C. E.; Ramsey, J. M. Microfluidic Devices for the High-Throughput Chemical Analysis of Cells Anal. Chem. 2003, 75, 5646-5655
27. Srinivasan, V.; Pamula, V. K.; Fair, R. B. An Integrated Digital Microfluidic Lab-on-a-Chip for Clinical Diagnostics on Human Physiological Fluids Lab Chip 2004, 4, 310-315
28. Jokerst, J. V.; Jacobson, J. W.; Bhagwandin, B. D.; Floriano, P. N.; Christodoulides, N.; McDevitt, J. T. Programmable Nano-Bio-Chip Sensors: Analytical Meets Clinical Anal. Chem. 2010, 82, 1571-1579
29. Zhou, J.; Ren, K.; Zhao, Y.; Dai, W.; Wu, H. Convenient Formation of Nanoparticle Aggregates on Microfluidic Chips for Highly Sensitive SERS Detection of Biomolecules Anal. Bioanal. Chem. 2012, 402, 1601-1609
30. Zhang, R. Q.; Liu, S. L.; Zhao, W.; Zhang, W. P.; Yu, X.; Li, Y.; Li, A. J.; Pang, D. W.; Zhang, Z. L. A Simple Point-of-Care Microfluidic Immunomagnetic Fluorescence Assay for Pathogens Anal. Chem. 2013, 85, 2645-2651
31. Ackermann, K. R.; Henkel, T.; Popp, J. Quantitative Online Detection of Low-Concentrated Drugs via a SERS Microfluidic System ChemPhysChem 2007, 8, 2665-2670
32. Andreou, C.; Hoonejani, M. R.; Barmi, M. R.; Moskovits, M.; Meinhart, C. D. Rapid Detection of Drugs of Abuse in Saliva Using Surface Enhanced Raman Spectroscopy and Microfluidics ACS Nano 2013, 7, 7157-7164
33. Mcdonald, J. C.; Duffy, D. C.; Anderson, J. R.; Chiu, D. T.; Wu, H.; Schueller, O. J. A.; Whitesides, G. M. Fabrication of Microfluidic Systems in Poly (Dimethylsiloxane) Electrophoresis 2000, 21, 27-40
34. Ren, K.; Zhou, J.; Wu, H. Materials for Microfluidic Chip Fabrication Acc. Chem. Res. 2013, 46, 2396-2406
35. Martinez, A. W.; Phillips, S. T.; Carrilho, E.; Thomas, S. W., III; Sindi, H.; Whitesides, G. M. Simple Telemedicine for Developing Regions: Camera Phones and Paper-Based Microfluidic Devices for Real-Time, Off-Site Diagnosis Anal. Chem. 2008, 80, 3699-3707
36. Fang, X.; Chen, H.; Jiang, X.; Kong, J. Microfluidic Devices Constructed by a Marker Pen on a Silica Gel Plate for Multiplex Assays Anal. Chem. 2011, 83, 3596-3599
37. Lee, C. H.; Hankus, M. E.; Tian, L.; Pellegrino, P. M.; Singamaneni, S. Highly Sensitive Surface Enhanced Raman Scattering Substrates Based on Filter Paper Loaded with Plasmonic Nanostructures Anal. Chem. 2011, 83, 8953-8958
38. Li, X.; Ballerini, D. R.; Shen, W. A Perspective on Paper-Based Microfluidics: Current Status and Future Trends Biomicrofluidics 2012, 6, 011301
39. Schilling, K. M.; Lepore, A. L.; Kurian, J. A.; Martinez, A. W. Fully Enclosed Microfluidic Paper-Based Analytical Devices Anal. Chem. 2012, 84, 1579-1585
40. Qu, L.; Song, Q.; Li, Y.; Peng, M. P.; Li, D. W.; Chen, L. X.; Fossey, J. S.; Long, Y. T. Fabrication of Bimetallic Microfluidic Surface-Enhanced Raman Scattering Sensors on Paper by Screen Printing Anal. Chim. Acta 2013, 792, 86-92
41. Betz, J. F.; Yu, W. W.; Cheng, Y.; White, I. M.; Rubloff, G. W. Simple SERS Substrates: Powerful, Portable, and Full of Potential Phys. Chem. Chem. Phys. 2014, 16, 2224-2239
42. Warren, A. D.; Kwong, G. A.; Wood, D. K.; Lin, K. Y.; Bhatia, S. N. Point-of-Care Diagnostics for Noncommunicable Diseases Using Synthetic Urinary Biomarkers and Paper Microfluidics Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 3671-3676
43. Chen, L.; Choo, J. Recent Advances in Surface-Enhanced Raman Scattering Detection Technology for Microfluidic Chips Electrophoresis 2008, 29, 1815-1828
44. Tong, L.; Righini, M.; Gonzalez, M. U.; Quidant, R.; Kall, M. Optical Aggregation of Metal Nanoparticles in a Microfluidic Channel for Surface-Enhanced Raman Scattering Analysis Lab Chip 2009, 9, 193-195
