Magnolol protects neurons against ischemia injury via the downregulation of p38/MAPK, CHOP and nitrotyrosine

Toxicology and Applied Pharmacology

Volumn 279, Issue 3, 2014, Pages 294-302

  Chen, Jiann Hwa ^a,b,c   Kuo, Hsing Chun ^d,e   Lee, Kam Fai ^f   Tsai, Tung Hu ^a,g,h  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c CATHAY GENERAL HOSPITAL   (Taiwan)

^d CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e Department of Nursing Chronic Diseases and Health Promotion Research Center Chang Gung University of Science and Technology Chiayi Campus   (Taiwan)

^f CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^g CHINA MEDICAL UNIVERSITY   (Taiwan)

^h TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

Akt; Inducible NO synthase; Magnolol; NF B; P38 mitogen activated protein kinases; Stroke animal model

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAGNOLOL; MITOGEN ACTIVATED PROTEIN KINASE P38; PLASMA PROTEIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN ISCHEMIA; CELL ACTIVATION; COMMON CAROTID ARTERY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; ENZYME INHIBITION; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MAGNOLIA OFFICINALIS; MALE; NEUROPROTECTION; NONHUMAN; RAT; REPERFUSION INJURY; UPREGULATION; WESTERN BLOTTING; ANIMAL CELL; BRAIN INFARCTION; BRAIN INJURY; CAROTID ARTERY OBSTRUCTION; CELL SURVIVAL; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; IN VIVO STUDY; LIGHT CHAIN; NERVE CELL;

AKT; INDUCIBLE NO SYNTHASE; MAGNOLOL; NF-ΚB; P38 MITOGEN-ACTIVATED PROTEIN KINASES; STROKE ANIMAL MODEL;

ANIMALS; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; BRAIN; BRAIN ISCHEMIA; CELL DEATH; ENDOPLASMIC RETICULUM STRESS; IMMUNOHISTOCHEMISTRY; INDICATORS AND REAGENTS; ISCHEMIC ATTACK, TRANSIENT; LIGNANS; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; ONCOGENE PROTEIN V-AKT; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; STROKE; TRANSCRIPTION FACTOR CHOP; TYROSINE;

EID: 84907161167     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.07.005     Document Type: Article

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