Stilbene glucoside inhibits the glucuronidation of emodin in rats through the down-regulation of UDP-glucuronosyltransferases 1A8: Application to a drug-drug interaction study in Radix Polygoni Multiflori

Journal of Ethnopharmacology

Volumn 147, Issue 2, 2013, Pages 335-340

  Ma, Jiang ^a   Zheng, Li ^a   Deng, Ting ^a   Li, Cui Li ^a   He, Yi Sheng ^a   Li, Hui Jun ^a   Li, Ping ^a  

^a China Pharmaceutical University   (China)

Author keywords

Drug drug interactions; Emodin; Multiflori; Pharmacokinetics; Polygoni; Radix; Stilbene glucoside; UDP glucuronosyltransferases

Indexed keywords

ANTHRAQUINONE DERIVATIVE; BETA GLUCURONIDASE; DRUG METABOLITE; EMODIN; FALLOPIA MULTIFLORA EXTRACT; GLUCOSIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A2; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; MESSENGER RNA; PLANT EXTRACT; STILBENE GLUCOSIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG GLUCURONIDATION; DRUG INHIBITION; DRUG STABILITY; FALLOPIA MULTIFLORA; GENE EXPRESSION; GENETIC ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INTESTINE; LIVER; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PROTEIN HYDROLYSIS; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VALIDATION PROCESS;

ANIMALS; DOWN-REGULATION; DRUG INTERACTIONS; EMODIN; GLUCOSIDES; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; INTESTINES; LIVER; MALE; PLANT EXTRACTS; PLANT ROOTS; POLYGONUM; RATS; RATS, WISTAR; RNA, MESSENGER; STILBENES;

RATTUS;

EID: 84876939998     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.03.013     Document Type: Article

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