-
1
-
-
79960205374
-
ESC/EAS Guidelines for the management of dyslipidaemias the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
-
Catapano AL, Reiner Z, De Backer G, et al. ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Atherosclerosis 2011;217:3-46
-
(2011)
Atherosclerosis
, vol.217
, pp. 3-46
-
-
Catapano, A.L.1
Reiner, Z.2
De Backer, G.3
-
2
-
-
84897970506
-
2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the american college of cardiology/American Heart Association task force on practice guidelines
-
Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: a Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014;129:S1-S45
-
(2014)
Circulation
, vol.129
, pp. S1-S45
-
-
Stone, N.J.1
Robinson, J.G.2
Lichtenstein, A.H.3
-
3
-
-
84860383419
-
The biology and therapeutic targeting of the proprotein convertases
-
Seidah NG, Prat A. The biology and therapeutic targeting of the proprotein convertases. Nat Rev Drug Discov 2012;11:367-83
-
(2012)
Nat Rev Drug Discov
, Issue.11
, pp. 367-383
-
-
Seidah, N.G.1
Prat, A.2
-
4
-
-
2342451128
-
Adenoviral-mediated expression of PCSK9 in mice results in a low-density lipoprotein receptor knockout phenotype
-
Maxwell KN, Breslow JL. Adenoviral-mediated expression of PCSK9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proc Natl Acad Sci USA 2004;101:7100-5
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 7100-7105
-
-
Maxwell, K.N.1
Breslow, J.L.2
-
5
-
-
9644266673
-
Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
-
Park SW, Moon YA, Horton JD. Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. J Biol Chem 2004;279:50630-8
-
(2004)
J Biol Chem
, vol.279
, pp. 50630-50638
-
-
Park, S.W.1
Moon, Y.A.2
Horton, J.D.3
-
7
-
-
0037603589
-
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
-
Abifadel M, Varret M, Rabes JP, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 2003;34:154-6
-
(2003)
Nat Genet
, vol.34
, pp. 154-156
-
-
Abifadel, M.1
Varret, M.2
Rabes, J.P.3
-
8
-
-
13944265645
-
Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
-
Cohen J, Pertsemlidis A, Kotowski IK, et al. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 2005;37:161-5
-
(2005)
Nat Genet
, vol.37
, pp. 161-165
-
-
Cohen, J.1
Pertsemlidis, A.2
Kotowski, I.K.3
-
9
-
-
84875055214
-
PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells
-
Levy E, Ben Djoudi Ouadda A, Spahis S, et al. PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells. Atherosclerosis 2013;227:297-306
-
(2013)
Atherosclerosis
, vol.227
, pp. 297-306
-
-
Levy, E.1
Ben Djoudi Ouadda, A.2
Spahis, S.3
-
10
-
-
77649274263
-
PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
-
Mbikay M, Sirois F, Mayne J, et al. PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. FEBS Lett 2010;584:701-6
-
(2010)
FEBS Lett
, vol.584
, pp. 701-706
-
-
Mbikay, M.1
Sirois, F.2
Mayne, J.3
-
11
-
-
84881238159
-
The multifaceted proprotein convertases: Their unique, redundant, complementary, and opposite functions
-
Seidah NG, Sadr MS, Chretien M, Mbikay M. The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. J Biol Chem 2013;288:21473-81
-
(2013)
J Biol Chem
, vol.288
, pp. 21473-21481
-
-
Seidah, N.G.1
Sadr, M.S.2
Chretien, M.3
Mbikay, M.4
-
12
-
-
79957793377
-
The role of proprotein convertase subtilisin/kexin type 9 in hyperlipidemia: Focus on therapeutic implications
-
Farnier M. The role of proprotein convertase subtilisin/kexin type 9 in hyperlipidemia: focus on therapeutic implications. Am J Cardiovasc Drugs 2011;11:145-52
-
(2011)
Am J Cardiovasc Drugs
, vol.11
, pp. 145-152
-
-
Farnier, M.1
-
13
-
-
84895075938
-
PCSK9: From discovery to therapeutic applications
-
Farnier M. PCSK9: from discovery to therapeutic applications. Arch Cardiovasc Dis 2014;107:58-66
-
(2014)
Arch Cardiovasc Dis
, vol.107
, pp. 58-66
-
-
Farnier, M.1
-
14
-
-
84873927641
-
Anti-PCSK9 therapies for the treatment of hypercholesterolemia
-
Hooper AJ, Burnett JR. Anti-PCSK9 therapies for the treatment of hypercholesterolemia. Expert Opin Biol Ther 2013;13:429-35
-
(2013)
Expert Opin Biol Ther
, vol.13
, pp. 429-435
-
-
Hooper, A.J.1
Burnett, J.R.2
-
15
-
-
50149101511
-
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
-
Frank-Kamenetsky M, Grefhorst A, Anderson NN, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci USA 2008;105:11915-20
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 11915-11920
-
-
Frank-Kamenetsky, M.1
Grefhorst, A.2
Anderson, N.N.3
-
16
-
-
34147136507
-
Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
-
Graham MJ, Lemonidis KM, Whipple CP, et al. Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice. J Lipid Res 2007;48:763-7
-
(2007)
J Lipid Res
, vol.48
, pp. 763-767
-
-
Graham, M.J.1
Lemonidis, K.M.2
Whipple, C.P.3
-
17
-
-
84876801739
-
The safety of therapeutic monoclonal antibodies: Implications for cardiovascular disease and targeting the PCSK9 pathway
-
Catapano AL, Papadopoulos N. The safety of therapeutic monoclonal antibodies: implications for cardiovascular disease and targeting the PCSK9 pathway. Atherosclerosis 2013;228:18-28
-
(2013)
Atherosclerosis
, vol.228
, pp. 18-28
-
-
Catapano, A.L.1
Papadopoulos, N.2
-
18
-
-
84909960850
-
Proprotein convertase subtilisin/Kexin 9 inhibitors: An emerging lipid-lowering therapy?
