Honokiol protects brain against ischemia-reperfusion injury in rats through disrupting PSD95-nNOS interaction

Brain Research

Volumn 1491, Issue , 2013, Pages 204-212

  Hu, Zhenyu ^a   Bian, Xiling ^a   Liu, Xiaoyan ^a   Zhu, Yuanjun ^a   Zhang, Xiaoyi ^b   Chen, Shizhong ^a   Wang, Kewei ^a   Wang, Yinye ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Cerebral ischemia reperfusion; Honokiol; NMDA; PSD95 nNOS; Therapeutic time window

Indexed keywords

GLUCOSE; GLUTAMIC ACID; HONOKIOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NEURONAL NITRIC OXIDE SYNTHASE; OXYGEN; POSTSYNAPTIC DENSITY PROTEIN 95;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PROTECTION; BRAIN WATER; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; CYTOSOL; IMMUNOPRECIPITATION; MALE; MICROEMULSION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

ANIMALS; BIPHENYL COMPOUNDS; BISBENZIMIDAZOLE; BLOTTING, WESTERN; CELL HYPOXIA; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CEREBRAL CORTEX; COLORING AGENTS; CYTOSOL; GLUCOSE; GLUTAMIC ACID; IMMUNOPRECIPITATION; INFARCTION, MIDDLE CEREBRAL ARTERY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; L-LACTATE DEHYDROGENASE; LIGNANS; MALE; MEMBRANE PROTEINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; REPERFUSION INJURY; TRANSLOCATION, GENETIC;

MAGNOLIA OFFICINALIS; RATTUS;

EID: 84874017901     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.11.004     Document Type: Article

References (35)

