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Volumn 61, Issue 1, 2015, Pages 214-226

FAK Is required for c-Met/β-catenin-driven hepatocarcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D1; FOCAL ADHESION KINASE 1; FOCAL ADHESION KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SCATTER FACTOR RECEPTOR; CCND1 PROTEIN, MOUSE; CTNNB1 PROTEIN, MOUSE; PTK2 PROTEIN, MOUSE; PTK2B PROTEIN, MOUSE;

EID: 84921000808     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27402     Document Type: Article
Times cited : (68)

References (47)
  • 1
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • Bruix J, Sherman M, Practice Guidelines Committee AAftSoLD. Management of hepatocellular carcinoma. Hepatology 2005;42:1208-1236.
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 2
    • 84873726893 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of hepatocellular carcinoma: an update
    • Aravalli RN, Cressman EN, Steer CJ. Cellular and molecular mechanisms of hepatocellular carcinoma: an update. Arch Toxicol 2013;87:227-247.
    • (2013) Arch Toxicol , vol.87 , pp. 227-247
    • Aravalli, R.N.1    Cressman, E.N.2    Steer, C.J.3
  • 3
    • 15844387736 scopus 로고    scopus 로고
    • Surgical treatment of hepatocellular carcinoma
    • Belghiti J, Kianmanesh R. Surgical treatment of hepatocellular carcinoma. HPB (Oxford) 2005;7:42-49.
    • (2005) HPB (Oxford) , vol.7 , pp. 42-49
    • Belghiti, J.1    Kianmanesh, R.2
  • 4
    • 15844428989 scopus 로고    scopus 로고
    • Non-surgical treatment of hepatocellular carcinoma
    • Johnson PJ. Non-surgical treatment of hepatocellular carcinoma. HPB (Oxford) 2005;7:50-55.
    • (2005) HPB (Oxford) , vol.7 , pp. 50-55
    • Johnson, P.J.1
  • 7
    • 79959971564 scopus 로고    scopus 로고
    • Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis
    • Zhao X, Guan JL. Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Adv Drug Deliv Rev 2011;63:610-615.
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 610-615
    • Zhao, X.1    Guan, J.L.2
  • 9
    • 61749094852 scopus 로고    scopus 로고
    • Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling
    • Pylayeva Y, Gillen KM, Gerald W, Beggs HE, Reichardt LF, Giancotti FG. Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest 2009;119:252-266.
    • (2009) J Clin Invest , vol.119 , pp. 252-266
    • Pylayeva, Y.1    Gillen, K.M.2    Gerald, W.3    Beggs, H.E.4    Reichardt, L.F.5    Giancotti, F.G.6
  • 10
    • 77955587900 scopus 로고    scopus 로고
    • Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling
    • Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, et al. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell 2010;19:259-269.
    • (2010) Dev Cell , vol.19 , pp. 259-269
    • Ashton, G.H.1    Morton, J.P.2    Myant, K.3    Phesse, T.J.4    Ridgway, R.A.5    Marsh, V.6
  • 11
    • 78650413746 scopus 로고    scopus 로고
    • Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma
    • Lee J, Borboa AK, Chun HB, Baird A, Eliceiri BP. Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma. Cancer Res 2010;70:10131-10140.
    • (2010) Cancer Res , vol.70 , pp. 10131-10140
    • Lee, J.1    Borboa, A.K.2    Chun, H.B.3    Baird, A.4    Eliceiri, B.P.5
  • 12
    • 1942534181 scopus 로고    scopus 로고
    • Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma
    • Itoh S, Maeda T, Shimada M, Aishima S, Shirabe K, Tanaka S, et al. Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. Clin Cancer Res 2004;10:2812-2817.
    • (2004) Clin Cancer Res , vol.10 , pp. 2812-2817
    • Itoh, S.1    Maeda, T.2    Shimada, M.3    Aishima, S.4    Shirabe, K.5    Tanaka, S.6
  • 13
    • 3442890219 scopus 로고    scopus 로고
    • Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor
    • Fujii T, Koshikawa K, Nomoto S, Okochi O, Kaneko T, Inoue S, et al. Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor. J Hepatol 2004;41:104-111.