45. Han, B.; Choi, N.; Kim, K. H.; Lim, D. W.; Choo, J. Application of Silver-Coated Magnetic Microspheres to a SERS-Based Optofluidic Sensor J. Phys. Chem. C 2011, 115, 6290-6296
46. Li, Q.; Li, B.; Wang, Y. Surface-Enhanced Raman Scattering Microfluidic Sensor RSC Adv. 2013, 3, 13015-13026
47. Kneip, K.; Wang, Y.; Kneipp, H.; Perelman, L. T.; Itzkan, I.; Dasari, R.; Feld, M. S. Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS) Phys. Rev. Lett. 1997, 78, 1667-1670
48. Nie, S. M.; Emery, S. R. Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering Science 1997, 275, 1102-1106
49. Michaels, A. M.; Jiang, J.; Brus, L. Ag Nanocrystal Junctions as the Site for Surface-Enhanced Raman Scattering of Single Rhodamine 6G Molecules J. Phys. Chem. B 2000, 104, 11965-11971
50. Lim, D. K.; Jeon, K. S.; Hwang, J. H.; Kim, H.; Kwon, S.; Suh, Y. D.; Nam, J. M. Highly Uniform and Reproducible Surface-Enhanced Raman Scattering from DNA-Tailorable Nanoparticles with 1-nm Interior Gap Nat. Nanotechnol. 2011, 6, 452-460
51. Saha, A.; Palmal, S.; Jana, N. R. Highly Reproducible and Sensitive Surface-Enhanced Raman Scattering from Colloidal Plasmonic Nanoparticle via Stabilization of Hot Spots in Graphene Oxide Liquid Crystal Nanoscale 2012, 4, 6649-6657
52. Saha, A.; Jana, N. R. Detection of Cellular Glutathione and Oxidized Glutathione Using Magnetic-Plasmonic Nanocomposite-Based Turn-Off Surface Enhanced Raman Scattering Anal. Chem. 2013, 85, 9221-9228
53. Manimaran, M.; Jana, N. R. Detection of Protein Molecules by Surface-Enhanced Raman Spectroscopy-Based Immunoassay Using 2-5 nm Gold Nanoparticle Labels J. Raman Spectrosc. 2007, 38, 1326-1331
54. Mulvihill, M. J.; Ling, X. Y.; Henzie, J.; Yang, P. Anisotropic Etching of Silver Nanoparticles for Plasmonic Structures Capable of Single-Particle SERS J. Am. Chem. Soc. 2010, 132, 268-274
55. Zhu, Z.; Meng, H.; Liu, W.; Liu, X.; Gong, J.; Qiu, X.; Jiang, L.; Wang, D.; Tang, Z. Superstructures and SERS Properties of Gold Nanocrystals with Different Shapes Angew. Chem., Int. Ed. 2011, 50, 1593-1596
56. Chen, T.; Wang, H.; Chen, G.; Wang, Y.; Feng, Y.; Teo, S. W.; Wu, T.; Chen, H. G. Hotspot-Induced Transformation of Surface-Enhanced Raman Scattering Fingerprints ACS Nano 2010, 4, 3087-3094
57. Yokota, Y.; Ueno, K.; Misawa, H. Essential Nanogap Effects on Surface-Enhanced Raman Scattering Signals from Closely Spaced Gold Nanoparticles Chem. Commun. 2011, 47, 3505-3507
58. Jana, N. R. Silver Coated Gold Nanoparticles as New Surface Enhanced Raman Substrate at Low Analyte Concentration Analyst 2003, 128, 954-956
59. Jana, N. R.; Pal, T. Anisotropic Metal Nanoparticles for Use as Surface-Enhanced Raman Substrates Adv. Mater. 2007, 19, 1761-1765
60. Wustholz, K. L.; Henry, A.-I.; McMahon, J. M.; Freeman, R. G.; Valley, N.; Piotti, M. E.; Natan, M. J.; Schatz, G. C.; Van Duyne, R. P. Structure-Activity Relationships in Gold Nanoparticle Dimers and Trimers for Surface-Enhanced Raman Spectroscopy J. Am. Chem. Soc. 2010, 132, 10903-10910
61. Charles Cao, Y.; Jin, R.; Nam, J. M.; Shad Thaxton, C.; Mirkin, C. A. Raman Dye-Labelled Nanoparticle Probes for Proteins J. Am. Chem. Soc. 2003, 125, 14676-14677
62. Wang, Y.; Wei, H.; Li, B.; Ren, W.; Guo, S.; Dong, S.; Wang, E. SERS Opens a New Way in Aptasensor for Protein Recognition with High Sensitivity and Selectivity Chem. Commun. 2007, 5220-5222
63. Zengin, A.; Tamer, U.; Caykara, T. A SERS-Based Sandwich Assay for Ultrasensitive and Selective Detection of Alzheimer's Tau Protein Biomacromolecules 2013, 14, 3001-3009