1. M. Aarts, Y. Liu, L. Liu, S. Besshoh, M. Arundine, J.W. Gurd, and Y.T. Wang Salter MW, Tymianski M. treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions Science 298 2002 846 850
2. L. Belayev, R. Alonso, W.Z. Zhao, and M.D. Ginsberg Middle cerebral artery occlusion in the rat by intraluminal suture: neurological and pathological evaluation of an improved model Stroke 27 1996 1616 1622
3. X. Chao, J. Zhou, T. Chen, W. Liu, W. Dong, Y. Qu, X. Jiang, X. Ji, H. Zhen, and Z. Fei Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats Brain Res. 1363 2010 206 211
4. K.S. Christopherson, B.J. Hillier, W.A. Lim, and D.S. Bredt PSD-95 assembles a ternary complex with the N-methyl-d-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain J. Biol. Chem. 274 1999 27467 27473
5. H.S. Cui, L.S. Huang, D.E. Sok, J. Shin, B.M. Kwon, U.J. Youn, and K. Bae Protective action of honokiol, administered orally, against oxidative stress in brain of mice challenged with NMDA Phytomedicine 14 2007 696 700
6. U. Dirnagl, C. Ladecola, and M.A. Moskowitz Pathobiology of ischaemic stroke: an integrated view Trends Neurosci. 22 1999 391 397
7. W.L. Du, J.B. Huang, H.L. Yao, K.C. Zhou, B. Duan, and Y.Z. Wang Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats J. Clin. Invest. 120 2010 3480 3492
8. J. Fan, O.C. Vasuta, L.Y. Zhang, L. Wang., A. George, and L.A. Raymond N-methyl-d-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95 J. Neurochem. 115 2010 1045 1056
9. H. Hu, Z.Y. Tang, S.Z. Chen, and Y.Y. Wang Honokiol ameliorates focal cerebral ischemia and enhances tissue reactive oxygen species scavenging capacity after cerebral ischemia/reperfusion Chin. J. Pharmacol. Toxicol. 6 2006 455 460
10. J.B. Kelley, M.A. Balda, K.L. Anderson, and Y. Itzhak Impairments in fear conditioning in mice lacking the nNOS gene Learn. Mem 16 2009 371 378
11. R.G. Keynes, and J. Garthwaite Nitric oxide and its role in ischaemic brain injury Curr. Mol. Med. 4 2004 179 191
12. H. Kuribara, E. Kishi, M. Kimura, S.T. Weintraub, and Y. Maruyama Comparative assessment of the anxiolytic like activities of honokiol and derivatives Pharmacol. Biochem. Behav. 67 2000 597 601
13. T.W. Lai, W.C. Shyu, and Y.T. Wang Stroke intervention pathways: NMDA receptors and beyond Trends Mol. Med. 17 2011 266 275
14. Y.R. Lin, H.H. Chen, C.H. Ko, and M.H. Chan Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures Neuropharmacology 49 2005 542 550
15. Y.R. Lin, H.H. Chen, C.H. Ko, and M.H. Chan Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage Eur. J. Pharmacol. 537 2006 64 69
16. K.T. Liou, S.M. Lin, S.S. Huang, C.L. Chih, and S.K. Tsai Honokiol ameliorates cerebral infarction from ischemia/reperfusion injury in rats Planta. Med. 69 2003 130 134
17. F.D. Liu, and L.D. McCullough Middle cerebral artery occlusion model in rodents: methods and potential pitfalls J. Biomed. Biotech. 2011 2011 1 9
18. R. Liu, M. Gao, Z.H. Yang, and G.H. Du Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia/reperfusion both in vivo and in vitro Brain Res. 1216 2008 104 115
19. E.H. Lo, T. Dalkara, and M.A. Moskowitz Mechanisms, challenges and opportunities in stroke Nat. Rev. Neurosci. 4 2003 399 415
20. E.Z. Longa, P.R. Weinstein, S. Carlson, and R. Cummins Reversible middle cerebral artery occlusion without craniectomy in rats Stroke 20 1989 84 91
21. J.F. MacDonald, and M.F. Jackson Transient receptor potential channels of the melastatin family and ischemic responses of central neurons Stroke 38 2007 665 669
22. M.A. Moskowitz, E.H. Lo, and C. Ladecola The science of stroke: mechanisms in search of treatments Neuron 67 2010 181 198
23. S. Onoue, K. Endo, T. Yajima, and K. Kashimoto Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide attenuate glutamate-induced nNOS activation and cytotoxicity Regul. Pept. 107 2002 43 47
24. T. Papouin, L. Ladepeche, J. Ruel, S. Sacchi, and M. labasque Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists Cell 150 2012 633 646
25. J.E. Su, L. Fredriksson, M. Geyer, and E. Folestad Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke Nat. Med. 14 2008 731 737
26. Y. Terasaki, T. Sasaki, Y. Yagita, S. Okazaki, Y. Sugiyama, N. Oyama, E. Omura-Matsuoka, S. Sakoda, and K. Kitagawa Activation of NR2A receptors induces ischemic tolerance through CREB signaling J. Cereb. Blood Flow. Metab. 30 2010 1441 1449
27. W. Tu, X. Xu, L. Peng, and X. Zhong DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke Cell. 140 2010 222 234
28. R. Veltkamp, D.A. Siebing, S. Heiland, and K. Bieber Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia Stroke. 36 2005 1679 1683
29. X.H. Wang, X.M. Duan, G.L Yang, X.Y. Zhang, and L.Y. Deng Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9L intracerebral gliosarcoma model and human U251 Xenograft glioma model PLoS One 6 2011 1 12
30. K. Watanabe, H. Watanabe, Y. Goto, M. Yamaguchi, N. Yamamoto, and K. Hagino Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis: central depressant effects Planta Med. 49 1983 103 108
31. B. Xing, H. Chen, M. Zhang, D. Zhao, R. Jiang, X. Liu, and S. Zhang Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat Stroke. 39 2008 2362 2369
32. S. Yang, X.Y. Liu, Z.Y. Hu, S.Z. Chen, and Y.Y. Wang Honokiol protects global brain ischemia in mice through inhibiting MPTP opening and PARP-1 activity Chin. Pharmacol. Bull. 28 2012 218 221
33. S.W. Yu, H. Wang, M.F. Poitras, and C. Coombs Mediation of poly (ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor Science. 297 2002 259 263
34. Y. Zhang, P. Su, P. Liang, and T. Liu The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit J. Neurosci. 30 2010 7575 7586
35. L. Zhou, F. Li, H.B. Xu, C.X. Luo, H.Y. Wu, M.M. Zhu, W. Lu, X. Ji, Q.G. Zhou, and D.Y. Zhu Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95 Nat. Med. 16 2010 1439 1443