    • (2004) J Hepatol , vol.41 , pp. 104-111
    • Fujii, T.1    Koshikawa, K.2    Nomoto, S.3    Okochi, O.4    Kaneko, T.5    Inoue, S.6
  • 14
    • 33745220780 scopus 로고    scopus 로고
    • Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    • Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouarn C, Factor VM, Thorgeirsson SS. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest 2006;116:1582-1595.
    • (2006) J Clin Invest , vol.116 , pp. 1582-1595
    • Kaposi-Novak, P.1    Lee, J.S.2    Gomez-Quiroz, L.3    Coulouarn, C.4    Factor, V.M.5    Thorgeirsson, S.S.6
  • 15
    • 35548966020 scopus 로고    scopus 로고
    • Distinct pathways of genomic progression to benign and malignant tumors of the liver
    • Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, Chen X, et al. Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A 2007;104:14771-14776.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 14771-14776
    • Tward, A.D.1    Jones, K.D.2    Yant, S.3    Cheung, S.T.4    Fan, S.T.5    Chen, X.6
  • 16
    • 63349098247 scopus 로고    scopus 로고
    • Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene
    • Cieply B, Zeng G, Proverbs-Singh T, Geller DA, Monga SP. Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. Hepatology 2009;49:821-831.
    • (2009) Hepatology , vol.49 , pp. 821-831
    • Cieply, B.1    Zeng, G.2    Proverbs-Singh, T.3    Geller, D.A.4    Monga, S.P.5
  • 18
    • 58249117627 scopus 로고    scopus 로고
    • Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis
    • Patil MA, Lee SA, Macias E, Lam ET, Xu C, Jones KD, et al. Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis. Cancer Res 2009;69:253-261.
    • (2009) Cancer Res , vol.69 , pp. 253-261
    • Patil, M.A.1    Lee, S.A.2    Macias, E.3    Lam, E.T.4    Xu, C.5    Jones, K.D.6
  • 19
    • 17844408441 scopus 로고    scopus 로고
    • Deletion of Bid impedes cell proliferation and hepatic carcinogenesis
    • Bai L, Ni HM, Chen X, DiFrancesca D, Yin XM. Deletion of Bid impedes cell proliferation and hepatic carcinogenesis. Am J Pathol 2005;166:1523-1532.
    • (2005) Am J Pathol , vol.166 , pp. 1523-1532
    • Bai, L.1    Ni, H.M.2    Chen, X.3    DiFrancesca, D.4    Yin, X.M.5
  • 20
    • 77952972412 scopus 로고    scopus 로고
    • Isolation and culture of adult mouse hepatocytes
    • Li WC, Ralphs KL, Tosh D. Isolation and culture of adult mouse hepatocytes. Methods Mol Biol 2010;633:185-196.
    • (2010) Methods Mol Biol , vol.633 , pp. 185-196
    • Li, W.C.1    Ralphs, K.L.2    Tosh, D.3
  • 21
    • 80053331459 scopus 로고    scopus 로고
    • PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice
    • Qiu W, Wang X, Leibowitz B, Yang W, Zhang L, Yu J. PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice. Hepatology 2011;54:1249-1258.
    • (2011) Hepatology , vol.54 , pp. 1249-1258
    • Qiu, W.1    Wang, X.2    Leibowitz, B.3    Yang, W.4    Zhang, L.5    Yu, J.6
  • 22
  • 23
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001;411:342-348.
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 24
    • 0029741102 scopus 로고    scopus 로고
    • Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation
    • Gilmore AP, Romer LH. Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol Biol Cell 1996;7:1209-1224.
