Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK

Toxicology and Applied Pharmacology

Volumn 273, Issue 1, 2013, Pages 130-139

  Song, Mi Kyung ^a,b   Park, Yong Keun ^b   Ryu, Jae Chun ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

Author keywords

Hepatocellular carcinoma (HCC); MAPK phosphatase (MKP); MicroRNA (miRNA); Migration; P38 MAPK; Polycyclic aromatic hydrocarbons (PAHs)

Indexed keywords

BENZ[A]ANTHRACENE; BENZO[K]FLUORANTHENE; MICRORNA; MICRORNA 181; MICRORNA 181A; MICRORNA 181B; MICRORNA 181D; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 5; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CANCER CELL; CANCER GROWTH; CELL ASSAY; CELL CULTURE; CELL GROWTH; CELL LYSATE; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MICROARRAY ANALYSIS; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; WOUND HEALING;

HEPATOCELLULAR CARCINOMA (HCC); MAPK PHOSPHATASE (MKP); MICRORNA (MIRNA); MIGRATION; P38 MAPK; POLYCYCLIC AROMATIC HYDROCARBONS (PAHS);

BENZ(A)ANTHRACENES; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; DUAL-SPECIFICITY PHOSPHATASES; FLUORENES; HEP G2 CELLS; HUMANS; LIVER; LIVER NEOPLASMS; MICRORNAS; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; UP-REGULATION;

EID: 84884725701     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.08.016     Document Type: Article

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