Small molecule-based disruption of the Axin/Β-catenin protein complex regulates mesenchymal stem cell differentiation

Cell Research

Volumn 22, Issue 1, 2012, Pages 237-247

  Gwak, Jungsug ^a   Hwang, Sun Gwan ^b,c   Park, Hyung Soon ^d   Choi, Sang Rak ^b   Park, Sun Hee ^e   Kim, Hyunjoon ^f   Ha, Nam Chul ^e   Bae, Sung Jin ^b   Han, Jin Kwan ^f   Kim, Dong Eun ^g   Cho, Jeong Woo ^b   Oh, Sangtaek ^a  

^a Kookmin University   (South Korea)

^b SK Biopharmaceuticals Co   (South Korea)

^c Korea University College of Medicine   (South Korea)

^d Probiond Co Ltd   (South Korea)

^e Pusan National University   (South Korea)

^f Pohang University of Science and Technology (POSTECH)   (South Korea)

^g Konkuk University   (South Korea)

Author keywords

Catenin complex; Axin ; Mesenchymal stem cell; Small molecule; Wnt pathway

Indexed keywords

5 FURAN 2YL ISOXAZOLE 3 CARBOXYLIC ACID (3 IMIDAZOL 1YL PROPYL) AMIDE; 5-FURAN-2YL-ISOXAZOLE-3-CARBOXYLIC ACID (3-IMIDAZOL-1YL-PROPYL)-AMIDE; AXIN; BETA CATENIN; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; IMIDAZOLE DERIVATIVE; ISOXAZOLE DERIVATIVE; SERINE; THREONINE;

ADIPOCYTE; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN HEK293; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ASSAY; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOPRECIPITATION; MESENCHYMAL STEM CELL; METABOLISM; OSTEOBLAST; PHOSPHORYLATION; PLASMID; PROTEIN ANALYSIS; PROTEIN DEGRADATION; WNT SIGNALING PATHWAY;

ADIPOCYTES; AXIN SIGNALING COMPLEX; BETA CATENIN; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME ASSAYS; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HEK293 CELLS; HUMANS; IMIDAZOLES; IMMUNOPRECIPITATION; ISOXAZOLES; MESENCHYMAL STEM CELLS; OSTEOBLASTS; PHOSPHORYLATION; PLASMIDS; PROTEIN INTERACTION MAPPING; PROTEOLYSIS; SERINE; THREONINE; TRANSFECTION; WNT SIGNALING PATHWAY;

EID: 84855497795     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2011.127     Document Type: Article

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