-
[Epub ahead of print]
-
Dragan S, Serban MC, Banach M. Proprotein convertase subtilisin/Kexin 9 inhibitors: an emerging lipid-lowering therapy? J Cardiovasc Pharmacol Ther 2014. [Epub ahead of print]
-
(2014)
J Cardiovasc Pharmacol Ther
-
-
Dragan, S.1
Serban, M.C.2
Banach, M.3
-
19
-
-
84871975694
-
PCSK9 inhibition-a novel mechanism to treat lipid disorders?
-
Banach M, Rizzo M, Obradovic M, et al. PCSK9 inhibition-a novel mechanism to treat lipid disorders? Curr Pharm Des 2013;19:3869-77.
-
(2013)
Curr Pharm des
, vol.19
, pp. 3869-3877
-
-
Banach, M.1
Rizzo, M.2
Obradovic, M.3
-
20
-
-
84892741671
-
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: A randomised, single-blind, placebo-controlled, phase 1 trial
-
Fitzgerald K, Frank-Kamenetsky M, Shulga-Morskaya S, et al. Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial. Lancet 2014;383:60-8
-
(2014)
Lancet
, Issue.383
, pp. 60-68
-
-
Fitzgerald, K.1
Frank-Kamenetsky, M.2
Shulga-Morskaya, S.3
-
21
-
-
67649834056
-
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
-
Chan JC, Piper DE, Cao Q, et al. A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci USA 2009;106:9820-5
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 9820-9825
-
-
Chan, J.C.1
Piper, D.E.2
Cao, Q.3
-
22
-
-
78650904300
-
A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo
-
Ni YG, Di Marco S, Condra JH, et al. A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo. J Lipid Res 2011;52:78-86
-
(2011)
J Lipid Res
, vol.52
, pp. 78-86
-
-
Ni, Y.G.1
Di Marco, S.2
Condra, J.H.3
-
23
-
-
84871592782
-
Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver
-
Sun X, Essalmani R, Day R, et al. Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver. Neoplasia 2012;14:1122-31
-
(2012)
Neoplasia
, vol.14
, pp. 1122-1131
-
-
Sun, X.1
Essalmani, R.2
Day, R.3
-
24
-
-
84868206496
-
Effects of AMG 145 on lowdensity lipoprotein cholesterol levels: Results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins
-
Dias CS, Shaywitz AJ, Wasserman SM, et al. Effects of AMG 145 on lowdensity lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins. J Am Coll Cardiol 2012;60:1888-98
-
(2012)
J Am Coll Cardiol
, vol.60
, pp. 1888-1898
-
-
Dias, C.S.1
Shaywitz, A.J.2
Wasserman, S.M.3
-
25
-
-
84858638369
-
Effect of a. Monoclonal antibody to PCSK9 on LDL cholesterol
-
Stein EA, Mellis S, Yancopoulos GD, et al. Effect of a. monoclonal antibody to PCSK9 on LDL cholesterol. N Engl J Med 2012;366:1108-18
-
(2012)
N Engl J Med
, vol.366
, pp. 1108-1118
-
-
Stein, E.A.1
Mellis, S.2
Yancopoulos, G.D.3
-
26
-
-
84892679366
-
Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial
-
Koren MJ, Giugliano RP, Raal FJ, et al. Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial. Circulation 2014;129:234-43
-
(2014)
Circulation
, vol.129
, pp. 234-243
-
-
Koren, M.J.1
Giugliano, R.P.2
Raal, F.J.3
-
27
-
-
84870494510
-
Efficacy, safety, and tolerability of a. Monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): A randomised, double-blind, placebocontrolled, phase 2 study
-
Koren MJ, Scott R, Kim JB, et al. Efficacy, safety, and tolerability of a. monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebocontrolled, phase 2 study. Lancet 2012;380:1995-2006
-
(2012)
Lancet
, vol.380
, pp. 1995-2006
-
-
Koren, M.J.1
Scott, R.2
Kim, J.B.3
-
28
-
-
84871326497
-
Effect of a. Monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: The GAUSS randomized trial
-
Sullivan D, Olsson AG, Scott R, et al. Effect of a. monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial. JAMA 2012;308:2497-506
-
(2012)
JAMA
, vol.308
, pp. 2497-2506
-
-
Sullivan, D.1
Olsson, A.G.2
Scott, R.3
-
29
-
-
84869220345
-
