Magnolol reduces glutamate-induced neuronal excitotoxicity and protects against permanent focal cerebral ischemia up to 4 hours

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Lee, Wei Ting ^a,b   Lin, Miao Hui ^c   Lee, E Jian ^a   Hung, Yu Chang ^a   Tai, Shih Huang ^a   Chen, Hung Yi ^d   Chen, Tsung Ying ^e   Wu, Tian Shung ^b  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c NATIONAL UNIVERSITY OF TAINAN   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GLUTAMIC ACID; MACROGOL; MAGNOLOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFICACY; DRUG SAFETY; EXCITOTOXICITY; LD 50; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT; TREATMENT RESPONSE;

ANIMALS; BIPHENYL COMPOUNDS; BRAIN; CALCIUM; CELLS, CULTURED; CEREBRAL INFARCTION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; INFARCTION, MIDDLE CEREBRAL ARTERY; INJECTIONS, INTRAPERITONEAL; LIGNANS; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROPSYCHOLOGICAL TESTS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 84863622614     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039952     Document Type: Article

References (32)

1. Choi DW, (1998) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634.
2. Papadia S, Stevenson P, Hardingham NR, Bading H, Hardingham GE, (2005) Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection. J Neurosci 25: 4279-4287.
3. Papadia S, Soriano FX, Leveille F, Martel MA, Dakin KA, et al. (2008) Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci 11: 476-487.
4. Zhang M, Xu JT, Zhu X, Wang Z, Zhao X, et al. (2010) Postsynaptic density-93 deficiency protects cultured cortical neurons from N-methyl-D-aspartate receptor-triggered neurotoxicity. Neuroscience 166: 1083-1090.
5. Fan J, Vasuta OC, Zhang LY, Wang L, George A, et al. (2010) N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95. J Neurochem 115: 1045-1056.
6. Clemens JA, (2000) Cerebral ischemia: gene activation, neuronal injury, and the protective role of antioxidants. Free Radic Biol Med 28: 1526-1531.
7. Markgraf CG, Velayo NL, Johnson MP, McCarty DR, Medhi S, et al. (1998) Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats. Stroke 29: 152-158.
8. Lee EJ, Chen HY, Wu TS, Chen TY, Ayoub IA, et al. (2002) Acute administration of Ginkgo biloba extract (EGb 761) affords neuroprotection against permanent and transient focal cerebral ischemia in Sprague-Dawley rats. J Neurosci Res 68: 636-645.
9. Lee EJ, Chen HY, Lee MY, Chen TY, Hsu YS, et al. (2005) Cinnamophilin reduces oxidative damage and protects against transient focal cerebral ischemia in mice. Free Radic Biol Med 39: 495-510.
10. Ritz MF, Curin Y, Mendelowitsch A, Andriantsitohaina R, (2008) Acute treatment with red wine polyphenols protects from ischemia-induced excitotoxicity, energy failure and oxidative stress in rats. Brain Res 1239: 226-234.
11. Lin SP, Tsai SY, Lee Chao PD, Chen YC, Hou YC, (2011) Pharmacokinetics, bioavailability, and tissue distribution of magnolol following single and repeated dosing of magnolol to rats. Planta Med 77: 1800-1805.
12. Watanebe K, Watanabe H, Goto Y, Yamaguchi M, Yamamoto N, et al. (1983) Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis: central depressant effects. Planta Med 49: 103-108.
13. Chen HY, Hung YC, Lee EJ, Chen TY, Chuang IC, et al. (2009) The protective efficacy of magnolol in hind limb ischemia-reperfusion injury. Phytomedicine 16: 976-981.
14. Chang CP, Hsu YC, Lin MT, (2003) Magnolol protects against cerebral ischaemic injury of rat heatstroke. Clin Exp Pharmacol Physiol 30: 387-392.
15. Lee MM, Hseih MT, Kuo JS, Yeh FT, Huang HM, (1998) Magnolol protects cortical neuronal cells from chemical hypoxia in rats. NeuroReport 9: 3451-3456.
16. Lin YR, Chen HH, Ko CH, Chan MH, (2006) Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage. Eur J Pharmacol 537: 64-69.
17. Teng CM, Yu SM, Chen CC, Huang YL, Huang TF, (1990) EDRF-release and Ca+2-channel blockade by magnolol, an antiplatelet agent isolated from Chinese herb Magnolia officinalis, in rat thoracic aorta. Life Sci 47: 1153-1161.
18. Tai SH, Hung YC, Lee EJ, Lee AC, Chen TY, et al. (2011) Melatonin protects against transient focal cerebral ischemia in both reproductively active and estrogen-deficient female rats: the impact of circulating estrogen on its hormetic dose-response. J Pineal Res 50: 292-303.
19. Lee EJ, Hung YC, Chen HY, Wu TS, Chen TY, (2009) Delayed treatment with carboxy-PTIO permits a 4-hour therapeutic window of opportunity and prevents against ischemia-induced energy depletion following permanent focal cerebral ischemia in mice. Neurochem Res 34: 1157-1166.
20. Hsieh MT, Chueh FY, Lin MT, (1988) Magnolol decreases body temperature by reducing 5-hydroxytryptamine release in the rat hypothalamus. Clin Exp Pharmacol Physiol 25: 813-817.
21. Yanamoto H, Nagata I, Niitsu Y, Zhang Z, Xue JH, et al. (2001) Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia. Stroke 32: 232-239.
22. Hatfield RH, Gill R, Brazell C, (1992) The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model. Eur J Pharmacol 216: 1-7.
23. Chen TY, Tai SH, Lee EJ, Huang CC, Lee AC, et al. (2011) Cinnamophilin offers prolonged neuroprotection against gray and white matter damage and improves functional and electrophysiological outcomes following transient focal cerebral ischemia. Crit Care Med 39: 1130-1137.
24. Lee EJ, Chen HY, Hung YC, Chen TY, Lee MY, et al. (2009) Therapeutic window for cinnamophilin following oxygen-glucose deprivation and transient focal cerebral ischemia. Exp Neurol 217: 74-83.
25. Chen TY, Lin MH, Lee WT, Huang SY, Chen YH, et al. (2012) Nicotinamide inhibits nuclear factor-kappa B translocation after transient focal cerebral ischemia. Crit Care Med 40: 532-537.
26. Williams DA, Fay FS, (1990) Intracellular calibration of the fluorescent calcium indicator Fura-2. Cell Calcium 11: 75-83.
27. Hedrick MS, Fahlman CS, Bickler PE, (2005) Intracellular calcium and survival of tadpole forebrain cells in anoxia. J Exp Biol 208: 681-686.
28. Grynkiewicz G, Poenie M, Tsien RY, (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450.
29. Sun DA, Sombati S, DeLorenzo RJ, (2001) Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced "epilepsy" Stroke 32: 2344-2350.
30. DeLorenzo RJ, Sun DA, Blair RE, Sombati S, (2007) An in vitro model of stroke-induced epilepsy: elucidation of the roles of glutamate and calcium in the induction and maintenance of stroke-induced epileptogenesis. Int Rev Neurobiol 81: 59-84.
31. Chen HY, Hung YC, Chen TY, Huang SY, Wang YH, et al. (2009) Melatonin improves presynaptic protein, SNAP-25, expression and dendritic spine density and enhances functional and electrophysiological recovery following transient focal cerebral ischemia in rats. J Pineal Res 47: 260-270.
32. Tai SH, Chen HY, Lee EJ, Chen TY, Lin HW, et al. (2010) Melatonin inhibits postischemic matrix metalloproteinase-9 (MMP-9) activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral ischemia. J Pineal Res 49: 332-341.