Magnolol derivative 002C-3 protects brain against ischemia-reperfusion injury via inhibiting apoptosis and autophagy

Neuroscience Letters

Volumn 588, Issue , 2015, Pages 178-183

  Li, Hongfei ^a   Liu, Xiaoyan ^a   Zhu, Yuanjun ^a   Liu, Ye ^b   Wang, Yinye ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b Beijing Honghui New Medical Technology Co Ltd Beijing Daxing Biological Medicine Industry Base   (China)

Author keywords

002C 3; Apoptosis; Autophagy; Cerebral ischemia reperfusion

Indexed keywords

002C 3; BECLIN 1; CASPASE 3; MAGNOLOL; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; BIPHENYL DERIVATIVE; LIGNAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; BODY WEIGHT; BRAIN ISCHEMIA; BRAIN WATER; COMMON CAROTID ARTERY; CONTROLLED STUDY; DRUG EFFECT; EXTERNAL CAROTID ARTERY; HEMISPHERE; INTERNAL CAROTID ARTERY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; ANIMAL; BRAIN; BRAIN INFARCTION; CEREBRAL ARTERY DISEASE; COMPLICATION; DRUG EFFECTS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; AUTOPHAGY; BIPHENYL COMPOUNDS; BRAIN; BRAIN INFARCTION; CASPASE 3; INFARCTION, MIDDLE CEREBRAL ARTERY; LIGNANS; MALE; MICE; NEUROPROTECTIVE AGENTS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84921049043     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.01.007     Document Type: Article

References (22)

1. Fisher M., Feuerstein G., Howells D.W., Hurn P.D., Kent T.A., Savitz S.I., Lo E.H. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 2009, 40:2244-2250.
2. Wang Y.L. Current situation and the future of neuroprotective drugs for stroke. Chin. J. New Drug 2011, 20:985-987.
3. Ginsberg Myron D. Neuroprotection for ischemic stroke: past present and future. Neuropharmacology 2008, 55:363-389.
4. Lees K.R. NXY-059 for acute ischemic stroke. N. Engl. J. Med. 2006, 354:588-600.
5. Lee W.T. Magnolol reduces glutamate-induced neuronal excitotoxicity and protects against permanent focal cerebral ischemia up to 4 hours. PLoS One 2012, 7:e39952.
6. Hu H., Tang Z.Y., Chen S.Z., Wang Y.Y. Honokiol ameliorates focal cerebral ischemia and enhances tissue reactive oxygen species scavenging capacity after cerebral ischemia-reperfusion. Chin. J. Pharmacol. Toxicol. 2006, 20:455-460.
7. Hu Z.Y., Bian X.L., Liu X.Y., Zhu Y.J., Zhang X.Y., Chen S.Z., Wang K.W., Wang Y.Y. Honokiol protects brain against ischemia-reperfusion injury in rats through disrupting PSD95-nNOS interaction. Brain Res. 2013, 1491:204-212.
8. Chen Y.H. Magnolol: a multifunctional compound isolated from the Chinese medicinal Plant Magnolia officinalis. Eur. J. Integr. Med. 2011, 3:e317-e324.
9. Liu K.Y., Huang X.Z. Changes of TNF-α and IL-1β in focal cerebral ischemia-reperfusion injury in rats and effects of magnolol on them. Lishizhen Med. Mater. Medic. Res. 2006, 17:719-721.
10. Chen J.H., Kuo H.C., Lee K.F., Tsai T.H. Magnolol protects neurons against ischemia injury via the down regulation of p38/MAPK, CHOP and nitrotyrosine. Toxicol. Appl. Pharmacol. 2014, 279:294-302.
11. Liu K.Y., Huang X.Z. Neuroprotective effect of magnolol against focal cerebral ischemia-reperfusion injury and the relation to GABA in rats. Lishizhen Med. Mater. Medic. Res. 2006, 17:971-972.
12. Ai J. Honokiol and magnolol selectively interact with GABA receptor subtypes in vitro. Pharmacology 2001, 63:34-41.
13. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20:84-91.
14. Chao X., Zhou J., Chen T., Liu W., Dong W., Qu Y., Fei Z. Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats. Brain Res. 2010, 1363:206-211.
15. Xu X.H., Zhang S.M., Yan W.M., Li X.R., Zhang H.Y., Zheng X.X. Development of cerebral infarction, apoptotic cell death and expression of X-chromosome-linked inhibitor of apoptosis protein following focal cerebral ischemia in rats. Life Sci. 2006, 78:704-712.
16. Charriaut-Marlangue C., Remolleau S., Aggoun-Zouaoui D., Ben-Ari Y. Apoptosis and programmed cell death: a role in cerebral ischemia. Biomed. Pharmacother. 1998, 52:264-269.
17. Zhang X.X., Chen S.Z., Wang Y.Y. Honokiol up-regulates prostacyclin synthase protein expression and inhibits endothelial cell apoptosis. Eur. J. Pharmacol. 2007, 554:1-7.
18. Yang E.J., Lee J.Y., Park S.H., Lee T., Song K.S. Neuroprotective effects of neolignans isolated from Magnoliae Cortex against glutamate-induced apoptotic stimuli in HT22 cells. Food Chem. Toxicol. 2013, 56:304-312.
19. Adhami F., Liao G., Morozov Y.M., Schloemer A., Schmithorst V.J., Lorenz J.N., Kuan C.Y. Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am. J. Pathol. 2006, 169:566-583.
20. Rami A., Langhagen A., Steiger S. Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death. Neurobiol. Dis. 2008, 29:132-141.
21. Mizushima N., Yoshimori T., Levine B. Methods in mammalian autophagy research. Cell 2010, 140:313-326.
22. Barth S., Glick D., Macleod K.F. Autophagy: assays and artifacts. J. Pathol. 2010, 221:117-124.