Assessment of the renal protection and hepatotoxicity of rhubarb extract in rats

Journal of Ethnopharmacology

Volumn 124, Issue 1, 2009, Pages 18-25

  Wang, Jiabo ^a   Zhao, Yanling ^a   Xiao, Xiaohe ^a   Li, Huifang ^a   Zhao, Haiping ^a   Zhang, Ping ^a   Jin, Cheng ^a  

^a 302 MILITARY HOSPITAL   (China)

Author keywords

Anthraquinones; Chronic renal failure (CRF); High performance liquid chromatography (HPLC); Renal protection; Rhubarb; Toxicity

Indexed keywords

ANTHRAQUINONE DERIVATIVE; HYALIN; RHEIN; RHUBARB EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BIOCHEMISTRY; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EFFECT; DRUG MEGADOSE; DRUG SAFETY; DRUG STRUCTURE; FEMALE; HISTOPATHOLOGY; LIVER TOXICITY; LOW DRUG DOSE; MALE; NEPHROTOXICITY; NONHUMAN; RAT; RENAL PROTECTION; SYSTEMIC CIRCULATION; TOXICOKINETICS; TREATMENT DURATION;

ANIMALS; ANTHRAQUINONES; AREA UNDER CURVE; BLOOD CHEMICAL ANALYSIS; BLOOD PROTEINS; BLOOD UREA NITROGEN; CALCIUM; CREATININE; FEMALE; HYALIN; KIDNEY; KIDNEY FAILURE, CHRONIC; LIVER; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RHEUM; TRANSAMINASES;

RATTUS; RHEUM X HYBRIDUM;

EID: 67349185556     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.04.018     Document Type: Article

References (30)

1. Dictionary of Traditional Chinese Medicine, 1st ed., 1997. New Medical College of Jiangsu, People's Published of Shanghai, p. 102
2. European Pharmacopoeia, 4th ed., 2001. European Directorate for the Quality of Medicines, Council of Europe, Strasbourg, p. 1858.
3. Huang K.C. The Pharmacology of Chinese Herbs (1993), CRC Press, Boca Raton, FL pp. 233-234
4. Japanese Pharmacopoeia, 15th ed., 2006. Pharmaceutical and Food Safety Bureau, Ministry of Health, Labour and Welfare, Tokyo, p. 1344.
5. Kashiwada Y., Nonaka G.I., and Nishioka I. Studies on Rhubarb (Rhei Rhizoma). XV. Simultaneous determination of phenolic constituents by high-performance liquid chromatography. Chemical and Pharmaceutical Bulletin 37 (1989) 999-1004
6. Lacour B., Lucas A., Auchère D., Ruellan N., De Serre Patey N.M., and Drueke T.B. Chronic renal failure is associated with increased tissue deposition of lanthanum after 28-day oral administration. Kidney International 67 (2005) 1062-1069
7. Lee J.H., Kim J.M., and Kim C. Pharmacokinetic analysis of rhein in Rheum undulatum L. Journal of Ethnopharmacology 84 (2003) 5-9
8. Li L. End-stage renal disease in China. Kidney International 49 (1996) 287-301
9. Li X., and Wang H. Chinese herbal medicine in the treatment of chronic kidney disease. Advances in Chronic Kidney Diseases 12 (2005) 276-281
10. Li Z., Qing P., Ji L., Su B.H., He L., and Fan J.M. Systematic review of rhubarb for chronic renal failure. Chinese Journal of Evidence-Based Medicine 4 (2004) 468-473
11. Liu Z.H., Li L.S., Hu W.X., and Zhou H. Effect of emodin on c-myc proto-oncogene expression in cultured rat mesangial cells. Acta Pharmacology Sinica 17 (1996) 61-63
12. Mengs U., Krumbiegel G., and Völkner W. Lack of emodin genotoxicity in the mouse micronucleus assay. Mutation Research 393 (1997) 289-293
13. Mitsuma T., Terasawa K., Yokozawa T., and Oura H. Rhubarb therapy in patients with chronic renal failure (Part 1). Journal of Medical and Pharmaceutical Society for Wakan-Yaku 1 (1984) 266-278
14. Mitsuma T., Yokozawa T., Oura H., and Terasawa K. Rhubarb therapy in patients with chronic renal failure (Part 2). Japanese Journal of Nephrology 29 (1987) 195-207
15. Mueller S.O., Lutz W.K., and Stopper H. Factors affecting the genotoxic potency ranking of natural anthraquinones in mammalian cell culture systems. Mutation Research 414 (1998) 125-129
16. Mueller S.O., Stopper H., and Dekant W. Biotransformation of the anthraquinones emodin and chrysophanol by cytochrome P450 enzymes: bioactivation to genotoxic metabolites. Drug Metabolism and Disposition 26 (1998) 540-546
17. National Toxicology Program, 2001. Technical report on the toxicology and carcinogenesis studies of emodin in F344/N rats and B6C3F1 mice. Series No. 493. NIH Publication No. 01-3952. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC.
18. Pharmacopoeia of the People's Republic of China, First Div., 2005. China Chemical Industry Press, Beijing, pp. 17-18.
19. Terzi F., Beaufils H., Laouari D., Burtin M., and Kleinknecht C. Renal effect of antihypertensive drugs depends on sodium diet in the excision remnant kidney model. Kidney International 42 (1992) 354-363
20. Wang C.F., Wu X.D., Chen M., Duan W.G., Sun L.X., Yan M., and Zhang L.Y. Emodin induces apoptosis through caspase 3-dependent pathway in HK-2 cells. Toxicology 231 (2007) 120-128
21. Wang Q.X., Wu C.Q., and Liao M.Y. Study on the toxicity of rhubarb and main components contained in it. Journal of Toxicology 21 (2007) 301-302
22. Wang X.H., Wang X.Y., Xiong M.X., Zhang F.F., Wang N.N., Li J., He D.Y., and Yang J.W. Administration of rhubarb extract attenuates renal fibrosis in mice. Chinese Journal of Nephrology 22 (2006) 360-363
23. Xiao W., Deng H.Z., and Ma Y. Summarization of the clinical and laboratory study on the rhubarb in treating chronic renal failure. Chinese Journal of Chinese Materia Medica 27 (2002) 4-7 25
24. Xiao X.R. The correct application of rhubarb on chronic renal failure. Liaoning Journal of Traditional Chinese Medicine 29 (2002) 311-312
25. Yan M., Zhang L.Y., Sun L.X., Jiang Z.Z., and Xiao X.H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. Journal of Ethnopharmacology 107 (2006) 308-311
26. Yokozawa T., Suzuki N., Okuda I., Oura H., and Nishioka I. Changes in the urinary constituents in rats with chronic renal failure during oral administration of rhubarb extract. Chemical and Pharmaceutical Bulletin 33 (1985) 4508-4514
27. Yokozawa T., Zheng P.D., Oura H., and Koizumi F. Animal model of adenine-induced chronic renal failure in rats. Nephron 44 (1986) 230-234
28. Zhan Y.T., Wei H.S., Wang Z.R., Huang X., Xu Q.F., Li D.G., and Lu H.M. Effects of emodin on hepatic fibrosis in rats. Chinese Journal of Hepatology 9 (2001) 235-239
29. Zhang J.H., Yao X.D., and Song Y. The long-term effect of retarding chronic renal failure progression with rhubarb and catopril. Journal of Chinese Nephrology 9 (1993) 197-201
30. Zhou Y.P., and Jiang J.L. Review on the pharmacological researches of rhubarb. Pharmacology and Clinics of Chinese Materia Medica 7 (1991) 41-43