Hepatotoxic assessment of Polygoni Multiflori Radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in rats

Journal of Ethnopharmacology

Volumn 162, Issue , 2015, Pages 61-68

  Ma, Jiang ^a   Zheng, Li ^a   He, Yi Sheng ^a   Li, Hui Jun ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Emodin exposure; Extensiveconsumption; Hepatocellular damage; PolygoniMultiflori; Radix; Toxicokinetics

Indexed keywords

2,3,5,4' TETRAHYDROXYSTILBENE 2 O BETA DEXTRO GLUCOSIDE; ALANINE AMINOTRANSFERASE; ANTHRAQUINONE DERIVATIVE; ASPARTATE AMINOTRANSFERASE; EMODIN; EMODIN 8 O BETA DEXTRO GLUCOSIDE; PHYSCION; PLANT EXTRACT; POLYGONI MULTIFLORI EXTRACT; STILBENE; UNCLASSIFIED DRUG; 2',3',4',5'-TETRAHYDROXYSTILBENE-2-O-BETA-D-GLUCOSIDE; GLUCOSIDE; STILBENE DERIVATIVE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY COLOR CHANGE; CELL DEATH; CELL INFILTRATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIARRHEA; DRUG BLOOD LEVEL; DRUG EXPOSURE; DRUG INDUCED DISEASE; DRUG MEGADOSE; DRUG METABOLISM; FALLOPIA MULTIFLORA; HISTOPATHOLOGY; IN VIVO STUDY; INFLAMMATION; INFLAMMATORY CELL; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER TOXICITY; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; QUANTITATIVE ANALYSIS; RAT; RISK BENEFIT ANALYSIS; STEATOSIS; TOXICOKINETICS; TREATMENT DURATION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; DRUG EFFECTS; LIVER; METABOLISM; PATHOLOGY; PLANT ROOT; POLYGONUM; SPRAGUE DAWLEY RAT; TOXIC HEPATITIS;

RATTUS;

ANIMALS; DRUG-INDUCED LIVER INJURY; EMODIN; GLUCOSIDES; LIVER; MALE; PLANT EXTRACTS; PLANT ROOTS; POLYGONUM; RATS, SPRAGUE-DAWLEY; STILBENES; TOXICOKINETICS;

EID: 84921062153     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.12.045     Document Type: Article

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