    • (1996) Mol Biol Cell , vol.7 , pp. 1209-1224
    • Gilmore, A.P.1    Romer, L.H.2
  • 25
    • 0029739950 scopus 로고    scopus 로고
    • Control of adhesion-dependent cell survival by focal adhesion kinase
    • Frisch SM, Vuori K, Ruoslahti E, Chan-Hui PY. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 1996;134:793-799.
    • (1996) J Cell Biol , vol.134 , pp. 793-799
    • Frisch, S.M.1    Vuori, K.2    Ruoslahti, E.3    Chan-Hui, P.Y.4
  • 26
    • 34250026140 scopus 로고    scopus 로고
    • Structural basis for the autoinhibition of focal adhesion kinase
    • Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ. Structural basis for the autoinhibition of focal adhesion kinase. Cell 2007;129:1177-1187.
    • (2007) Cell , vol.129 , pp. 1177-1187
    • Lietha, D.1    Cai, X.2    Ceccarelli, D.F.3    Li, Y.4    Schaller, M.D.5    Eck, M.J.6
  • 27
    • 13944282937 scopus 로고    scopus 로고
    • Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior
    • Brunton VG, Avizienyte E, Fincham VJ, Serrels B, Metcalf CA 3rd, Sawyer TK, et al. Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. Cancer Res 2005;65:1335-1342.
    • (2005) Cancer Res , vol.65 , pp. 1335-1342
    • Brunton, V.G.1    Avizienyte, E.2    Fincham, V.J.3    Serrels, B.4    Metcalf, C.A.5    Sawyer, T.K.6
  • 28
    • 80052033164 scopus 로고    scopus 로고
    • c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma
    • You H, Ding W, Dang H, Jiang Y, Rountree CB. c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma. Hepatology 2011;54:879-889.
    • (2011) Hepatology , vol.54 , pp. 879-889
    • You, H.1    Ding, W.2    Dang, H.3    Jiang, Y.4    Rountree, C.B.5
  • 29
    • 33746628448 scopus 로고    scopus 로고
    • Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation
    • Koga F, Xu W, Karpova TS, McNally JG, Baron R, Neckers L. Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation. Proc Natl Acad Sci U S A 2006;103:11318-11322.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11318-11322
    • Koga, F.1    Xu, W.2    Karpova, T.S.3    McNally, J.G.4    Baron, R.5    Neckers, L.6
  • 30
    • 0036531819 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
    • Monga SP, Mars WM, Pediaditakis P, Bell A, Mule K, Bowen WC, et al. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res 2002;62:2064-2071.
    • (2002) Cancer Res , vol.62 , pp. 2064-2071
    • Monga, S.P.1    Mars, W.M.2    Pediaditakis, P.3    Bell, A.4    Mule, K.5    Bowen, W.C.6
  • 31
    • 33749117134 scopus 로고    scopus 로고
    • Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions
    • Zeng G, Apte U, Micsenyi A, Bell A, Monga SP. Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions. Exp Cell Res 2006;312:3620-3630.
    • (2006) Exp Cell Res , vol.312 , pp. 3620-3630
    • Zeng, G.1    Apte, U.2    Micsenyi, A.3    Bell, A.4    Monga, S.P.5
  • 32
    • 33847014441 scopus 로고    scopus 로고
    • A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth
    • Rasola A, Fassetta M, De Bacco F, D'Alessandro L, Gramaglia D, Di Renzo MF, et al. A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth. Oncogene 2007;26:1078-1087.
    • (2007) Oncogene , vol.26 , pp. 1078-1087
    • Rasola, A.1    Fassetta, M.2    De Bacco, F.3    D'Alessandro, L.4    Gramaglia, D.5    Di Renzo, M.F.6
  • 33
    • 0028292294 scopus 로고
    • Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma
    • Nishida N, Fukuda Y, Komeda T, Kita R, Sando T, Furukawa M, et al. Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res 1994;54:3107-3110.