Low-density lipoprotein cholesterollowering effects of AMG 145, a. Monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: The Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial
-
Raal F, Scott R, Somaratne R, et al. Low-density lipoprotein cholesterollowering effects of AMG 145, a. monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial. Circulation 2012;126:2408-17
-
(2012)
Circulation
, vol.126
, pp. 2408-2417
-
-
Raal, F.1
Scott, R.2
Somaratne, R.3
-
30
-
-
84870478439
-
Efficacy, safety, and tolerability of a mAb to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): A randomised, placebo-controlled, dose-ranging, phase 2 study
-
Giugliano RP, Desai NR, Kohli P, et al. Efficacy, safety, and tolerability of a mAb to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study. Lancet 2012;380:2007-17
-
(2012)
Lancet
, vol.380
, pp. 2007-2017
-
-
Giugliano, R.P.1
Desai, N.R.2
Kohli, P.3
-
31
-
-
84897471477
-
Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): A pooled analysis of more than 1,300 patients in 4 phase II trials
-
Raal FJ, Giugliano RP, Sabatine MS, et al. Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1,300 patients in 4 phase II trials. J Am Coll Cardiol 2014;63:1278-88
-
(2014)
J Am Coll Cardiol
, vol.63
, pp. 1278-1288
-
-
Raal, F.J.1
Giugliano, R.P.2
Sabatine, M.S.3
-
32
-
-
84862219022
-
Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
-
McKenney JM, Koren MJ, Kereiakes DJ, et al. Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol 2012;59:2344-53
-
(2012)
J Am Coll Cardiol
, vol.59
, pp. 2344-2353
-
-
McKenney, J.M.1
Koren, M.J.2
Kereiakes, D.J.3
-
33
-
-
84868689211
-
Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia
-
Roth EM, McKenney JM, Hanotin C, et al. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med 2012;367:1891-900
-
(2012)
N Engl J Med
, vol.367
, pp. 1891-1900
-
-
Roth, E.M.1
McKenney, J.M.2
Hanotin, C.3
-
34
-
-
84859510090
-
Increasing serum halflife and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9
-
Chaparro-Riggers J, Liang H, DeVay RM, et al. Increasing serum halflife and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9. J Biol Chem 2012;287:11090-7
-
(2012)
J Biol Chem
, vol.287
, pp. 11090-11097
-
-
Chaparro-Riggers, J.1
Liang, H.2
Devay, R.M.3
-
35
-
-
84898597389
-
Antihyperlipidemic therapies targeting PCSK9
-
Weinreich M, Frishman WH. Antihyperlipidemic therapies targeting PCSK9. Cardiol Rev 2014;22:140-6
-
(2014)
Cardiol Rev
, vol.22
, pp. 140-146
-
-
Weinreich, M.1
Frishman, W.H.2
-
36
-
-
84902157271
-
Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: The GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab
-
Stroes E, Colquhoun D, Sullivan D, et al. Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab. J Am Coll Cardiol 2014;63:2541-8
-
(2014)
J Am Coll Cardiol
, vol.63
, pp. 2541-2548
-
-
Stroes, E.1
Colquhoun, D.2
Sullivan, D.3
-
37
-
-
84900303213
-
Effect of evolocumab or ezetimibe added to moderate-or highintensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: The LAPLACE-2 randomized clinical trial
-
Robinson JG, Nedergaard BS, Rogers WJ, et al. Effect of evolocumab or ezetimibe added to moderate-or highintensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. JAMA 2014;311:1870-82
-
(2014)
JAMA
, vol.311
, pp. 1870-1882
-
-
Robinson, J.G.1
Nedergaard, B.S.2
Rogers, W.J.3
-
38
-
-
84921483643
-
PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): A randomised, double-blind, placebocontrolled trial
-
pii: S0140-6736(14)61399-4;
-
Raal FJ, Stein EA, Dufour R, et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebocontrolled trial. Lancet 2014;pii: S0140-6736(14)61399-4; doi: 10.1016/S0140-6736(14)61399-4
-
(2014)
Lancet
-
-
Raal, F.J.1
Stein, E.A.2
Dufour, R.3
-
39
-
-
84921459685
-
Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): A randomised, double-blind, placebocontrolled trial
-
pii: S0140-6736(14)61374-X
-
Raal FJ, Honarpour N, Blom DJ, et al. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebocontrolled trial. Lancet 2014;pii: S0140-6736(14)61374-X; doi: 10.1016/S0140-6736(14)61374-X
-
(2014)
Lancet
-
-
Raal, F.J.1
Honarpour, N.2
Blom, D.J.3
-
40
-
-
84899846576
-
A 52-week placebo-controlled trial of evolocumab in hyperlipidemia
-
Blom DJ, Hala T, Bolognese M, et al. A 52-week placebo-controlled trial of evolocumab in hyperlipidemia. N Engl J Med 2014;370:1809-19
-
(2014)
N Engl J Med
, vol.370
, pp. 1809-1819
-
-
Blom, D.J.1
Hala, T.2
Bolognese, M.3
-
41
-
-
84902142901
-
Anti-PCSK9 monotherapy for hypercholesterolemia: The MENDEL-2 randomized, controlled phase III clinical trial of evolocumab
-
Koren MJ, Lundqvist P, Bolognese M, et al. Anti-PCSK9 monotherapy for hypercholesterolemia: the MENDEL-2 randomized, controlled phase III clinical trial of evolocumab. J Am Coll Cardiol 2014;63:2531-40
-
(2014)
J Am Coll Cardiol
, vol.63
, pp. 2531-2540
-
-
Koren, M.J.1
Lundqvist, P.2
Bolognese, M.3
-
42
-
-
84906323762
-
Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: Results of a 24week, double-blind, randomized Phase 3 trial
-
Roth EM, Taskinen MR, Ginsberg HN, et al. Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: results of a 24week, double-blind, randomized Phase 3 trial. Int J Cardiol 2014;176(1):55-61
-
(2014)
Int J Cardiol
, vol.176
, Issue.1
, pp. 55-61
-
-
Roth, E.M.1
Taskinen, M.R.2
Ginsberg, H.N.3
-
43
-
-
84904472197
-
Safety and tolerability of injectable lipidlowering drugs: A review of available clinical data
-
Cicero AF, Tartagni E, Ertek S. Safety and tolerability of injectable lipidlowering drugs: a review of available clinical data. Expert Opin Drug Saf 2014;13:1023-30
-
(2014)
Expert Opin Drug Saf
, vol.13
, pp. 1023-1030
-
-
Cicero, A.F.1
Tartagni, E.2
Ertek, S.3
-
44
-
-
84863494422
-
Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy a phase 2 randomised controlled trial
-
Stein EA, Gipe D, Bergeron J, et al. Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy a phase 2 randomised controlled trial. Lancet 2012;380:29-36
-
(2012)
Lancet
, vol.380
, pp. 29-36
-
-
Stein, E.A.1
Gipe, D.2
Bergeron, J.3
-
45
-
-
33748661502
-
Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote
-
Zhao Z, Tuakli-Wosornu Y, Lagace TA, et al. Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote. Am J Hum Genet 2006;79:514-23
-
(2006)
Am J Hum Genet
, vol.79
, pp. 514-523
-
-
Zhao, Z.1
Tuakli-Wosornu, Y.2
Lagace, T.A.3
-
46
-
-
84895548648
-
Lomitapide and mipomersen: Two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia
-
Rader DJ, Kastelein JJ. Lomitapide and mipomersen: two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia. Circulation 2014;129:1022-32
-
(2014)
Circulation
, vol.129
, pp. 1022-1032
-
-
Rader, D.J.1
Kastelein, J.J.2
-
47
-
-
84883232230
-
AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein (a) in hypercholesterolemic patients receiving statin therapy: An analysis from the LDL-C Assessment with Proprotein Convertase Subtilisin Kexin Type 9 Monoclonal Antibody Inhibition Combined with Statin Therapy (LAPLACE)-Thrombolysis in Myocardial Infarction (TIMI) 57 trial
-
Desai NR, Kohli P, Giugliano RP, et al. AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein (a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-C Assessment with Proprotein Convertase Subtilisin Kexin Type 9 Monoclonal Antibody Inhibition Combined with Statin Therapy (LAPLACE)-Thrombolysis in Myocardial Infarction (TIMI) 57 trial. Circulation 2013;128:962-9
-
(2013)
Circulation
, vol.128
, pp. 962-969
-
-
Desai, N.R.1
Kohli, P.2
Giugliano, R.P.3
|