    • (1994) Cancer Res , vol.54 , pp. 3107-3110
    • Nishida, N.1    Fukuda, Y.2    Komeda, T.3    Kita, R.4    Sando, T.5    Furukawa, M.6
  • 37
    • 0032531732 scopus 로고    scopus 로고
    • Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK-cell migration
    • Sieg DJ, Ilic D, Jones KC, Damsky CH, Hunter T, Schlaepfer DD. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK-cell migration. EMBO J 1998;17:5933-5947.
    • (1998) EMBO J , vol.17 , pp. 5933-5947
    • Sieg, D.J.1    Ilic, D.2    Jones, K.C.3    Damsky, C.H.4    Hunter, T.5    Schlaepfer, D.D.6
  • 38
    • 42049113411 scopus 로고    scopus 로고
    • Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK
    • Weis SM, Lim ST, Lutu-Fuga KM, Barnes LA, Chen XL, Gothert JR, et al. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol 2008;181:43-50.
    • (2008) J Cell Biol , vol.181 , pp. 43-50
    • Weis, S.M.1    Lim, S.T.2    Lutu-Fuga, K.M.3    Barnes, L.A.4    Chen, X.L.5    Gothert, J.R.6
  • 39
    • 79956306365 scopus 로고    scopus 로고
    • Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity
    • Fan H, Guan JL. Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity. J Biol Chem 2011;286:18573-18582.
    • (2011) J Biol Chem , vol.286 , pp. 18573-18582
    • Fan, H.1    Guan, J.L.2
  • 40
    • 84856527774 scopus 로고    scopus 로고
    • Oncogenic beta-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice
    • Anson M, Crain-Denoyelle AM, Baud V, Chereau F, Gougelet A, Terris B, et al. Oncogenic beta-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice. J Clin Invest 2012;122:586-599.
    • (2012) J Clin Invest , vol.122 , pp. 586-599
    • Anson, M.1    Crain-Denoyelle, A.M.2    Baud, V.3    Chereau, F.4    Gougelet, A.5    Terris, B.6
  • 41
    • 33745468872 scopus 로고    scopus 로고
    • Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion
    • Chen SY, Chen HC. Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol Cell Biol 2006;26:5155-5167.
    • (2006) Mol Cell Biol , vol.26 , pp. 5155-5167
    • Chen, S.Y.1    Chen, H.C.2
  • 42
    • 80051710743 scopus 로고    scopus 로고
    • FAK and WNT signaling: the meeting of two pathways in cancer and development
    • Fonar Y, Frank D. FAK and WNT signaling: the meeting of two pathways in cancer and development. Anticancer Agents Med Chem 2011;11:600-606.
    • (2011) Anticancer Agents Med Chem , vol.11 , pp. 600-606
    • Fonar, Y.1    Frank, D.2
  • 43
    • 73149114381 scopus 로고    scopus 로고
    • Early activation of the beta-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase
    • Santos A, Bakker AD, Zandieh-Doulabi B, de Blieck-Hogervorst JM, Klein-Nulend J. Early activation of the beta-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase. Biochem Biophys Res Commun 2010;391:364-369.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 364-369
    • Santos, A.1    Bakker, A.D.2    Zandieh-Doulabi, B.3    de Blieck-Hogervorst, J.M.4    Klein-Nulend, J.5
  • 45
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999;398:422-426.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 46
    • 77952469195 scopus 로고    scopus 로고
    • Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer
    • Schultze A, Fiedler W. Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer. Expert Opin Investig Drugs 2010;19:777-788.
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 777-788
    • Schultze, A.1    Fiedler, W.2
  • 47
    • 84862990976 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors
    • Infante JR, Camidge DR, Mileshkin LR, Chen EX, Hicks RJ, Rischin D, et al. Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors. J Clin Oncol 2012;30:1527-1533.
    • (2012) J Clin Oncol , vol.30 , pp. 1527-1533
    • Infante, J.R.1    Camidge, D.R.2    Mileshkin, L.R.3    Chen, E.X.4    Hicks, R.J.5    Rischin, D.6


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